PTMA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Gene Symbol	PTMA
Entrez Gene ID	5757
Full Name	prothymosin, alpha
Synonyms	TMSA
General protein information	Preferred Names prothymosin, alpha Names prothymosin alpha gene sequence 28 prothymosin alpha protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q37.1
Disorder MIM:	188390

mRNA and Protein(s)

mRNA	Protein	Name
XM_011511519.1	XP_011509821.1	prothymosin alpha isoform X2
NM_001099285.1	NP_001092755.1	prothymosin alpha isoform 1
XM_011511518.1	XP_011509820.1	prothymosin alpha isoform X1
XM_011511521.1	XP_011509823.1	prothymosin alpha isoform X4
XM_011511522.2	XP_011509824.1	prothymosin alpha isoform X5
NM_002823.4	NP_002814.3	prothymosin alpha isoform 2
XM_011511520.1	XP_011509822.1	prothymosin alpha isoform X3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PTMA	NP_001231564.1
	LOC694887	XP_001085972.1
Pan troglodytes (chimpanzee)	LOC101058118	XP_003952271.1
Homo sapiens (human)	PTMA	NP_002814.3
Canis lupus familiaris (dog)	PTMA	NP_001239127.1

Gene Ontology
Bibliography

Related articles in PubMed

Prothymosin ? interacts with SET, ANP32A and ANP32B and other cytoplasmic and mitochondrial proteins in proliferating cells.
Barbeito P, Sarandeses CS, D?az-Jullien C, Muras J, Covelo G, Moreira D, Freire-Cobo C, Freire M
Archives of biochemistry and biophysics63574-86(2017 Dec)

Prothymosin-? Variants Elicit Anti-HIV-1 Response via TLR4 Dependent and Independent Pathways.
Gusella GL, Teixeira A, Aberg J, Uversky VN, Mosoian A
PloS one11(6)e0156486(2016)

Prothymosin-? Overexpression Contributes to the Development of Insulin Resistance.
Su YC, Ou HY, Wu HT, Wu P, Chen YC, Su BH, Shiau AL, Chang CJ, Wu CL
The Journal of clinical endocrinology and metabolism100(11)4114-23(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

According to the cellular function of the characterized targets of ProTalpha, and the evolution in the composition of the diverse ProTalpha-complexes when proliferation activity was reduced or apoptosis induced, leads to hypothesized that ProTalpha interactions might be related to the proliferation activity and control of the cell survival.
Title: Prothymosin ? interacts with SET, ANP32A and ANP32B and other cytoplasmic and mitochondrial proteins in proliferating cells.

Prothymosin-alpha variants elicit anti-HIV-1 response via TLR4 dependent and independent pathways.
Title: Prothymosin-? Variants Elicit Anti-HIV-1 Response via TLR4 Dependent and Independent Pathways.

PTMA is a potential novel therapeutic target for type 2 diabetes
Title: Prothymosin-? Overexpression Contributes to the Development of Insulin Resistance.

Data suggest that KEAP1 (kelch-like ECH-associated protein 1) mutations (as those observed in lung cancer patients) affect conformation/folding/stability of KEAP1 and binding affinity for ligands PTMA and NRF2 (nuclear factor erythroid 2-like 2).
Title: Molecular effects of cancer-associated somatic mutations on the structural and target recognition properties of Keap1.

disease-free survival and overall survival rates were significantly lower among colorectal cancer patients with PTMA- and TP53-positive tumors
Title: Increased expression of prothymosin-?, independently or combined with TP53, correlates with poor prognosis in colorectal cancer.

The following PTMA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTMA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14053	NM_002823.4 Latest version!	Homo sapiens prothymosin alpha (PTMA), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu14138	NM_001099285.1 Latest version!	Homo sapiens prothymosin alpha (PTMA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu60026	XM_011511518.1 Latest version!	Homo sapiens prothymosin alpha (PTMA), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu60027	XM_011511519.1 Latest version!	Homo sapiens prothymosin alpha (PTMA), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu60028	XM_011511520.1 Latest version!	Homo sapiens prothymosin alpha (PTMA), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu60029	XM_011511521.1 Latest version!	Homo sapiens prothymosin alpha (PTMA), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu60030	XM_011511522.2 Latest version!	Homo sapiens prothymosin alpha (PTMA), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PTMA ( NM_002823.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002814.3 Homo sapiens prothymosin alpha (PTMA), transcript variant 2, mRNA.

