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WRAP53 cDNA ORF clone, Homo sapiens (human)

Gene Symbol WRAP53
Entrez Gene ID 55135
Full Name WD repeat containing, antisense to TP53
Synonyms DKCB3, TCAB1, WDR79
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p13.1

Summary This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]. lac of sum
Disorder MIM:

612661


mRNA and Protein(s)

mRNA Protein Name
NM_001143991 NP_001137463 telomerase Cajal body protein 1
NM_001143990 NP_001137462 telomerase Cajal body protein 1
XM_011523952 XP_011522254 telomerase Cajal body protein 1 isoform X1
NM_018081 NP_060551 telomerase Cajal body protein 1
NM_001143992 NP_001137464 telomerase Cajal body protein 1



Homo sapiens (human) WRAP53 NP_001137462.1
Pan troglodytes (chimpanzee) WRAP53 XP_001172037.1
Macaca mulatta (Rhesus monkey) WRAP53 XP_001110427.1
Canis lupus familiaris (dog) WRAP53 XP_005620047.1
Bos taurus (cattle) WRAP53 NP_001030245.1
Mus musculus (house mouse) Wrap53 NP_659073.1
Rattus norvegicus (Norway rat) Wrap53 NP_001007611.1
Danio rerio (zebrafish) wrap53 NP_001242957.1
Drosophila melanogaster (fruit fly) WDR79 NP_608997.3
Arabidopsis thaliana (thale cress) AT4G21520 NP_193883.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following WRAP53 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the WRAP53 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu16517
NM_001143991 Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$219.50-$307.30
$439.00
OHu16517
NM_001143990 Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$219.50-$307.30
$439.00
OHu69065 XM_011523952 PREDICTED: Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $223.30
$319.00
OHu16517
NM_018081 Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$219.50-$307.30
$439.00
OHu16517
NM_001143992 Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$219.50-$307.30
$439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu16517
Clone ID Related Accession (Same CDS sequence) NM_001143990 , NM_001143991 , NM_001143992 , NM_018081
Accession Version NM_001143991.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1647bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 20-APR-2014
Organism Homo sapiens (human)
Product telomerase Cajal body protein 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY766322.1. Transcript Variant: This variant (3, also known as WRAP53alpha) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY766322.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGAAGACTT TGGAGACTCA ACCGTTAGCT CCGGACTGCT GTCCTTCAGA CCAGGACCCA 
GCTCCAGCCC ATCCTTCTCC CCACGCTTCC CCGATGAATA AAAATGCGGA CTCTGAACTG
ATGCCACCGC CTCCCGAAAG GGGGGATCCG CCCCGGTTGT CCCCAGATCC TGTGGCTGGC
TCAGCTGTGT CCCAGGAGCT ACGGGAGGGG GACCCAGTTT CTCTCTCCAC TCCCCTGGAA
ACAGAGTTTG GTTCCCCTAG TGAGTTGAGT CCTCGAATCG AGGAGCAAGA ACTTTCTGAA
AATACAAGCC TTCCTGCAGA AGAAGCAAAC GGGAGCCTTT CTGAAGAAGA AGCGAACGGG
CCAGAGTTGG GGTCTGGAAA AGCCATGGAA GATACCTCTG GGGAACCCGC TGCAGAGGAC
GAGGGAGACA CCGCTTGGAA CTACAGCTTC TCCCAGCTGC CTCGATTTCT CAGTGGTTCC
TGGTCAGAGT TCAGCACCCA ACCTGAGAAC TTCTTGAAAG GCTGTAAGTG GGCTCCTGAC
GGTTCCTGCA TCTTGACCAA TAGTGCTGAT AACATCTTGC GAATTTATAA CCTGCCCCCA
GAGCTGTACC ATGAGGGGGA GCAGGTGGAA TATGCAGAAA TGGTCCCTGT CCTTCGAATG
GTGGAAGGTG ATACCATCTA TGATTACTGC TGGTATTCTC TGATGTCCTC AGCCCAGCCA
GACACCTCCT ACGTGGCCAG CAGCAGCCGG GAGAACCCGA TTCATATCTG GGACGCATTC
ACTGGAGAGC TCCGGGCTTC CTTTCGCGCC TACAACCACC TGGATGAGCT GACGGCAGCC
CATTCGCTCT GCTTCTCCCC GGATGGCTCC CAGCTCTTCT GTGGCTTCAA CCGGACTGTG
CGTGTTTTTT CCACGGCCCG GCCTGGCCGA GACTGCGAGG TCCGAGCCAC ATTTGCAAAA
AAGCAGGGCC AGAGCGGCAT CATCTCCTGC ATAGCCTTCA GCCCAGCCCA GCCCCTCTAT
GCCTGTGGCT CCTACGGCCG CTCCCTGGGT CTGTATGCCT GGGATGATGG CTCCCCTCTC
GCCTTGCTGG GAGGGCACCA AGGGGGCATC ACCCACCTCT GCTTTCATCC CGATGGCAAC
CGCTTCTTCT CAGGAGCCCG CAAGGATGCT GAGCTCCTGT GCTGGGATCT CCGGCAGTCT
GGTTACCCAC TGTGGTCCCT GGGTCGAGAG GTGACCACCA ATCAGCGCAT CTACTTCGAT
CTGGACCCGA CCGGGCAGTT CCTAGTGAGT GGCAGCACGA GCGGGGCTGT CTCTGTGTGG
GACACGGACG GGCCTGGCAA TGATGGGAAG CCGGAGCCCG TGTTGAGTTT TCTGCCCCAG
AAGGACTGCA CCAATGGCGT GAGCCTGCAC CCTAGCCTGC CTCTCCTGGC CACTGCCTCC
GGTCAGCGTG TGTTTCCTGA GCCCACAGAG AGTGGGGACG AAGGAGAGGA GCTGGGCCTT
CCCTTGCTCT CCACGCGCCA CGTCCACCTT GAATGTCGGC TTCAGCTCTG GTGGTGTGGG
GGGGCGCCAG ACTCCAGCAT CCCTGATGAT CACCAGGGCG AGAAAGGGCA GGGAGGAACG
GAGGGAGGTG TGGGTGAGCT GATATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001137463.1
CDS166..1812
Misc Feature(1)160..162(+)
Misc Feature(2)241..243(+)
Misc Feature(3)253..255(+)
Misc Feature(4)325..327(+)
Misc Feature(5)418..420(+)
Misc Feature(6)433..435(+)
Misc Feature(7)499..501(+)
Misc Feature(8)505..507(+)
Misc Feature(9)664..783(+)
Misc Feature(10)688..1605(+)
Misc Feature(11)721..1599(+)
Misc Feature(12)829..966(+)
Misc Feature(13)883..>1605(+)
Misc Feature(14)979..1104(+)
Misc Feature(15)1132..1257(+)
Misc Feature(16)1258..1380(+)
Misc Feature(17)1396..1515(+)
Misc Feature(18)1630..1632(+)
Misc Feature(19)1636..1638(+)
Exon (1)1..164
Gene:WRAP53
Gene Synonym:
Exon (2)165..596
Gene:WRAP53
Gene Synonym:
Exon (3)597..695
Gene:WRAP53
Gene Synonym:
Exon (4)696..807
Gene:WRAP53
Gene Synonym:
Exon (5)808..896
Gene:WRAP53
Gene Synonym:
Exon (6)897..987
Gene:WRAP53
Gene Synonym:
Exon (7)988..1120
Gene:WRAP53
Gene Synonym:
Exon (8)1121..1329
Gene:WRAP53
Gene Synonym:
Exon (9)1330..1433
Gene:WRAP53
Gene Synonym:
Exon (10)1434..1568
Gene:WRAP53
Gene Synonym:
Exon (11)1569..1828
Gene:WRAP53
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001143991
Organism Homo sapiens (human)
Definition Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001143991

