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COMMD8 cDNA ORF clone, Homo sapiens(Human)

Summary

Gene Symbol COMMD8
Entrez Gene ID 54951
Full Name COMM domain containing 8
General protein information
Preferred Names

COMM domain containing 8

Names

COMM domain-containing protein 8
Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

4

4p12
Summary The protein encoded by this gene binds coiled-coil domain-containing protein 22 (CCDC22), and this complex can regulate the turnover of I-kappa-B and the activation of NF-kappa-B. [provided by RefSeq, Jul 2016].
Disorder MIM:

616656


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_017008330.1 XP_016863819.1 COMM domain-containing protein 8 isoform X1
NM_001329668.1 NP_001316597.1 COMM domain-containing protein 8 isoform 2
NM_017845.4 NP_060315.1 COMM domain-containing protein 8 isoform 1
NM_017845.3 NP_060315.1 COMM domain-containing protein 8

Pathways from BioSystems


Homologies


Homo sapiens (human) COMMD8 NP_060315.1
Rattus norvegicus (Norway rat) Commd8 NP_001099474.1
Danio rerio (zebrafish) commd8 NP_001071186.1
COMMD8 XP_001101515.1
Bos taurus (cattle) COMMD8 XP_002688283.1
Mus musculus (house mouse) Commd8 NP_848714.1
Gallus gallus (chicken) COMMD8 NP_001264750.1
Xenopus tropicalis (tropical clawed frog) commd8 NP_001016404.1
Pan troglodytes (chimpanzee) COMMD8 XP_001154216.1
Canis lupus familiaris (dog) COMMD8 XP_532368.2

Gene Ontology


Bibliography

Related articles in PubMed

CCDC22 deficiency in humans blunts activation of proinflammatory NF-?B signaling.
Starokadomskyy P, Gluck N, Li H, Chen B, Wallis M, Maine GN, Mao X, Zaidi IW, Hein MY, McDonald FJ, Lenzner S, Zecha A, Ropers HH, Kuss AW, McGaughran J, Gecz J, Burstein E
The Journal of clinical investigation123(5)2244-56(2013 May)

COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
Mao X, Gluck N, Chen B, Starokadomskyy P, Li H, Maine GN, Burstein E
The Journal of biological chemistry286(37)32355-65(2011 Sep)

COMMD proteins, a novel family of structural and functional homologs of MURR1.
Burstein E, Hoberg JE, Wilkinson AS, Rumble JM, Csomos RA, Komarck CM, Maine GN, Wilkinson JC, Mayo MW, Duckett CS
The Journal of biological chemistry280(23)22222-32(2005 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following COMMD8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COMMD8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone
***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu02586 NM_017845.4
Latest version!		 Homo sapiens COMM domain containing 8 (COMMD8), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu38575 NM_001329668.1
Latest version!		 Homo sapiens COMM domain containing 8 (COMMD8), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu95246 XM_017008330.1
Latest version!		 Homo sapiens COMM domain containing 8 (COMMD8), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
View Old Accession Versions >>
OHu02586 NM_017845.3 Homo sapiens COMM domain containing 8 (COMMD8), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
Hide Old Accession Versions >>

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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu02586
Clone ID Related Accession (Same CDS sequence) NM_017845.4 , NM_017845.3
Accession Version NM_017845.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 552bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-09-10
Organism Homo sapiens(human)
Product COMM domain-containing protein 8 isoform 1
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY051002.1, BC008371.1, BC015145.1 and AC107398.4. On Jul 22, 2016 this sequence version replaced NM_017845.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1163655.41953.1, SRR1163657.559674.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGG TAAAGCTTGC ACTTTCCAGT GACAAGATTG CTGCATTACG AATGCCACTT 
TTAAGCCTGC ATCTAGATGT AAAAGAAAAT GGTGAAGTAA AACCTTATTC TATTGAAATG 
AGTAGAGAGG AGCTGCAGAA TCTAATACAG TCCTTGGAAG CAGCGAATAA GGTGGTCCTG 
CAGTTGAAAT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_060315.1
CDS80..631
Misc Feature(1)53..55
Misc Feature(2)98..625
Exon (1)1..145
Exon (2)146..301
Exon (3)302..454
Exon (4)455..610
Exon (5)611..1489
Translation

Target ORF information:

RefSeq Version NM_017845.4
Organism Homo sapiens(human)
Definition Homo sapiens COMM domain containing 8 (COMMD8), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_017845.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGG TAAAGCTTGC ACTTTCCAGT GACAAGATTG CTGCATTACG AATGCCACTT 
TTAAGCCTGC ATCTAGATGT AAAAGAAAAT GGTGAAGTAA AACCTTATTC TATTGAAATG 
AGTAGAGAGG AGCTGCAGAA TCTAATACAG TCCTTGGAAG CAGCGAATAA GGTGGTCCTG 
CAGTTGAAAT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu02586
Clone ID Related Accession (Same CDS sequence) NM_017845.4 , NM_017845.3
Accession Version NM_017845.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 552bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-15
Organism Homo sapiens(Human)
Product COMM domain-containing protein 8
Comment 

1
61
121
181
241
301
361
421
481
541
ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGG TAAAGCTTGC ACTTTCCAGT GACAAGATTG CTGCATTACG AATGCCACTT 
TTAAGCCTGC ATCTAGATGT AAAAGAAAAT GGTGAAGTAA AACCTTATTC TATTGAAATG 
AGTAGAGAGG AGCTGCAGAA TCTAATACAG TCCTTGGAAG CAGCGAATAA GGTGGTCCTG 
CAGTTGAAAT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_060315.1
Translation

