COMMD8 cDNA ORF clone, Homo sapiens(Human)
| Gene Symbol | COMMD8 |
| Entrez Gene ID | 54951 |
| Full Name | COMM domain containing 8 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(Human) |
| Genome | |
| Summary | The protein encoded by this gene binds coiled-coil domain-containing protein 22 (CCDC22), and this complex can regulate the turnover of I-kappa-B and the activation of NF-kappa-B. [provided by RefSeq, Jul 2016]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| XM_017008330.1 | XP_016863819.1 | COMM domain-containing protein 8 isoform X1 |
| NM_017845.4 | NP_060315.1 | COMM domain-containing protein 8 isoform 1 |
| NM_001329668.1 | NP_001316597.1 | COMM domain-containing protein 8 isoform 2 |
| NM_017845.5 | NP_060315.1 | COMM domain-containing protein 8 isoform 1 |
| NM_017845.3 | NP_060315.1 | COMM domain-containing protein 8 |
| Homo sapiens (human) | COMMD8 | NP_060315.1 |
| Rattus norvegicus (Norway rat) | Commd8 | NP_001099474.1 |
| Danio rerio (zebrafish) | commd8 | NP_001071186.1 |
| COMMD8 | XP_001101515.1 | |
| Bos taurus (cattle) | COMMD8 | XP_002688283.1 |
| Mus musculus (house mouse) | Commd8 | NP_848714.1 |
| Gallus gallus (chicken) | COMMD8 | NP_001264750.1 |
| Xenopus tropicalis (tropical clawed frog) | commd8 | NP_001016404.1 |
| Pan troglodytes (chimpanzee) | COMMD8 | XP_001154216.1 |
| Canis lupus familiaris (dog) | COMMD8 | XP_532368.2 |
Related articles in PubMed
Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.
McNally KE, Faulkner R, Steinberg F, Gallon M, Ghai R, Pim D, Langton P, Pearson N, Danson CM, N?gele H, Morris LL, Singla A, Overlee BL, Heesom KJ, Sessions R, Banks L, Collins BM, Berger I, Billadeau DD, Burstein E, Cullen PJ
Nature cell biology19(10)1214-1225(2017 Oct)
Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)
CCDC22 deficiency in humans blunts activation of proinflammatory NF-?B signaling.
Starokadomskyy P, Gluck N, Li H, Chen B, Wallis M, Maine GN, Mao X, Zaidi IW, Hein MY, McDonald FJ, Lenzner S, Zecha A, Ropers HH, Kuss AW, McGaughran J, Gecz J, Burstein E
The Journal of clinical investigation123(5)2244-56(2013 May)
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Science signaling4(189)rs8(2011 Sep)
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Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
The following COMMD8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COMMD8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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| CloneID | OHu02586 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_017845.4 , NM_017845.5 , NM_017845.3 | |
| Accession Version | NM_017845.4 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-09-09 | |
| Organism | Homo sapiens(human) | |
| Product | COMM domain-containing protein 8 isoform 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY051002.1, BC008371.1, BC015145.1 and AC107398.4. On Jul 22, 2016 this sequence version replaced NM_017845.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1163655.41953.1, SRR1163657.559674.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_060315.1 |
| CDS | 80..631 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_017845.4 |
ORF Insert Sequence:
1 | ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu02586 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_017845.4 , NM_017845.5 , NM_017845.3 | |
| Accession Version | NM_017845.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-10 | |
| Organism | Homo sapiens(human) | |
| Product | COMM domain-containing protein 8 isoform 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC107398.4. On Nov 23, 2018 this sequence version replaced NM_017845.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR3476690.734432.1, SRR5189667.132089.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000381571.6/ ENSP00000370984.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_060315.1 |
| CDS | 52..603 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_017845.5 |
ORF Insert Sequence:
1 | ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu02586 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_017845.4 , NM_017845.5 , NM_017845.3 | |
| Accession Version | NM_017845.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-03-14 | |
| Organism | Homo sapiens(Human) | |
| Product | COMM domain-containing protein 8 | |
| Comment | ||
1 | ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_060315.1 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_017845.3 |
ORF Insert Sequence:
1 | ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu38575 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001329668.1 | |
| Accession Version | NM_001329668.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-10 | |
| Organism | Homo sapiens(human) | |
| Product | COMM domain-containing protein 8 isoform 2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC107398.4 and BC015145.1. Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.120040.1, SRR1163658.457962.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001316597.1 |
| CDS | 80..625 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001329668.1 |
ORF Insert Sequence:
1 | ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu95246 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017008330.1 | |
| Accession Version | XM_017008330.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-05 | |
| Organism | Homo sapiens(human) | |
| Product | COMM domain-containing protein 8 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_016863819.1 |
| CDS | 52..621 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_017008330.1 |
ORF Insert Sequence:
1 | ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. |
|
Architecture of the human interactome defines protein communities and disease networks. |
|
CCDC22 deficiency in humans blunts activation of proinflammatory NF-?B signaling. |
|
A directed protein interaction network for investigating intracellular signal transduction. |