×

POU4F2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol POU4F2
Entrez Gene ID 5458
Full Name POU class 4 homeobox 2
Synonyms BRN3.2, BRN3B, Brn-3b
General protein information
Preferred Names
POU domain, class 4, transcription factor 2
Names
POU domain, class 4, transcription factor 2
brain-3B
POU domain protein
Brn3b POU domain transcription factor
POU domain class 4 transcription factor 2
brain-specific homeobox/POU domain protein 3B
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q31.2

Summary The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. [provided by RefSeq, Sep 2011]. lac of sum
Disorder MIM:

113725


mRNA and Protein(s)

mRNA Protein Name
NM_004575 NP_004566 POU domain, class 4, transcription factor 2



Homo sapiens (human) POU4F2 NP_004566.2
Pan troglodytes (chimpanzee) POU4F2 XP_526699.2
Macaca mulatta (Rhesus monkey) POU4F2 XP_001098227.1
Canis lupus familiaris (dog) POU4F2 XP_853453.1
Bos taurus (cattle) POU4F2 NP_001179881.1
Mus musculus (house mouse) Pou4f2 NP_620394.2
Rattus norvegicus (Norway rat) Pou4f2 NP_599182.1
Danio rerio (zebrafish) pou4f2 NP_997972.1
Xenopus (Silurana) tropicalis (western clawed frog) pou4f2 XP_004911191.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following POU4F2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POU4F2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

New! ORF Clone Sale

Up to 50% OFF! Starting
from $49/clone

Free DYK Tag Antibody

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu04465 NM_004575 Homo sapiens POU class 4 homeobox 2 (POU4F2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $265.30
$379.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu04465
Clone ID Related Accession (Same CDS sequence) NM_004575
Accession Version NM_004575.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1230bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product POU domain, class 4, transcription factor 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB082745.1, BY796838.2, U06233.1 and X71488.1. On Jul 14, 2006 this sequence version replaced gi:4758947. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U06233.1, EU439706.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGATGATGA TGTCCCTGAA CAGCAAGCAG GCGTTTAGCA TGCCGCACGG CGGCAGCCTG 
CACGTGGAGC CCAAGTACTC GGCACTGCAC AGCACCTCGC CGGGCTCCTC GGCTCCCATC
GCGCCCTCGG CCAGCTCCCC CAGCAGCTCG AGCAACGCTG GTGGTGGCGG CGGCGGCGGC
GGCGGCGGCG GCGGCGGCGG AGGCCGAAGC AGCAGCTCCA GCAGCAGTGG CAGCAGCGGC
GGCGGGGGCT CGGAGGCTAT GCGGAGAGCC TGTCTTCCAA CCCCACCGAG CAATATATTC
GGCGGGCTGG ATGAGAGTCT GCTGGCCCGC GCCGAGGCTC TGGCAGCCGT GGACATCGTC
TCCCAGAGCA AGAGCCACCA CCACCATCCA CCCCACCACA GCCCCTTCAA ACCGGACGCC
ACCTACCACA CTATGAATAC CATCCCGTGC ACGTCGGCCG CCTCTTCTTC ATCGGTGCCC
ATCTCGCACC CTTCCGCGTT GGCGGGCACG CACCACCACC ACCACCATCA CCACCACCAC
CACCACCAAC CGCACCAGGC GCTGGAGGGC GAGCTGCTGG AGCACCTGAG TCCCGGGCTG
GCCCTGGGCG CTATGGCGGG CCCCGACGGC GCTGTGGTGT CCACGCCGGC TCACGCGCCG
CACATGGCCA CCATGAACCC CATGCACCAA GCAGCGCTCA GCATGGCCCA CGCGCACGGG
CTGCCGTCGC ACATGGGCTG CATGAGCGAC GTGGACGCCG ACCCGCGGGA CCTGGAGGCA
TTCGCCGAGC GCTTCAAGCA GCGACGCATC AAGCTGGGGG TGACCCAGGC AGATGTGGGC
TCCGCGCTGG CCAACCTCAA GATCCCCGGC GTGGGCTCGC TTAGCCAGAG CACCATCTGC
AGGTTCGAGT CCCTCACACT GTCCCACAAT AATATGATCG CGCTCAAACC CATCCTGCAG
GCATGGCTCG AGGAGGCCGA GAAGTCCCAC CGCGAGAAGC TCACCAAGCC TGAACTCTTC
AATGGCGCGG AGAAGAAGCG CAAGCGCACG TCCATCGCTG CGCCAGAGAA GCGCTCGCTC
GAAGCCTACT TTGCCATTCA GCCTCGGCCC TCCTCTGAAA AGATCGCCGC CATCGCGGAG
AAGCTGGACC TGAAGAAAAA CGTGGTGCGC GTCTGGTTCT GCAACCAGAG GCAGAAACAG
AAAAGAATGA AATATTCCGC CGGCATTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004566.2
CDS249..1478
Misc Feature(1)210..212(+)
Misc Feature(2)576..605(+)
Misc Feature(3)996..1229(+)
Misc Feature(4)1284..1460(+)
Misc Feature(5)1284..1454(+)
Misc Feature(6)1290..1442(+)
Exon (1)1..536
Gene:POU4F2
Gene Synonym:
Exon (2)537..3141
Gene:POU4F2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_004575
Organism Homo sapiens (human)
Definition Homo sapiens POU class 4 homeobox 2 (POU4F2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004575

