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PML cDNA ORF clone, Homo sapiens (human)

Gene Symbol PML
Entrez Gene ID 5371
Full Name promyelocytic leukemia
Synonyms MYL, PP8675, RNF71, TRIM19
General protein information
Preferred Names
protein PML
Names
protein PML
RING finger protein 71
promyelocytic leukemia protein
tripartite motif protein TRIM19
probable transcription factor PML
promyelocytic leukemia, inducer of
tripartite motif-containing protein 19
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q22

Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

102578

Disorder Html: Leukemia, acute promyelocytic, PML/RARA type (3)

mRNA and Protein(s)

mRNA Protein Name
NM_033246 NP_150249 protein PML isoform 7
NM_033239 NP_150242 protein PML isoform 9
NM_002675 NP_002666 protein PML isoform 6
NM_033247 NP_150250 protein PML isoform 8
NM_033240 NP_150243 protein PML isoform 2
NM_033250 NP_150253 protein PML isoform 11
NM_033244 NP_150247 protein PML isoform 5
NM_033238 NP_150241 protein PML isoform 1
NM_033249 NP_150252 protein PML isoform 10



Homo sapiens (human) PML NP_150241.2
Pan troglodytes (chimpanzee) PML NP_001035900.1
Macaca mulatta (Rhesus monkey) PML NP_001035899.1
Canis lupus familiaris (dog) PML XP_544766.4
Mus musculus (house mouse) Pml NP_835188.2
Rattus norvegicus (Norway rat) Pml XP_006243244.1
Gallus gallus (chicken) LOC100857563 XP_004943755.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PML gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PML cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu25542 NM_033246 Homo sapiens promyelocytic leukemia (PML), transcript variant 7, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu25586 NM_033239 Homo sapiens promyelocytic leukemia (PML), transcript variant 9, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $580.30
$829.00
OHu25484
NM_002675 Homo sapiens promyelocytic leukemia (PML), transcript variant 6, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu25346 NM_033247 Homo sapiens promyelocytic leukemia (PML), transcript variant 8, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu25497 NM_033240 Homo sapiens promyelocytic leukemia (PML), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $307.30
$439.00
OHu25441 NM_033250 Homo sapiens promyelocytic leukemia (PML), transcript variant 11, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $265.30
$379.00
OHu25457 NM_033244 Homo sapiens promyelocytic leukemia (PML), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $307.30
$439.00
OHu25455
NM_033238 Homo sapiens promyelocytic leukemia (PML), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$339.50-$475.30
$679.00
OHu25540
NM_033249 Homo sapiens promyelocytic leukemia (PML), transcript variant 10, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$219.50-$307.30
$439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25542
Clone ID Related Accession (Same CDS sequence) NM_033246
Accession Version NM_033246.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1272bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product protein PML isoform 7
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X63131.1 and BF510860.1. On or before Mar 4, 2006 this sequence version replaced gi:89039089, gi:89039091, gi:89039093, gi:15451774. Transcript Variant: This variant (7) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (7, also known as PML-6B, PML-VIB, TRIM19eta and TRIM19iota) has a distinct C-terminus and is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF230407.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGAGGAAC
GCGTTGTGGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_150249.1
CDS141..1412
Misc Feature(1)162..164(+)
Misc Feature(2)222..224(+)
Misc Feature(3)246..248(+)
Misc Feature(4)252..254(+)
Misc Feature(5)258..260(+)
Misc Feature(6)264..266(+)
Misc Feature(7)309..425(+)
Misc Feature(8)309..413(+)
Misc Feature(9)333..335(+)
Misc Feature(10)489..491(+)
Misc Feature(11)510..638(+)
Misc Feature(12)618..620(+)
Misc Feature(13)816..818(+)
Misc Feature(14)858..>1394(+)
Misc Feature(15)1320..1325(+)
Misc Feature(16)1347..1349(+)
Misc Feature(17)1365..1367(+)
Exon (1)1..269
Gene:PML
Gene Synonym:
Exon (2)270..742
Gene:PML
Gene Synonym:
Exon (3)743..1323
Gene:PML
Gene Synonym:
Exon (4)1324..1394
Gene:PML
Gene Synonym:
Exon (5)1395..1447
Gene:PML
Gene Synonym:
Exon (6)1448..1835
Gene:PML
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_033246
Organism Homo sapiens (human)
Definition Homo sapiens promyelocytic leukemia (PML), transcript variant 7, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_033246

