PTGER1 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | PTGER1 |
| Entrez Gene ID | 5731 |
| Full Name | prostaglandin E receptor 1 |
| Synonyms | EP1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_000955.2 | NP_000946.2 | prostaglandin E2 receptor EP1 subtype |
| NM_000955.3 | NP_000946.2 | prostaglandin E2 receptor EP1 subtype |
| Danio rerio (zebrafish) | ptger1b | NP_001159805.1 |
| Bos taurus (cattle) | PTGER1 | NP_001179077.1 |
| Danio rerio (zebrafish) | ptger1a | NP_001159802.1 |
| Homo sapiens (human) | PTGER1 | NP_000946.2 |
| Canis lupus familiaris (dog) | PTGER1 | XP_003639810.1 |
| Mus musculus (house mouse) | Ptger1 | NP_038669.1 |
| PTGER1 | NP_001028205.1 | |
| Rattus norvegicus (Norway rat) | Ptger1 | NP_001265404.1 |
Related articles in PubMed
Prostaglandin E2 receptor EP1 in healthy and diseased human endometrium.
Zhu J, Mayr D, Kuhn C, Mahner S, Jeschke U, von Sch?nfeldt V
Histochemistry and cell biology(2017 Nov)
Cyclooxygenase-2 expression is associated with initiation of hepatocellular carcinoma, while prostaglandin receptor-1 expression predicts survival.
Yang HJ, Jiang JH, Yang YT, Yang XD, Guo Z, Qi YP, Zeng FH, Zhang KL, Chen NZ, Xiang BD, Li LQ
World journal of gastroenterology22(39)8798-8805(2016 Oct)
Copy number variation in ALOX5 and PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema.
Plaza-Ser?n Mdel C, Ayuso P, P?rez-S?nchez N, Do?a I, Blanca-Lopez N, Flores C, Galindo L, Molina A, Perkins JR, Cornejo-Garc?a JA, Ag?ndez JA, Garc?a-Mart?n E, Campo P, Canto G, Blanca M
Pharmacogenetics and genomics26(6)280-7(2016 06)
Retinoic acid morpholine amide (RAMA) inhibits expression of Fas ligand through EP1 receptor in colon cancer cells.
Chen SX, Du SY, Wang YT, Zhao HC, Zhang YL, Yao L
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(1)323-9(2016 Jan)
Prostaglandin E2 stimulates ?1-integrin expression in hepatocellular carcinoma through the EP1 receptor/PKC/NF-?B pathway.
Bai X, Wang J, Guo Y, Pan J, Yang Q, Zhang M, Li H, Zhang L, Ma J, Shi F, Shu W, Wang Y, Leng J
Scientific reports46538(2014 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
COX-2 expression appears to be linked to early hepatocellular carcinoma events (initiation), while EP1 receptor expression may participate in tumor progression and predict survival
Title: Cyclooxygenase-2 expression is associated with initiation of hepatocellular carcinoma, while prostaglandin receptor-1 expression predicts survival.
Copy number variation in PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema
Title: Copy number variation in ALOX5 and PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema.
suppression of EP1 prevented RAMA-induced FasL suppression in CLT85 cells at both the mRNA and protein levels
Title: Retinoic acid morpholine amide (RAMA) inhibits expression of Fas ligand through EP1 receptor in colon cancer cells.
NF-kappaB inhibitor suppressed 17-PT-PGE2-mediated FoxC2 upregulation. Immunohistochemistry showed p65, FoxC2, EP1 receptor and beta1-integrin were all highly expressed in the HCC cases
Title: Prostaglandin E2 stimulates ?1-integrin expression in hepatocellular carcinoma through the EP1 receptor/PKC/NF-?B pathway.
A transient interaction between COX-2 and EP1 constitutes a feedback loop whereby an increase in COX-2 expression elevates EP1.
Title: Upregulation of prostaglandin receptor EP1 expression involves its association with cyclooxygenase-2.
The following PTGER1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTGER1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu26575 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_000955.2 , NM_000955.3 | |
| Accession Version | NM_000955.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1209bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-05 | |
| Organism | Homo sapiens(human) | |
| Product | prostaglandin E2 receptor EP1 subtype | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC051286.1 and BC039034.1. On Nov 25, 2003 this sequence version replaced NM_000955.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC051286.1, L22647.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGAGCCCTT GCGGGCCCCT CAACCTGAGC CTGGCGGGCG AGGCGACCAC ATGCGCGGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_000946.2 |
| CDS | 119..1327 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_000955.2 |
ORF Insert Sequence:
1 | ATGAGCCCTT GCGGGCCCCT CAACCTGAGC CTGGCGGGCG AGGCGACCAC ATGCGCGGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu26575 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_000955.2 , NM_000955.3 | |
| Accession Version | NM_000955.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1209bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-07 | |
| Organism | Homo sapiens(human) | |
| Product | prostaglandin E2 receptor EP1 subtype | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC051286.1 and BC039034.1. On Nov 23, 2018 this sequence version replaced NM_000955.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC051286.1, L22647.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000292513.4/ ENSP00000292513.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGAGCCCTT GCGGGCCCCT CAACCTGAGC CTGGCGGGCG AGGCGACCAC ATGCGCGGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_000946.2 |
| CDS | 111..1319 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_000955.3 |
ORF Insert Sequence:
1 | ATGAGCCCTT GCGGGCCCCT CAACCTGAGC CTGGCGGGCG AGGCGACCAC ATGCGCGGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Prostaglandin E2 receptor EP1 in healthy and diseased human endometrium. |
|
Cyclooxygenase-2 expression is associated with initiation of hepatocellular carcinoma, while prostaglandin receptor-1 expression predicts survival. |
|
Copy number variation in ALOX5 and PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema. |
|
Retinoic acid morpholine amide (RAMA) inhibits expression of Fas ligand through EP1 receptor in colon cancer cells. |
|
Prostaglandin E2 stimulates ?1-integrin expression in hepatocellular carcinoma through the EP1 receptor/PKC/NF-?B pathway. |