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PITX2 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol PITX2
Entrez Gene ID 5308
Full Name paired like homeodomain 2
Synonyms ARP1,ASGD4,Brx1,IDG2,IGDS,IGDS2,IHG2,IRID2,Otlx2,PTX2,RGS,RIEG,RIEG1,RS
General protein information
Preferred Names

paired like homeodomain 2

Names

pituitary homeobox 2
ALL1-responsive protein ARP1
all1-responsive gene 1
homeobox protein PITX2
paired-like homeodomain transcription factor 2
rieg bicoid-related homeobox transcription factor 1
solurshin

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

4

4q25

Summary This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Disorder MIM:

601542

Disorder Html: Axenfeld-Rieger syndrome, type 1, 180500 (3); Iridogoniodysgenesis,

mRNA and Protein(s)

mRNA Protein Name
XM_011532027.2 XP_011530329.1 pituitary homeobox 2 isoform X1
XM_011532027.1 XP_011530329.1 pituitary homeobox 2 isoform X2
NM_001204398.1 NP_001191327.1 pituitary homeobox 2 isoform b
NM_153427.2 NP_700476.1 pituitary homeobox 2 isoform a
NM_153426.2 NP_700475.1 pituitary homeobox 2 isoform b
NM_000325.5 NP_000316.2 pituitary homeobox 2 isoform c
NM_001204397.1 NP_001191326.1 pituitary homeobox 2 isoform b
NM_001204399.1 NP_001191328.1 pituitary homeobox 2 isoform a



Danio rerio (zebrafish) pitx2 NP_571050.1
Drosophila melanogaster (fruit fly) Ptx1 NP_733410.2
Macaca mulatta (rhesus monkey) PITX2 XP_001091288.1
Homo sapiens (human) PITX2 NP_000316.2
Pan troglodytes (chimpanzee) PITX2 XP_001141234.1
Canis lupus familiaris (dog) PITX2 XP_851370.1
Bos taurus (cattle) PITX2 NP_001091460.1
Mus musculus (house mouse) Pitx2 NP_001035967.1
Gallus gallus (chicken) PITX2 NP_990341.1
Xenopus tropicalis (tropical clawed frog) pitx2 NP_001017227.1
Rattus norvegicus (Norway rat) Pitx2 NP_001035970.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP000190 XP_310944.5


Related articles in PubMed

Novel PITX2 gene mutations in patients with Axenfeld-Rieger syndrome.
Seifi M, Footz T, Taylor SA, Elhady GM, Abdalla EM, Walter MA
Acta ophthalmologica94(7)e571-e579(2016 Nov)

Expression of CXCL6 and BBS5 that may be glaucoma relevant genes is regulated by PITX2.
Moazzeni H, Akbari MT, Yazdani S, Elahi E
Gene593(1)76-83(2016 Nov)

Prediction efficiency of PITX2 DNA methylation for prostate cancer survival.
Luan ZM, Zhang H, Qu XL
Genetics and molecular research : GMR15(2)(2016 Apr)

PANCR, the PITX2 Adjacent Noncoding RNA, Is Expressed in Human Left Atria and Regulates PITX2c Expression.
Gore-Panter SR, Hsu J, Barnard J, Moravec CS, Van Wagoner DR, Chung MK, Smith JD
Circulation. Arrhythmia and electrophysiology9(1)e003197(2016 Jan)


Holmes EE, Goltz D, Sailer V, Jung M, Meller S, Uhl B, Dietrich J, Röhler M, Ellinger J, Kristiansen G, Dietrich D
Clinical epigenetics8104(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings suggest ESR1 and PITX2 promoter methylation may be correlated with a worse survival of patients with breast cancer. The clinical utility of aberrantly methylated ESR1 and PITX2 could be a promising factor for the prognosis of breast cancer.
Title: Prognostic role of methylated GSTP1, p16, ESR1 and PITX2 in patients with breast cancer: A systematic meta-analysis under the guideline of PRISMA.

PITX2 methylation was significantly increased in tumor-positive biopsies and strongly correlated with International Society of Urological Pathology (ISUP) grade groups.
Title: PITX2 DNA Methylation as Biomarker for Individualized Risk Assessment of Prostate Cancer in Core Biopsies.

the atrial fibrillation (AF)-associated SNP rs2595104 altered PITX2c expression via interaction with TFAP2a; such a pathway could ultimately contribute to AF susceptibility at the PITX2 locus associated with AF
Title: A Functional Variant Associated with Atrial Fibrillation Regulates PITX2c Expression through TFAP2a.

The role of PITX2 in glaucoma may be mediated partly by regulating the expression of CXCL6 and BBS5 and thus affecting immune functions and intraocular pressure.
Title: Expression of CXCL6 and BBS5 that may be glaucoma relevant genes is regulated by PITX2.

Study showed that PITX3 and PITX2 were hypermethylated in prostate carcinomas (PCa) and significantly associated with established clinicopathologic parameters characteristic of PCa.

The following PITX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PITX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu17360 NM_000325.5
Latest version!
Homo sapiens paired like homeodomain 2 (PITX2), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
OHu17480 NM_153427.2
Latest version!
Homo sapiens paired like homeodomain 2 (PITX2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
OHu17480 NM_001204399.1
Latest version!
Homo sapiens paired like homeodomain 2 (PITX2), transcript variant 6, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
OHu17480 XM_011532027.2
Latest version!
Homo sapiens paired like homeodomain 2 (PITX2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
OHu17508 NM_153426.2
Latest version!
Homo sapiens paired like homeodomain 2 (PITX2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu17508 NM_001204398.1
Latest version!
Homo sapiens paired like homeodomain 2 (PITX2), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu17508 NM_001204397.1
Latest version!
Homo sapiens paired like homeodomain 2 (PITX2), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
View Old Accession Versions >>
OHu17480 XM_011532027.1 Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu17360
Clone ID Related Accession (Same CDS sequence) NM_000325.5
Accession Version NM_000325.5 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 975bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product pituitary homeobox 2 isoform c
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC017068.7 and BC013998.2. On Jul 24, 2007 this sequence version replaced NM_000325.4. Transcript Variant: This variant (3), also known as ARP1c, lacks several exons at the 5' end and has an alternate 5' exon, as compared to variant 2. The resulting isoform (c) has a longer and distinct N-terminus, as compared to isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013998.2, AK313987.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

