TERF2IP cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | TERF2IP |
| Entrez Gene ID | 54386 |
| Full Name | TERF2 interacting protein |
| Synonyms | DRIP5,RAP1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_018975.4 | NP_061848.2 | telomeric repeat-binding factor 2-interacting protein 1 |
| NM_018975.3 | NP_061848.2 | telomeric repeat-binding factor 2-interacting protein 1 |
| Homo sapiens (human) | TERF2IP | NP_061848.2 |
| Canis lupus familiaris (dog) | TERF2IP | XP_536776.2 |
| Pan troglodytes (chimpanzee) | TERF2IP | XP_511116.3 |
| Gallus gallus (chicken) | TERF2IP | NP_989799.1 |
| Mus musculus (house mouse) | Terf2ip | NP_065609.2 |
| Rattus norvegicus (Norway rat) | Terf2ip | NP_001013161.1 |
| Xenopus tropicalis (tropical clawed frog) | terf2ip | NP_001137395.1 |
| TERF2IP | XP_001110856.2 | |
| Bos taurus (cattle) | TERF2IP | NP_001068880.1 |
Related articles in PubMed
Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it.
Necasov? I, Janou?kov? E, Klumpler T, Hofr C
Nucleic acids research45(21)12170-12180(2017 Dec)
EPAC-RAP1 Axis-Mediated Switch in the Response of Primary and Metastatic Melanoma to Cyclic AMP.
Rodr?guez CI, Castro-P?rez E, Prabhakar K, Block L, Longley BJ, Wisinski JA, Kimple ME, Setaluri V
Molecular cancer research : MCR15(12)1792-1802(2017 Dec)
Decoding telomere protein Rap1: Its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy.
Cai Y, Kandula V, Kosuru R, Ye X, Irwin MG, Xia Z
Cell cycle (Georgetown, Tex.)16(19)1765-1773(2017 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The formation of the Rap1-TRF2 complex restored DNA unwinding.
Title: Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it.
RAP1 promotes colorectal cell migration through the regulation of Vimentin and RAP1 may act as a potential target for the diagnosis and therapy of CRC.
Title: Repressor activator protein 1-promoted colorectal cell migration is associated with the regulation of Vimentin.
Rap1 activation was dependent on PKA and required Src family kinases and the Rap1 exchanger C3G.
Title: Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP.
The Rap1-RIAM-talin axis of integrin activation and blood cell function
Title: The Rap1-RIAM-talin axis of integrin activation and blood cell function.
Rap1 may induce hepatic ischemia reperfusion injury (IRI) through promoting neutrophils inflammatory response. Rap1 may be the potential therapeutic target of attenuating hepatic IRI.
Title: Repressor and activator protein accelerates hepatic ischemia reperfusion injury by promoting neutrophil inflammatory response.
The following TERF2IP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TERF2IP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu09595 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_018975.4 , NM_018975.3 | |
| Accession Version | NM_018975.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-25 | |
| Organism | Homo sapiens(human) | |
| Product | telomeric repeat-binding factor 2-interacting protein 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK307901.1, BC022428.1 and AA769291.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_018975.3. Transcript Variant: This variant (1) encodes the supported protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK000669.1, SRR1660805.235161.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000300086.5/ ENSP00000300086.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGGCGGAGG CGATGGATTT GGGCAAAGAC CCCAACGGGC CCACCCATTC CTCGACTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_061848.2 |
| CDS | 111..1310 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_018975.4 |
ORF Insert Sequence:
1 | ATGGCGGAGG CGATGGATTT GGGCAAAGAC CCCAACGGGC CCACCCATTC CTCGACTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu09595 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_018975.4 , NM_018975.3 | |
| Accession Version | NM_018975.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-31 | |
| Organism | Homo sapiens(human) | |
| Product | telomeric repeat-binding factor 2-interacting protein 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK307901.1, BC022428.1 and AA769291.1. This sequence is a reference standard in the RefSeqGene project. On Apr 21, 2010 this sequence version replaced NM_018975.2. Transcript Variant: This variant (1) encodes the supported protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.215911.1, AK000669.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCGGAGG CGATGGATTT GGGCAAAGAC CCCAACGGGC CCACCCATTC CTCGACTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_061848.2 |
| CDS | 147..1346 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_018975.3 |
ORF Insert Sequence:
1 | ATGGCGGAGG CGATGGATTT GGGCAAAGAC CCCAACGGGC CCACCCATTC CTCGACTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it. |
|
EPAC-RAP1 Axis-Mediated Switch in the Response of Primary and Metastatic Melanoma to Cyclic AMP. |
|
Decoding telomere protein Rap1: Its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy. |