Target ORF information:

RefSeq Version NM_017845.3
Organism Homo sapiens(Human)
Definition Homo sapiens COMM domain containing 8 (COMMD8), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_017845.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGG TAAAGCTTGC ACTTTCCAGT GACAAGATTG CTGCATTACG AATGCCACTT 
TTAAGCCTGC ATCTAGATGT AAAAGAAAAT GGTGAAGTAA AACCTTATTC TATTGAAATG 
AGTAGAGAGG AGCTGCAGAA TCTAATACAG TCCTTGGAAG CAGCGAATAA GGTGGTCCTG 
CAGTTGAAAT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu38575
Clone ID Related Accession (Same CDS sequence) NM_001329668.1
Accession Version NM_001329668.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 546bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-09-10
Organism Homo sapiens(human)
Product COMM domain-containing protein 8 isoform 2
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC107398.4 and BC015145.1. Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.120040.1, SRR1163658.457962.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGC TTGCACTTTC CAGTGACAAG ATTGCTGCAT TACGAATGCC ACTTTTAAGC 
CTGCATCTAG ATGTAAAAGA AAATGGTGAA GTAAAACCTT ATTCTATTGA AATGAGTAGA 
GAGGAGCTGC AGAATCTAAT ACAGTCCTTG GAAGCAGCGA ATAAGGTGGT CCTGCAGTTG 
AAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001316597.1
CDS80..625
Misc Feature(1)53..55
Misc Feature(2)98..619
Exon (1)1..145
Exon (2)146..301
Exon (3)302..448
Exon (4)449..604
Exon (5)605..1483
Translation

Target ORF information:

RefSeq Version NM_001329668.1
Organism Homo sapiens(human)
Definition Homo sapiens COMM domain containing 8 (COMMD8), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001329668.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGC TTGCACTTTC CAGTGACAAG ATTGCTGCAT TACGAATGCC ACTTTTAAGC 
CTGCATCTAG ATGTAAAAGA AAATGGTGAA GTAAAACCTT ATTCTATTGA AATGAGTAGA 
GAGGAGCTGC AGAATCTAAT ACAGTCCTTG GAAGCAGCGA ATAAGGTGGT CCTGCAGTTG 
AAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu95246
Clone ID Related Accession (Same CDS sequence) XM_017008330.1
Accession Version XM_017008330.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 570bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(human)
Product COMM domain-containing protein 8 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGG TAAAGCTTGC ACTTTCCAGT GACAAGATTG CTGCATTACG AATGCCACTT 
TTAAGCCTGC ATCTAGATGT AAAAGAAAAT GGTGAAGTAA AACCTTATTC TATTGAAATG 
AGTAGAGAGG AGCTGCAGAA TCTAATACAG TCCTTGGAAG CAGCGAATAA GGTATTTGCT 
ATAATTTTGT CATATGATTT GAATGTTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016863819.1
CDS52..621
Translation

Target ORF information:

RefSeq Version XM_017008330.1
Organism Homo sapiens(human)
Definition Homo sapiens COMM domain containing 8 (COMMD8), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017008330.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGAGCCGG AAGAGGGGAC GCCCTTGTGG CGGCTGCAGA AGCTGCCGGC CGAGCTGGGC 
CCGCAGCTTC TTCACAAAAT AATTGATGGC ATTTGTGGTC GAGCTTATCC TGTGTACCAA 
GATTATCACA CTGTTTGGGA ATCAGAAGAA TGGATGCACG TTTTAGAAGA TATTGCCAAA 
TTTTTCAAAG CCATAGTTGG TAAAAACTTA CCTGATGAAG AGATATTTCA GCAGTTGAAT 
CAGTTGAATT CACTTCATCA AGAAACTATC ATGAAATGCG TGAAAAGTAG GAAAGATGAA 
ATCAAACAGG CTCTGTCAAG AGAAATAGTT GCTATTTCCT CTGCACAGCT ACAGGATTTT 
GATTGGCAGG TAAAGCTTGC ACTTTCCAGT GACAAGATTG CTGCATTACG AATGCCACTT 
TTAAGCCTGC ATCTAGATGT AAAAGAAAAT GGTGAAGTAA AACCTTATTC TATTGAAATG 
AGTAGAGAGG AGCTGCAGAA TCTAATACAG TCCTTGGAAG CAGCGAATAA GGTATTTGCT 
ATAATTTTGT CATATGATTT GAATGTTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

CCDC22 deficiency in humans blunts activation of proinflammatory NF-?B signaling.
The Journal of clinical investigation123(5)2244-56(2013 May)
Starokadomskyy P,Gluck N,Li H,Chen B,Wallis M,Maine GN,Mao X,Zaidi IW,Hein MY,McDonald FJ,Lenzner S,Zecha A,Ropers HH,Kuss AW,McGaughran J,Gecz J,Burstein E


book

COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
The Journal of biological chemistry286(37)32355-65(2011 Sep)
Mao X,Gluck N,Chen B,Starokadomskyy P,Li H,Maine GN,Burstein E


book

COMMD proteins, a novel family of structural and functional homologs of MURR1.
The Journal of biological chemistry280(23)22222-32(2005 Jun)
Burstein E,Hoberg JE,Wilkinson AS,Rumble JM,Csomos RA,Komarck CM,Maine GN,Wilkinson JC,Mayo MW,Duckett CS