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361
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661
721
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841
901
961
ATGAACTGCA TGAAAGGCCC GCTTCACTTG GAGCACCGAG CAGCGGGGAC CAAGCTGTCG 
GCCGTCTCCT CATCTTCCTG TCACCATCCC CAGCCGTTAG CCATGGCTTC GGTTCTGGCT
CCCGGTCAGC CCCGGTCGCT GGACTCCTCC AAGCACAGGC TGGAGGTGCA CACCATCTCC
GACACCTCCA GCCCGGAGGC CGCAGAGAAA GATAAAAGCC AGCAGGGGAA GAATGAGGAC
GTGGGCGCCG AGGACCCGTC TAAGAAGAAG CGGCAAAGGC GGCAGCGGAC TCACTTTACC
AGCCAGCAGC TCCAGGAGCT GGAGGCCACT TTCCAGAGGA ACCGCTACCC GGACATGTCC
ACACGCGAAG AAATCGCTGT GTGGACCAAC CTTACGGAAG CCCGAGTCCG GGTTTGGTTC
AAGAATCGTC GGGCCAAATG GAGAAAGAGG GAGCGCAACC AGCAGGCCGA GCTATGCAAG
AATGGCTTCG GGCCGCAGTT CAATGGGCTC ATGCAGCCCT ACGACGACAT GTACCCAGGC
TATTCCTACA ACAACTGGGC CGCCAAGGGC CTTACATCCG CCTCCCTATC CACCAAGAGC
TTCCCCTTCT TCAACTCTAT GAACGTCAAC CCCCTGTCAT CACAGAGCAT GTTTTCCCCA
CCCAACTCTA TCTCGTCCAT GAGCATGTCG TCCAGCATGG TGCCCTCAGC AGTGACAGGC
GTCCCGGGCT CCAGTCTCAA CAGCCTGAAT AACTTGAACA ACCTGAGTAG CCCGTCGCTG
AATTCCGCGG TGCCGACGCC TGCCTGTCCT TACGCGCCGC CGACTCCTCC GTATGTTTAT
AGGGACACGT GTAACTCGAG CCTGGCCAGC CTGAGACTGA AAGCAAAGCA GCACTCCAGC
TTCGGCTACG CCAGCGTGCA GAACCCGGCC TCCAACCTGA GTGCTTGCCA GTATGCAGTG
GACCGGCCCG TGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000316.2
CDS639..1613
Misc Feature(1)429..431
Misc Feature(2)810..812
Misc Feature(3)816..818
Misc Feature(4)822..824
Misc Feature(5)<825..1007
Misc Feature(6)825..827
Misc Feature(7)828..830
Misc Feature(8)order(915..929,933..935,984..986,1002..1004,1041..1043,1047..1052,1059..1064,1068..1076,1080..1085)
Misc Feature(9)order(921..923,930..932,1050..1052,1059..1064,1071..1073)
Misc Feature(10)924..1082
Misc Feature(11)1482..1535
Exon (1)1..843
Exon (2)844..1049
Exon (3)1050..2315
Translation

Target ORF information:

RefSeq Version NM_000325.5
Organism Homo sapiens(Human)
Definition Homo sapiens paired like homeodomain 2 (PITX2), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000325.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGAACTGCA TGAAAGGCCC GCTTCACTTG GAGCACCGAG CAGCGGGGAC CAAGCTGTCG 
GCCGTCTCCT CATCTTCCTG TCACCATCCC CAGCCGTTAG CCATGGCTTC GGTTCTGGCT
CCCGGTCAGC CCCGGTCGCT GGACTCCTCC AAGCACAGGC TGGAGGTGCA CACCATCTCC
GACACCTCCA GCCCGGAGGC CGCAGAGAAA GATAAAAGCC AGCAGGGGAA GAATGAGGAC
GTGGGCGCCG AGGACCCGTC TAAGAAGAAG CGGCAAAGGC GGCAGCGGAC TCACTTTACC
AGCCAGCAGC TCCAGGAGCT GGAGGCCACT TTCCAGAGGA ACCGCTACCC GGACATGTCC
ACACGCGAAG AAATCGCTGT GTGGACCAAC CTTACGGAAG CCCGAGTCCG GGTTTGGTTC
AAGAATCGTC GGGCCAAATG GAGAAAGAGG GAGCGCAACC AGCAGGCCGA GCTATGCAAG
AATGGCTTCG GGCCGCAGTT CAATGGGCTC ATGCAGCCCT ACGACGACAT GTACCCAGGC
TATTCCTACA ACAACTGGGC CGCCAAGGGC CTTACATCCG CCTCCCTATC CACCAAGAGC
TTCCCCTTCT TCAACTCTAT GAACGTCAAC CCCCTGTCAT CACAGAGCAT GTTTTCCCCA
CCCAACTCTA TCTCGTCCAT GAGCATGTCG TCCAGCATGG TGCCCTCAGC AGTGACAGGC
GTCCCGGGCT CCAGTCTCAA CAGCCTGAAT AACTTGAACA ACCTGAGTAG CCCGTCGCTG
AATTCCGCGG TGCCGACGCC TGCCTGTCCT TACGCGCCGC CGACTCCTCC GTATGTTTAT
AGGGACACGT GTAACTCGAG CCTGGCCAGC CTGAGACTGA AAGCAAAGCA GCACTCCAGC
TTCGGCTACG CCAGCGTGCA GAACCCGGCC TCCAACCTGA GTGCTTGCCA GTATGCAGTG
GACCGGCCCG TGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17480
Clone ID Related Accession (Same CDS sequence) XM_011532027.2 , XM_011532027.1 , NM_153427.2 , NM_001204399.1
Accession Version NM_153427.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 816bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product pituitary homeobox 2 isoform a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP372081.1, AK127829.1, BX380370.2, U69961.1 and BC106010.1. This sequence is a reference standard in the RefSeqGene project. On Mar 1, 2011 this sequence version replaced NM_153427.1. Transcript Variant: This variant (1), also known as ARP1a, lacks an in-frame exon in the 5' region, as compared to variant 2. The resulting isoform (a) lacks an internal segment, as compared to isoform b. Variants 1 and 6 encode the same isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: U69961.1, AF048720.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