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGAGGAAC
GCGTTGTGGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25586
Clone ID Related Accession (Same CDS sequence) NM_033239
Accession Version NM_033239.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2490bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product protein PML isoform 9
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X63131.1 and BC034251.1. On or before Jun 24, 2006 this sequence version replaced gi:67089161, gi:15451764. Transcript Variant: This variant (9) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (9, also known as PML-II and TRIM19kappa) contains a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF230403.1, AF230410.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCCCGAG
GAGGCAGAGA GAGTGAAGGC CCAGGTTCAG GCCCTGGGGC TGGCTGAAGC CCAGCCTATG
GCTGTGGTAC AGTCAGTGCC CGGGGCACAC CCCGTGCCAG TGTACGCCTT CTCCATCAAA
GGCCCTTCCT ATGGAGAGGA TGTCTCCAAT ACAACGACAG CCCAGAAGAG GAAGTGCAGC
CAGACCCAGT GCCCCAGGAA GGTCATCAAG ATGGAGTCTG AGGAGGGGAA GGAGGCAAGG
TTGGCTCGGA GCTCCCCGGA GCAGCCCAGG CCCAGCACCT CCAAGGCAGT CTCACCACCC
CACCTGGATG GACCGCCTAG CCCCAGGAGC CCCGTCATAG GAAGTGAGGT CTTCCTGCCC
AACAGCAACC ACGTGGCCAG TGGCGCCGGG GAGGCAGAGG AACGCGTTGT GGTGATCAGC
AGCTCGGAAG ACTCAGATGC CGAAAACTCG TGCATGGAGC CCATGGAGAC CGCCGAGCCA
CAGTCCTCGC CAGCCCACTC CTCGCCAGCC CACTCCTCGC CAGCCCACTC CTCGCCAGTC
CAGTCTCTGC TGAGAGCACA AGGAGCCTCC AGCCTGCCCT GTGGCACATA CCACCCCCCA
GCTTGGCCTC CCCACCAGCC CGCTGAGCAG GCTGCCACCC CCGATGCTGA GCCTCACAGC
GAGCCTCCTG ATCACCAGGA GCGCCCTGCC GTCCACCGTG GGATCCGCTA CCTGTTGTAC
AGAGCACAGA GAGCCATCCG CCTTCGCCAT GCCCTCCGCT TGCACCCTCA ATTGCATCGG
GCCCCTATTC GGACTTGGTC TCCCCATGTG GTCCAAGCCA GCACTCCTGC CATCACAGGG
CCCCTCAACC ATCCTGCCAA TGCCCAGGAA CATCCTGCCC AGCTGCAAAG GGGCATCAGC
CCACCCCACC GGATACGAGG GGCTGTGCGA TCCCGCAGCC GCTCCCTCCG GGGCTCCTCC
CATTTATCCC AGTGGCTCAA CAACTTTTTT GCCCTCCCCT TCTCCTCCAT GGCTTCCCAG
CTTGACATGT CTTCCGTGGT GGGGGCAGGG GAAAGCAGAG CCCAGACTCT TGGAGCAGGT
GTTCCCCCTG GGGACTCTGT CAGAGGCTCC ATGGAGGCCT CTCAAGTCCA AGTGCCTCTG
GAAGCCTCTC CAATTACATT CCCACCACCC TGTGCCCCAG AAAGGCCCCC CATCAGCCCA
GTCCCAGGCG CCCGTCAAGC AGGCCTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_150242.1
CDS141..2630
Misc Feature(1)162..164(+)
Misc Feature(2)222..224(+)
Misc Feature(3)246..248(+)
Misc Feature(4)252..254(+)
Misc Feature(5)258..260(+)
Misc Feature(6)264..266(+)
Misc Feature(7)309..425(+)
Misc Feature(8)309..413(+)
Misc Feature(9)333..335(+)
Misc Feature(10)489..491(+)
Misc Feature(11)510..638(+)
Misc Feature(12)618..620(+)
Misc Feature(13)816..818(+)
Misc Feature(14)858..1850(+)
Misc Feature(15)1320..1325(+)
Misc Feature(16)1347..1349(+)
Misc Feature(17)1347..1349(+)
Misc Feature(18)1365..1367(+)
Misc Feature(19)1482..1805(+)
Misc Feature(20)1566..1610(+)
Misc Feature(21)1599..1601(+)
Misc Feature(22)1608..1610(+)
Misc Feature(23)1650..1652(+)
Misc Feature(24)1653..1655(+)
Misc Feature(25)1653..1655(+)
Misc Feature(26)1656..>1937(+)
Misc Feature(27)1677..1679(+)
Misc Feature(28)1683..1685(+)
Misc Feature(29)1692..1694(+)
Misc Feature(30)1692..1694(+)
Misc Feature(31)1719..1721(+)
Misc Feature(32)1719..1721(+)
Misc Feature(33)1728..1730(+)
Misc Feature(34)1728..1730(+)
Misc Feature(35)1743..1745(+)
Misc Feature(36)1794..1799(+)
Misc Feature(37)1806..1826(+)
Misc Feature(38)1833..1835(+)
Exon (1)1..269
Gene:PML
Gene Synonym:
Exon (2)270..742
Gene:PML
Gene Synonym:
Exon (3)743..1323
Gene:PML
Gene Synonym:
Exon (4)1324..1394
Gene:PML
Gene Synonym:
Exon (5)1395..1538
Gene:PML
Gene Synonym:
Exon (6)1539..1797
Gene:PML
Gene Synonym:
Exon (7)1798..1850
Gene:PML
Gene Synonym:
Exon (8)1851..3073
Gene:PML
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_033239
Organism Homo sapiens (human)
Definition Homo sapiens promyelocytic leukemia (PML), transcript variant 9, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_033239

