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PSEN2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol PSEN2
Entrez Gene ID 5664
Full Name presenilin 2
Synonyms AD3L, AD4, CMD1V, PS2, STM2
General protein information
Preferred Names
presenilin-2
Names
presenilin-2
AD5
E5-1
PS-2
AD3LP
STM-2
NP_000438.2
NP_036618.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q42.13

Summary Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

600759

Disorder Html: Alzheimer disease-4, 606889 (3); Cardiomyopathy, dilated, 1V, 613697

mRNA and Protein(s)

mRNA Protein Name
XM_005273199 XP_005273256 presenilin-2 isoform X1
XM_011544236 XP_011542538 presenilin-2 isoform X2
NM_000447 NP_000438 presenilin-2 isoform 1
NM_012486 NP_036618 presenilin-2 isoform 2



Homo sapiens (human) PSEN2 NP_000438.2
Pan troglodytes (chimpanzee) PSEN2 XP_003949755.1
Macaca mulatta (Rhesus monkey) PSEN2 XP_002801954.1
Canis lupus familiaris (dog) PSEN2 XP_005622685.1
Bos taurus (cattle) PSEN2 NP_776865.2
Mus musculus (house mouse) Psen2 NP_001122077.1
Rattus norvegicus (Norway rat) Psen2 NP_112349.2
Gallus gallus (chicken) PSEN2 NP_989633.1
Danio rerio (zebrafish) psen2 NP_571589.2
Drosophila melanogaster (fruit fly) Psn NP_001137988.1
Xenopus (Silurana) tropicalis (western clawed frog) psen2 NP_001017181.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PSEN2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSEN2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu24950
XM_005273199 PREDICTED: Homo sapiens presenilin 2 (PSEN2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
OHu59977 XM_011544236 PREDICTED: Homo sapiens presenilin 2 (PSEN2), transcript variant X4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $139.30
$199.00
OHu24950
NM_000447 Homo sapiens presenilin 2 (PSEN2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
OHu24919 NM_012486 Homo sapiens presenilin 2 (PSEN2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu24950
Clone ID Related Accession (Same CDS sequence) NM_000447 , XM_005273199
Accession Version XM_005273199.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1347bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product presenilin-2 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_167186.2) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:530366341. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005273256.1
CDS241..1587
Misc Feature(1)466..1557(+)
Translation

Target ORF information:

RefSeq Version XM_005273199
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens presenilin 2 (PSEN2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005273199

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu59977
Clone ID Related Accession (Same CDS sequence) XM_011544236
Accession Version XM_011544236.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 915bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product presenilin-2 isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_167186.2) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGATCAGCG TCATCGTGGT TATGACCATC TTCTTGGTGG TGCTCTACAA GTACCGCTGC 
TACAAGTTCA TCCATGGCTG GTTGATCATG TCTTCACTGA TGCTGCTGTT CCTCTTCACC
TATATCTACC TTGGGGAAGT GCTCAAGACC TACAATGTGG CCATGGACTA CCCCACCCTC
TTGCTGACTG TCTGGAACTT CGGGGCAGTG GGCATGGTGT GCATCCACTG GAAGGGCCCT
CTGGTGCTGC AGCAGGCCTA CCTCATCATG ATCAGTGCGC TCATGGCCCT AGTGTTCATC
AAGTACCTCC CAGAGTGGTC CGCGTGGGTC ATCCTGGGCG CCATCTCTGT GTATGATCTC
GTGGCTGTGC TGTGTCCCAA AGGGCCTCTG AGAATGCTGG TAGAAACTGC CCAGGAGAGA
AATGAGCCCA TATTCCCTGC CCTGATATAC TCATCTGCCA TGGTGTGGAC GGTTGGCATG
GCGAAGCTGG ACCCCTCCTC TCAGGGTGCC CTCCAGCTCC CCTACGACCC GGAGATGGAA
GAAGACTCCT ATGACAGTTT TGGGGAGCCT TCATACCCCG AAGTCTTTGA GCCTCCCTTG
ACTGGCTACC CAGGGGAGGA GCTGGAGGAA GAGGAGGAAA GGGGCGTGAA GCTTGGCCTC
GGGGACTTCA TCTTCTACAG TGTGCTGGTG GGCAAGGCGG CTGCCACGGG CAGCGGGGAC
TGGAATACCA CGCTGGCCTG CTTCGTGGCC ATCCTCATTG GCTTGTGTCT GACCCTCCTG
CTGCTTGCTG TGTTCAAGAA GGCGCTGCCC GCCCTCCCCA TCTCCATCAC GTTCGGGCTC
ATCTTTTACT TCTCCACGGA CAACCTGGTG CGGCCGTTCA TGGACACCCT GGCCTCCCAT
CAGCTCTACA TCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011542538.1
CDS406..1320
Misc Feature(1)406..1290(+)
Translation