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61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGACCA ACTGCCGCAA ACTGGTGTCG GCGTGTGTGC AATTAGAGAA AGATAAAAGC 
CAGCAGGGGA AGAATGAGGA CGTGGGCGCC GAGGACCCGT CTAAGAAGAA GCGGCAAAGG
CGGCAGCGGA CTCACTTTAC CAGCCAGCAG CTCCAGGAGC TGGAGGCCAC TTTCCAGAGG
AACCGCTACC CGGACATGTC CACACGCGAA GAAATCGCTG TGTGGACCAA CCTTACGGAA
GCCCGAGTCC GGGTTTGGTT CAAGAATCGT CGGGCCAAAT GGAGAAAGAG GGAGCGCAAC
CAGCAGGCCG AGCTATGCAA GAATGGCTTC GGGCCGCAGT TCAATGGGCT CATGCAGCCC
TACGACGACA TGTACCCAGG CTATTCCTAC AACAACTGGG CCGCCAAGGG CCTTACATCC
GCCTCCCTAT CCACCAAGAG CTTCCCCTTC TTCAACTCTA TGAACGTCAA CCCCCTGTCA
TCACAGAGCA TGTTTTCCCC ACCCAACTCT ATCTCGTCCA TGAGCATGTC GTCCAGCATG
GTGCCCTCAG CAGTGACAGG CGTCCCGGGC TCCAGTCTCA ACAGCCTGAA TAACTTGAAC
AACCTGAGTA GCCCGTCGCT GAATTCCGCG GTGCCGACGC CTGCCTGTCC TTACGCGCCG
CCGACTCCTC CGTATGTTTA TAGGGACACG TGTAACTCGA GCCTGGCCAG CCTGAGACTG
AAAGCAAAGC AGCACTCCAG CTTCGGCTAC GCCAGCGTGC AGAACCCGGC CTCCAACCTG
AGTGCTTGCC AGTATGCAGT GGACCGGCCC GTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_700476.1
CDS1590..2405
Misc Feature(1)1581..1583
Misc Feature(2)order(1707..1721,1725..1727,1776..1778,1794..1796,1833..1835,1839..1844,1851..1856,1860..1868,1872..1877)
Misc Feature(3)order(1713..1715,1722..1724,1842..1844,1851..1856,1863..1865)
Misc Feature(4)1716..1874
Misc Feature(5)2274..2327
Exon (1)1..205
Exon (2)206..1579
Exon (3)1580..1635
Exon (4)1636..1841
Exon (5)1842..3107
Translation

Target ORF information:

RefSeq Version NM_153427.2
Organism Homo sapiens(Human)
Definition Homo sapiens paired like homeodomain 2 (PITX2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_153427.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGACCA ACTGCCGCAA ACTGGTGTCG GCGTGTGTGC AATTAGAGAA AGATAAAAGC 
CAGCAGGGGA AGAATGAGGA CGTGGGCGCC GAGGACCCGT CTAAGAAGAA GCGGCAAAGG
CGGCAGCGGA CTCACTTTAC CAGCCAGCAG CTCCAGGAGC TGGAGGCCAC TTTCCAGAGG
AACCGCTACC CGGACATGTC CACACGCGAA GAAATCGCTG TGTGGACCAA CCTTACGGAA
GCCCGAGTCC GGGTTTGGTT CAAGAATCGT CGGGCCAAAT GGAGAAAGAG GGAGCGCAAC
CAGCAGGCCG AGCTATGCAA GAATGGCTTC GGGCCGCAGT TCAATGGGCT CATGCAGCCC
TACGACGACA TGTACCCAGG CTATTCCTAC AACAACTGGG CCGCCAAGGG CCTTACATCC
GCCTCCCTAT CCACCAAGAG CTTCCCCTTC TTCAACTCTA TGAACGTCAA CCCCCTGTCA
TCACAGAGCA TGTTTTCCCC ACCCAACTCT ATCTCGTCCA TGAGCATGTC GTCCAGCATG
GTGCCCTCAG CAGTGACAGG CGTCCCGGGC TCCAGTCTCA ACAGCCTGAA TAACTTGAAC
AACCTGAGTA GCCCGTCGCT GAATTCCGCG GTGCCGACGC CTGCCTGTCC TTACGCGCCG
CCGACTCCTC CGTATGTTTA TAGGGACACG TGTAACTCGA GCCTGGCCAG CCTGAGACTG
AAAGCAAAGC AGCACTCCAG CTTCGGCTAC GCCAGCGTGC AGAACCCGGC CTCCAACCTG
AGTGCTTGCC AGTATGCAGT GGACCGGCCC GTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17480
Clone ID Related Accession (Same CDS sequence) XM_011532027.2 , XM_011532027.1 , NM_153427.2 , NM_001204399.1
Accession Version NM_001204399.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 816bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product pituitary homeobox 2 isoform a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP372081.1 and BC106010.1. Transcript Variant: This variant (6) lacks an exon in the 5' UTR and an in-frame exon in the 5' CDS, as compared to variant 2. The resulting isoform (a) lacks an internal segment, as compared to isoform b. Variants 1 and 6 encode the same isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM706464.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2149398 [ECO:0000348] ##Evidence-Data-END##