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGAAGACTT TGGAGACTCA ACCGTTAGCT CCGGACTGCT GTCCTTCAGA CCAGGACCCA 
GCTCCAGCCC ATCCTTCTCC CCACGCTTCC CCGATGAATA AAAATGCGGA CTCTGAACTG
ATGCCACCGC CTCCCGAAAG GGGGGATCCG CCCCGGTTGT CCCCAGATCC TGTGGCTGGC
TCAGCTGTGT CCCAGGAGCT ACGGGAGGGG GACCCAGTTT CTCTCTCCAC TCCCCTGGAA
ACAGAGTTTG GTTCCCCTAG TGAGTTGAGT CCTCGAATCG AGGAGCAAGA ACTTTCTGAA
AATACAAGCC TTCCTGCAGA AGAAGCAAAC GGGAGCCTTT CTGAAGAAGA AGCGAACGGG
CCAGAGTTGG GGTCTGGAAA AGCCATGGAA GATACCTCTG GGGAACCCGC TGCAGAGGAC
GAGGGAGACA CCGCTTGGAA CTACAGCTTC TCCCAGCTGC CTCGATTTCT CAGTGGTTCC
TGGTCAGAGT TCAGCACCCA ACCTGAGAAC TTCTTGAAAG GCTGTAAGTG GGCTCCTGAC
GGTTCCTGCA TCTTGACCAA TAGTGCTGAT AACATCTTGC GAATTTATAA CCTGCCCCCA
GAGCTGTACC ATGAGGGGGA GCAGGTGGAA TATGCAGAAA TGGTCCCTGT CCTTCGAATG
GTGGAAGGTG ATACCATCTA TGATTACTGC TGGTATTCTC TGATGTCCTC AGCCCAGCCA
GACACCTCCT ACGTGGCCAG CAGCAGCCGG GAGAACCCGA TTCATATCTG GGACGCATTC
ACTGGAGAGC TCCGGGCTTC CTTTCGCGCC TACAACCACC TGGATGAGCT GACGGCAGCC
CATTCGCTCT GCTTCTCCCC GGATGGCTCC CAGCTCTTCT GTGGCTTCAA CCGGACTGTG
CGTGTTTTTT CCACGGCCCG GCCTGGCCGA GACTGCGAGG TCCGAGCCAC ATTTGCAAAA
AAGCAGGGCC AGAGCGGCAT CATCTCCTGC ATAGCCTTCA GCCCAGCCCA GCCCCTCTAT
GCCTGTGGCT CCTACGGCCG CTCCCTGGGT CTGTATGCCT GGGATGATGG CTCCCCTCTC
GCCTTGCTGG GAGGGCACCA AGGGGGCATC ACCCACCTCT GCTTTCATCC CGATGGCAAC
CGCTTCTTCT CAGGAGCCCG CAAGGATGCT GAGCTCCTGT GCTGGGATCT CCGGCAGTCT
GGTTACCCAC TGTGGTCCCT GGGTCGAGAG GTGACCACCA ATCAGCGCAT CTACTTCGAT
CTGGACCCGA CCGGGCAGTT CCTAGTGAGT GGCAGCACGA GCGGGGCTGT CTCTGTGTGG
GACACGGACG GGCCTGGCAA TGATGGGAAG CCGGAGCCCG TGTTGAGTTT TCTGCCCCAG
AAGGACTGCA CCAATGGCGT GAGCCTGCAC CCTAGCCTGC CTCTCCTGGC CACTGCCTCC
GGTCAGCGTG TGTTTCCTGA GCCCACAGAG AGTGGGGACG AAGGAGAGGA GCTGGGCCTT
CCCTTGCTCT CCACGCGCCA CGTCCACCTT GAATGTCGGC TTCAGCTCTG GTGGTGTGGG
GGGGCGCCAG ACTCCAGCAT CCCTGATGAT CACCAGGGCG AGAAAGGGCA GGGAGGAACG
GAGGGAGGTG TGGGTGAGCT GATATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16517
Clone ID Related Accession (Same CDS sequence) NM_001143990 , NM_001143991 , NM_001143992 , NM_018081
Accession Version NM_001143990.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1647bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 20-APR-2014
Organism Homo sapiens (human)
Product telomerase Cajal body protein 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ431241.1. Transcript Variant: This variant (2, also known as WRAP53gamma) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ431241.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGAAGACTT TGGAGACTCA ACCGTTAGCT CCGGACTGCT GTCCTTCAGA CCAGGACCCA 
GCTCCAGCCC ATCCTTCTCC CCACGCTTCC CCGATGAATA AAAATGCGGA CTCTGAACTG
ATGCCACCGC CTCCCGAAAG GGGGGATCCG CCCCGGTTGT CCCCAGATCC TGTGGCTGGC
TCAGCTGTGT CCCAGGAGCT ACGGGAGGGG GACCCAGTTT CTCTCTCCAC TCCCCTGGAA
ACAGAGTTTG GTTCCCCTAG TGAGTTGAGT CCTCGAATCG AGGAGCAAGA ACTTTCTGAA
AATACAAGCC TTCCTGCAGA AGAAGCAAAC GGGAGCCTTT CTGAAGAAGA AGCGAACGGG
CCAGAGTTGG GGTCTGGAAA AGCCATGGAA GATACCTCTG GGGAACCCGC TGCAGAGGAC
GAGGGAGACA CCGCTTGGAA CTACAGCTTC TCCCAGCTGC CTCGATTTCT CAGTGGTTCC
TGGTCAGAGT TCAGCACCCA ACCTGAGAAC TTCTTGAAAG GCTGTAAGTG GGCTCCTGAC
GGTTCCTGCA TCTTGACCAA TAGTGCTGAT AACATCTTGC GAATTTATAA CCTGCCCCCA
GAGCTGTACC ATGAGGGGGA GCAGGTGGAA TATGCAGAAA TGGTCCCTGT CCTTCGAATG
GTGGAAGGTG ATACCATCTA TGATTACTGC TGGTATTCTC TGATGTCCTC AGCCCAGCCA
GACACCTCCT ACGTGGCCAG CAGCAGCCGG GAGAACCCGA TTCATATCTG GGACGCATTC
ACTGGAGAGC TCCGGGCTTC CTTTCGCGCC TACAACCACC TGGATGAGCT GACGGCAGCC
CATTCGCTCT GCTTCTCCCC GGATGGCTCC CAGCTCTTCT GTGGCTTCAA CCGGACTGTG
CGTGTTTTTT CCACGGCCCG GCCTGGCCGA GACTGCGAGG TCCGAGCCAC ATTTGCAAAA
AAGCAGGGCC AGAGCGGCAT CATCTCCTGC ATAGCCTTCA GCCCAGCCCA GCCCCTCTAT
GCCTGTGGCT CCTACGGCCG CTCCCTGGGT CTGTATGCCT GGGATGATGG CTCCCCTCTC
GCCTTGCTGG GAGGGCACCA AGGGGGCATC ACCCACCTCT GCTTTCATCC CGATGGCAAC
CGCTTCTTCT CAGGAGCCCG CAAGGATGCT GAGCTCCTGT GCTGGGATCT CCGGCAGTCT
GGTTACCCAC TGTGGTCCCT GGGTCGAGAG GTGACCACCA ATCAGCGCAT CTACTTCGAT
CTGGACCCGA CCGGGCAGTT CCTAGTGAGT GGCAGCACGA GCGGGGCTGT CTCTGTGTGG
GACACGGACG GGCCTGGCAA TGATGGGAAG CCGGAGCCCG TGTTGAGTTT TCTGCCCCAG
AAGGACTGCA CCAATGGCGT GAGCCTGCAC CCTAGCCTGC CTCTCCTGGC CACTGCCTCC
GGTCAGCGTG TGTTTCCTGA GCCCACAGAG AGTGGGGACG AAGGAGAGGA GCTGGGCCTT
CCCTTGCTCT CCACGCGCCA CGTCCACCTT GAATGTCGGC TTCAGCTCTG GTGGTGTGGG
GGGGCGCCAG ACTCCAGCAT CCCTGATGAT CACCAGGGCG AGAAAGGGCA GGGAGGAACG
GAGGGAGGTG TGGGTGAGCT GATATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001137462.1
CDS156..1802
Misc Feature(1)231..233(+)
Misc Feature(2)243..245(+)
Misc Feature(3)315..317(+)
Misc Feature(4)408..410(+)
Misc Feature(5)423..425(+)
Misc Feature(6)489..491(+)
Misc Feature(7)495..497(+)
Misc Feature(8)654..773(+)
Misc Feature(9)678..1595(+)
Misc Feature(10)711..1589(+)
Misc Feature(11)819..956(+)
Misc Feature(12)873..>1595(+)
Misc Feature(13)969..1094(+)
Misc Feature(14)1122..1247(+)
Misc Feature(15)1248..1370(+)
Misc Feature(16)1386..1505(+)
Misc Feature(17)1620..1622(+)
Misc Feature(18)1626..1628(+)
Exon (1)1..154
Gene:WRAP53
Gene Synonym:
Exon (2)155..586
Gene:WRAP53
Gene Synonym:
Exon (3)587..685
Gene:WRAP53
Gene Synonym:
Exon (4)686..797
Gene:WRAP53
Gene Synonym:
Exon (5)798..886
Gene:WRAP53
Gene Synonym:
Exon (6)887..977
Gene:WRAP53
Gene Synonym:
Exon (7)978..1110
Gene:WRAP53
Gene Synonym:
Exon (8)1111..1319
Gene:WRAP53
Gene Synonym:
Exon (9)1320..1423
Gene:WRAP53
Gene Synonym:
Exon (10)1424..1558
Gene:WRAP53
Gene Synonym:
Exon (11)1559..1818
Gene:WRAP53
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001143990
Organism Homo sapiens (human)
Definition Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001143990