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCCCGAG
GAGGCAGAGA GAGTGAAGGC CCAGGTTCAG GCCCTGGGGC TGGCTGAAGC CCAGCCTATG
GCTGTGGTAC AGTCAGTGCC CGGGGCACAC CCCGTGCCAG TGTACGCCTT CTCCATCAAA
GGCCCTTCCT ATGGAGAGGA TGTCTCCAAT ACAACGACAG CCCAGAAGAG GAAGTGCAGC
CAGACCCAGT GCCCCAGGAA GGTCATCAAG ATGGAGTCTG AGGAGGGGAA GGAGGCAAGG
TTGGCTCGGA GCTCCCCGGA GCAGCCCAGG CCCAGCACCT CCAAGGCAGT CTCACCACCC
CACCTGGATG GACCGCCTAG CCCCAGGAGC CCCGTCATAG GAAGTGAGGT CTTCCTGCCC
AACAGCAACC ACGTGGCCAG TGGCGCCGGG GAGGCAGAGG AACGCGTTGT GGTGATCAGC
AGCTCGGAAG ACTCAGATGC CGAAAACTCG TGCATGGAGC CCATGGAGAC CGCCGAGCCA
CAGTCCTCGC CAGCCCACTC CTCGCCAGCC CACTCCTCGC CAGCCCACTC CTCGCCAGTC
CAGTCTCTGC TGAGAGCACA AGGAGCCTCC AGCCTGCCCT GTGGCACATA CCACCCCCCA
GCTTGGCCTC CCCACCAGCC CGCTGAGCAG GCTGCCACCC CCGATGCTGA GCCTCACAGC
GAGCCTCCTG ATCACCAGGA GCGCCCTGCC GTCCACCGTG GGATCCGCTA CCTGTTGTAC
AGAGCACAGA GAGCCATCCG CCTTCGCCAT GCCCTCCGCT TGCACCCTCA ATTGCATCGG
GCCCCTATTC GGACTTGGTC TCCCCATGTG GTCCAAGCCA GCACTCCTGC CATCACAGGG
CCCCTCAACC ATCCTGCCAA TGCCCAGGAA CATCCTGCCC AGCTGCAAAG GGGCATCAGC
CCACCCCACC GGATACGAGG GGCTGTGCGA TCCCGCAGCC GCTCCCTCCG GGGCTCCTCC
CATTTATCCC AGTGGCTCAA CAACTTTTTT GCCCTCCCCT TCTCCTCCAT GGCTTCCCAG
CTTGACATGT CTTCCGTGGT GGGGGCAGGG GAAAGCAGAG CCCAGACTCT TGGAGCAGGT
GTTCCCCCTG GGGACTCTGT CAGAGGCTCC ATGGAGGCCT CTCAAGTCCA AGTGCCTCTG
GAAGCCTCTC CAATTACATT CCCACCACCC TGTGCCCCAG AAAGGCCCCC CATCAGCCCA
GTCCCAGGCG CCCGTCAAGC AGGCCTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25484
Clone ID Related Accession (Same CDS sequence) NM_002675
Accession Version NM_002675.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1902bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product protein PML isoform 6
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X63131.1 and BF510860.1. On or before Sep 20, 2006 this sequence version replaced gi:113425704, gi:15451782. Transcript Variant: This variant (6) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (6, also known as PML-IV, PML-X and TRIM19zeta) contains a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X63131.1, AF230406.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCCCGAG
GAGGCAGAGA GAGTGAAGGC CCAGGTTCAG GCCCTGGGGC TGGCTGAAGC CCAGCCTATG
GCTGTGGTAC AGTCAGTGCC CGGGGCACAC CCCGTGCCAG TGTACGCCTT CTCCATCAAA
GGCCCTTCCT ATGGAGAGGA TGTCTCCAAT ACAACGACAG CCCAGAAGAG GAAGTGCAGC
CAGACCCAGT GCCCCAGGAA GGTCATCAAG ATGGAGTCTG AGGAGGGGAA GGAGGCAAGG
TTGGCTCGGA GCTCCCCGGA GCAGCCCAGG CCCAGCACCT CCAAGGCAGT CTCACCACCC
CACCTGGATG GACCGCCTAG CCCCAGGAGC CCCGTCATAG GAAGTGAGGT CTTCCTGCCC
AACAGCAACC ACGTGGCCAG TGGCGCCGGG GAGGCAGAGG AACGCGTTGT GGTGATCAGC
AGCTCGGAAG ACTCAGATGC CGAAAACTCG TCCTCCCGAG AGCTGGATGA CAGCAGCAGT
GAGTCCAGTG ACCTCCAGCT GGAAGGCCCC AGCACCCTCA GGGTCCTGGA CGAGAACCTT
GCTGACCCCC AAGCAGAAGA CAGACCTCTG GTTTTCTTTG ACCTCAAGAT TGACAATGAA
AGTGGGTTCT CCTGGGGCTA CCCCCACCCC TTTCTAATTT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002666.1
CDS141..2042
Misc Feature(1)162..164(+)
Misc Feature(2)222..224(+)
Misc Feature(3)246..248(+)
Misc Feature(4)252..254(+)
Misc Feature(5)258..260(+)
Misc Feature(6)264..266(+)
Misc Feature(7)309..425(+)
Misc Feature(8)309..413(+)
Misc Feature(9)333..335(+)
Misc Feature(10)489..491(+)
Misc Feature(11)510..638(+)
Misc Feature(12)618..620(+)
Misc Feature(13)816..818(+)
Misc Feature(14)858..1853(+)
Misc Feature(15)1320..1325(+)
Misc Feature(16)1347..1349(+)
Misc Feature(17)1347..1349(+)
Misc Feature(18)1365..1367(+)
Misc Feature(19)1482..1805(+)
Misc Feature(20)1566..1610(+)
Misc Feature(21)1599..1601(+)
Misc Feature(22)1608..1610(+)
Misc Feature(23)1650..1652(+)
Misc Feature(24)1653..1655(+)
Misc Feature(25)1653..1655(+)
Misc Feature(26)1677..1679(+)
Misc Feature(27)1683..1685(+)
Misc Feature(28)1692..1694(+)
Misc Feature(29)1692..1694(+)
Misc Feature(30)1719..1721(+)
Misc Feature(31)1719..1721(+)
Misc Feature(32)1728..1730(+)
Misc Feature(33)1728..1730(+)
Misc Feature(34)1743..1745(+)
Misc Feature(35)1794..1799(+)
Misc Feature(36)1806..1826(+)
Misc Feature(37)1818..1820(+)
Misc Feature(38)1821..1823(+)
Misc Feature(39)1824..1826(+)
Misc Feature(40)1833..1835(+)
Misc Feature(41)1833..1835(+)
Misc Feature(42)1872..1874(+)
Misc Feature(43)1875..1877(+)
Misc Feature(44)1878..1880(+)
Misc Feature(45)1884..1886(+)
Misc Feature(46)1887..1889(+)
Misc Feature(47)1986..1988(+)
Exon (1)1..269
Gene:PML
Gene Synonym:
Exon (2)270..742
Gene:PML
Gene Synonym:
Exon (3)743..1323
Gene:PML
Gene Synonym:
Exon (4)1324..1394
Gene:PML
Gene Synonym:
Exon (5)1395..1538
Gene:PML
Gene Synonym:
Exon (6)1539..1797
Gene:PML
Gene Synonym:
Exon (7)1798..1850
Gene:PML
Gene Synonym:
Exon (8)1851..2238
Gene:PML
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002675
Organism Homo sapiens (human)
Definition Homo sapiens promyelocytic leukemia (PML), transcript variant 6, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002675

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCCCGAG
GAGGCAGAGA GAGTGAAGGC CCAGGTTCAG GCCCTGGGGC TGGCTGAAGC CCAGCCTATG
GCTGTGGTAC AGTCAGTGCC CGGGGCACAC CCCGTGCCAG TGTACGCCTT CTCCATCAAA
GGCCCTTCCT ATGGAGAGGA TGTCTCCAAT ACAACGACAG CCCAGAAGAG GAAGTGCAGC
CAGACCCAGT GCCCCAGGAA GGTCATCAAG ATGGAGTCTG AGGAGGGGAA GGAGGCAAGG
TTGGCTCGGA GCTCCCCGGA GCAGCCCAGG CCCAGCACCT CCAAGGCAGT CTCACCACCC
CACCTGGATG GACCGCCTAG CCCCAGGAGC CCCGTCATAG GAAGTGAGGT CTTCCTGCCC
AACAGCAACC ACGTGGCCAG TGGCGCCGGG GAGGCAGAGG AACGCGTTGT GGTGATCAGC
AGCTCGGAAG ACTCAGATGC CGAAAACTCG TCCTCCCGAG AGCTGGATGA CAGCAGCAGT
GAGTCCAGTG ACCTCCAGCT GGAAGGCCCC AGCACCCTCA GGGTCCTGGA CGAGAACCTT
GCTGACCCCC AAGCAGAAGA CAGACCTCTG GTTTTCTTTG ACCTCAAGAT TGACAATGAA
AGTGGGTTCT CCTGGGGCTA CCCCCACCCC TTTCTAATTT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25346
Clone ID Related Accession (Same CDS sequence) NM_033247
Accession Version NM_033247.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1308bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product protein PML isoform 8
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X63131.1 and BC034251.1. On Jun 9, 2005 this sequence version replaced gi:15451776. Transcript Variant: This variant (8) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (8, also known as PML-VII and TRIM19theta) has a distinct C-terminus and is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF230408.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCTGCCT
CCTCCAGCCC ATGCTCTTAC AGGCCCTGCA CAGAGTAGCA CTCATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_150250.2
CDS141..1448
Misc Feature(1)162..164(+)
Misc Feature(2)222..224(+)
Misc Feature(3)246..248(+)
Misc Feature(4)252..254(+)
Misc Feature(5)258..260(+)
Misc Feature(6)264..266(+)
Misc Feature(7)309..425(+)
Misc Feature(8)309..413(+)
Misc Feature(9)333..335(+)
Misc Feature(10)489..491(+)
Misc Feature(11)510..638(+)
Misc Feature(12)618..620(+)
Misc Feature(13)816..818(+)
Misc Feature(14)858..>1394(+)
Misc Feature(15)1320..1325(+)
Misc Feature(16)1347..1349(+)
Misc Feature(17)1365..1367(+)
Exon (1)1..269
Gene:PML
Gene Synonym:
Exon (2)270..742
Gene:PML
Gene Synonym:
Exon (3)743..1323
Gene:PML
Gene Synonym:
Exon (4)1324..1394
Gene:PML
Gene Synonym:
Exon (5)1395..1782
Gene:PML
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_033247
Organism Homo sapiens (human)
Definition Homo sapiens promyelocytic leukemia (PML), transcript variant 8, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_033247