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61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGACCA ACTGCCGCAA ACTGGTGTCG GCGTGTGTGC AATTAGAGAA AGATAAAAGC 
CAGCAGGGGA AGAATGAGGA CGTGGGCGCC GAGGACCCGT CTAAGAAGAA GCGGCAAAGG
CGGCAGCGGA CTCACTTTAC CAGCCAGCAG CTCCAGGAGC TGGAGGCCAC TTTCCAGAGG
AACCGCTACC CGGACATGTC CACACGCGAA GAAATCGCTG TGTGGACCAA CCTTACGGAA
GCCCGAGTCC GGGTTTGGTT CAAGAATCGT CGGGCCAAAT GGAGAAAGAG GGAGCGCAAC
CAGCAGGCCG AGCTATGCAA GAATGGCTTC GGGCCGCAGT TCAATGGGCT CATGCAGCCC
TACGACGACA TGTACCCAGG CTATTCCTAC AACAACTGGG CCGCCAAGGG CCTTACATCC
GCCTCCCTAT CCACCAAGAG CTTCCCCTTC TTCAACTCTA TGAACGTCAA CCCCCTGTCA
TCACAGAGCA TGTTTTCCCC ACCCAACTCT ATCTCGTCCA TGAGCATGTC GTCCAGCATG
GTGCCCTCAG CAGTGACAGG CGTCCCGGGC TCCAGTCTCA ACAGCCTGAA TAACTTGAAC
AACCTGAGTA GCCCGTCGCT GAATTCCGCG GTGCCGACGC CTGCCTGTCC TTACGCGCCG
CCGACTCCTC CGTATGTTTA TAGGGACACG TGTAACTCGA GCCTGGCCAG CCTGAGACTG
AAAGCAAAGC AGCACTCCAG CTTCGGCTAC GCCAGCGTGC AGAACCCGGC CTCCAACCTG
AGTGCTTGCC AGTATGCAGT GGACCGGCCC GTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001191328.1
CDS216..1031
Misc Feature(1)207..209
Misc Feature(2)order(333..347,351..353,402..404,420..422,459..461,465..470,477..482,486..494,498..503)
Misc Feature(3)order(339..341,348..350,468..470,477..482,489..491)
Misc Feature(4)342..500
Misc Feature(5)900..953
Exon (1)1..205
Exon (2)206..261
Exon (3)262..467
Exon (4)468..1733
Translation

Target ORF information:

RefSeq Version NM_001204399.1
Organism Homo sapiens(Human)
Definition Homo sapiens paired like homeodomain 2 (PITX2), transcript variant 6, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001204399.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGACCA ACTGCCGCAA ACTGGTGTCG GCGTGTGTGC AATTAGAGAA AGATAAAAGC 
CAGCAGGGGA AGAATGAGGA CGTGGGCGCC GAGGACCCGT CTAAGAAGAA GCGGCAAAGG
CGGCAGCGGA CTCACTTTAC CAGCCAGCAG CTCCAGGAGC TGGAGGCCAC TTTCCAGAGG
AACCGCTACC CGGACATGTC CACACGCGAA GAAATCGCTG TGTGGACCAA CCTTACGGAA
GCCCGAGTCC GGGTTTGGTT CAAGAATCGT CGGGCCAAAT GGAGAAAGAG GGAGCGCAAC
CAGCAGGCCG AGCTATGCAA GAATGGCTTC GGGCCGCAGT TCAATGGGCT CATGCAGCCC
TACGACGACA TGTACCCAGG CTATTCCTAC AACAACTGGG CCGCCAAGGG CCTTACATCC
GCCTCCCTAT CCACCAAGAG CTTCCCCTTC TTCAACTCTA TGAACGTCAA CCCCCTGTCA
TCACAGAGCA TGTTTTCCCC ACCCAACTCT ATCTCGTCCA TGAGCATGTC GTCCAGCATG
GTGCCCTCAG CAGTGACAGG CGTCCCGGGC TCCAGTCTCA ACAGCCTGAA TAACTTGAAC
AACCTGAGTA GCCCGTCGCT GAATTCCGCG GTGCCGACGC CTGCCTGTCC TTACGCGCCG
CCGACTCCTC CGTATGTTTA TAGGGACACG TGTAACTCGA GCCTGGCCAG CCTGAGACTG
AAAGCAAAGC AGCACTCCAG CTTCGGCTAC GCCAGCGTGC AGAACCCGGC CTCCAACCTG
AGTGCTTGCC AGTATGCAGT GGACCGGCCC GTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17480
Clone ID Related Accession (Same CDS sequence) XM_011532027.2 , XM_011532027.1 , NM_153427.2 , NM_001204399.1
Accession Version XM_011532027.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 816bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product pituitary homeobox 2 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011532027.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGACCA ACTGCCGCAA ACTGGTGTCG GCGTGTGTGC AATTAGAGAA AGATAAAAGC 
CAGCAGGGGA AGAATGAGGA CGTGGGCGCC GAGGACCCGT CTAAGAAGAA GCGGCAAAGG
CGGCAGCGGA CTCACTTTAC CAGCCAGCAG CTCCAGGAGC TGGAGGCCAC TTTCCAGAGG
AACCGCTACC CGGACATGTC CACACGCGAA GAAATCGCTG TGTGGACCAA CCTTACGGAA
GCCCGAGTCC GGGTTTGGTT CAAGAATCGT CGGGCCAAAT GGAGAAAGAG GGAGCGCAAC
CAGCAGGCCG AGCTATGCAA GAATGGCTTC GGGCCGCAGT TCAATGGGCT CATGCAGCCC
TACGACGACA TGTACCCAGG CTATTCCTAC AACAACTGGG CCGCCAAGGG CCTTACATCC
GCCTCCCTAT CCACCAAGAG CTTCCCCTTC TTCAACTCTA TGAACGTCAA CCCCCTGTCA
TCACAGAGCA TGTTTTCCCC ACCCAACTCT ATCTCGTCCA TGAGCATGTC GTCCAGCATG
GTGCCCTCAG CAGTGACAGG CGTCCCGGGC TCCAGTCTCA ACAGCCTGAA TAACTTGAAC
AACCTGAGTA GCCCGTCGCT GAATTCCGCG GTGCCGACGC CTGCCTGTCC TTACGCGCCG
CCGACTCCTC CGTATGTTTA TAGGGACACG TGTAACTCGA GCCTGGCCAG CCTGAGACTG
AAAGCAAAGC AGCACTCCAG CTTCGGCTAC GCCAGCGTGC AGAACCCGGC CTCCAACCTG
AGTGCTTGCC AGTATGCAGT GGACCGGCCC GTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011530329.1
CDS1466..2281
Misc Feature(1)order(1583..1597,1601..1603,1652..1654,1670..1672,1709..1711,1715..1720,1727..1732,1736..1744,1748..1753)
Misc Feature(2)order(1589..1591,1598..1600,1718..1720,1727..1732,1739..1741)
Misc Feature(3)1592..1750
Misc Feature(4)2150..2203
Translation

Target ORF information:

RefSeq Version XM_011532027.2
Organism Homo sapiens(Human)
Definition Homo sapiens paired like homeodomain 2 (PITX2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011532027.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGACCA ACTGCCGCAA ACTGGTGTCG GCGTGTGTGC AATTAGAGAA AGATAAAAGC 
CAGCAGGGGA AGAATGAGGA CGTGGGCGCC GAGGACCCGT CTAAGAAGAA GCGGCAAAGG
CGGCAGCGGA CTCACTTTAC CAGCCAGCAG CTCCAGGAGC TGGAGGCCAC TTTCCAGAGG
AACCGCTACC CGGACATGTC CACACGCGAA GAAATCGCTG TGTGGACCAA CCTTACGGAA
GCCCGAGTCC GGGTTTGGTT CAAGAATCGT CGGGCCAAAT GGAGAAAGAG GGAGCGCAAC
CAGCAGGCCG AGCTATGCAA GAATGGCTTC GGGCCGCAGT TCAATGGGCT CATGCAGCCC
TACGACGACA TGTACCCAGG CTATTCCTAC AACAACTGGG CCGCCAAGGG CCTTACATCC
GCCTCCCTAT CCACCAAGAG CTTCCCCTTC TTCAACTCTA TGAACGTCAA CCCCCTGTCA
TCACAGAGCA TGTTTTCCCC ACCCAACTCT ATCTCGTCCA TGAGCATGTC GTCCAGCATG
GTGCCCTCAG CAGTGACAGG CGTCCCGGGC TCCAGTCTCA ACAGCCTGAA TAACTTGAAC
AACCTGAGTA GCCCGTCGCT GAATTCCGCG GTGCCGACGC CTGCCTGTCC TTACGCGCCG
CCGACTCCTC CGTATGTTTA TAGGGACACG TGTAACTCGA GCCTGGCCAG CCTGAGACTG
AAAGCAAAGC AGCACTCCAG CTTCGGCTAC GCCAGCGTGC AGAACCCGGC CTCCAACCTG
AGTGCTTGCC AGTATGCAGT GGACCGGCCC GTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17480
Clone ID Related Accession (Same CDS sequence) XM_011532027.2 , XM_011532027.1 , NM_153427.2 , NM_001204399.1
Accession Version XM_011532027.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 816bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-12
Organism Homo sapiens(Human)
Product pituitary homeobox 2 isoform X2
Comment

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGACCA ACTGCCGCAA ACTGGTGTCG GCGTGTGTGC AATTAGAGAA AGATAAAAGC 
CAGCAGGGGA AGAATGAGGA CGTGGGCGCC GAGGACCCGT CTAAGAAGAA GCGGCAAAGG
CGGCAGCGGA CTCACTTTAC CAGCCAGCAG CTCCAGGAGC TGGAGGCCAC TTTCCAGAGG
AACCGCTACC CGGACATGTC CACACGCGAA GAAATCGCTG TGTGGACCAA CCTTACGGAA
GCCCGAGTCC GGGTTTGGTT CAAGAATCGT CGGGCCAAAT GGAGAAAGAG GGAGCGCAAC
CAGCAGGCCG AGCTATGCAA GAATGGCTTC GGGCCGCAGT TCAATGGGCT CATGCAGCCC
TACGACGACA TGTACCCAGG CTATTCCTAC AACAACTGGG CCGCCAAGGG CCTTACATCC
GCCTCCCTAT CCACCAAGAG CTTCCCCTTC TTCAACTCTA TGAACGTCAA CCCCCTGTCA
TCACAGAGCA TGTTTTCCCC ACCCAACTCT ATCTCGTCCA TGAGCATGTC GTCCAGCATG
GTGCCCTCAG CAGTGACAGG CGTCCCGGGC TCCAGTCTCA ACAGCCTGAA TAACTTGAAC
AACCTGAGTA GCCCGTCGCT GAATTCCGCG GTGCCGACGC CTGCCTGTCC TTACGCGCCG
CCGACTCCTC CGTATGTTTA TAGGGACACG TGTAACTCGA GCCTGGCCAG CCTGAGACTG
AAAGCAAAGC AGCACTCCAG CTTCGGCTAC GCCAGCGTGC AGAACCCGGC CTCCAACCTG
AGTGCTTGCC AGTATGCAGT GGACCGGCCC GTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011530329.1
Translation

Target ORF information:

RefSeq Version XM_011532027.1
Organism Homo sapiens(Human)
Definition Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011532027.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGACCA ACTGCCGCAA ACTGGTGTCG GCGTGTGTGC AATTAGAGAA AGATAAAAGC 
CAGCAGGGGA AGAATGAGGA CGTGGGCGCC GAGGACCCGT CTAAGAAGAA GCGGCAAAGG
CGGCAGCGGA CTCACTTTAC CAGCCAGCAG CTCCAGGAGC TGGAGGCCAC TTTCCAGAGG
AACCGCTACC CGGACATGTC CACACGCGAA GAAATCGCTG TGTGGACCAA CCTTACGGAA
GCCCGAGTCC GGGTTTGGTT CAAGAATCGT CGGGCCAAAT GGAGAAAGAG GGAGCGCAAC
CAGCAGGCCG AGCTATGCAA GAATGGCTTC GGGCCGCAGT TCAATGGGCT CATGCAGCCC
TACGACGACA TGTACCCAGG CTATTCCTAC AACAACTGGG CCGCCAAGGG CCTTACATCC
GCCTCCCTAT CCACCAAGAG CTTCCCCTTC TTCAACTCTA TGAACGTCAA CCCCCTGTCA
TCACAGAGCA TGTTTTCCCC ACCCAACTCT ATCTCGTCCA TGAGCATGTC GTCCAGCATG
GTGCCCTCAG CAGTGACAGG CGTCCCGGGC TCCAGTCTCA ACAGCCTGAA TAACTTGAAC
AACCTGAGTA GCCCGTCGCT GAATTCCGCG GTGCCGACGC CTGCCTGTCC TTACGCGCCG
CCGACTCCTC CGTATGTTTA TAGGGACACG TGTAACTCGA GCCTGGCCAG CCTGAGACTG
AAAGCAAAGC AGCACTCCAG CTTCGGCTAC GCCAGCGTGC AGAACCCGGC CTCCAACCTG
AGTGCTTGCC AGTATGCAGT GGACCGGCCC GTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17508
Clone ID Related Accession (Same CDS sequence) NM_001204398.1 , NM_153426.2 , NM_001204397.1
Accession Version NM_001204398.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 954bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product pituitary homeobox 2 isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP372081.1 and BC106010.1. Transcript Variant: This variant (5) lacks an exon in the 5' UTR, as compared to variant 2. Variants 2, 4 and 5 encode the same isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX403546.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153307 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGAGACCA ACTGCCGCAA ACTGGTGTCG GCGTGTGTGC AATTAGGCGT GCAGCCGGCG 
GCCGTTGAAT GTCTCTTCTC CAAAGACTCC GAAATCAAAA AGGTCGAGTT CACGGACTCT
CCTGAGAGCC GAAAAGAGGC AGCCAGCAGC AAGTTCTTCC CGCGGCAGCA TCCTGGCGCC
AATGAGAAAG ATAAAAGCCA GCAGGGGAAG AATGAGGACG TGGGCGCCGA GGACCCGTCT
AAGAAGAAGC GGCAAAGGCG GCAGCGGACT CACTTTACCA GCCAGCAGCT CCAGGAGCTG
GAGGCCACTT TCCAGAGGAA CCGCTACCCG GACATGTCCA CACGCGAAGA AATCGCTGTG
TGGACCAACC TTACGGAAGC CCGAGTCCGG GTTTGGTTCA AGAATCGTCG GGCCAAATGG
AGAAAGAGGG AGCGCAACCA GCAGGCCGAG CTATGCAAGA ATGGCTTCGG GCCGCAGTTC
AATGGGCTCA TGCAGCCCTA CGACGACATG TACCCAGGCT ATTCCTACAA CAACTGGGCC
GCCAAGGGCC TTACATCCGC CTCCCTATCC ACCAAGAGCT TCCCCTTCTT CAACTCTATG
AACGTCAACC CCCTGTCATC ACAGAGCATG TTTTCCCCAC CCAACTCTAT CTCGTCCATG
AGCATGTCGT CCAGCATGGT GCCCTCAGCA GTGACAGGCG TCCCGGGCTC CAGTCTCAAC
AGCCTGAATA ACTTGAACAA CCTGAGTAGC CCGTCGCTGA ATTCCGCGGT GCCGACGCCT
GCCTGTCCTT ACGCGCCGCC GACTCCTCCG TATGTTTATA GGGACACGTG TAACTCGAGC
CTGGCCAGCC TGAGACTGAA AGCAAAGCAG CACTCCAGCT TCGGCTACGC CAGCGTGCAG
AACCCGGCCT CCAACCTGAG TGCTTGCCAG TATGCAGTGG ACCGGCCCGT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001191327.1
CDS216..1169
Misc Feature(1)207..209
Misc Feature(2)order(471..485,489..491,540..542,558..560,597..599,603..608,615..620,624..632,636..641)
Misc Feature(3)order(477..479,486..488,606..608,615..620,627..629)
Misc Feature(4)480..638
Misc Feature(5)483..485
Misc Feature(6)1038..1091
Misc Feature(7)1050..1091
Misc Feature(8)1068..1082
Exon (1)1..205
Exon (2)206..261
Exon (3)262..399
Exon (4)400..605
Exon (5)606..1871
Translation

Target ORF information:

RefSeq Version NM_001204398.1
Organism Homo sapiens(Human)
Definition Homo sapiens paired like homeodomain 2 (PITX2), transcript variant 5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001204398.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGAGACCA ACTGCCGCAA ACTGGTGTCG GCGTGTGTGC AATTAGGCGT GCAGCCGGCG 
GCCGTTGAAT GTCTCTTCTC CAAAGACTCC GAAATCAAAA AGGTCGAGTT CACGGACTCT
CCTGAGAGCC GAAAAGAGGC AGCCAGCAGC AAGTTCTTCC CGCGGCAGCA TCCTGGCGCC
AATGAGAAAG ATAAAAGCCA GCAGGGGAAG AATGAGGACG TGGGCGCCGA GGACCCGTCT
AAGAAGAAGC GGCAAAGGCG GCAGCGGACT CACTTTACCA GCCAGCAGCT CCAGGAGCTG
GAGGCCACTT TCCAGAGGAA CCGCTACCCG GACATGTCCA CACGCGAAGA AATCGCTGTG
TGGACCAACC TTACGGAAGC CCGAGTCCGG GTTTGGTTCA AGAATCGTCG GGCCAAATGG
AGAAAGAGGG AGCGCAACCA GCAGGCCGAG CTATGCAAGA ATGGCTTCGG GCCGCAGTTC
AATGGGCTCA TGCAGCCCTA CGACGACATG TACCCAGGCT ATTCCTACAA CAACTGGGCC
GCCAAGGGCC TTACATCCGC CTCCCTATCC ACCAAGAGCT TCCCCTTCTT CAACTCTATG
AACGTCAACC CCCTGTCATC ACAGAGCATG TTTTCCCCAC CCAACTCTAT CTCGTCCATG
AGCATGTCGT CCAGCATGGT GCCCTCAGCA GTGACAGGCG TCCCGGGCTC CAGTCTCAAC
AGCCTGAATA ACTTGAACAA CCTGAGTAGC CCGTCGCTGA ATTCCGCGGT GCCGACGCCT
GCCTGTCCTT ACGCGCCGCC GACTCCTCCG TATGTTTATA GGGACACGTG TAACTCGAGC
CTGGCCAGCC TGAGACTGAA AGCAAAGCAG CACTCCAGCT TCGGCTACGC CAGCGTGCAG
AACCCGGCCT CCAACCTGAG TGCTTGCCAG TATGCAGTGG ACCGGCCCGT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17508
Clone ID Related Accession (Same CDS sequence) NM_001204398.1 , NM_153426.2 , NM_001204397.1
Accession Version NM_153426.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 954bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product pituitary homeobox 2 isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP372081.1, AK127829.1, BX380370.2, U69961.1, BC106010.1 and BC013998.2. On or before Aug 31, 2013 this sequence version replaced XM_005263064.1, NM_153426.1. Transcript Variant: This variant (2), also known as ARP1b, encodes the predominant isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AF048721.1, AK127829.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGAGACCA ACTGCCGCAA ACTGGTGTCG GCGTGTGTGC AATTAGGCGT GCAGCCGGCG 
GCCGTTGAAT GTCTCTTCTC CAAAGACTCC GAAATCAAAA AGGTCGAGTT CACGGACTCT
CCTGAGAGCC GAAAAGAGGC AGCCAGCAGC AAGTTCTTCC CGCGGCAGCA TCCTGGCGCC
AATGAGAAAG ATAAAAGCCA GCAGGGGAAG AATGAGGACG TGGGCGCCGA GGACCCGTCT
AAGAAGAAGC GGCAAAGGCG GCAGCGGACT CACTTTACCA GCCAGCAGCT CCAGGAGCTG
GAGGCCACTT TCCAGAGGAA CCGCTACCCG GACATGTCCA CACGCGAAGA AATCGCTGTG
TGGACCAACC TTACGGAAGC CCGAGTCCGG GTTTGGTTCA AGAATCGTCG GGCCAAATGG
AGAAAGAGGG AGCGCAACCA GCAGGCCGAG CTATGCAAGA ATGGCTTCGG GCCGCAGTTC
AATGGGCTCA TGCAGCCCTA CGACGACATG TACCCAGGCT ATTCCTACAA CAACTGGGCC
GCCAAGGGCC TTACATCCGC CTCCCTATCC ACCAAGAGCT TCCCCTTCTT CAACTCTATG
AACGTCAACC CCCTGTCATC ACAGAGCATG TTTTCCCCAC CCAACTCTAT CTCGTCCATG
AGCATGTCGT CCAGCATGGT GCCCTCAGCA GTGACAGGCG TCCCGGGCTC CAGTCTCAAC
AGCCTGAATA ACTTGAACAA CCTGAGTAGC CCGTCGCTGA ATTCCGCGGT GCCGACGCCT
GCCTGTCCTT ACGCGCCGCC GACTCCTCCG TATGTTTATA GGGACACGTG TAACTCGAGC
CTGGCCAGCC TGAGACTGAA AGCAAAGCAG CACTCCAGCT TCGGCTACGC CAGCGTGCAG
AACCCGGCCT CCAACCTGAG TGCTTGCCAG TATGCAGTGG ACCGGCCCGT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_700475.1
CDS1590..2543
Misc Feature(1)1581..1583
Misc Feature(2)order(1845..1859,1863..1865,1914..1916,1932..1934,1971..1973,1977..1982,1989..1994,1998..2006,2010..2015)
Misc Feature(3)order(1851..1853,1860..1862,1980..1982,1989..1994,2001..2003)
Misc Feature(4)1854..2012
Misc Feature(5)1857..1859
Misc Feature(6)2412..2465
Misc Feature(7)2424..2465
Misc Feature(8)2442..2456
Exon (1)1..205
Exon (2)206..1579
Exon (3)1580..1635
Exon (4)1636..1773
Exon (5)1774..1979
Exon (6)1980..3245
Translation