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGAAGACTT TGGAGACTCA ACCGTTAGCT CCGGACTGCT GTCCTTCAGA CCAGGACCCA 
GCTCCAGCCC ATCCTTCTCC CCACGCTTCC CCGATGAATA AAAATGCGGA CTCTGAACTG
ATGCCACCGC CTCCCGAAAG GGGGGATCCG CCCCGGTTGT CCCCAGATCC TGTGGCTGGC
TCAGCTGTGT CCCAGGAGCT ACGGGAGGGG GACCCAGTTT CTCTCTCCAC TCCCCTGGAA
ACAGAGTTTG GTTCCCCTAG TGAGTTGAGT CCTCGAATCG AGGAGCAAGA ACTTTCTGAA
AATACAAGCC TTCCTGCAGA AGAAGCAAAC GGGAGCCTTT CTGAAGAAGA AGCGAACGGG
CCAGAGTTGG GGTCTGGAAA AGCCATGGAA GATACCTCTG GGGAACCCGC TGCAGAGGAC
GAGGGAGACA CCGCTTGGAA CTACAGCTTC TCCCAGCTGC CTCGATTTCT CAGTGGTTCC
TGGTCAGAGT TCAGCACCCA ACCTGAGAAC TTCTTGAAAG GCTGTAAGTG GGCTCCTGAC
GGTTCCTGCA TCTTGACCAA TAGTGCTGAT AACATCTTGC GAATTTATAA CCTGCCCCCA
GAGCTGTACC ATGAGGGGGA GCAGGTGGAA TATGCAGAAA TGGTCCCTGT CCTTCGAATG
GTGGAAGGTG ATACCATCTA TGATTACTGC TGGTATTCTC TGATGTCCTC AGCCCAGCCA
GACACCTCCT ACGTGGCCAG CAGCAGCCGG GAGAACCCGA TTCATATCTG GGACGCATTC
ACTGGAGAGC TCCGGGCTTC CTTTCGCGCC TACAACCACC TGGATGAGCT GACGGCAGCC
CATTCGCTCT GCTTCTCCCC GGATGGCTCC CAGCTCTTCT GTGGCTTCAA CCGGACTGTG
CGTGTTTTTT CCACGGCCCG GCCTGGCCGA GACTGCGAGG TCCGAGCCAC ATTTGCAAAA
AAGCAGGGCC AGAGCGGCAT CATCTCCTGC ATAGCCTTCA GCCCAGCCCA GCCCCTCTAT
GCCTGTGGCT CCTACGGCCG CTCCCTGGGT CTGTATGCCT GGGATGATGG CTCCCCTCTC
GCCTTGCTGG GAGGGCACCA AGGGGGCATC ACCCACCTCT GCTTTCATCC CGATGGCAAC
CGCTTCTTCT CAGGAGCCCG CAAGGATGCT GAGCTCCTGT GCTGGGATCT CCGGCAGTCT
GGTTACCCAC TGTGGTCCCT GGGTCGAGAG GTGACCACCA ATCAGCGCAT CTACTTCGAT
CTGGACCCGA CCGGGCAGTT CCTAGTGAGT GGCAGCACGA GCGGGGCTGT CTCTGTGTGG
GACACGGACG GGCCTGGCAA TGATGGGAAG CCGGAGCCCG TGTTGAGTTT TCTGCCCCAG
AAGGACTGCA CCAATGGCGT GAGCCTGCAC CCTAGCCTGC CTCTCCTGGC CACTGCCTCC
GGTCAGCGTG TGTTTCCTGA GCCCACAGAG AGTGGGGACG AAGGAGAGGA GCTGGGCCTT
CCCTTGCTCT CCACGCGCCA CGTCCACCTT GAATGTCGGC TTCAGCTCTG GTGGTGTGGG
GGGGCGCCAG ACTCCAGCAT CCCTGATGAT CACCAGGGCG AGAAAGGGCA GGGAGGAACG
GAGGGAGGTG TGGGTGAGCT GATATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu69065
Clone ID Related Accession (Same CDS sequence) XM_011523952
Accession Version XM_011523952.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1008bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product telomerase Cajal body protein 1 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_010718.17) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGTCCCTG TCCTTCGAAT GGTGGAAGGT GATACCATCT ATGATTACTG CTGGTATTCT 
CTGATGTCCT CAGCCCAGCC AGACACCTCC TACGTGGCCA GCAGCAGCCG GGAGAACCCG
ATTCATATCT GGGACGCATT CACTGGAGAG CTCCGGGCTT CCTTTCGCGC CTACAACCAC
CTGGATGAGC TGACGGCAGC CCATTCGCTC TGCTTCTCCC CGGATGGCTC CCAGCTCTTC
TGTGGCTTCA ACCGGACTGT GCGTGTTTTT TCCACGGCCC GGCCTGGCCG AGACTGCGAG
GTCCGAGCCA CATTTGCAAA AAAGCAGGGC CAGAGCGGCA TCATCTCCTG CATAGCCTTC
AGCCCAGCCC AGCCCCTCTA TGCCTGTGGC TCCTACGGCC GCTCCCTGGG TCTGTATGCC
TGGGATGATG GCTCCCCTCT CGCCTTGCTG GGAGGGCACC AAGGGGGCAT CACCCACCTC
TGCTTTCATC CCGATGGCAA CCGCTTCTTC TCAGGAGCCC GCAAGGATGC TGAGCTCCTG
TGCTGGGATC TCCGGCAGTC TGGTTACCCA CTGTGGTCCC TGGGTCGAGA GGTGACCACC
AATCAGCGCA TCTACTTCGA TCTGGACCCG ACCGGGCAGT TCCTAGTGAG TGGCAGCACG
AGCGGGGCTG TCTCTGTGTG GGACACGGAC GGGCCTGGCA ATGATGGGAA GCCGGAGCCC
GTGTTGAGTT TTCTGCCCCA GAAGGACTGC ACCAATGGCG TGAGCCTGCA CCCTAGCCTG
CCTCTCCTGG CCACTGCCTC CGGTCAGCGT GTGTTTCCTG AGCCCACAGA GAGTGGGGAC
GAAGGAGAGG AGCTGGGCCT TCCCTTGCTC TCCACGCGCC ACGTCCACCT TGAATGTCGG
CTTCAGCTCT GGTGGTGTGG GGGGGCGCCA GACTCCAGCA TCCCTGATGA TCACCAGGGC
GAGAAAGGGC AGGGAGGAAC GGAGGGAGGT GTGGGTGAGC TGATATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011522254.1
CDS202..1209
Misc Feature(1)280..1002(+)
Misc Feature(2)280..>1002(+)
Misc Feature(3)301..996(+)
Translation