Target ORF information:

RefSeq Version XM_011544236
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens presenilin 2 (PSEN2), transcript variant X4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011544236

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGATCAGCG TCATCGTGGT TATGACCATC TTCTTGGTGG TGCTCTACAA GTACCGCTGC 
TACAAGTTCA TCCATGGCTG GTTGATCATG TCTTCACTGA TGCTGCTGTT CCTCTTCACC
TATATCTACC TTGGGGAAGT GCTCAAGACC TACAATGTGG CCATGGACTA CCCCACCCTC
TTGCTGACTG TCTGGAACTT CGGGGCAGTG GGCATGGTGT GCATCCACTG GAAGGGCCCT
CTGGTGCTGC AGCAGGCCTA CCTCATCATG ATCAGTGCGC TCATGGCCCT AGTGTTCATC
AAGTACCTCC CAGAGTGGTC CGCGTGGGTC ATCCTGGGCG CCATCTCTGT GTATGATCTC
GTGGCTGTGC TGTGTCCCAA AGGGCCTCTG AGAATGCTGG TAGAAACTGC CCAGGAGAGA
AATGAGCCCA TATTCCCTGC CCTGATATAC TCATCTGCCA TGGTGTGGAC GGTTGGCATG
GCGAAGCTGG ACCCCTCCTC TCAGGGTGCC CTCCAGCTCC CCTACGACCC GGAGATGGAA
GAAGACTCCT ATGACAGTTT TGGGGAGCCT TCATACCCCG AAGTCTTTGA GCCTCCCTTG
ACTGGCTACC CAGGGGAGGA GCTGGAGGAA GAGGAGGAAA GGGGCGTGAA GCTTGGCCTC
GGGGACTTCA TCTTCTACAG TGTGCTGGTG GGCAAGGCGG CTGCCACGGG CAGCGGGGAC
TGGAATACCA CGCTGGCCTG CTTCGTGGCC ATCCTCATTG GCTTGTGTCT GACCCTCCTG
CTGCTTGCTG TGTTCAAGAA GGCGCTGCCC GCCCTCCCCA TCTCCATCAC GTTCGGGCTC
ATCTTTTACT TCTCCACGGA CAACCTGGTG CGGCCGTTCA TGGACACCCT GGCCTCCCAT
CAGCTCTACA TCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu24950
Clone ID Related Accession (Same CDS sequence) NM_000447 , XM_005273199
Accession Version NM_000447.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1347bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product presenilin-2 isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA198818.1, DA915823.1, BT006984.1, L43964.1 and AI091221.1. This sequence is a reference standard in the RefSeqGene project. On Aug 17, 2007 this sequence version replaced gi:4506164. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L43964.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000438.2
CDS428..1774
Misc Feature(1)341..343(+)
Misc Feature(2)491..493(+)
Misc Feature(3)500..502(+)
Misc Feature(4)653..1744(+)
Misc Feature(5)689..751(+)
Misc Feature(6)842..904(+)
Misc Feature(7)926..988(+)
Misc Feature(8)1028..1090(+)
Misc Feature(9)1097..1159(+)
Misc Feature(10)1175..1237(+)
Misc Feature(11)1511..1573(+)
Misc Feature(12)1592..1654(+)
Misc Feature(13)1667..1675(+)
Exon (1)1..78
Gene:PSEN2
Gene Synonym:
Exon (2)79..221
Gene:PSEN2
Gene Synonym:
Exon (3)222..407
Gene:PSEN2
Gene Synonym:
Exon (4)408..568
Gene:PSEN2
Gene Synonym:
Exon (5)569..783
Gene:PSEN2
Gene Synonym:
Exon (6)784..925
Gene:PSEN2
Gene Synonym:
Exon (7)926..993
Gene:PSEN2
Gene Synonym:
Exon (8)994..1214
Gene:PSEN2
Gene Synonym:
Exon (9)1215..1313
Gene:PSEN2
Gene Synonym:
Exon (10)1314..1397
Gene:PSEN2
Gene Synonym:
Exon (11)1398..1499
Gene:PSEN2
Gene Synonym:
Exon (12)1500..1618
Gene:PSEN2
Gene Synonym:
Exon (13)1619..2298
Gene:PSEN2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000447
Organism Homo sapiens (human)
Definition Homo sapiens presenilin 2 (PSEN2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000447