Target ORF information:

RefSeq Version NM_153426.2
Organism Homo sapiens(Human)
Definition Homo sapiens paired like homeodomain 2 (PITX2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_153426.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGAGACCA ACTGCCGCAA ACTGGTGTCG GCGTGTGTGC AATTAGGCGT GCAGCCGGCG 
GCCGTTGAAT GTCTCTTCTC CAAAGACTCC GAAATCAAAA AGGTCGAGTT CACGGACTCT
CCTGAGAGCC GAAAAGAGGC AGCCAGCAGC AAGTTCTTCC CGCGGCAGCA TCCTGGCGCC
AATGAGAAAG ATAAAAGCCA GCAGGGGAAG AATGAGGACG TGGGCGCCGA GGACCCGTCT
AAGAAGAAGC GGCAAAGGCG GCAGCGGACT CACTTTACCA GCCAGCAGCT CCAGGAGCTG
GAGGCCACTT TCCAGAGGAA CCGCTACCCG GACATGTCCA CACGCGAAGA AATCGCTGTG
TGGACCAACC TTACGGAAGC CCGAGTCCGG GTTTGGTTCA AGAATCGTCG GGCCAAATGG
AGAAAGAGGG AGCGCAACCA GCAGGCCGAG CTATGCAAGA ATGGCTTCGG GCCGCAGTTC
AATGGGCTCA TGCAGCCCTA CGACGACATG TACCCAGGCT ATTCCTACAA CAACTGGGCC
GCCAAGGGCC TTACATCCGC CTCCCTATCC ACCAAGAGCT TCCCCTTCTT CAACTCTATG
AACGTCAACC CCCTGTCATC ACAGAGCATG TTTTCCCCAC CCAACTCTAT CTCGTCCATG
AGCATGTCGT CCAGCATGGT GCCCTCAGCA GTGACAGGCG TCCCGGGCTC CAGTCTCAAC
AGCCTGAATA ACTTGAACAA CCTGAGTAGC CCGTCGCTGA ATTCCGCGGT GCCGACGCCT
GCCTGTCCTT ACGCGCCGCC GACTCCTCCG TATGTTTATA GGGACACGTG TAACTCGAGC
CTGGCCAGCC TGAGACTGAA AGCAAAGCAG CACTCCAGCT TCGGCTACGC CAGCGTGCAG
AACCCGGCCT CCAACCTGAG TGCTTGCCAG TATGCAGTGG ACCGGCCCGT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17508
Clone ID Related Accession (Same CDS sequence) NM_001204398.1 , NM_153426.2 , NM_001204397.1
Accession Version NM_001204397.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 954bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product pituitary homeobox 2 isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP372081.1, AK127829.1, BX380370.2, U69961.1 and BC106010.1. Transcript Variant: This variant (4) has an additional exon in the 5' UTR, as compared to variant 2. Variants 2, 4 and 5 encode the same isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK127829.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2153307 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGAGACCA ACTGCCGCAA ACTGGTGTCG GCGTGTGTGC AATTAGGCGT GCAGCCGGCG 
GCCGTTGAAT GTCTCTTCTC CAAAGACTCC GAAATCAAAA AGGTCGAGTT CACGGACTCT
CCTGAGAGCC GAAAAGAGGC AGCCAGCAGC AAGTTCTTCC CGCGGCAGCA TCCTGGCGCC
AATGAGAAAG ATAAAAGCCA GCAGGGGAAG AATGAGGACG TGGGCGCCGA GGACCCGTCT
AAGAAGAAGC GGCAAAGGCG GCAGCGGACT CACTTTACCA GCCAGCAGCT CCAGGAGCTG
GAGGCCACTT TCCAGAGGAA CCGCTACCCG GACATGTCCA CACGCGAAGA AATCGCTGTG
TGGACCAACC TTACGGAAGC CCGAGTCCGG GTTTGGTTCA AGAATCGTCG GGCCAAATGG
AGAAAGAGGG AGCGCAACCA GCAGGCCGAG CTATGCAAGA ATGGCTTCGG GCCGCAGTTC
AATGGGCTCA TGCAGCCCTA CGACGACATG TACCCAGGCT ATTCCTACAA CAACTGGGCC
GCCAAGGGCC TTACATCCGC CTCCCTATCC ACCAAGAGCT TCCCCTTCTT CAACTCTATG
AACGTCAACC CCCTGTCATC ACAGAGCATG TTTTCCCCAC CCAACTCTAT CTCGTCCATG
AGCATGTCGT CCAGCATGGT GCCCTCAGCA GTGACAGGCG TCCCGGGCTC CAGTCTCAAC
AGCCTGAATA ACTTGAACAA CCTGAGTAGC CCGTCGCTGA ATTCCGCGGT GCCGACGCCT
GCCTGTCCTT ACGCGCCGCC GACTCCTCCG TATGTTTATA GGGACACGTG TAACTCGAGC
CTGGCCAGCC TGAGACTGAA AGCAAAGCAG CACTCCAGCT TCGGCTACGC CAGCGTGCAG
AACCCGGCCT CCAACCTGAG TGCTTGCCAG TATGCAGTGG ACCGGCCCGT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001191326.1
CDS1824..2777
Misc Feature(1)1815..1817
Misc Feature(2)order(2079..2093,2097..2099,2148..2150,2166..2168,2205..2207,2211..2216,2223..2228,2232..2240,2244..2249)
Misc Feature(3)order(2085..2087,2094..2096,2214..2216,2223..2228,2235..2237)
Misc Feature(4)2088..2246
Misc Feature(5)2091..2093
Misc Feature(6)2646..2699
Misc Feature(7)2658..2699
Misc Feature(8)2676..2690
Exon (1)1..205
Exon (2)206..1579
Exon (3)1580..1813
Exon (4)1814..1869
Exon (5)1870..2007
Exon (6)2008..2213
Exon (7)2214..3479
Translation

