NUP107 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | NUP107 |
| Entrez Gene ID | 57122 |
| Full Name | nucleoporin 107 |
| Synonyms | NPHS11,NUP84 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: | |
| Disorder Html: | Nephrotic syndrome, type 11, 616730 (3) |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| XM_005269037.3 | XP_005269094.1 | nuclear pore complex protein Nup107 isoform X1 |
| NM_001330192.1 | NP_001317121.1 | nuclear pore complex protein Nup107 isoform 2 |
| NM_020401.3 | NP_065134.1 | nuclear pore complex protein Nup107 isoform 1 |
| Homo sapiens (human) | NUP107 | NP_065134.1 |
| Pan troglodytes (chimpanzee) | NUP107 | XP_001153762.1 |
| Mus musculus (house mouse) | Nup107 | NP_598771.1 |
| Canis lupus familiaris (dog) | NUP107 | XP_531670.3 |
| Drosophila melanogaster (fruit fly) | Nup107 | NP_609446.1 |
| NUP107 | XP_001117201.1 | |
| Danio rerio (zebrafish) | nup107 | NP_001025338.1 |
| Bos taurus (cattle) | NUP107 | XP_002687439.1 |
| Gallus gallus (chicken) | NUP107 | XP_004937621.1 |
| Rattus norvegicus (Norway rat) | Nup107 | NP_446282.2 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001685 | XP_001238474.3 |
| Xenopus tropicalis (tropical clawed frog) | nup107 | XP_004912994.1 |
Related articles in PubMed
Systematic Protein-Protein Interaction Analysis Reveals Intersubcomplex Contacts in the Nuclear Pore Complex.
Apelt L, Knockenhauer KE, Leksa NC, Benlasfer N, Schwartz TU, Stelzl U
Molecular & cellular proteomics : MCP15(8)2594-606(2016 08)
A mutation in the nucleoporin-107 gene causes XX gonadal dysgenesis.
Weinberg-Shukron A, Renbaum P, Kalifa R, Zeligson S, Ben-Neriah Z, Dreifuss A, Abu-Rayyan A, Maatuk N, Fardian N, Rekler D, Kanaan M, Samson AO, Levy-Lahad E, Gerlitz O, Zangen D
The Journal of clinical investigation125(11)4295-304(2015 Nov)
Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome.
Miyake N, Tsukaguchi H, Koshimizu E, Shono A, Matsunaga S, Shiina M, Mimura Y, Imamura S, Hirose T, Okudela K, Nozu K, Akioka Y, Hattori M, Yoshikawa N, Kitamura A, Cheong HI, Kagami S, Yamashita M, Fujita A, Miyatake S, Tsurusaki Y, Nakashima M, Saitsu H, Ohashi K, Imamoto N, Ryo A, Ogata K, Iijima K, Matsumoto N
American journal of human genetics97(4)555-66(2015 Oct)
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)
Intranuclear dynamics of the Nup107-160 complex.
Morchoisne-Bolhy S, Geoffroy MC, Bouhlel IB, Alves A, Audug? N, Baudin X, Van Bortle K, Powers MA, Doye V
Molecular biology of the cell26(12)2343-56(2015 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
a variant in the 3'-UTR region Nup107 unique to sensitivity to platinum in ovarian cancer, was identified.
Title: Single nucleotide variant in Nucleoporin 107 may be predictive of sensitivity to chemotherapy in patients with ovarian cancer.
Associations between biallelic NUP107 mutations and age at onset in children with steroid-resistant nephrotic syndrome.
Title: NUP107 mutations in children with steroid-resistant nephrotic syndrome.
a recessive missense mutation in nucleoporin-107 (NUP107, c.1339G>A, p.D447N). This mutation segregated with the XX-GD phenotype and was not present in available databases or in 150 healthy ethnically matched controls.
Title: A mutation in the nucleoporin-107 gene causes XX gonadal dysgenesis.
Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome.
Title: Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome.
Nup107-160 complex and its partner Elys dynamically colocalize with Nup98 and CRM1 into endogenous GLFG bodies present in specific HeLa sublines.
Title: Intranuclear dynamics of the Nup107-160 complex.
