PPP3R2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Gene Symbol	PPP3R2
Entrez Gene ID	5535
Full Name	protein phosphatase 3 regulatory subunit B, beta
Synonyms	PPP3RL
General protein information	Preferred Names protein phosphatase 3 regulatory subunit B, beta Names calcineurin subunit B type 2 CBLP CNBII calcineurin B, type II (19kDa) calcineurin B-like protein calcineurin BII protein phosphatase 2B regulatory subunit 2 protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), beta isoform (calcineurin B, type II) protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, beta isoform (calcineurin B, type II) protein phosphatase 3 (formerly 2B), regulatory subunit B, beta isoform protein phosphatase 3 regulatory subunit B beta isoform
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q31.1
Disorder MIM:	613821

mRNA and Protein(s)

mRNA Protein Name

NM_147180.4 NP_671709.2 calcineurin subunit B type 2

NM_147180.3 NP_671709.1 calcineurin subunit B type 2
Pathways from BioSystems

mRNA	Protein	Name
NM_147180.4	NP_671709.2	calcineurin subunit B type 2
NM_147180.3	NP_671709.1	calcineurin subunit B type 2

Homologies

Homo sapiens (human)	PPP3R2	NP_671709.1
	PPP3R2	XP_001110425.1
Bos taurus (cattle)	PPP3R2	NP_001073099.1
Rattus norvegicus (Norway rat)	Ppp3r2	NP_067733.1
Mus musculus (house mouse)	Ppp3r2	NP_001004025.1
Pan troglodytes (chimpanzee)	PPP3R2	NP_001230035.1
Canis lupus familiaris (dog)	PPP3R2	XP_005626939.1

Gene Ontology
Bibliography

Related articles in PubMed

Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults.
He ZH, Hu Y, Li YC, Bao DP, Ruiz JR, Lucia A
European journal of applied physiology110(4)761-7(2010 Nov)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Are calcineurin genes associated with endurance phenotype traits?
He ZH, Hu Y, Wang HY, Li YC, Lu YL, Zhang L, Bao BP, Ruiz JR, Lucia A
European journal of applied physiology109(3)359-69(2010 Jun)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

Mitotic regulation of CDK4 by the serine/threonine phosphatase, calcineurin.
Chow R, Olesen J, Onyskiw C, Baksh S
Biochemical and biophysical research communications363(3)506-12(2007 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Data suggest an association between polymorphisms in PPP3CA, PPP3R1 and PPP3R2 and baseline levels or trainability of endurance phenotype traits.
Title: Are calcineurin genes associated with endurance phenotype traits?

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.

The following PPP3R2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPP3R2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu29794	NM_147180.3 Latest version!	Homo sapiens protein phosphatase 3 regulatory subunit B, beta (PPP3R2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu107046	NM_147180.4 Latest version!	Homo sapiens protein phosphatase 3 regulatory subunit B, beta (PPP3R2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PPP3R2 ( NM_147180.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_671709.1 Homo sapiens protein phosphatase 3 regulatory subunit B, beta (PPP3R2), mRNA.

Price & Availability↑

CloneID	OHu29794
Clone ID Related Accession (Same CDS sequence)	NM_147180.3
Accession Version	NM_147180.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	calcineurin subunit B type 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC030595.2 and AL591377.4. On Feb 14, 2015 this sequence version replaced NM_147180.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC030595.2 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCACAA TGGGAAACGA GGCCAGTTAC CCGGCGGAGA TGTGCTCCCA CTTTGACAAT 
GATGAAATTA AAAGGCTGGG CAGGAGGTTT AAGAAGTTGG ACTTGGACAA ATCAGGGTCT 
CTGAGCGTGG AGGAGTTCAT GTCCCTGCCG GAGCTGCGCC ACAACCCGTT GGTGCGGCGA 
GTGATCGACG TCTTCGACAC CGACGGTGAT GGAGAAGTGG ACTTCAAGGA ATTCATCCTG 
GGGACCTCCC AGTTCAGCGT CAAGGGCGAC GAGGAGCAGA AGTTGAGGTT TGCGTTCAGC 
ATTTACGACA TGGATAAAGA TGGCTACATT TCCAACGGGG AGCTCTTCCA GGTGCTGAAG 
ATGATGGTGG GCAACAACCT GACGGACTGG CAGCTCCAGC AGCTGGTCGA CAAAACCATC 
ATCATCCTGG ACAAGGATGG CGATGGGAAG ATATCCTTTG AGGAATTCAG TGCTGTGGTC 
AGAGACCTGG AGATCCACAA GAAGCTGGTC CTCATCGTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_671709.1
CDS	72..593
Translation	MSTMGNEASYPAEMCSHFDNDEIKRLGRRFKKLDLDKSGSLSVEEFMSLPELRHNPLVRRVIDVFDTDGDGEVDFKEFILGTSQFSVKGDEEQKLRFAFSIYDMDKDGYISNGELFQVLKMMVGNNLTDWQLQQLVDKTIIILDKDGDGKISFEEFSAVVRDLEIHKKLVLIV

Target ORF information:

RefSeq Version	NM_147180.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 3 regulatory subunit B, beta (PPP3R2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_147180.3

ORF Insert Sequence:

ATGTCCACAA TGGGAAACGA GGCCAGTTAC CCGGCGGAGA TGTGCTCCCA CTTTGACAAT 
GATGAAATTA AAAGGCTGGG CAGGAGGTTT AAGAAGTTGG ACTTGGACAA ATCAGGGTCT 
CTGAGCGTGG AGGAGTTCAT GTCCCTGCCG GAGCTGCGCC ACAACCCGTT GGTGCGGCGA 
GTGATCGACG TCTTCGACAC CGACGGTGAT GGAGAAGTGG ACTTCAAGGA ATTCATCCTG 
GGGACCTCCC AGTTCAGCGT CAAGGGCGAC GAGGAGCAGA AGTTGAGGTT TGCGTTCAGC 
ATTTACGACA TGGATAAAGA TGGCTACATT TCCAACGGGG AGCTCTTCCA GGTGCTGAAG 
ATGATGGTGG GCAACAACCT GACGGACTGG CAGCTCCAGC AGCTGGTCGA CAAAACCATC 
ATCATCCTGG ACAAGGATGG CGATGGGAAG ATATCCTTTG AGGAATTCAG TGCTGTGGTC 
AGAGACCTGG AGATCCACAA GAAGCTGGTC CTCATCGTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP3R2 ( NM_147180.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_671709.2 Homo sapiens protein phosphatase 3 regulatory subunit B, beta (PPP3R2), mRNA.

Price & Availability↑

CloneID	OHu107046
Clone ID Related Accession (Same CDS sequence)	NM_147180.4
Accession Version	NM_147180.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 513bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	calcineurin subunit B type 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC030595.2, AL591377.4 and AA904764.1. On Oct 19, 2018 this sequence version replaced NM_147180.3. CCDS Note: The coding region has been updated to shorten the N-terminus, using a downstream start codon, to one that is more supported by available conservation data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC030595.2, AK057524.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved MANE Ensembl match :: ENST00000374806.2/ ENSP00000363939.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGAAACG AGGCCAGTTA CCCGGCGGAG ATGTGCTCCC ACTTTGACAA TGATGAAATT 
AAAAGGCTGG GCAGGAGGTT TAAGAAGTTG GACTTGGACA AATCAGGGTC TCTGAGCGTG 
GAGGAGTTCA TGTCCCTGCC GGAGCTGCGC CACAACCCGT TGGTGCGGCG AGTGATCGAC 
GTCTTCGACA CCGACGGTGA TGGAGAAGTG GACTTCAAGG AATTCATCCT GGGGACCTCC 
CAGTTCAGCG TCAAGGGCGA CGAGGAGCAG AAGTTGAGGT TTGCGTTCAG CATTTACGAC 
ATGGATAAAG ATGGCTACAT TTCCAACGGG GAGCTCTTCC AGGTGCTGAA GATGATGGTG 
GGCAACAACC TGACGGACTG GCAGCTCCAG CAGCTGGTCG ACAAAACCAT CATCATCCTG 
GACAAGGATG GCGATGGGAA GATATCCTTT GAGGAATTCA GTGCTGTGGT CAGAGACCTG 
GAGATCCACA AGAAGCTGGT CCTCATCGTA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_671709.2
CDS	49..561
Translation	MGNEASYPAEMCSHFDNDEIKRLGRRFKKLDLDKSGSLSVEEFMSLPELRHNPLVRRVIDVFDTDGDGEVDFKEFILGTSQFSVKGDEEQKLRFAFSIYDMDKDGYISNGELFQVLKMMVGNNLTDWQLQQLVDKTIIILDKDGDGKISFEEFSAVVRDLEIHKKLVLIV

Target ORF information:

RefSeq Version	NM_147180.4
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 3 regulatory subunit B, beta (PPP3R2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_147180.4

ORF Insert Sequence:

ATGGGAAACG AGGCCAGTTA CCCGGCGGAG ATGTGCTCCC ACTTTGACAA TGATGAAATT 
AAAAGGCTGG GCAGGAGGTT TAAGAAGTTG GACTTGGACA AATCAGGGTC TCTGAGCGTG 
GAGGAGTTCA TGTCCCTGCC GGAGCTGCGC CACAACCCGT TGGTGCGGCG AGTGATCGAC 
GTCTTCGACA CCGACGGTGA TGGAGAAGTG GACTTCAAGG AATTCATCCT GGGGACCTCC 
CAGTTCAGCG TCAAGGGCGA CGAGGAGCAG AAGTTGAGGT TTGCGTTCAG CATTTACGAC 
ATGGATAAAG ATGGCTACAT TTCCAACGGG GAGCTCTTCC AGGTGCTGAA GATGATGGTG 
GGCAACAACC TGACGGACTG GCAGCTCCAG CAGCTGGTCG ACAAAACCAT CATCATCCTG 
GACAAGGATG GCGATGGGAA GATATCCTTT GAGGAATTCA GTGCTGTGGT CAGAGACCTG 
GAGATCCACA AGAAGCTGGT CCTCATCGTA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults.
European journal of applied physiology110(4)761-7(2010 Nov)
He ZH,Hu Y,Li YC,Bao DP,Ruiz JR,Lucia A

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Are calcineurin genes associated with endurance phenotype traits?
European journal of applied physiology109(3)359-69(2010 Jun)
He ZH,Hu Y,Wang HY,Li YC,Lu YL,Zhang L,Bao BP,Ruiz JR,Lucia A

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

Mitotic regulation of CDK4 by the serine/threonine phosphatase, calcineurin.
Biochemical and biophysical research communications363(3)506-12(2007 Nov)
Chow R,Olesen J,Onyskiw C,Baksh S

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PPP3R2 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

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