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCTGCCT
CCTCCAGCCC ATGCTCTTAC AGGCCCTGCA CAGAGTAGCA CTCATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25497
Clone ID Related Accession (Same CDS sequence) NM_033240
Accession Version NM_033240.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1836bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product protein PML isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X63131.1 and BX647287.1. On or before Jun 24, 2006 this sequence version replaced gi:67089158, gi:15451766. Transcript Variant: This variant (2) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (2, also known PML-2, PML-V and TRIM19beta) contains a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF230402.1, M79463.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCCCGAG
GAGGCAGAGA GAGTGAAGGC CCAGGTTCAG GCCCTGGGGC TGGCTGAAGC CCAGCCTATG
GCTGTGGTAC AGTCAGTGCC CGGGGCACAC CCCGTGCCAG TGTACGCCTT CTCCATCAAA
GGCCCTTCCT ATGGAGAGGA TGTCTCCAAT ACAACGACAG CCCAGAAGAG GAAGTGCAGC
CAGACCCAGT GCCCCAGGAA GGTCATCAAG ATGGAGTCTG AGGAGGGGAA GGAGGCAAGG
TTGGCTCGGA GCTCCCCGGA GCAGCCCAGG CCCAGCACCT CCAAGGCAGT CTCACCACCC
CACCTGGATG GACCGCCTAG CCCCAGGAGC CCCGTCATAG GAAGTGAGGT CTTCCTGCCC
AACAGCAACC ACGTGGCCAG TGGCGCCGGG GAGGCAGAGG AACGCGTTGT GGTGATCAGC
AGCTCGGAAG ACTCAGATGC CGAAAACTCG GTGAGTGGCC CAGAAGTTCA GCCCAGGACT
CCTGCCTCCC CCCATTTCAG GTCCCAGGGG GCACAGCCAC AGCAGGTGAC TCTCAGACTT
GCCTTGCGCC TGGGGAATTT TCCAGTGAGG CATTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_150243.2
CDS141..1976
Misc Feature(1)162..164(+)
Misc Feature(2)222..224(+)
Misc Feature(3)246..248(+)
Misc Feature(4)252..254(+)
Misc Feature(5)258..260(+)
Misc Feature(6)264..266(+)
Misc Feature(7)309..425(+)
Misc Feature(8)309..413(+)
Misc Feature(9)333..335(+)
Misc Feature(10)489..491(+)
Misc Feature(11)510..638(+)
Misc Feature(12)618..620(+)
Misc Feature(13)816..818(+)
Misc Feature(14)858..1850(+)
Misc Feature(15)1320..1325(+)
Misc Feature(16)1347..1349(+)
Misc Feature(17)1347..1349(+)
Misc Feature(18)1365..1367(+)
Misc Feature(19)1482..1805(+)
Misc Feature(20)1566..1610(+)
Misc Feature(21)1599..1601(+)
Misc Feature(22)1608..1610(+)
Misc Feature(23)1650..1652(+)
Misc Feature(24)1653..1655(+)
Misc Feature(25)1653..1655(+)
Misc Feature(26)1677..1679(+)
Misc Feature(27)1683..1685(+)
Misc Feature(28)1692..1694(+)
Misc Feature(29)1692..1694(+)
Misc Feature(30)1719..1721(+)
Misc Feature(31)1719..1721(+)
Misc Feature(32)1728..1730(+)
Misc Feature(33)1728..1730(+)
Misc Feature(34)1743..1745(+)
Misc Feature(35)1794..1799(+)
Misc Feature(36)1806..1826(+)
Misc Feature(37)1833..1835(+)
Exon (1)1..269
Gene:PML
Gene Synonym:
Exon (2)270..742
Gene:PML
Gene Synonym:
Exon (3)743..1323
Gene:PML
Gene Synonym:
Exon (4)1324..1394
Gene:PML
Gene Synonym:
Exon (5)1395..1538
Gene:PML
Gene Synonym:
Exon (6)1539..1797
Gene:PML
Gene Synonym:
Exon (7)1798..3714
Gene:PML
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_033240
Organism Homo sapiens (human)
Definition Homo sapiens promyelocytic leukemia (PML), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_033240