Target ORF information:

RefSeq Version XM_011523952
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011523952

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGTCCCTG TCCTTCGAAT GGTGGAAGGT GATACCATCT ATGATTACTG CTGGTATTCT 
CTGATGTCCT CAGCCCAGCC AGACACCTCC TACGTGGCCA GCAGCAGCCG GGAGAACCCG
ATTCATATCT GGGACGCATT CACTGGAGAG CTCCGGGCTT CCTTTCGCGC CTACAACCAC
CTGGATGAGC TGACGGCAGC CCATTCGCTC TGCTTCTCCC CGGATGGCTC CCAGCTCTTC
TGTGGCTTCA ACCGGACTGT GCGTGTTTTT TCCACGGCCC GGCCTGGCCG AGACTGCGAG
GTCCGAGCCA CATTTGCAAA AAAGCAGGGC CAGAGCGGCA TCATCTCCTG CATAGCCTTC
AGCCCAGCCC AGCCCCTCTA TGCCTGTGGC TCCTACGGCC GCTCCCTGGG TCTGTATGCC
TGGGATGATG GCTCCCCTCT CGCCTTGCTG GGAGGGCACC AAGGGGGCAT CACCCACCTC
TGCTTTCATC CCGATGGCAA CCGCTTCTTC TCAGGAGCCC GCAAGGATGC TGAGCTCCTG
TGCTGGGATC TCCGGCAGTC TGGTTACCCA CTGTGGTCCC TGGGTCGAGA GGTGACCACC
AATCAGCGCA TCTACTTCGA TCTGGACCCG ACCGGGCAGT TCCTAGTGAG TGGCAGCACG
AGCGGGGCTG TCTCTGTGTG GGACACGGAC GGGCCTGGCA ATGATGGGAA GCCGGAGCCC
GTGTTGAGTT TTCTGCCCCA GAAGGACTGC ACCAATGGCG TGAGCCTGCA CCCTAGCCTG
CCTCTCCTGG CCACTGCCTC CGGTCAGCGT GTGTTTCCTG AGCCCACAGA GAGTGGGGAC
GAAGGAGAGG AGCTGGGCCT TCCCTTGCTC TCCACGCGCC ACGTCCACCT TGAATGTCGG
CTTCAGCTCT GGTGGTGTGG GGGGGCGCCA GACTCCAGCA TCCCTGATGA TCACCAGGGC
GAGAAAGGGC AGGGAGGAAC GGAGGGAGGT GTGGGTGAGC TGATATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16517
Clone ID Related Accession (Same CDS sequence) NM_001143990 , NM_001143991 , NM_001143992 , NM_018081
Accession Version NM_018081.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1647bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product telomerase Cajal body protein 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ431240.1 and AK225411.1. This sequence is a reference standard in the RefSeqGene project. On Jan 22, 2009 this sequence version replaced gi:8922395. Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK056669.1, AK001247.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGAAGACTT TGGAGACTCA ACCGTTAGCT CCGGACTGCT GTCCTTCAGA CCAGGACCCA 
GCTCCAGCCC ATCCTTCTCC CCACGCTTCC CCGATGAATA AAAATGCGGA CTCTGAACTG
ATGCCACCGC CTCCCGAAAG GGGGGATCCG CCCCGGTTGT CCCCAGATCC TGTGGCTGGC
TCAGCTGTGT CCCAGGAGCT ACGGGAGGGG GACCCAGTTT CTCTCTCCAC TCCCCTGGAA
ACAGAGTTTG GTTCCCCTAG TGAGTTGAGT CCTCGAATCG AGGAGCAAGA ACTTTCTGAA
AATACAAGCC TTCCTGCAGA AGAAGCAAAC GGGAGCCTTT CTGAAGAAGA AGCGAACGGG
CCAGAGTTGG GGTCTGGAAA AGCCATGGAA GATACCTCTG GGGAACCCGC TGCAGAGGAC
GAGGGAGACA CCGCTTGGAA CTACAGCTTC TCCCAGCTGC CTCGATTTCT CAGTGGTTCC
TGGTCAGAGT TCAGCACCCA ACCTGAGAAC TTCTTGAAAG GCTGTAAGTG GGCTCCTGAC
GGTTCCTGCA TCTTGACCAA TAGTGCTGAT AACATCTTGC GAATTTATAA CCTGCCCCCA
GAGCTGTACC ATGAGGGGGA GCAGGTGGAA TATGCAGAAA TGGTCCCTGT CCTTCGAATG
GTGGAAGGTG ATACCATCTA TGATTACTGC TGGTATTCTC TGATGTCCTC AGCCCAGCCA
GACACCTCCT ACGTGGCCAG CAGCAGCCGG GAGAACCCGA TTCATATCTG GGACGCATTC
ACTGGAGAGC TCCGGGCTTC CTTTCGCGCC TACAACCACC TGGATGAGCT GACGGCAGCC
CATTCGCTCT GCTTCTCCCC GGATGGCTCC CAGCTCTTCT GTGGCTTCAA CCGGACTGTG
CGTGTTTTTT CCACGGCCCG GCCTGGCCGA GACTGCGAGG TCCGAGCCAC ATTTGCAAAA
AAGCAGGGCC AGAGCGGCAT CATCTCCTGC ATAGCCTTCA GCCCAGCCCA GCCCCTCTAT
GCCTGTGGCT CCTACGGCCG CTCCCTGGGT CTGTATGCCT GGGATGATGG CTCCCCTCTC
GCCTTGCTGG GAGGGCACCA AGGGGGCATC ACCCACCTCT GCTTTCATCC CGATGGCAAC
CGCTTCTTCT CAGGAGCCCG CAAGGATGCT GAGCTCCTGT GCTGGGATCT CCGGCAGTCT
GGTTACCCAC TGTGGTCCCT GGGTCGAGAG GTGACCACCA ATCAGCGCAT CTACTTCGAT
CTGGACCCGA CCGGGCAGTT CCTAGTGAGT GGCAGCACGA GCGGGGCTGT CTCTGTGTGG
GACACGGACG GGCCTGGCAA TGATGGGAAG CCGGAGCCCG TGTTGAGTTT TCTGCCCCAG
AAGGACTGCA CCAATGGCGT GAGCCTGCAC CCTAGCCTGC CTCTCCTGGC CACTGCCTCC
GGTCAGCGTG TGTTTCCTGA GCCCACAGAG AGTGGGGACG AAGGAGAGGA GCTGGGCCTT
CCCTTGCTCT CCACGCGCCA CGTCCACCTT GAATGTCGGC TTCAGCTCTG GTGGTGTGGG
GGGGCGCCAG ACTCCAGCAT CCCTGATGAT CACCAGGGCG AGAAAGGGCA GGGAGGAACG
GAGGGAGGTG TGGGTGAGCT GATATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_060551.2
CDS301..1947
Misc Feature(1)274..276(+)
Misc Feature(2)376..378(+)
Misc Feature(3)388..390(+)
Misc Feature(4)460..462(+)
Misc Feature(5)553..555(+)
Misc Feature(6)568..570(+)
Misc Feature(7)634..636(+)
Misc Feature(8)640..642(+)
Misc Feature(9)799..918(+)
Misc Feature(10)823..1740(+)
Misc Feature(11)856..1734(+)
Misc Feature(12)964..1101(+)
Misc Feature(13)1018..>1740(+)
Misc Feature(14)1114..1239(+)
Misc Feature(15)1267..1392(+)
Misc Feature(16)1393..1515(+)
Misc Feature(17)1531..1650(+)
Misc Feature(18)1765..1767(+)
Misc Feature(19)1771..1773(+)
Exon (1)1..731
Gene:WRAP53
Gene Synonym:
Exon (2)732..830
Gene:WRAP53
Gene Synonym:
Exon (3)831..942
Gene:WRAP53
Gene Synonym:
Exon (4)943..1031
Gene:WRAP53
Gene Synonym:
Exon (5)1032..1122
Gene:WRAP53
Gene Synonym:
Exon (6)1123..1255
Gene:WRAP53
Gene Synonym:
Exon (7)1256..1464
Gene:WRAP53
Gene Synonym:
Exon (8)1465..1568
Gene:WRAP53
Gene Synonym:
Exon (9)1569..1703
Gene:WRAP53
Gene Synonym:
Exon (10)1704..1963
Gene:WRAP53
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_018081
Organism Homo sapiens (human)
Definition Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_018081