Target ORF information:

RefSeq Version NM_001204397.1
Organism Homo sapiens(Human)
Definition Homo sapiens paired like homeodomain 2 (PITX2), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001204397.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGAGACCA ACTGCCGCAA ACTGGTGTCG GCGTGTGTGC AATTAGGCGT GCAGCCGGCG 
GCCGTTGAAT GTCTCTTCTC CAAAGACTCC GAAATCAAAA AGGTCGAGTT CACGGACTCT
CCTGAGAGCC GAAAAGAGGC AGCCAGCAGC AAGTTCTTCC CGCGGCAGCA TCCTGGCGCC
AATGAGAAAG ATAAAAGCCA GCAGGGGAAG AATGAGGACG TGGGCGCCGA GGACCCGTCT
AAGAAGAAGC GGCAAAGGCG GCAGCGGACT CACTTTACCA GCCAGCAGCT CCAGGAGCTG
GAGGCCACTT TCCAGAGGAA CCGCTACCCG GACATGTCCA CACGCGAAGA AATCGCTGTG
TGGACCAACC TTACGGAAGC CCGAGTCCGG GTTTGGTTCA AGAATCGTCG GGCCAAATGG
AGAAAGAGGG AGCGCAACCA GCAGGCCGAG CTATGCAAGA ATGGCTTCGG GCCGCAGTTC
AATGGGCTCA TGCAGCCCTA CGACGACATG TACCCAGGCT ATTCCTACAA CAACTGGGCC
GCCAAGGGCC TTACATCCGC CTCCCTATCC ACCAAGAGCT TCCCCTTCTT CAACTCTATG
AACGTCAACC CCCTGTCATC ACAGAGCATG TTTTCCCCAC CCAACTCTAT CTCGTCCATG
AGCATGTCGT CCAGCATGGT GCCCTCAGCA GTGACAGGCG TCCCGGGCTC CAGTCTCAAC
AGCCTGAATA ACTTGAACAA CCTGAGTAGC CCGTCGCTGA ATTCCGCGGT GCCGACGCCT
GCCTGTCCTT ACGCGCCGCC GACTCCTCCG TATGTTTATA GGGACACGTG TAACTCGAGC
CTGGCCAGCC TGAGACTGAA AGCAAAGCAG CACTCCAGCT TCGGCTACGC CAGCGTGCAG
AACCCGGCCT CCAACCTGAG TGCTTGCCAG TATGCAGTGG ACCGGCCCGT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Novel PITX2 gene mutations in patients with Axenfeld-Rieger syndrome.
Acta ophthalmologica94(7)e571-e579(2016 Nov)
Seifi M,Footz T,Taylor SA,Elhady GM,Abdalla EM,Walter MA


book

Expression of CXCL6 and BBS5 that may be glaucoma relevant genes is regulated by PITX2.
Gene593(1)76-83(2016 Nov)
Moazzeni H,Akbari MT,Yazdani S,Elahi E


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Prediction efficiency of PITX2 DNA methylation for prostate cancer survival.
Genetics and molecular research : GMR15(2)(2016 Apr)
Luan ZM,Zhang H,Qu XL


book

PANCR, the PITX2 Adjacent Noncoding RNA, Is Expressed in Human Left Atria and Regulates PITX2c Expression.
Circulation. Arrhythmia and electrophysiology9(1)e003197(2016 Jan)
Gore-Panter SR,Hsu J,Barnard J,Moravec CS,Van Wagoner DR,Chung MK,Smith JD


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Clinical epigenetics8104(2016)
Holmes EE,Goltz D,Sailer V,Jung M,Meller S,Uhl B,Dietrich J,Röhler M,Ellinger J,Kristiansen G,Dietrich D


 
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