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCCCGAG
GAGGCAGAGA GAGTGAAGGC CCAGGTTCAG GCCCTGGGGC TGGCTGAAGC CCAGCCTATG
GCTGTGGTAC AGTCAGTGCC CGGGGCACAC CCCGTGCCAG TGTACGCCTT CTCCATCAAA
GGCCCTTCCT ATGGAGAGGA TGTCTCCAAT ACAACGACAG CCCAGAAGAG GAAGTGCAGC
CAGACCCAGT GCCCCAGGAA GGTCATCAAG ATGGAGTCTG AGGAGGGGAA GGAGGCAAGG
TTGGCTCGGA GCTCCCCGGA GCAGCCCAGG CCCAGCACCT CCAAGGCAGT CTCACCACCC
CACCTGGATG GACCGCCTAG CCCCAGGAGC CCCGTCATAG GAAGTGAGGT CTTCCTGCCC
AACAGCAACC ACGTGGCCAG TGGCGCCGGG GAGGCAGAGG AACGCGTTGT GGTGATCAGC
AGCTCGGAAG ACTCAGATGC CGAAAACTCG GTGAGTGGCC CAGAAGTTCA GCCCAGGACT
CCTGCCTCCC CCCATTTCAG GTCCCAGGGG GCACAGCCAC AGCAGGTGAC TCTCAGACTT
GCCTTGCGCC TGGGGAATTT TCCAGTGAGG CATTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25441
Clone ID Related Accession (Same CDS sequence) NM_033250
Accession Version NM_033250.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2346bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product protein PML isoform 11
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X63131.1 and BC034251.1. On Jun 9, 2005 this sequence version replaced gi:15451780. Transcript Variant: This variant (11) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (11, also known as PML-2A and PML-IIA) has a distinct C-terminus and is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000080.2, BT009911.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGGATGTC
TCCAATACAA CGACAGCCCA GAAGAGGAAG TGCAGCCAGA CCCAGTGCCC CAGGAAGGTC
ATCAAGATGG AGTCTGAGGA GGGGAAGGAG GCAAGGTTGG CTCGGAGCTC CCCGGAGCAG
CCCAGGCCCA GCACCTCCAA GGCAGTCTCA CCACCCCACC TGGATGGACC GCCTAGCCCC
AGGAGCCCCG TCATAGGAAG TGAGGTCTTC CTGCCCAACA GCAACCACGT GGCCAGTGGC
GCCGGGGAGG CAGAGGAACG CGTTGTGGTG ATCAGCAGCT CGGAAGACTC AGATGCCGAA
AACTCGTGCA TGGAGCCCAT GGAGACCGCC GAGCCACAGT CCTCGCCAGC CCACTCCTCG
CCAGCCCACT CCTCGCCAGC CCACTCCTCG CCAGTCCAGT CTCTGCTGAG AGCACAAGGA
GCCTCCAGCC TGCCCTGTGG CACATACCAC CCCCCAGCTT GGCCTCCCCA CCAGCCCGCT
GAGCAGGCTG CCACCCCCGA TGCTGAGCCT CACAGCGAGC CTCCTGATCA CCAGGAGCGC
CCTGCCGTCC ACCGTGGGAT CCGCTACCTG TTGTACAGAG CACAGAGAGC CATCCGCCTT
CGCCATGCCC TCCGCTTGCA CCCTCAATTG CATCGGGCCC CTATTCGGAC TTGGTCTCCC
CATGTGGTCC AAGCCAGCAC TCCTGCCATC ACAGGGCCCC TCAACCATCC TGCCAATGCC
CAGGAACATC CTGCCCAGCT GCAAAGGGGC ATCAGCCCAC CCCACCGGAT ACGAGGGGCT
GTGCGATCCC GCAGCCGCTC CCTCCGGGGC TCCTCCCATT TATCCCAGTG GCTCAACAAC
TTTTTTGCCC TCCCCTTCTC CTCCATGGCT TCCCAGCTTG ACATGTCTTC CGTGGTGGGG
GCAGGGGAAA GCAGAGCCCA GACTCTTGGA GCAGGTGTTC CCCCTGGGGA CTCTGTCAGA
GGCTCCATGG AGGCCTCTCA AGTCCAAGTG CCTCTGGAAG CCTCTCCAAT TACATTCCCA
CCACCCTGTG CCCCAGAAAG GCCCCCCATC AGCCCAGTCC CAGGCGCCCG TCAAGCAGGC
CTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_150253.2
CDS141..2486
Misc Feature(1)309..425(+)
Misc Feature(2)309..413(+)
Misc Feature(3)333..335(+)
Misc Feature(4)510..638(+)
Misc Feature(5)618..620(+)
Misc Feature(6)816..818(+)
Misc Feature(7)858..1706(+)
Misc Feature(8)1464..1466(+)
Misc Feature(9)1509..1511(+)
Misc Feature(10)1512..>1793(+)
Misc Feature(11)1533..1535(+)
Misc Feature(12)1548..1550(+)
Misc Feature(13)1575..1577(+)
Misc Feature(14)1584..1586(+)
Exon (1)1..269
Gene:PML
Gene Synonym:
Exon (2)270..742
Gene:PML
Gene Synonym:
Exon (3)743..1323
Gene:PML
Gene Synonym:
Exon (4)1324..1394
Gene:PML
Gene Synonym:
Exon (5)1395..1653
Gene:PML
Gene Synonym:
Exon (6)1654..1706
Gene:PML
Gene Synonym:
Exon (7)1707..2929
Gene:PML
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_033250
Organism Homo sapiens (human)
Definition Homo sapiens promyelocytic leukemia (PML), transcript variant 11, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_033250

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGGATGTC
TCCAATACAA CGACAGCCCA GAAGAGGAAG TGCAGCCAGA CCCAGTGCCC CAGGAAGGTC
ATCAAGATGG AGTCTGAGGA GGGGAAGGAG GCAAGGTTGG CTCGGAGCTC CCCGGAGCAG
CCCAGGCCCA GCACCTCCAA GGCAGTCTCA CCACCCCACC TGGATGGACC GCCTAGCCCC
AGGAGCCCCG TCATAGGAAG TGAGGTCTTC CTGCCCAACA GCAACCACGT GGCCAGTGGC
GCCGGGGAGG CAGAGGAACG CGTTGTGGTG ATCAGCAGCT CGGAAGACTC AGATGCCGAA
AACTCGTGCA TGGAGCCCAT GGAGACCGCC GAGCCACAGT CCTCGCCAGC CCACTCCTCG
CCAGCCCACT CCTCGCCAGC CCACTCCTCG CCAGTCCAGT CTCTGCTGAG AGCACAAGGA
GCCTCCAGCC TGCCCTGTGG CACATACCAC CCCCCAGCTT GGCCTCCCCA CCAGCCCGCT
GAGCAGGCTG CCACCCCCGA TGCTGAGCCT CACAGCGAGC CTCCTGATCA CCAGGAGCGC
CCTGCCGTCC ACCGTGGGAT CCGCTACCTG TTGTACAGAG CACAGAGAGC CATCCGCCTT
CGCCATGCCC TCCGCTTGCA CCCTCAATTG CATCGGGCCC CTATTCGGAC TTGGTCTCCC
CATGTGGTCC AAGCCAGCAC TCCTGCCATC ACAGGGCCCC TCAACCATCC TGCCAATGCC
CAGGAACATC CTGCCCAGCT GCAAAGGGGC ATCAGCCCAC CCCACCGGAT ACGAGGGGCT
GTGCGATCCC GCAGCCGCTC CCTCCGGGGC TCCTCCCATT TATCCCAGTG GCTCAACAAC
TTTTTTGCCC TCCCCTTCTC CTCCATGGCT TCCCAGCTTG ACATGTCTTC CGTGGTGGGG
GCAGGGGAAA GCAGAGCCCA GACTCTTGGA GCAGGTGTTC CCCCTGGGGA CTCTGTCAGA
GGCTCCATGG AGGCCTCTCA AGTCCAAGTG CCTCTGGAAG CCTCTCCAAT TACATTCCCA
CCACCCTGTG CCCCAGAAAG GCCCCCCATC AGCCCAGTCC CAGGCGCCCG TCAAGCAGGC
CTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25457
Clone ID Related Accession (Same CDS sequence) NM_033244
Accession Version NM_033244.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1683bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product protein PML isoform 5
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X63131.1, AF230405.1 and BC034251.1. On Jun 23, 2006 this sequence version replaced gi:67089163. Transcript Variant: This variant (5) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (5, also known as PML-3B, PML-VI and TRIM19epsilon) contains a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF230405.1, M80185.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCCCGAG
GAGGCAGAGA GAGTGAAGGC CCAGGTTCAG GCCCTGGGGC TGGCTGAAGC CCAGCCTATG
GCTGTGGTAC AGTCAGTGCC CGGGGCACAC CCCGTGCCAG TGTACGCCTT CTCCATCAAA
GGCCCTTCCT ATGGAGAGGA TGTCTCCAAT ACAACGACAG CCCAGAAGAG GAAGTGCAGC
CAGACCCAGT GCCCCAGGAA GGTCATCAAG ATGGAGTCTG AGGAGGGGAA GGAGGCAAGG
TTGGCTCGGA GCTCCCCGGA GCAGCCCAGG CCCAGCACCT CCAAGGCAGT CTCACCACCC
CACCTGGATG GACCGCCTAG CCCCAGGAGC CCCGTCATAG GAAGTGAGGT CTTCCTGCCC
AACAGCAACC ACGTGGCCAG TGGCGCCGGG GAGGCAGGTA GGGAGAGGAA CGCGTTGTGG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_150247.2
CDS141..1823
Misc Feature(1)162..164(+)
Misc Feature(2)222..224(+)
Misc Feature(3)246..248(+)
Misc Feature(4)252..254(+)
Misc Feature(5)258..260(+)
Misc Feature(6)264..266(+)
Misc Feature(7)309..425(+)
Misc Feature(8)309..413(+)
Misc Feature(9)333..335(+)
Misc Feature(10)489..491(+)
Misc Feature(11)510..638(+)
Misc Feature(12)618..620(+)
Misc Feature(13)858..1805(+)
Misc Feature(14)1320..1325(+)
Misc Feature(15)1347..1349(+)
Misc Feature(16)1347..1349(+)
Misc Feature(17)1365..1367(+)
Misc Feature(18)1566..1610(+)
Misc Feature(19)1599..1601(+)
Misc Feature(20)1608..1610(+)
Misc Feature(21)1608..1610(+)
Misc Feature(22)1650..1652(+)
Misc Feature(23)1653..1655(+)
Misc Feature(24)1653..1655(+)
Misc Feature(25)1677..1679(+)
Misc Feature(26)1683..1685(+)
Misc Feature(27)1692..1694(+)
Misc Feature(28)1692..1694(+)
Misc Feature(29)1719..1721(+)
Misc Feature(30)1719..1721(+)
Misc Feature(31)1728..1730(+)
Misc Feature(32)1728..1730(+)
Misc Feature(33)1743..1745(+)
Misc Feature(34)1743..1745(+)
Exon (1)1..269
Gene:PML
Gene Synonym:
Exon (2)270..742
Gene:PML
Gene Synonym:
Exon (3)743..1323
Gene:PML
Gene Synonym:
Exon (4)1324..1394
Gene:PML
Gene Synonym:
Exon (5)1395..1538
Gene:PML
Gene Synonym:
Exon (6)1539..1805
Gene:PML
Gene Synonym:
Exon (7)1806..1858
Gene:PML
Gene Synonym:
Exon (8)1859..3081
Gene:PML
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_033244
Organism Homo sapiens (human)
Definition Homo sapiens promyelocytic leukemia (PML), transcript variant 5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_033244