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGAAGACTT TGGAGACTCA ACCGTTAGCT CCGGACTGCT GTCCTTCAGA CCAGGACCCA 
GCTCCAGCCC ATCCTTCTCC CCACGCTTCC CCGATGAATA AAAATGCGGA CTCTGAACTG
ATGCCACCGC CTCCCGAAAG GGGGGATCCG CCCCGGTTGT CCCCAGATCC TGTGGCTGGC
TCAGCTGTGT CCCAGGAGCT ACGGGAGGGG GACCCAGTTT CTCTCTCCAC TCCCCTGGAA
ACAGAGTTTG GTTCCCCTAG TGAGTTGAGT CCTCGAATCG AGGAGCAAGA ACTTTCTGAA
AATACAAGCC TTCCTGCAGA AGAAGCAAAC GGGAGCCTTT CTGAAGAAGA AGCGAACGGG
CCAGAGTTGG GGTCTGGAAA AGCCATGGAA GATACCTCTG GGGAACCCGC TGCAGAGGAC
GAGGGAGACA CCGCTTGGAA CTACAGCTTC TCCCAGCTGC CTCGATTTCT CAGTGGTTCC
TGGTCAGAGT TCAGCACCCA ACCTGAGAAC TTCTTGAAAG GCTGTAAGTG GGCTCCTGAC
GGTTCCTGCA TCTTGACCAA TAGTGCTGAT AACATCTTGC GAATTTATAA CCTGCCCCCA
GAGCTGTACC ATGAGGGGGA GCAGGTGGAA TATGCAGAAA TGGTCCCTGT CCTTCGAATG
GTGGAAGGTG ATACCATCTA TGATTACTGC TGGTATTCTC TGATGTCCTC AGCCCAGCCA
GACACCTCCT ACGTGGCCAG CAGCAGCCGG GAGAACCCGA TTCATATCTG GGACGCATTC
ACTGGAGAGC TCCGGGCTTC CTTTCGCGCC TACAACCACC TGGATGAGCT GACGGCAGCC
CATTCGCTCT GCTTCTCCCC GGATGGCTCC CAGCTCTTCT GTGGCTTCAA CCGGACTGTG
CGTGTTTTTT CCACGGCCCG GCCTGGCCGA GACTGCGAGG TCCGAGCCAC ATTTGCAAAA
AAGCAGGGCC AGAGCGGCAT CATCTCCTGC ATAGCCTTCA GCCCAGCCCA GCCCCTCTAT
GCCTGTGGCT CCTACGGCCG CTCCCTGGGT CTGTATGCCT GGGATGATGG CTCCCCTCTC
GCCTTGCTGG GAGGGCACCA AGGGGGCATC ACCCACCTCT GCTTTCATCC CGATGGCAAC
CGCTTCTTCT CAGGAGCCCG CAAGGATGCT GAGCTCCTGT GCTGGGATCT CCGGCAGTCT
GGTTACCCAC TGTGGTCCCT GGGTCGAGAG GTGACCACCA ATCAGCGCAT CTACTTCGAT
CTGGACCCGA CCGGGCAGTT CCTAGTGAGT GGCAGCACGA GCGGGGCTGT CTCTGTGTGG
GACACGGACG GGCCTGGCAA TGATGGGAAG CCGGAGCCCG TGTTGAGTTT TCTGCCCCAG
AAGGACTGCA CCAATGGCGT GAGCCTGCAC CCTAGCCTGC CTCTCCTGGC CACTGCCTCC
GGTCAGCGTG TGTTTCCTGA GCCCACAGAG AGTGGGGACG AAGGAGAGGA GCTGGGCCTT
CCCTTGCTCT CCACGCGCCA CGTCCACCTT GAATGTCGGC TTCAGCTCTG GTGGTGTGGG
GGGGCGCCAG ACTCCAGCAT CCCTGATGAT CACCAGGGCG AGAAAGGGCA GGGAGGAACG
GAGGGAGGTG TGGGTGAGCT GATATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16517
Clone ID Related Accession (Same CDS sequence) NM_001143990 , NM_001143991 , NM_001143992 , NM_018081
Accession Version NM_001143992.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1647bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product telomerase Cajal body protein 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ431240.1. Transcript Variant: This variant (4, also known as WRAP53beta) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ431240.1, BC002336.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGAAGACTT TGGAGACTCA ACCGTTAGCT CCGGACTGCT GTCCTTCAGA CCAGGACCCA 
GCTCCAGCCC ATCCTTCTCC CCACGCTTCC CCGATGAATA AAAATGCGGA CTCTGAACTG
ATGCCACCGC CTCCCGAAAG GGGGGATCCG CCCCGGTTGT CCCCAGATCC TGTGGCTGGC
TCAGCTGTGT CCCAGGAGCT ACGGGAGGGG GACCCAGTTT CTCTCTCCAC TCCCCTGGAA
ACAGAGTTTG GTTCCCCTAG TGAGTTGAGT CCTCGAATCG AGGAGCAAGA ACTTTCTGAA
