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POU3F3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol POU3F3
Entrez Gene ID 5455
Full Name POU class 3 homeobox 3
Synonyms BRN1, OTF8, brain-1, oct-8
General protein information
Preferred Names
POU domain, class 3, transcription factor 3
Names
POU domain, class 3, transcription factor 3
OTF-8
brn-1
oct-8
brain-1
octamer-binding protein 8
octamer-binding transcription factor 8
brain-specific homeobox/POU domain protein 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q12.1

Summary This gene encodes a POU-domain containing protein that functions as a transcription factor. The encoded protein recognizes an octamer sequence in the DNA of target genes. This protein may play a role in development of the nervous system. [provided by RefSeq, Apr 2015]. lac of sum
Disorder MIM:

602480


mRNA and Protein(s)

mRNA Protein Name
NM_006236 NP_006227 POU domain, class 3, transcription factor 3


Homo sapiens (human) POU3F3 NP_006227.1
Mus musculus (house mouse) Pou3f3 NP_032926.2
Rattus norvegicus (Norway rat) Pou3f3 NP_620192.1
Danio rerio (zebrafish) pou3f3b NP_571177.2
Danio rerio (zebrafish) pou3f3a NP_571225.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100497507 XP_004911849.1


The following POU3F3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POU3F3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu30942 NM_006236 Homo sapiens POU class 3 homeobox 3 (POU3F3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $293.30
$419.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu30942
Clone ID Related Accession (Same CDS sequence) NM_006236
Accession Version NM_006236.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1503bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 03-APR-2015
Organism Homo sapiens (human)
Product POU domain, class 3, transcription factor 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC018730.8, CX873380.1 and CX873394.1. On Apr 3, 2015 this sequence version replaced gi:5453935. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGGCCACGG CGGCTTCTAA CCCCTACCTG CCGGGGAACA GCCTGCTCGC GGCCGGCTCT 
ATTGTGCACT CGGACGCGGC AGGGGCTGGC GGCGGCGGGG GTGGCGGCGG CGGCGGCGGC
GGGGGCGGCG CAGGGGGCGG GGGCGGCGGC ATGCAGCCGG GCAGCGCCGC CGTGACCTCG
GGCGCCTACC GGGGGGACCC GTCCTCTGTC AAGATGGTCC AGAGCGACTT CATGCAGGGG
GCCATGGCCG CCAGCAACGG CGGCCATATG CTGAGCCACG CGCACCAGTG GGTCACAGCC
CTGCCCCACG CCGCCGCCGC CGCCGCCGCT GCCGCCGCCG CCGCCGTGGA GGCGAGCTCG
CCGTGGTCGG GCAGCGCCGT GGGCATGGCT GGCAGCCCCC AGCAGCCACC GCAGCCGCCG
CCGCCACCGC CGCAGGGCCC CGACGTGAAG GGCGGCGCCG GGCGCGACGA CCTGCACGCG
GGCACAGCGC TGCACCACCG CGGGCCGCCG CACCTCGGAC CCCCGCCGCC GCCCCCACAC
CAGGGCCACC CTGGGGGCTG GGGGGCGGCC GCCGCTGCCG CAGCCGCAGC CGCCGCCGCC
GCCGCCGCCG CGCACCTCCC GTCCATGGCC GGGGGCCAGC AGCCGCCGCC GCAGAGTCTG
CTCTACTCGC AGCCCGGAGG CTTCACGGTG AACGGCATGC TGAGCGCGCC ACCGGGGCCC
GGCGGCGGCG GCGGCGGCGC GGGCGGTGGA GCCCAGAGCT TGGTGCACCC GGGGCTGGTG
CGCGGGGACA CGCCAGAGCT GGCCGAGCAC CACCACCACC ACCACCACCA CGCGCATCCT
CACCCGCCGC ACCCGCACCA CGCGCAGGGA CCCCCGCACC ACGGCGGCGG CGGCGGCGGC
GCGGGGCCTG GACTCAACAG CCACGACCCG CACTCGGACG AGGACACGCC GACGTCGGAC
GACCTGGAGC AGTTCGCCAA GCAGTTCAAG CAGCGGCGCA TCAAGCTGGG CTTCACGCAG
GCCGACGTGG GGTTGGCGCT GGGCACACTC TACGGCAACG TGTTCTCGCA GACCACCATC
TGCCGCTTCG AGGCCCTGCA GCTGAGCTTC AAGAACATGT GCAAGCTCAA GCCGCTGCTG
AACAAGTGGC TGGAGGAGGC GGACTCAAGC ACCGGCAGCC CCACAAGCAT CGACAAGATC
GCGGCGCAGG GCCGCAAGCG CAAGAAGCGG ACCTCTATCG AGGTGAGCGT CAAGGGCGCG
CTGGAGAGCC ACTTCCTCAA GTGCCCCAAG CCCTCCGCGC AGGAGATCAC CAACCTGGCC
GACAGCCTGC AGCTCGAGAA GGAGGTGGTG CGGGTCTGGT TCTGCAATCG GCGCCAAAAG
GAGAAGCGCA TGACGCCGCC CGGGATCCAA CAGCAGACGC CCGACGACGT CTACTCGCAG
GTGGGCACCG TGAGCGCCGA CACGCCGCCG CCTCACCACG GGCTGCAGAC GAGCGTTCAG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006227.1
CDS1444..2946
Misc Feature(1)889..891(+)
Misc Feature(2)2383..2607(+)
Misc Feature(3)2662..2835(+)
Misc Feature(4)2662..2832(+)
Misc Feature(5)2668..2820(+)
Exon (1)1..4507
Gene:POU3F3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_006236
Organism Homo sapiens (human)
Definition Homo sapiens POU class 3 homeobox 3 (POU3F3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_006236