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCCCGAG
GAGGCAGAGA GAGTGAAGGC CCAGGTTCAG GCCCTGGGGC TGGCTGAAGC CCAGCCTATG
GCTGTGGTAC AGTCAGTGCC CGGGGCACAC CCCGTGCCAG TGTACGCCTT CTCCATCAAA
GGCCCTTCCT ATGGAGAGGA TGTCTCCAAT ACAACGACAG CCCAGAAGAG GAAGTGCAGC
CAGACCCAGT GCCCCAGGAA GGTCATCAAG ATGGAGTCTG AGGAGGGGAA GGAGGCAAGG
TTGGCTCGGA GCTCCCCGGA GCAGCCCAGG CCCAGCACCT CCAAGGCAGT CTCACCACCC
CACCTGGATG GACCGCCTAG CCCCAGGAGC CCCGTCATAG GAAGTGAGGT CTTCCTGCCC
AACAGCAACC ACGTGGCCAG TGGCGCCGGG GAGGCAGGTA GGGAGAGGAA CGCGTTGTGG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25455
Clone ID Related Accession (Same CDS sequence) NM_033238
Accession Version NM_033238.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2649bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product protein PML isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X63131.1, AB209411.1, M79462.1 and AC013486.12. This sequence is a reference standard in the RefSeqGene project. On Jun 9, 2005 this sequence version replaced gi:15451762. Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (1, also known as TRIM19alpha). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M79462.1, AF230401.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCCCGAG
GAGGCAGAGA GAGTGAAGGC CCAGGTTCAG GCCCTGGGGC TGGCTGAAGC CCAGCCTATG
GCTGTGGTAC AGTCAGTGCC CGGGGCACAC CCCGTGCCAG TGTACGCCTT CTCCATCAAA
GGCCCTTCCT ATGGAGAGGA TGTCTCCAAT ACAACGACAG CCCAGAAGAG GAAGTGCAGC
CAGACCCAGT GCCCCAGGAA GGTCATCAAG ATGGAGTCTG AGGAGGGGAA GGAGGCAAGG
TTGGCTCGGA GCTCCCCGGA GCAGCCCAGG CCCAGCACCT CCAAGGCAGT CTCACCACCC
CACCTGGATG GACCGCCTAG CCCCAGGAGC CCCGTCATAG GAAGTGAGGT CTTCCTGCCC
AACAGCAACC ACGTGGCCAG TGGCGCCGGG GAGGCAGAGG AACGCGTTGT GGTGATCAGC
AGCTCGGAAG ACTCAGATGC CGAAAACTCG TCCTCCCGAG AGCTGGATGA CAGCAGCAGT
GAGTCCAGTG ACCTCCAGCT GGAAGGCCCC AGCACCCTCA GGGTCCTGGA CGAGAACCTT
GCTGACCCCC AAGCAGAAGA CAGACCTCTG GTTTTCTTTG ACCTCAAGAT TGACAATGAA
ACCCAGAAGA TTAGCCAGCT GGCTGCGGTG AACCGGGAAA GCAAGTTCCG CGTGGTCATC
CAGCCTGAAG CCTTCTTCAG CATCTACTCC AAGGCCGTGT CCCTGGAGGT GGGGCTGCAG
CACTTCCTCA GCTTTCTGAG CTCCATGCGC CGCCCTATCT TGGCCTGCTA CAAGCTGTGG
GGGCCTGGCC TCCCAAACTT CTTCCGGGCC CTGGAGGACA TTAACAGGCT GTGGGAATTC
CAGGAGGCCA TCTCGGGCTT CCTGGCTGCC CTGCCTCTCA TCCGGGAGCG TGTGCCCGGG
GCCAGCAGCT TCAAACTCAA GAACCTGGCC CAGACCTACC TGGCGAGAAA CATGAGCGAG
CGCAGCGCCA TGGCTGCCGT GCTGGCCATG CGTGACCTGT GCCGCCTCCT CGAGGTCTCC
CCGGGCCCCC AGCTGGCCCA GCATGTCTAC CCCTTCAGTA GCCTGCAGTG CTTTGCCTCC
CTGCAGCCCC TGGTGCAGGC AGCTGTGCTG CCCCGGGCTG AGGCCCGCCT CCTGGCCCTA
CACAACGTGA GCTTCATGGA GCTGCTGAGT GCACACCGCC GTGACCGGCA GGGGGGCCTG
AAGAAGTACA GCCGCTATCT AAGCCTGCAG ACCACCACGT TGCCCCCTGC CCAGCCTGCT
TTCAACCTGC AGGCTCTGGG CACCTACTTT GAAGGCCTGT TGGAGGGTCC GGCGCTGGCA
CGGGCAGAAG GAGTCTCCAC CCCACTTGCT GGCCGTGGCT TGGCAGAGAG GGCCTCCCAG
CAGAGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_150241.2
CDS141..2789
Misc Feature(1)162..164(+)
Misc Feature(2)222..224(+)
Misc Feature(3)246..248(+)
Misc Feature(4)252..254(+)
Misc Feature(5)258..260(+)
Misc Feature(6)264..266(+)
Misc Feature(7)309..425(+)
Misc Feature(8)309..413(+)
Misc Feature(9)489..491(+)
Misc Feature(10)510..638(+)
Misc Feature(11)816..818(+)
Misc Feature(12)858..1853(+)
Misc Feature(13)1320..1325(+)
Misc Feature(14)1347..1349(+)
Misc Feature(15)1347..1349(+)
Misc Feature(16)1365..1367(+)
Misc Feature(17)1482..1805(+)
Misc Feature(18)1566..1610(+)
Misc Feature(19)1599..1601(+)
Misc Feature(20)1608..1610(+)
Misc Feature(21)1650..1652(+)
Misc Feature(22)1653..1655(+)
Misc Feature(23)1653..1655(+)
Misc Feature(24)1677..1679(+)
Misc Feature(25)1683..1685(+)
Misc Feature(26)1692..1694(+)
Misc Feature(27)1692..1694(+)
Misc Feature(28)1719..1721(+)
Misc Feature(29)1719..1721(+)
Misc Feature(30)1728..1730(+)
Misc Feature(31)1728..1730(+)
Misc Feature(32)1743..1745(+)
Misc Feature(33)1794..1799(+)
Misc Feature(34)1806..1826(+)
Misc Feature(35)1818..1820(+)
Misc Feature(36)1821..1823(+)
Misc Feature(37)1824..1826(+)
Misc Feature(38)1833..1835(+)
Misc Feature(39)1833..1835(+)
Misc Feature(40)1872..1874(+)
Misc Feature(41)1875..1877(+)
Misc Feature(42)1878..1880(+)
Misc Feature(43)1884..1886(+)
Misc Feature(44)1887..1889(+)
Misc Feature(45)1968..2414(+)
Misc Feature(46)1986..1988(+)
Exon (1)1..269
Gene:PML
Gene Synonym:
Exon (2)270..742
Gene:PML
Gene Synonym:
Exon (3)743..1323
Gene:PML
Gene Synonym:
Exon (4)1324..1394
Gene:PML
Gene Synonym:
Exon (5)1395..1538
Gene:PML
Gene Synonym:
Exon (6)1539..1797
Gene:PML
Gene Synonym:
Exon (7)1798..1850
Gene:PML
Gene Synonym:
Exon (8)1851..2001
Gene:PML
Gene Synonym:
Exon (9)2002..5600
Gene:PML
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_033238
Organism Homo sapiens (human)
Definition Homo sapiens promyelocytic leukemia (PML), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_033238