The following NUP107 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NUP107 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu25465 | |
| Clone ID Related Accession (Same CDS sequence) | NM_020401.3 | |
| Accession Version | NM_020401.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2778bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-09-14 | |
| Organism | Homo sapiens(human) | |
| Product | nuclear pore complex protein Nup107 isoform 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ295745.1, AC124890.8 and BE326877.1. This sequence is a reference standard in the RefSeqGene project. On Aug 19, 2016 this sequence version replaced NM_020401.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ295745.1, SRR1803617.198004.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGACAGGA GTGGCTTTGG AGAGATATCA TCCCCTGTAA TCCGGGAGGC AGAGGTGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_065134.1 |
| CDS | 116..2893 |
| Misc Feature(1) | 68..70 |
| Misc Feature(2) | 116..118 |
| Misc Feature(3) | 125..127 |
| Misc Feature(4) | 143..145 |
| Misc Feature(5) | 146..148 |
| Misc Feature(6) | 224..226 |
| Misc Feature(7) | 251..253 |
| Misc Feature(8) | 278..280 |
| Misc Feature(9) | 284..286 |
| Misc Feature(10) | 287..289 |
| Misc Feature(11) | 293..295 |
| Misc Feature(12) | 305..307 |
| Misc Feature(13) | 317..319 |
| Misc Feature(14) | 320..322 |
| Misc Feature(15) | 371..373 |
| Misc Feature(16) | 740..2839 |
| Exon (1) | 1..123 |
| Exon (2) | 124..215 |
| Exon (3) | 216..302 |
| Exon (4) | 303..418 |
| Exon (5) | 419..563 |
| Exon (6) | 564..667 |
| Exon (7) | 668..795 |
| Exon (8) | 796..844 |
| Exon (9) | 845..916 |
| Exon (10) | 917..1005 |
| Exon (11) | 1006..1084 |
| Exon (12) | 1085..1198 |
| Exon (13) | 1199..1289 |
| Exon (14) | 1290..1366 |
| Exon (15) | 1367..1426 |
| Exon (16) | 1427..1572 |
| Exon (17) | 1573..1621 |
| Exon (18) | 1622..1691 |
| Exon (19) | 1692..1810 |
| Exon (20) | 1811..1849 |
| Exon (21) | 1850..2000 |
| Exon (22) | 2001..2113 |
| Exon (23) | 2114..2216 |
| Exon (24) | 2217..2377 |
| Exon (25) | 2378..2503 |
| Exon (26) | 2504..2617 |
| Exon (27) | 2618..2785 |
| Exon (28) | 2786..6245 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_020401.3 |
ORF Insert Sequence:
1 | ATGGACAGGA GTGGCTTTGG AGAGATATCA TCCCCTGTAA TCCGGGAGGC AGAGGTGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu70318 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001330192.1 | |
| Accession Version | NM_001330192.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2691bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-09-10 | |
| Organism | Homo sapiens(human) | |
| Product | nuclear pore complex protein Nup107 isoform 2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ295745.1, AC124890.8 and BE326877.1. On Aug 19, 2016 this sequence version replaced XM_011538576.1. Transcript Variant: This variant (2) uses an alternate splice site in its 5' coding region which also results in a longer 5' UTR compared to variant 1. This variant represents translation initiation at an alternate start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (2) that has a shorter and distinct N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.36966.1, SRR1660807.222692.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGAAAATTT TGGTAATACT ACACCAAGAA ACCAGGTTAT CCCTCGAACT CCTAGCTCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001317121.1 |
| CDS | 231..2921 |
| Misc Feature(1) | 171..173 |
| Exon (1) | 1..123 |
| Exon (2) | 124..215 |
| Exon (3) | 216..302 |
| Exon (4) | 303..446 |
| Exon (5) | 447..591 |
| Exon (6) | 592..695 |
| Exon (7) | 696..823 |
| Exon (8) | 824..872 |
| Exon (9) | 873..944 |
| Exon (10) | 945..1033 |
| Exon (11) | 1034..1112 |
| Exon (12) | 1113..1226 |
| Exon (13) | 1227..1317 |
| Exon (14) | 1318..1394 |
| Exon (15) | 1395..1454 |
| Exon (16) | 1455..1600 |
| Exon (17) | 1601..1649 |
| Exon (18) | 1650..1719 |
| Exon (19) | 1720..1838 |
| Exon (20) | 1839..1877 |
| Exon (21) | 1878..2028 |
| Exon (22) | 2029..2141 |
| Exon (23) | 2142..2244 |
| Exon (24) | 2245..2405 |
| Exon (25) | 2406..2531 |
| Exon (26) | 2532..2645 |
| Exon (27) | 2646..2813 |
| Exon (28) | 2814..6273 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001330192.1 |
ORF Insert Sequence:
1 | ATGAAAATTT TGGTAATACT ACACCAAGAA ACCAGGTTAT CCCTCGAACT CCTAGCTCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu46723 | |
| Clone ID Related Accession (Same CDS sequence) | XM_005269037.3 | |
| Accession Version | XM_005269037.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2718bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-06-06 | |
| Organism | Homo sapiens(human) | |
| Product | nuclear pore complex protein Nup107 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005269037.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGACAGGA GTGGCTTTGG AGAGATATCA TCCCCTGTAA TCCGGGAGGC AGAGGTGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_005269094.1 |
| CDS | 107..2824 |
| Misc Feature(1) | 731..2770 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_005269037.3 |
ORF Insert Sequence:
1 | ATGGACAGGA GTGGCTTTGG AGAGATATCA TCCCCTGTAA TCCGGGAGGC AGAGGTGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Systematic Protein-Protein Interaction Analysis Reveals Intersubcomplex Contacts in the Nuclear Pore Complex. |
|
A mutation in the nucleoporin-107 gene causes XX gonadal dysgenesis. |
|
Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome. |
|
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. |
|
Intranuclear dynamics of the Nup107-160 complex. |