Gene Symbol | MCUB |
Entrez Gene ID | 55013 |
Full Name | mitochondrial calcium uniporter dominant negative beta subunit |
Synonyms | CCDC109B |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
ORF » Species Summary » Homo sapiens » MCUB cDNA ORF clone
gRNAs
Gene Symbol | MCUB |
Entrez Gene ID | 55013 |
Full Name | mitochondrial calcium uniporter dominant negative beta subunit |
Synonyms | CCDC109B |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006714246.3 | XP_006714309.1 | calcium uniporter regulatory subunit MCUb, mitochondrial isoform X1 |
NM_017918.4 | NP_060388.2 | calcium uniporter regulatory subunit MCUb, mitochondrial |
NM_017918.5 | NP_060388.2 | calcium uniporter regulatory subunit MCUb, mitochondrial |
Xenopus tropicalis (tropical clawed frog) | ccdc109b | NP_001120048.1 |
Homo sapiens (human) | CCDC109B | NP_060388.2 |
Pan troglodytes (chimpanzee) | CCDC109B | XP_517392.2 |
Mus musculus (house mouse) | Ccdc109b | NP_080055.2 |
Rattus norvegicus (Norway rat) | Ccdc109b | XP_006233342.1 |
Gallus gallus (chicken) | CCDC109B | XP_420651.4 |
LOC698670 | XP_001087164.1 | |
Canis lupus familiaris (dog) | CCDC109B | XP_005639324.1 |
Bos taurus (cattle) | CCDC109B | NP_001068639.1 |
Coiled-coil domain containing 109B is a HIF1?-regulated gene critical for progression of human gliomas.
Xu R, Han M, Xu Y, Zhang X, Zhang C, Zhang D, Ji J, Wei Y, Wang S, Huang B, Chen A, Zhang Q, Li W, Sun T, Wang F, Li X, Wang J
Journal of translational medicine15(1)165(2017 Jul)
EMRE is an essential component of the mitochondrial calcium uniporter complex.
Sancak Y, Markhard AL, Kitami T, Kov?cs-Bogd?n E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK
Science (New York, N.Y.)342(6164)1379-82(2013 Dec)
The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit.
Raffaello A, De Stefani D, Sabbadin D, Teardo E, Merli G, Picard A, Checchetto V, Moro S, Szab? I, Rizzuto R
The EMBO journal32(17)2362-76(2013 Aug)
Seven new loci associated with age-related macular degeneration.
Fritsche LG, Chen W, Schu M, Yaspan BL, Yu Y, Thorleifsson G, Zack DJ, Arakawa S, Cipriani V, Ripke S, Igo RP Jr, Buitendijk GH, Sim X, Weeks DE, Guymer RH, Merriam JE, Francis PJ, Hannum G, Agarwal A, Armbrecht AM, Audo I, Aung T, Barile GR, Benchaboune M, Bird AC, Bishop PN, Branham KE, Brooks M, Brucker AJ, Cade WH, Cain MS, Campochiaro PA, Chan CC, Cheng CY, Chew EY, Chin KA, Chowers I, Clayton DG, Cojocaru R, Conley YP, Cornes BK, Daly MJ, Dhillon B, Edwards AO, Evangelou E, Fagerness J, Ferreyra HA, Friedman JS, Geirsdottir A, George RJ, Gieger C, Gupta N, Hagstrom SA, Harding SP, Haritoglou C, Heckenlively JR, Holz FG, Hughes G, Ioannidis JP, Ishibashi T, Joseph P, Jun G, Kamatani Y, Katsanis N, N Keilhauer C, Khan JC, Kim IK, Kiyohara Y, Klein BE, Klein R, Kovach JL, Kozak I, Lee CJ, Lee KE, Lichtner P, Lotery AJ, Meitinger T, Mitchell P, Mohand-Sa?d S, Moore AT, Morgan DJ, Morrison MA, Myers CE, Naj AC, Nakamura Y, Okada Y, Orlin A, Ortube MC, Othman MI, Pappas C, Park KH, Pauer GJ, Peachey NS, Poch O, Priya RR, Reynolds R, Richardson AJ, Ripp R, Rudolph G, Ryu E, Sahel JA, Schaumberg DA, Scholl HP, Schwartz SG, Scott WK, Shahid H, Sigurdsson H, Silvestri G, Sivakumaran TA, Smith RT, Sobrin L, Souied EH, Stambolian DE, Stefansson H, Sturgill-Short GM, Takahashi A, Tosakulwong N, Truitt BJ, Tsironi EE, Uitterlinden AG, van Duijn CM, Vijaya L, Vingerling JR, Vithana EN, Webster AR, Wichmann HE, Winkler TW, Wong TY, Wright AF, Zelenika D, Zhang M, Zhao L, Zhang K, Klein ML, Hageman GS, Lathrop GM, Stefansson K, Allikmets R, Baird PN, Gorin MB, Wang JJ, Klaver CC, Seddon JM, Pericak-Vance MA, Iyengar SK, Yates JR, Swaroop A, Weber BH, Kubo M, Deangelis MM, L?veillard T, Thorsteinsdottir U, Haines JL, Farrer LA, Heid IM, Abecasis GR,
Nature genetics45(4)433-9, 439e1-2(2013 Apr)