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGGCCACGG CGGCTTCTAA CCCCTACCTG CCGGGGAACA GCCTGCTCGC GGCCGGCTCT 
ATTGTGCACT CGGACGCGGC AGGGGCTGGC GGCGGCGGGG GTGGCGGCGG CGGCGGCGGC
GGGGGCGGCG CAGGGGGCGG GGGCGGCGGC ATGCAGCCGG GCAGCGCCGC CGTGACCTCG
GGCGCCTACC GGGGGGACCC GTCCTCTGTC AAGATGGTCC AGAGCGACTT CATGCAGGGG
GCCATGGCCG CCAGCAACGG CGGCCATATG CTGAGCCACG CGCACCAGTG GGTCACAGCC
CTGCCCCACG CCGCCGCCGC CGCCGCCGCT GCCGCCGCCG CCGCCGTGGA GGCGAGCTCG
CCGTGGTCGG GCAGCGCCGT GGGCATGGCT GGCAGCCCCC AGCAGCCACC GCAGCCGCCG
CCGCCACCGC CGCAGGGCCC CGACGTGAAG GGCGGCGCCG GGCGCGACGA CCTGCACGCG
GGCACAGCGC TGCACCACCG CGGGCCGCCG CACCTCGGAC CCCCGCCGCC GCCCCCACAC
CAGGGCCACC CTGGGGGCTG GGGGGCGGCC GCCGCTGCCG CAGCCGCAGC CGCCGCCGCC
GCCGCCGCCG CGCACCTCCC GTCCATGGCC GGGGGCCAGC AGCCGCCGCC GCAGAGTCTG
CTCTACTCGC AGCCCGGAGG CTTCACGGTG AACGGCATGC TGAGCGCGCC ACCGGGGCCC
GGCGGCGGCG GCGGCGGCGC GGGCGGTGGA GCCCAGAGCT TGGTGCACCC GGGGCTGGTG
CGCGGGGACA CGCCAGAGCT GGCCGAGCAC CACCACCACC ACCACCACCA CGCGCATCCT
CACCCGCCGC ACCCGCACCA CGCGCAGGGA CCCCCGCACC ACGGCGGCGG CGGCGGCGGC
GCGGGGCCTG GACTCAACAG CCACGACCCG CACTCGGACG AGGACACGCC GACGTCGGAC
GACCTGGAGC AGTTCGCCAA GCAGTTCAAG CAGCGGCGCA TCAAGCTGGG CTTCACGCAG
GCCGACGTGG GGTTGGCGCT GGGCACACTC TACGGCAACG TGTTCTCGCA GACCACCATC
TGCCGCTTCG AGGCCCTGCA GCTGAGCTTC AAGAACATGT GCAAGCTCAA GCCGCTGCTG
AACAAGTGGC TGGAGGAGGC GGACTCAAGC ACCGGCAGCC CCACAAGCAT CGACAAGATC
GCGGCGCAGG GCCGCAAGCG CAAGAAGCGG ACCTCTATCG AGGTGAGCGT CAAGGGCGCG
CTGGAGAGCC ACTTCCTCAA GTGCCCCAAG CCCTCCGCGC AGGAGATCAC CAACCTGGCC
GACAGCCTGC AGCTCGAGAA GGAGGTGGTG CGGGTCTGGT TCTGCAATCG GCGCCAAAAG
GAGAAGCGCA TGACGCCGCC CGGGATCCAA CAGCAGACGC CCGACGACGT CTACTCGCAG
GTGGGCACCG TGAGCGCCGA CACGCCGCCG CCTCACCACG GGCTGCAGAC GAGCGTTCAG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Functional linc-POU3F3 is overexpressed and contributes to tumorigenesis in glioma
Gene 554 (1), 114-119 (2015)
Guo H, Wu L, Yang Q, Ye M and Zhu X.


