×

FEV cDNA ORF clone, Homo sapiens (human)

Gene Symbol FEV
Entrez Gene ID 54738
Full Name FEV (ETS oncogene family)
Synonyms HSRNAFEV, PET-1
General protein information
Preferred Names
protein FEV
Names
protein FEV
fifth Ewing variant protein
PC12 ETS domain-containing transcription factor 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q36

Summary This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

607150


mRNA and Protein(s)

mRNA Protein Name
NM_017521 NP_059991 protein FEV



Homo sapiens (human) FEV NP_059991.1
Pan troglodytes (chimpanzee) FEV XP_003309530.1
Macaca mulatta (Rhesus monkey) FEV XP_001095962.1
Bos taurus (cattle) FEV NP_001179532.1
Mus musculus (house mouse) Fev NP_694751.1
Rattus norvegicus (Norway rat) Fev NP_653354.2
Gallus gallus (chicken) LOC100857480 XP_003641694.1
Danio rerio (zebrafish) fev NP_001074126.1
Xenopus (Silurana) tropicalis (western clawed frog) fev XP_002934005.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following FEV gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FEV cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Free ORF Clone
for Every Scientist
More Detail >>

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19395
NM_017521 Homo sapiens FEV (ETS oncogene family) (FEV), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$134.50-$188.30
$269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19395
Clone ID Related Accession (Same CDS sequence) NM_017521
Accession Version NM_017521.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 717bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product protein FEV
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Y08976.1 and BC023511.2. This sequence is a reference standard in the RefSeqGene project. On Dec 10, 2004 this sequence version replaced gi:8923788. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y08976.1, CA867675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGAGACAGA GCGGCGCCTC CCAGCCCCTG CTGATCAACA TGTACCTGCC AGATCCCGTC 
GGAGACGGTC TCTTCAAGGA CGGGAAGAAC CCGAGCTGGG GGCCGCTGAG CCCCGCGGTT
CAGAAAGGCA GCGGACAGAT CCAGCTGTGG CAGTTTCTGC TGGAGCTGCT GGCTGACCGC
GCGAACGCCG GCTGCATCGC GTGGGAGGGC GGTCACGGCG AGTTCAAGCT CACGGACCCG
GACGAGGTGG CGCGGCGGTG GGGCGAGCGC AAGAGCAAGC CCAACATGAA CTACGACAAG
CTGAGCCGCG CCCTGCGCTA CTACTACGAC AAGAACATCA TGAGCAAGGT GCATGGCAAG
CGCTACGCCT ACCGCTTCGA CTTCCAGGGC CTGGCGCAGG CCTGCCAGCC GCCGCCCGCG
CACGCTCATG CCGCCGCCGC AGCTGCTGCC GCCGCCGCGG CCGCCCAGGA CGGCGCGCTC
TACAAGCTGC CCGCCGGCCT CGCCCCGCTG CCCTTCCCCG GCCTCTCCAA ACTCAACCTC
ATGGCCGCCT CGGCCGGGGT CGCGCCCGCC GGCTTCTCCT ACTGGCCGGG CCCGGGCCCC
GCCGCCACCG CTGCCGCCGC CACCGCCGCG CTCTACCCCA GTCCCAGCTT GCAGCCCCCG
CCCGGGCCCT TCGGGGCCGT GGCCGCAGCC TCGCACTTGG GGGGCCATTA CCACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_059991.1
CDS583..1299
Misc Feature(1)313..315(+)
Misc Feature(2)634..639(+)
Misc Feature(3)718..966(+)
Misc Feature(4)967..1296(+)
Exon (1)1..634
Gene:FEV
Gene Synonym:
Exon (2)635..709
Gene:FEV
Gene Synonym:
Exon (3)710..1879
Gene:FEV
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_017521
Organism Homo sapiens (human)
Definition Homo sapiens FEV (ETS oncogene family) (FEV), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_017521