A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J Jr, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP
Human molecular genetics19(12)2497-506(2010 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
MCUb (also known as CCDC109b) is a paralogue of MCU (CCDC109a). MCUb physically resides within the mitochondrial uniporter complex (uniplex), which consists of the MCU, MCUb, EMRE, MICU1, and MICU2.
Title: EMRE is an essential component of the mitochondrial calcium uniporter complex.
Observational study of gene-disease association. (HuGE Navigator)
Title: A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Observational study of gene-disease association. (HuGE Navigator)
Title: Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
The following MCUB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MCUB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu13258![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_017918.4 , NM_017918.5 | |
Accession Version | NM_017918.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1011bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | calcium uniporter regulatory subunit MCUb, mitochondrial | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN427680.1, AK291098.1, BM830891.1 and BC002633.2. On Jul 10, 2008 this sequence version replaced NM_017918.3. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.205818.1, SRR1163655.356914.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## |
1 | ATGCTCCAGA GGGGCCTCTG GCCGTGGCGC ACGCGGCTGC TGCCGACCCC TGGCACCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_060388.2 |
CDS | 140..1150 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCTCCAGA GGGGCCTCTG GCCGTGGCGC ACGCGGCTGC TGCCGACCCC TGGCACCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu13258![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_017918.4 , NM_017918.5 | |
Accession Version | NM_017918.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1011bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-26 | |
Organism | Homo sapiens(human) | |
Product | calcium uniporter regulatory subunit MCUb, mitochondrial | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK291098.1, BM830891.1, BC002633.2 and AC004067.1. On Nov 23, 2018 this sequence version replaced NM_017918.4. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.243268.1, AK095936.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology MANE Ensembl match :: ENST00000394650.7/ ENSP00000378145.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGCTCCAGA GGGGCCTCTG GCCGTGGCGC ACGCGGCTGC TGCCGACCCC TGGCACCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_060388.2 |
CDS | 93..1103 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCTCCAGA GGGGCCTCTG GCCGTGGCGC ACGCGGCTGC TGCCGACCCC TGGCACCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu38989 | |
Clone ID Related Accession (Same CDS sequence) | XM_006714246.3 | |
Accession Version | XM_006714246.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | calcium uniporter regulatory subunit MCUb, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006714246.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGTGTGC TGGTTTTGCG TGTGAAGCTG TGTGGAAATG TGAAATACTA CCAGTCACAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006714309.1 |
CDS | 338..1261 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGTGTGC TGGTTTTGCG TGTGAAGCTG TGTGGAAATG TGAAATACTA CCAGTCACAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Coiled-coil domain containing 109B is a HIF1?-regulated gene critical for progression of human gliomas. |
EMRE is an essential component of the mitochondrial calcium uniporter complex. |
The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit. |
Seven new loci associated with age-related macular degeneration. |
A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. |