book

Increased levels of the long intergenic non-protein coding RNA POU3F3 promote DNA methylation in esophageal squamous cell carcinoma cells
Gastroenterology 146 (7), 1714-1726 (2014)
Li W, Zheng J, Deng J, You Y, Wu H, Li N, Lu J and Zhou Y.


book

A de novo POU3F3 Deletion in a Boy with Intellectual Disability and Dysmorphic Features
Mol Syndromol 5 (1), 32-35 (2014)
Dheedene A, Maes M, Vergult S and Menten B.


book

POU-III transcription factors (Brn1, Brn2, and Oct6) influence neurogenesis, molecular identity, and migratory destination of upper-layer cells of the cerebral cortex
Cereb. Cortex 23 (11), 2632-2643 (2013)
Dominguez MH, Ayoub AE and Rakic P.


book

The class III POU domain protein Brn-1 can fully replace the related Oct-6 during schwann cell development and myelination
Mol. Cell. Biol. 25 (5), 1821-1829 (2005)
Friedrich RP, Schlierf B, Tamm ER, Bosl MR and Wegner M.


book

Cooperative function of POU proteins and SOX proteins in glial cells
J. Biol. Chem. 273 (26), 16050-16057 (1998)
Kuhlbrodt K, Herbarth B, Sock E, Enderich J, Hermans-Borgmeyer I and Wegner M.


book

Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2
Mamm. Genome 9 (2), 180-181 (1998)
Sumiyama K, Washio-Watanabe K, Ono T, Yoshida MC, Hayakawa T and Ueda S.


book

The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U
Brain Res. Mol. Brain Res. 45 (1), 99-107 (1997)
Malik KF, Jaffe H, Brady J and Young WS 3rd.


book

Class III POU genes: generation of homopolymeric amino acid repeats under GC pressure in mammals
J. Mol. Evol. 43 (3), 170-178 (1996)
Sumiyama K, Washio-Watanabe K, Saitou N, Hayakawa T and Ueda S.


book

Expression of a large family of POU-domain regulatory genes in mammalian brain development
Nature 340 (6228), 35-41 (1989)
He X, Treacy MN, Simmons DM, Ingraham HA, Swanson LW and Rosenfeld MG.


 
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