AATACAAGCC TTCCTGCAGA AGAAGCAAAC GGGAGCCTTT CTGAAGAAGA AGCGAACGGG
CCAGAGTTGG GGTCTGGAAA AGCCATGGAA GATACCTCTG GGGAACCCGC TGCAGAGGAC
GAGGGAGACA CCGCTTGGAA CTACAGCTTC TCCCAGCTGC CTCGATTTCT CAGTGGTTCC
TGGTCAGAGT TCAGCACCCA ACCTGAGAAC TTCTTGAAAG GCTGTAAGTG GGCTCCTGAC
GGTTCCTGCA TCTTGACCAA TAGTGCTGAT AACATCTTGC GAATTTATAA CCTGCCCCCA
GAGCTGTACC ATGAGGGGGA GCAGGTGGAA TATGCAGAAA TGGTCCCTGT CCTTCGAATG
GTGGAAGGTG ATACCATCTA TGATTACTGC TGGTATTCTC TGATGTCCTC AGCCCAGCCA
GACACCTCCT ACGTGGCCAG CAGCAGCCGG GAGAACCCGA TTCATATCTG GGACGCATTC
ACTGGAGAGC TCCGGGCTTC CTTTCGCGCC TACAACCACC TGGATGAGCT GACGGCAGCC
CATTCGCTCT GCTTCTCCCC GGATGGCTCC CAGCTCTTCT GTGGCTTCAA CCGGACTGTG
CGTGTTTTTT CCACGGCCCG GCCTGGCCGA GACTGCGAGG TCCGAGCCAC ATTTGCAAAA
AAGCAGGGCC AGAGCGGCAT CATCTCCTGC ATAGCCTTCA GCCCAGCCCA GCCCCTCTAT
GCCTGTGGCT CCTACGGCCG CTCCCTGGGT CTGTATGCCT GGGATGATGG CTCCCCTCTC
GCCTTGCTGG GAGGGCACCA AGGGGGCATC ACCCACCTCT GCTTTCATCC CGATGGCAAC
CGCTTCTTCT CAGGAGCCCG CAAGGATGCT GAGCTCCTGT GCTGGGATCT CCGGCAGTCT
GGTTACCCAC TGTGGTCCCT GGGTCGAGAG GTGACCACCA ATCAGCGCAT CTACTTCGAT
CTGGACCCGA CCGGGCAGTT CCTAGTGAGT GGCAGCACGA GCGGGGCTGT CTCTGTGTGG
GACACGGACG GGCCTGGCAA TGATGGGAAG CCGGAGCCCG TGTTGAGTTT TCTGCCCCAG
AAGGACTGCA CCAATGGCGT GAGCCTGCAC CCTAGCCTGC CTCTCCTGGC CACTGCCTCC
GGTCAGCGTG TGTTTCCTGA GCCCACAGAG AGTGGGGACG AAGGAGAGGA GCTGGGCCTT
CCCTTGCTCT CCACGCGCCA CGTCCACCTT GAATGTCGGC TTCAGCTCTG GTGGTGTGGG
GGGGCGCCAG ACTCCAGCAT CCCTGATGAT CACCAGGGCG AGAAAGGGCA GGGAGGAACG
GAGGGAGGTG TGGGTGAGCT GATATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001137464.1
CDS215..1861
Misc Feature(1)119..121(+)
Misc Feature(2)290..292(+)
Misc Feature(3)302..304(+)
Misc Feature(4)374..376(+)
Misc Feature(5)467..469(+)
Misc Feature(6)482..484(+)
Misc Feature(7)548..550(+)
Misc Feature(8)554..556(+)
Misc Feature(9)713..832(+)
Misc Feature(10)737..1654(+)
Misc Feature(11)770..1648(+)
Misc Feature(12)878..1015(+)
Misc Feature(13)932..>1654(+)
Misc Feature(14)1028..1153(+)
Misc Feature(15)1181..1306(+)
Misc Feature(16)1307..1429(+)
Misc Feature(17)1445..1564(+)
Misc Feature(18)1679..1681(+)
Misc Feature(19)1685..1687(+)
Exon (1)1..213
Gene:WRAP53
Gene Synonym:
Exon (2)214..645
Gene:WRAP53
Gene Synonym:
Exon (3)646..744
Gene:WRAP53
Gene Synonym:
Exon (4)745..856
Gene:WRAP53
Gene Synonym:
Exon (5)857..945
Gene:WRAP53
Gene Synonym:
Exon (6)946..1036
Gene:WRAP53
Gene Synonym:
Exon (7)1037..1169
Gene:WRAP53
Gene Synonym:
Exon (8)1170..1378
Gene:WRAP53
Gene Synonym:
Exon (9)1379..1482
Gene:WRAP53
Gene Synonym:
Exon (10)1483..1617
Gene:WRAP53
Gene Synonym:
Exon (11)1618..1877
Gene:WRAP53
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001143992
Organism Homo sapiens (human)
Definition Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001143992

