Gene Symbol | ITFG2 |
Entrez Gene ID | 55846 |
Full Name | integrin alpha FG-GAP repeat containing 2 |
Synonyms | FGGAP1,MDS028 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » ITFG2 cDNA ORF clone
gRNAs
Gene Symbol | ITFG2 |
Entrez Gene ID | 55846 |
Full Name | integrin alpha FG-GAP repeat containing 2 |
Synonyms | FGGAP1,MDS028 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_005253707.4 | XP_005253764.1 | integrin-alpha FG-GAP repeat-containing protein 2 isoform X1 |
NM_018463.4 | NP_060933.3 | KICSTOR complex protein ITFG2 |
XM_005253709.4 | XP_005253766.1 | KICSTOR complex protein ITFG2 isoform X3 |
NM_018463.3 | NP_060933.3 | KICSTOR complex protein ITFG2 |
XM_024449057.1 | XP_024304825.1 | KICSTOR complex protein ITFG2 isoform X2 |
XM_017019641.1 | XP_016875130.1 | KICSTOR complex protein ITFG2 isoform X4 |
XM_005253707.5 | XP_005253764.1 | KICSTOR complex protein ITFG2 isoform X1 |
Homo sapiens (human) | ITFG2 | NP_060933.3 |
Pan troglodytes (chimpanzee) | ITFG2 | XP_001154006.1 |
Rattus norvegicus (Norway rat) | Itfg2 | NP_001102118.1 |
ITFG2 | XP_001098179.2 | |
Xenopus tropicalis (tropical clawed frog) | itfg2 | NP_001120023.1 |
Bos taurus (cattle) | ITFG2 | NP_776987.1 |
Mus musculus (house mouse) | Itfg2 | NP_598688.1 |
Canis lupus familiaris (dog) | ITFG2 | XP_854667.2 |
Gallus gallus (chicken) | ITFG2 | XP_416486.2 |
Danio rerio (zebrafish) | itfg2 | NP_001017908.2 |
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM
Nature543(7645)438-442(2017 03)
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
identification of a protein complex (KICSTOR) that is composed of four proteins, KPTN, ITFG2, C12orf66 and SZT2, and that is required for amino acid or glucose deprivation to inhibit mTORC1 in cultured human cells
Title: KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
The following ITFG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ITFG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu32186![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_018463.4 , NM_018463.3 | |
Accession Version | NM_018463.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-05-01 | |
Organism | Homo sapiens(human) | |
Product | KICSTOR complex protein ITFG2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ058412.1, BC013399.2, BQ003916.1 and AC005841.3. On Nov 22, 2018 this sequence version replaced NM_018463.3. Transcript Variant: This variant (1) encodes a functional protein. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.170156.1, SRR1803617.232727.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000228799.7/ ENSP00000228799.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGAGGTCAG TTAGCTACGT GCAGCGCGTG GCGCTGGAGT TCAGCGGGAG CCTCTTCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_060933.3 |
CDS | 94..1437 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGGTCAG TTAGCTACGT GCAGCGCGTG GCGCTGGAGT TCAGCGGGAG CCTCTTCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu32186![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_018463.4 , NM_018463.3 | |
Accession Version | NM_018463.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | KICSTOR complex protein ITFG2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI261823.1, BQ058412.1, BC013399.2 and BQ003916.1. On Dec 11, 2009 this sequence version replaced NM_018463.2. Transcript Variant: This variant (1) encodes a functional protein. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.232727.1, SRR1803617.229050.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGGTCAG TTAGCTACGT GCAGCGCGTG GCGCTGGAGT TCAGCGGGAG CCTCTTCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_060933.3 |
CDS | 141..1484 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGGTCAG TTAGCTACGT GCAGCGCGTG GCGCTGGAGT TCAGCGGGAG CCTCTTCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu45982 | |
Clone ID Related Accession (Same CDS sequence) | XM_005253709.4 | |
Accession Version | XM_005253709.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 813bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | KICSTOR complex protein ITFG2 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005253709.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGGAGG GTCAGGTGGA CAGCCTCTCA GTGACTCTGG GGCCACTGGG TCTTCCTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005253766.1 |
CDS | 315..1127 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCTGGAGG GTCAGGTGGA CAGCCTCTCA GTGACTCTGG GGCCACTGGG TCTTCCTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu45980 | |
Clone ID Related Accession (Same CDS sequence) | XM_005253707.4 , XM_005253707.5 | |
Accession Version | XM_005253707.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1317bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | integrin-alpha FG-GAP repeat-containing protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005253707.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGGTCAG TTAGCTACGT GCAGCGCGTG GCGCTGGAGT TCAGCGGGAG CCTCTTCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005253764.1 |
CDS | 110..1426 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGGTCAG TTAGCTACGT GCAGCGCGTG GCGCTGGAGT TCAGCGGGAG CCTCTTCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu45980 | |
Clone ID Related Accession (Same CDS sequence) | XM_005253707.4 , XM_005253707.5 | |
Accession Version | XM_005253707.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1317bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | KICSTOR complex protein ITFG2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005253707.4. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGGTCAG TTAGCTACGT GCAGCGCGTG GCGCTGGAGT TCAGCGGGAG CCTCTTCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005253764.1 |
CDS | 99..1415 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGGTCAG TTAGCTACGT GCAGCGCGTG GCGCTGGAGT TCAGCGGGAG CCTCTTCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu45981 | |
Clone ID Related Accession (Same CDS sequence) | XM_024449057.1 | |
Accession Version | XM_024449057.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1008bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | KICSTOR complex protein ITFG2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCTACCT TTGCAGGCAG CCAGGAGAGT AGGAGTCAGT GGATACTAGA GCATATCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024304825.1 |
CDS | 477..1484 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTACCT TTGCAGGCAG CCAGGAGAGT AGGAGTCAGT GGATACTAGA GCATATCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu83980 | |
Clone ID Related Accession (Same CDS sequence) | XM_017019641.1 | |
Accession Version | XM_017019641.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | KICSTOR complex protein ITFG2 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGGAGG GTCAGGTGGA CAGCCTCTCA GTGACTCTGG GGCCACTGGG TCTTCCTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016875130.1 |
CDS | 286..1071 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCTGGAGG GTCAGGTGGA CAGCCTCTCA GTGACTCTGG GGCCACTGGG TCTTCCTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. |
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. |