PYY cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | PYY |
| Entrez Gene ID | 5697 |
| Full Name | peptide YY |
| Synonyms | PYY-I,PYY1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_004160.5 | NP_004151.3 | peptide YY preproprotein |
| XM_011525035.1 | XP_011523337.1 | peptide YY isoform X1 |
| PYY | XP_001113958.1 | |
| Bos taurus (cattle) | PYY | NP_001035677.1 |
| Rattus norvegicus (Norway rat) | Pyy | NP_001029252.1 |
| Xenopus tropicalis (tropical clawed frog) | pyy | NP_001072427.1 |
| Homo sapiens (human) | PYY | NP_004151.3 |
| Pan troglodytes (chimpanzee) | PYY | XP_523780.3 |
| Danio rerio (zebrafish) | pyya | NP_001157843.1 |
| Canis lupus familiaris (dog) | PYY | XP_005624470.1 |
| Mus musculus (house mouse) | Pyy | NP_663410.1 |
| Danio rerio (zebrafish) | pyyb | XP_001333222.2 |
Related articles in PubMed
Cross-talk between innate cytokines and the pancreatic polypeptide family in acute pancreatitis.
Pendharkar SA, Singh RG, Petrov MS
Cytokine90161-168(2017 Feb)
The role of gut hormone peptide YY in energy and glucose homeostasis: twelve years on.
Manning S, Batterham RL
Annual review of physiology76585-608(2014)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Peptide YY and PP are associated with circulating innate pro-inflammatory cytokines in patients after acute pancreatitis and cumulatively contribute to nearly half of the variance of IL-6, MCP-1, and TNFalpha. Future research is warranted to investigate the signaling pathways that underlie these associations.
Title: Cross-talk between innate cytokines and the pancreatic polypeptide family in acute pancreatitis.
Data suggest that dose/intensity-response relationships exist between exercise intensity and total plasma PYY levels, though the effects on total plasma GLP1 levels and hunger perceptions seem unclear. (PYY = peptide YY ; GLP1 = glucagon-like peptide 1)
Title: Total PYY and GLP-1 responses to submaximal continuous and supramaximal sprint interval cycling in men.
expression of PYY and its NPY receptors on mouse islets and immortalised rodent and human beta-cells was examined.
Title: Islet distribution of Peptide YY and its regulatory role in primary mouse islets and immortalised rodent and human beta-cell function and survival.
In extremely obese patients, fasting PYY3-36 concentrations were linked to systolic blood pressure, but not to other components of metabolic syndrome, suggesting divergence between pathways of blood pressure and glucose/body weight regulation.
Title: Associations of Circulating PYY
Angiotensin II stimulates PYY secretion, in turn inhibiting epithelial anion fluxes, thereby reducing net fluid secretion into the colonic lumen.
Title: Angiotensin II Type 1 Receptor-Dependent GLP-1 and PYY Secretion in Mice and Humans.
The following PYY gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PYY cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu20777 | |
| Clone ID Related Accession (Same CDS sequence) | NM_004160.5 | |
| Accession Version | NM_004160.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-28 | |
| Organism | Homo sapiens(human) | |
| Product | peptide YY preproprotein | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC041057.1, AC007993.15 and AI654355.1. This sequence is a reference standard in the RefSeqGene project. On Feb 20, 2016 this sequence version replaced NM_004160.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041057.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGTGTTCG TGCGCAGGCC GTGGCCCGCC TTGACCACAG TGCTTCTGGC CCTGCTCGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_004151.3 |
| CDS | 542..835 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_004160.5 |
ORF Insert Sequence:
1 | ATGGTGTTCG TGCGCAGGCC GTGGCCCGCC TTGACCACAG TGCTTCTGGC CCTGCTCGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu59986 | |
| Clone ID Related Accession (Same CDS sequence) | XM_011525035.1 | |
| Accession Version | XM_011525035.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-06-05 | |
| Organism | Homo sapiens(human) | |
| Product | peptide YY isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGTGTTCG TGCGCAGGCC GTGGCCCGCC TTGACCACAG TGCTTCTGGC CCTGCTCGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_011523337.1 |
| CDS | 1152..1445 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_011525035.1 |
ORF Insert Sequence:
1 | ATGGTGTTCG TGCGCAGGCC GTGGCCCGCC TTGACCACAG TGCTTCTGGC CCTGCTCGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Cross-talk between innate cytokines and the pancreatic polypeptide family in acute pancreatitis. |
|
The role of gut hormone peptide YY in energy and glucose homeostasis: twelve years on. |