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCCCGAG
GAGGCAGAGA GAGTGAAGGC CCAGGTTCAG GCCCTGGGGC TGGCTGAAGC CCAGCCTATG
GCTGTGGTAC AGTCAGTGCC CGGGGCACAC CCCGTGCCAG TGTACGCCTT CTCCATCAAA
GGCCCTTCCT ATGGAGAGGA TGTCTCCAAT ACAACGACAG CCCAGAAGAG GAAGTGCAGC
CAGACCCAGT GCCCCAGGAA GGTCATCAAG ATGGAGTCTG AGGAGGGGAA GGAGGCAAGG
TTGGCTCGGA GCTCCCCGGA GCAGCCCAGG CCCAGCACCT CCAAGGCAGT CTCACCACCC
CACCTGGATG GACCGCCTAG CCCCAGGAGC CCCGTCATAG GAAGTGAGGT CTTCCTGCCC
AACAGCAACC ACGTGGCCAG TGGCGCCGGG GAGGCAGAGG AACGCGTTGT GGTGATCAGC
AGCTCGGAAG ACTCAGATGC CGAAAACTCG TCCTCCCGAG AGCTGGATGA CAGCAGCAGT
GAGTCCAGTG ACCTCCAGCT GGAAGGCCCC AGCACCCTCA GGGTCCTGGA CGAGAACCTT
GCTGACCCCC AAGCAGAAGA CAGACCTCTG GTTTTCTTTG ACCTCAAGAT TGACAATGAA
ACCCAGAAGA TTAGCCAGCT GGCTGCGGTG AACCGGGAAA GCAAGTTCCG CGTGGTCATC
CAGCCTGAAG CCTTCTTCAG CATCTACTCC AAGGCCGTGT CCCTGGAGGT GGGGCTGCAG
CACTTCCTCA GCTTTCTGAG CTCCATGCGC CGCCCTATCT TGGCCTGCTA CAAGCTGTGG
GGGCCTGGCC TCCCAAACTT CTTCCGGGCC CTGGAGGACA TTAACAGGCT GTGGGAATTC
CAGGAGGCCA TCTCGGGCTT CCTGGCTGCC CTGCCTCTCA TCCGGGAGCG TGTGCCCGGG
GCCAGCAGCT TCAAACTCAA GAACCTGGCC CAGACCTACC TGGCGAGAAA CATGAGCGAG
CGCAGCGCCA TGGCTGCCGT GCTGGCCATG CGTGACCTGT GCCGCCTCCT CGAGGTCTCC
CCGGGCCCCC AGCTGGCCCA GCATGTCTAC CCCTTCAGTA GCCTGCAGTG CTTTGCCTCC
CTGCAGCCCC TGGTGCAGGC AGCTGTGCTG CCCCGGGCTG AGGCCCGCCT CCTGGCCCTA
CACAACGTGA GCTTCATGGA GCTGCTGAGT GCACACCGCC GTGACCGGCA GGGGGGCCTG
AAGAAGTACA GCCGCTATCT AAGCCTGCAG ACCACCACGT TGCCCCCTGC CCAGCCTGCT
TTCAACCTGC AGGCTCTGGG CACCTACTTT GAAGGCCTGT TGGAGGGTCC GGCGCTGGCA
CGGGCAGAAG GAGTCTCCAC CCCACTTGCT GGCCGTGGCT TGGCAGAGAG GGCCTCCCAG
CAGAGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25540
Clone ID Related Accession (Same CDS sequence) NM_033249
Accession Version NM_033249.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1758bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product protein PML isoform 10
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X63131.1 and BF510860.1. On Jun 9, 2005 this sequence version replaced gi:15451778. Transcript Variant: This variant (10) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (10, also known as PML-4A, PML-IVA and TRIM19lambda) has a distinct C-terminus and is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF230411.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGGATGTC
TCCAATACAA CGACAGCCCA GAAGAGGAAG TGCAGCCAGA CCCAGTGCCC CAGGAAGGTC
ATCAAGATGG AGTCTGAGGA GGGGAAGGAG GCAAGGTTGG CTCGGAGCTC CCCGGAGCAG
CCCAGGCCCA GCACCTCCAA GGCAGTCTCA CCACCCCACC TGGATGGACC GCCTAGCCCC
AGGAGCCCCG TCATAGGAAG TGAGGTCTTC CTGCCCAACA GCAACCACGT GGCCAGTGGC
GCCGGGGAGG CAGAGGAACG CGTTGTGGTG ATCAGCAGCT CGGAAGACTC AGATGCCGAA
AACTCGTCCT CCCGAGAGCT GGATGACAGC AGCAGTGAGT CCAGTGACCT CCAGCTGGAA
GGCCCCAGCA CCCTCAGGGT CCTGGACGAG AACCTTGCTG ACCCCCAAGC AGAAGACAGA
CCTCTGGTTT TCTTTGACCT CAAGATTGAC AATGAAAGTG GGTTCTCCTG GGGCTACCCC
CACCCCTTTC TAATTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_150252.1
CDS141..1898
Misc Feature(1)309..425(+)
Misc Feature(2)309..413(+)
Misc Feature(3)333..335(+)
Misc Feature(4)510..638(+)
Misc Feature(5)618..620(+)
Misc Feature(6)816..818(+)
Misc Feature(7)858..1709(+)
Misc Feature(8)1464..1466(+)
Misc Feature(9)1509..1511(+)
Misc Feature(10)1533..1535(+)
Misc Feature(11)1548..1550(+)
Misc Feature(12)1575..1577(+)
Misc Feature(13)1584..1586(+)
Misc Feature(14)1674..1676(+)
Misc Feature(15)1677..1679(+)
Misc Feature(16)1680..1682(+)
Misc Feature(17)1689..1691(+)
Misc Feature(18)1728..1730(+)
Misc Feature(19)1731..1733(+)
Misc Feature(20)1734..1736(+)
Misc Feature(21)1740..1742(+)
Misc Feature(22)1743..1745(+)
Misc Feature(23)1842..1844(+)
Exon (1)1..269
Gene:PML
Gene Synonym:
Exon (2)270..742
Gene:PML
Gene Synonym:
Exon (3)743..1323
Gene:PML
Gene Synonym:
Exon (4)1324..1394
Gene:PML
Gene Synonym:
Exon (5)1395..1653
Gene:PML
Gene Synonym:
Exon (6)1654..1706
Gene:PML
Gene Synonym:
Exon (7)1707..2094
Gene:PML
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_033249
Organism Homo sapiens (human)
Definition Homo sapiens promyelocytic leukemia (PML), transcript variant 10, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_033249