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGAAGACTT TGGAGACTCA ACCGTTAGCT CCGGACTGCT GTCCTTCAGA CCAGGACCCA 
GCTCCAGCCC ATCCTTCTCC CCACGCTTCC CCGATGAATA AAAATGCGGA CTCTGAACTG
ATGCCACCGC CTCCCGAAAG GGGGGATCCG CCCCGGTTGT CCCCAGATCC TGTGGCTGGC
TCAGCTGTGT CCCAGGAGCT ACGGGAGGGG GACCCAGTTT CTCTCTCCAC TCCCCTGGAA
ACAGAGTTTG GTTCCCCTAG TGAGTTGAGT CCTCGAATCG AGGAGCAAGA ACTTTCTGAA
AATACAAGCC TTCCTGCAGA AGAAGCAAAC GGGAGCCTTT CTGAAGAAGA AGCGAACGGG
CCAGAGTTGG GGTCTGGAAA AGCCATGGAA GATACCTCTG GGGAACCCGC TGCAGAGGAC
GAGGGAGACA CCGCTTGGAA CTACAGCTTC TCCCAGCTGC CTCGATTTCT CAGTGGTTCC
TGGTCAGAGT TCAGCACCCA ACCTGAGAAC TTCTTGAAAG GCTGTAAGTG GGCTCCTGAC
GGTTCCTGCA TCTTGACCAA TAGTGCTGAT AACATCTTGC GAATTTATAA CCTGCCCCCA
GAGCTGTACC ATGAGGGGGA GCAGGTGGAA TATGCAGAAA TGGTCCCTGT CCTTCGAATG
GTGGAAGGTG ATACCATCTA TGATTACTGC TGGTATTCTC TGATGTCCTC AGCCCAGCCA
GACACCTCCT ACGTGGCCAG CAGCAGCCGG GAGAACCCGA TTCATATCTG GGACGCATTC
ACTGGAGAGC TCCGGGCTTC CTTTCGCGCC TACAACCACC TGGATGAGCT GACGGCAGCC
CATTCGCTCT GCTTCTCCCC GGATGGCTCC CAGCTCTTCT GTGGCTTCAA CCGGACTGTG
CGTGTTTTTT CCACGGCCCG GCCTGGCCGA GACTGCGAGG TCCGAGCCAC ATTTGCAAAA
AAGCAGGGCC AGAGCGGCAT CATCTCCTGC ATAGCCTTCA GCCCAGCCCA GCCCCTCTAT
GCCTGTGGCT CCTACGGCCG CTCCCTGGGT CTGTATGCCT GGGATGATGG CTCCCCTCTC
GCCTTGCTGG GAGGGCACCA AGGGGGCATC ACCCACCTCT GCTTTCATCC CGATGGCAAC
CGCTTCTTCT CAGGAGCCCG CAAGGATGCT GAGCTCCTGT GCTGGGATCT CCGGCAGTCT
GGTTACCCAC TGTGGTCCCT GGGTCGAGAG GTGACCACCA ATCAGCGCAT CTACTTCGAT
CTGGACCCGA CCGGGCAGTT CCTAGTGAGT GGCAGCACGA GCGGGGCTGT CTCTGTGTGG
GACACGGACG GGCCTGGCAA TGATGGGAAG CCGGAGCCCG TGTTGAGTTT TCTGCCCCAG
AAGGACTGCA CCAATGGCGT GAGCCTGCAC CCTAGCCTGC CTCTCCTGGC CACTGCCTCC
GGTCAGCGTG TGTTTCCTGA GCCCACAGAG AGTGGGGACG AAGGAGAGGA GCTGGGCCTT
CCCTTGCTCT CCACGCGCCA CGTCCACCTT GAATGTCGGC TTCAGCTCTG GTGGTGTGGG
GGGGCGCCAG ACTCCAGCAT CCCTGATGAT CACCAGGGCG AGAAAGGGCA GGGAGGAACG
GAGGGAGGTG TGGGTGAGCT GATATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Association of common WRAP 53 variant with ovarian cancer risk in the Polish population
Mol. Biol. Rep. 40 (3), 2145-2147 (2013)
Medrek K, Magnowski P, Masojc B, Chudecka-Glaz A, Torbe B, Menkiszak J, Spaczynski M, Gronwald J, Lubinski J and Gorski B.