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu24919
Clone ID Related Accession (Same CDS sequence) NM_012486
Accession Version NM_012486.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1344bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product presenilin-2 isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA198818.1, DA915823.1, U34349.1, L43964.1 and AI091221.1. On Aug 17, 2007 this sequence version replaced gi:7108359. Transcript Variant: This variant (2) uses an alternate splice acceptor site at exon 10 compared to transcript variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292299.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC
CCGGAGATGG AAGACTCCTA TGACAGTTTT GGGGAGCCTT CATACCCCGA AGTCTTTGAG
CCTCCCTTGA CTGGCTACCC AGGGGAGGAG CTGGAGGAAG AGGAGGAAAG GGGCGTGAAG
CTTGGCCTCG GGGACTTCAT CTTCTACAGT GTGCTGGTGG GCAAGGCGGC TGCCACGGGC
AGCGGGGACT GGAATACCAC GCTGGCCTGC TTCGTGGCCA TCCTCATTGG CTTGTGTCTG
ACCCTCCTGC TGCTTGCTGT GTTCAAGAAG GCGCTGCCCG CCCTCCCCAT CTCCATCACG
TTCGGGCTCA TCTTTTACTT CTCCACGGAC AACCTGGTGC GGCCGTTCAT GGACACCCTG
GCCTCCCATC AGCTCTACAT CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_036618.2
CDS428..1771
Misc Feature(1)341..343(+)
Misc Feature(2)491..493(+)
Misc Feature(3)500..502(+)
Misc Feature(4)653..1741(+)
Misc Feature(5)689..751(+)
Misc Feature(6)842..904(+)
Misc Feature(7)926..988(+)
Misc Feature(8)1028..1090(+)
Misc Feature(9)1097..1159(+)
Misc Feature(10)1175..1237(+)
Misc Feature(11)1508..1570(+)
Misc Feature(12)1589..1651(+)
Misc Feature(13)1664..1672(+)
Exon (1)1..78
Gene:PSEN2
Gene Synonym:
Exon (2)79..221
Gene:PSEN2
Gene Synonym:
Exon (3)222..407
Gene:PSEN2
Gene Synonym:
Exon (4)408..568
Gene:PSEN2
Gene Synonym:
Exon (5)569..783
Gene:PSEN2
Gene Synonym:
Exon (6)784..925
Gene:PSEN2
Gene Synonym:
Exon (7)926..993
Gene:PSEN2
Gene Synonym:
Exon (8)994..1214
Gene:PSEN2
Gene Synonym:
Exon (9)1215..1313
Gene:PSEN2
Gene Synonym:
Exon (10)1314..1397
Gene:PSEN2
Gene Synonym:
Exon (11)1398..1496
Gene:PSEN2
Gene Synonym:
Exon (12)1497..1615
Gene:PSEN2
Gene Synonym:
Exon (13)1616..2295
Gene:PSEN2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_012486
Organism Homo sapiens (human)
Definition Homo sapiens presenilin 2 (PSEN2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_012486

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC
CCGGAGATGG AAGACTCCTA TGACAGTTTT GGGGAGCCTT CATACCCCGA AGTCTTTGAG
CCTCCCTTGA CTGGCTACCC AGGGGAGGAG CTGGAGGAAG AGGAGGAAAG GGGCGTGAAG
CTTGGCCTCG GGGACTTCAT CTTCTACAGT GTGCTGGTGG GCAAGGCGGC TGCCACGGGC
AGCGGGGACT GGAATACCAC GCTGGCCTGC TTCGTGGCCA TCCTCATTGG CTTGTGTCTG
ACCCTCCTGC TGCTTGCTGT GTTCAAGAAG GCGCTGCCCG CCCTCCCCAT CTCCATCACG
TTCGGGCTCA TCTTTTACTT CTCCACGGAC AACCTGGTGC GGCCGTTCAT GGACACCCTG
GCCTCCCATC AGCTCTACAT CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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