Gene Symbol | EIF5A2 |
Entrez Gene ID | 56648 |
Full Name | eukaryotic translation initiation factor 5A2 |
Synonyms | EIF-5A2,eIF5AII |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » EIF5A2 cDNA ORF clone
Gene Symbol | EIF5A2 |
Entrez Gene ID | 56648 |
Full Name | eukaryotic translation initiation factor 5A2 |
Synonyms | EIF-5A2,eIF5AII |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_020390.5 | NP_065123.1 | eukaryotic translation initiation factor 5A-2 |
NM_020390.6 | NP_065123.1 | eukaryotic translation initiation factor 5A-2 |
Rattus norvegicus (Norway rat) | Eif5a2 | NP_001094167.1 |
Pan troglodytes (chimpanzee) | EIF5A2 | XP_001163733.1 |
Bos taurus (cattle) | EIF5A2 | NP_001179018.1 |
Gallus gallus (chicken) | EIF5A2 | NP_990863.1 |
Homo sapiens (human) | EIF5A2 | NP_065123.1 |
EIF5A2 | XP_002802971.1 | |
Canis lupus familiaris (dog) | EIF5A2 | XP_005639970.1 |
Mus musculus (house mouse) | Eif5a2 | NP_808254.1 |
Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells.
Cao TT, Lin SH, Fu L, Tang Z, Che CM, Zhang LY, Ming XY, Liu TF, Tang XM, Tan BB, Xiang D, Li F, Chan OY, Xie D, Cai Z, Guan XY
Carcinogenesis38(1)94-104(2017 Jan)
Identification and validation of AIB1 and EIF5A2 for noninvasive detection of bladder cancer in urine samples.
Zhou BF, Wei JH, Chen ZH, Dong P, Lai YR, Fang Y, Jiang HM, Lu J, Zhou FJ, Xie D, Luo JH, Chen W
Oncotarget7(27)41703-41714(2016 Jul)
MiRNA-203 suppresses cell proliferation, migration and invasion in colorectal cancer via targeting of EIF5A2.
Deng B, Wang B, Fang J, Zhu X, Cao Z, Lin Q, Zhou L, Sun X
Scientific reports628301(2016 Jul)
Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species.
Liu RR, Lv YS, Tang YX, Wang YF, Chen XL, Zheng XX, Xie SZ, Cai Y, Yu J, Zhang XN
Oncotarget7(17)24348-60(2016 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
High EIF5A2 expression is associated with hepatocellular carcinoma.
Title: Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells.
EIF5A2 overexpression may contribute to cancer progression and poor prognosis. Therefore, EIF5A2 could be a novel potential prognostic marker for Federation of Gynecology and Obstetrics (FIGO) stage I-II cervical cancer.
Title: Overexpression of eukaryotic initiation factor 5A2 (EIF5A2) is associated with cancer progression and poor prognosis in patients with early-stage cervical cancer.
The model had 92% sensitivity and 92% specificity. We obtained similar results in the independent validation cohort. AIB1 and EIF5A2 show promise for the noninvasive detection of bladder cancer. The model based on AIB1, EIF5A2, and NMP22 outperformed each of the three individual biomarkers for detecting Bladder cancer.
Title: Identification and validation of AIB1 and EIF5A2 for noninvasive detection of bladder cancer in urine samples.
Data suggest that inhibition of eIF5A2 alters progression of the EMT to decrease the invasion and metastasis of HCC cells via ROS-related pathways.
Title: Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species.
Data indicate that regulation of sonic hedgehog (SHh)-GLI family zinc finger 1 (Gli1) signals to migration of pancreatic cancer AsPC-1 Cells through mediating eukaryotic translation initiation factor 5A (EIF5A2) gene expression.
Title: Sonic Hedgehog-GLI Family Zinc Finger 1 Signaling Pathway Promotes the Growth and Migration of Pancreatic Cancer Cells by Regulating the Transcription of Eukaryotic Translation Initiation Factor 5A2.
The following EIF5A2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EIF5A2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu26790 | |
Clone ID Related Accession (Same CDS sequence) | NM_020390.5 , NM_020390.6 | |
Accession Version | NM_020390.5 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-10 | |
Organism | Homo sapiens(human) | |
Product | eukaryotic translation initiation factor 5A-2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY205261.1. On Jul 24, 2003 this sequence version replaced NM_020390.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY205261.1, SRR1660805.199759.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGCAGACG AAATTGATTT CACTACTGGA GATGCCGGGG CTTCCAGCAC TTACCCTATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_065123.1 |
CDS | 131..592 |
Translation |
Target ORF information:
Target ORF information:
|
NM_020390.5 |
1 | ATGGCAGACG AAATTGATTT CACTACTGGA GATGCCGGGG CTTCCAGCAC TTACCCTATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu26790 | |
Clone ID Related Accession (Same CDS sequence) | NM_020390.5 , NM_020390.6 | |
Accession Version | NM_020390.6 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Homo sapiens(human) | |
Product | eukaryotic translation initiation factor 5A-2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY205261.1. On Nov 22, 2018 this sequence version replaced NM_020390.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY205261.1, SRR1660805.199759.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000295822.7/ ENSP00000295822.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGCAGACG AAATTGATTT CACTACTGGA GATGCCGGGG CTTCCAGCAC TTACCCTATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_065123.1 |
CDS | 131..592 |
Translation |
Target ORF information:
Target ORF information:
|
NM_020390.6 |
1 | ATGGCAGACG AAATTGATTT CACTACTGGA GATGCCGGGG CTTCCAGCAC TTACCCTATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells. |
Identification and validation of AIB1 and EIF5A2 for noninvasive detection of bladder cancer in urine samples. |
MiRNA-203 suppresses cell proliferation, migration and invasion in colorectal cancer via targeting of EIF5A2. |
Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species. |