book

Overlapping region of p53/wrap53 transcripts: mutational analysis and sequence similarity with microRNA-4732-5p
Asian Pac. J. Cancer Prev. 14 (6), 3503-3507 (2013)
Pouladi N, Kouhsari SM, Feizi MH, Gavgani RR and Azarfam P.


book

Telomerase recruitment requires both TCAB1 and Cajal bodies independently
Mol. Cell. Biol. 32 (13), 2384-2395 (2012)
Stern JL, Zyner KG, Pickett HA, Cohen SB and Bryan TM.


book

WRAP53 is an independent prognostic factor in rectal cancer- a study of Swedish clinical trial of preoperative radiotherapy in rectal cancer patients
BMC Cancer 12, 294 (2012)
Zhang H, Wang DW, Adell G and Sun XF.


book

Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms
Oncogene 30 (33), 3612-3624 (2011)
Bug M and Dobbelstein M.


book

Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity
Carcinogenesis 30 (1), 50-58 (2009)
Lan Q, Zhang L, Shen M, Jo WJ, Vermeulen R, Li G, Vulpe C, Lim S, Ren X, Rappaport SM, Berndt SI, Yeager M, Yuenger J, Hayes RB, Linet M, Yin S, Chanock S, Smith MT and Rothman N.


book

Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway
Carcinogenesis 29 (10), 1938-1943 (2008)
Hosgood HD 3rd, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T and Lan Q.


book

Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer
Int. J. Cancer 121 (11), 2532-2538 (2007)
Garcia-Closas M, Kristensen V, Langerod A, Qi Y, Yeager M, Burdett L, Welch R, Lissowska J, Peplonska B, Brinton L, Gerhard DS, Gram IT, Perou CM, Borresen-Dale AL and Chanock S.


book

Large-scale characterization of HeLa cell nuclear phosphoproteins
Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC and Gygi SP.


book

Dyskeratosis Congenita
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Savage,S.A.


 
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