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGGATGTC
TCCAATACAA CGACAGCCCA GAAGAGGAAG TGCAGCCAGA CCCAGTGCCC CAGGAAGGTC
ATCAAGATGG AGTCTGAGGA GGGGAAGGAG GCAAGGTTGG CTCGGAGCTC CCCGGAGCAG
CCCAGGCCCA GCACCTCCAA GGCAGTCTCA CCACCCCACC TGGATGGACC GCCTAGCCCC
AGGAGCCCCG TCATAGGAAG TGAGGTCTTC CTGCCCAACA GCAACCACGT GGCCAGTGGC
GCCGGGGAGG CAGAGGAACG CGTTGTGGTG ATCAGCAGCT CGGAAGACTC AGATGCCGAA
AACTCGTCCT CCCGAGAGCT GGATGACAGC AGCAGTGAGT CCAGTGACCT CCAGCTGGAA
GGCCCCAGCA CCCTCAGGGT CCTGGACGAG AACCTTGCTG ACCCCCAAGC AGAAGACAGA
CCTCTGGTTT TCTTTGACCT CAAGATTGAC AATGAAAGTG GGTTCTCCTG GGGCTACCCC
CACCCCTTTC TAATTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

SCP phosphatases suppress renal cell carcinoma by stabilizing PML and inhibiting mTOR/HIF signaling
Cancer Res. 74 (23), 6935-6946 (2014)
Lin YC, Lu LT, Chen HY, Duan X, Lin X, Feng XH, Tang MJ and Chen RH.


book

JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation
Blood 124 (13), 2104-2115 (2014)
Besancenot R, Roos-Weil D, Tonetti C, Abdelouahab H, Lacout C, Pasquier F, Willekens C, Rameau P, Lecluse Y, Micol JB, Constantinescu SN, Vainchenker W, Solary E and Giraudier S.


book

HIF factors cooperate with PML-RARalpha to promote acute promyelocytic leukemia progression and relapse
EMBO Mol Med 6 (5), 640-650 (2014)
Coltella N, Percio S, Valsecchi R, Cuttano R, Guarnerio J, Ponzoni M, Pandolfi PP, Melillo G, Pattini L and Bernardi R.


book

The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence
Mol. Cell. Biol. 34 (10), 1733-1746 (2014)
Munch S, Weidtkamp-Peters S, Klement K, Grigaravicius P, Monajembashi S, Salomoni P, Pandolfi PP, Weisshart K and Hemmerich P.


book

Implication of PMLIV in both intrinsic and innate immunity
PLoS Pathog. 10 (2), E1003975 (2014)
El Asmi F, Maroui MA, Dutrieux J, Blondel D, Nisole S and Chelbi-Alix MK.


book

The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML
EMBO J. 14 (7), 1532-1541 (1995)
Borden KL, Boddy MN, Lally J, O'Reilly NJ, Martin S, Howe K, Solomon E and Freemont PS.


book

Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms
Oncogene 7 (6), 1083-1091 (1992)
Fagioli M, Alcalay M, Pandolfi PP, Venturini L, Mencarelli A, Simeone A, Acampora D, Grignani F and Pelicci PG.


book

Molecular rearrangements of the MYL gene in acute promyelocytic leukemia (APL, M3) define a breakpoint cluster region as well as some molecular variants
Oncogene 7 (2), 311-316 (1992)
Tong JH, Dong S, Geng JP, Huang W, Wang ZY, Sun GL, Chen SJ, Chen Z, Larsen CJ and Berger R.


book

Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia
Science 254 (5036), 1371-1374 (1991)
Goddard AD, Borrow J, Freemont PS and Solomon E.


book

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML
Cell 66 (4), 663-674 (1991)
Kakizuka A, Miller WH Jr, Umesono K, Warrell RP Jr, Frankel SR, Murty VV, Dmitrovsky E and Evans RM.


 
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