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGAGACAGA GCGGCGCCTC CCAGCCCCTG CTGATCAACA TGTACCTGCC AGATCCCGTC 
GGAGACGGTC TCTTCAAGGA CGGGAAGAAC CCGAGCTGGG GGCCGCTGAG CCCCGCGGTT
CAGAAAGGCA GCGGACAGAT CCAGCTGTGG CAGTTTCTGC TGGAGCTGCT GGCTGACCGC
GCGAACGCCG GCTGCATCGC GTGGGAGGGC GGTCACGGCG AGTTCAAGCT CACGGACCCG
GACGAGGTGG CGCGGCGGTG GGGCGAGCGC AAGAGCAAGC CCAACATGAA CTACGACAAG
CTGAGCCGCG CCCTGCGCTA CTACTACGAC AAGAACATCA TGAGCAAGGT GCATGGCAAG
CGCTACGCCT ACCGCTTCGA CTTCCAGGGC CTGGCGCAGG CCTGCCAGCC GCCGCCCGCG
CACGCTCATG CCGCCGCCGC AGCTGCTGCC GCCGCCGCGG CCGCCCAGGA CGGCGCGCTC
TACAAGCTGC CCGCCGGCCT CGCCCCGCTG CCCTTCCCCG GCCTCTCCAA ACTCAACCTC
ATGGCCGCCT CGGCCGGGGT CGCGCCCGCC GGCTTCTCCT ACTGGCCGGG CCCGGGCCCC
GCCGCCACCG CTGCCGCCGC CACCGCCGCG CTCTACCCCA GTCCCAGCTT GCAGCCCCCG
CCCGGGCCCT TCGGGGCCGT GGCCGCAGCC TCGCACTTGG GGGGCCATTA CCACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing
Exp. Neurol. 250, 260-269 (2013)
Wellman CL, Camp M, Jones VM, MacPherson KP, Ihne J, Fitzgerald P, Maroun M, Drabant E, Bogdan R, Hariri AR and Holmes A.


book

Fev regulates hematopoietic stem cell development via ERK signaling
Blood 122 (3), 367-375 (2013)
Wang L, Liu T, Xu L, Gao Y, Wei Y, Duan C, Chen GQ, Lin S, Patient R, Zhang B, Hong D and Liu F.


book

Genome-wide association study of antibody response to smallpox vaccine
Vaccine 30 (28), 4182-4189 (2012)
Ovsyannikova IG, Kennedy RB, O'Byrne M, Jacobson RM, Pankratz VS and Poland GA.


book

The expression of the transcription factor FEV in adult human brain and its association with affective disorders
J Neural Transm 117 (7), 831-836 (2010)
Kriegebaum CB, Gutknecht L, Bartke L, Reif A, Buttenschon HN, Mors O, Lesch KP and Schmitt AG.


book

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature
BMC Med. Genet. 11, 96 (2010)
Zhao J, Li M, Bradfield JP, Zhang H, Mentch FD, Wang K, Sleiman PM, Kim CE, Glessner JT, Hou C, Keating BJ, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Chiavacci RM, Berkowitz RI, Hakonarson H and Grant SF.


book

A differentially autoregulated Pet-1 enhancer region is a critical target of the transcriptional cascade that governs serotonin neuron development
J. Neurosci. 25 (10), 2628-2636 (2005)
Scott MM, Krueger KC and Deneris ES.


book

The Ets transcription factor Fev is specifically expressed in the human central serotonergic neurons
Neurosci. Lett. 357 (3), 215-218 (2004)
Maurer P, Rorive S, de Kerchove d'Exaerde A, Schiffmann SN, Salmon I and de Launoit Y.


book

FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain
Oncogene 22 (21), 3319-3329 (2003)
Maurer P, T'Sas F, Coutte L, Callens N, Brenner C, Van Lint C, de Launoit Y and Baert JL.


book

A novel zinc finger gene is fused to EWS in small round cell tumor
Oncogene 19 (33), 3799-3804 (2000)
Mastrangelo T, Modena P, Tornielli S, Bullrich F, Testi MA, Mezzelani A, Radice P, Azzarelli A, Pilotti S, Croce CM, Pierotti MA and Sozzi G.


book

A new member of the ETS family fused to EWS in Ewing tumors
Oncogene 14 (10), 1159-1164 (1997)
Peter M, Couturier J, Pacquement H, Michon J, Thomas G, Magdelenat H and Delattre O.


 
*
*
*
*