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGATGATGA TGTCCCTGAA CAGCAAGCAG GCGTTTAGCA TGCCGCACGG CGGCAGCCTG 
CACGTGGAGC CCAAGTACTC GGCACTGCAC AGCACCTCGC CGGGCTCCTC GGCTCCCATC
GCGCCCTCGG CCAGCTCCCC CAGCAGCTCG AGCAACGCTG GTGGTGGCGG CGGCGGCGGC
GGCGGCGGCG GCGGCGGCGG AGGCCGAAGC AGCAGCTCCA GCAGCAGTGG CAGCAGCGGC
GGCGGGGGCT CGGAGGCTAT GCGGAGAGCC TGTCTTCCAA CCCCACCGAG CAATATATTC
GGCGGGCTGG ATGAGAGTCT GCTGGCCCGC GCCGAGGCTC TGGCAGCCGT GGACATCGTC
TCCCAGAGCA AGAGCCACCA CCACCATCCA CCCCACCACA GCCCCTTCAA ACCGGACGCC
ACCTACCACA CTATGAATAC CATCCCGTGC ACGTCGGCCG CCTCTTCTTC ATCGGTGCCC
ATCTCGCACC CTTCCGCGTT GGCGGGCACG CACCACCACC ACCACCATCA CCACCACCAC
CACCACCAAC CGCACCAGGC GCTGGAGGGC GAGCTGCTGG AGCACCTGAG TCCCGGGCTG
GCCCTGGGCG CTATGGCGGG CCCCGACGGC GCTGTGGTGT CCACGCCGGC TCACGCGCCG
CACATGGCCA CCATGAACCC CATGCACCAA GCAGCGCTCA GCATGGCCCA CGCGCACGGG
CTGCCGTCGC ACATGGGCTG CATGAGCGAC GTGGACGCCG ACCCGCGGGA CCTGGAGGCA
TTCGCCGAGC GCTTCAAGCA GCGACGCATC AAGCTGGGGG TGACCCAGGC AGATGTGGGC
TCCGCGCTGG CCAACCTCAA GATCCCCGGC GTGGGCTCGC TTAGCCAGAG CACCATCTGC
AGGTTCGAGT CCCTCACACT GTCCCACAAT AATATGATCG CGCTCAAACC CATCCTGCAG
GCATGGCTCG AGGAGGCCGA GAAGTCCCAC CGCGAGAAGC TCACCAAGCC TGAACTCTTC
AATGGCGCGG AGAAGAAGCG CAAGCGCACG TCCATCGCTG CGCCAGAGAA GCGCTCGCTC
GAAGCCTACT TTGCCATTCA GCCTCGGCCC TCCTCTGAAA AGATCGCCGC CATCGCGGAG
AAGCTGGACC TGAAGAAAAA CGTGGTGCGC GTCTGGTTCT GCAACCAGAG GCAGAAACAG
AAAAGAATGA AATATTCCGC CGGCATTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Diagnosis of bladder cancer recurrence based on urinary levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation
PLoS ONE 7 (10), E46297 (2012)
Reinert T, Borre M, Christiansen A, Hermann GG, Orntoft TF and Dyrskjot L.


book

Hsp-27 induction requires POU4F2/Brn-3b TF in doxorubicin-treated breast cancer cells, whereas phosphorylation alters its cellular localisation following drug treatment
Cell Stress Chaperones 16 (4), 427-439 (2011)
Fujita R, Ounzain S, Wang AC, Heads RJ and Budhram-Mahadeo VS.


book

A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors
J. Neurosci. 28 (13), 3392-3403 (2008)
Qiu F, Jiang H and Xiang M.


book

Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells
Oncogene 27 (1), 145-154 (2008)
Budhram-Mahadeo VS, Irshad S, Bowen S, Lee SA, Samady L, Tonini GP and Latchman DS.


book

Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells
FEBS Lett. 581 (13), 2490-2496 (2007)
Calissano M, Diss JK and Latchman DS.


book

Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor
J. Biol. Chem. 272 (2), 1382-1388 (1997)
Smith MD, Dawson SJ and Latchman DS.


book

The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons
J. Neurosci. 15 (7 PT 1), 4762-4785 (1995)
Xiang M, Zhou L, Macke JP, Yoshioka T, Hendry SH, Eddy RL, Shows TB and Nathans J.


book

Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells
Proc. Natl. Acad. Sci. U.S.A. 90 (21), 10260-10264 (1993)
Bhargava AK, Li Z and Weissman SM.


book

Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells
Neuron 11 (4), 689-701 (1993)
Xiang M, Zhou L, Peng YW, Eddy RL, Shows TB and Nathans J.


book

The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain
Nucleic Acids Res. 21 (12), 2946 (1993)
Ring CJ and Latchman DS.


 
*
*
*
*