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CloneID	OHu14053
Clone ID Related Accession (Same CDS sequence)	NM_002823.4
Accession Version	NM_002823.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	prothymosin alpha isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM839980.1 and BC071879.1. On Jul 5, 2007 this sequence version replaced NM_002823.3. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the mid-coding region, compared to variant 1, resulting in a shorter protein (isoform 2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223605.1, BC022433.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCAGACG CAGCCGTAGA CACCAGCTCC GAAATCACCA CCAAGGACTT AAAGGAGAAG 
AAGGAAGTTG TGGAAGAGGC AGAAAATGGA AGAGACGCCC CTGCTAACGG GAATGCTAAT 
GAGGAAAATG GGGAGCAGGA GGCTGACAAT GAGGTAGACG AAGAAGAGGA AGAAGGTGGG 
GAGGAAGAGG AGGAGGAAGA AGAAGGTGAT GGTGAGGAAG AGGATGGAGA TGAAGATGAG 
GAAGCTGAGT CAGCTACGGG CAAGCGGGCA GCTGAAGATG ATGAGGATGA CGATGTCGAT 
ACCAAGAAGC AGAAGACCGA CGAGGATGAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002814.3
CDS	183..515
Translation	MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNANEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD

Target ORF information:

RefSeq Version	NM_002823.4
Organism	Homo sapiens(human)
Definition	Homo sapiens prothymosin alpha (PTMA), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002823.4

ORF Insert Sequence:

ATGTCAGACG CAGCCGTAGA CACCAGCTCC GAAATCACCA CCAAGGACTT AAAGGAGAAG 
AAGGAAGTTG TGGAAGAGGC AGAAAATGGA AGAGACGCCC CTGCTAACGG GAATGCTAAT 
GAGGAAAATG GGGAGCAGGA GGCTGACAAT GAGGTAGACG AAGAAGAGGA AGAAGGTGGG 
GAGGAAGAGG AGGAGGAAGA AGAAGGTGAT GGTGAGGAAG AGGATGGAGA TGAAGATGAG 
GAAGCTGAGT CAGCTACGGG CAAGCGGGCA GCTGAAGATG ATGAGGATGA CGATGTCGAT 
ACCAAGAAGC AGAAGACCGA CGAGGATGAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTMA ( NM_001099285.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001092755.1 Homo sapiens prothymosin alpha (PTMA), transcript variant 1, mRNA.

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CloneID	OHu14138
Clone ID Related Accession (Same CDS sequence)	NM_001099285.1
Accession Version	NM_001099285.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 336bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	prothymosin alpha isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM839980.1, M14630.1 and BC071879.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.168892.1, SRR1163657.225265.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCAGACG CAGCCGTAGA CACCAGCTCC GAAATCACCA CCAAGGACTT AAAGGAGAAG 
AAGGAAGTTG TGGAAGAGGC AGAAAATGGA AGAGACGCCC CTGCTAACGG GAATGCTGAG 
AATGAGGAAA ATGGGGAGCA GGAGGCTGAC AATGAGGTAG ACGAAGAAGA GGAAGAAGGT 
GGGGAGGAAG AGGAGGAGGA AGAAGAAGGT GATGGTGAGG AAGAGGATGG AGATGAAGAT 
GAGGAAGCTG AGTCAGCTAC GGGCAAGCGG GCAGCTGAAG ATGATGAGGA TGACGATGTC 
GATACCAAGA AGCAGAAGAC CGACGAGGAT GACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001092755.1
CDS	183..518
Translation	MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNAENEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD

Target ORF information:

RefSeq Version	NM_001099285.1
Organism	Homo sapiens(human)
Definition	Homo sapiens prothymosin alpha (PTMA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001099285.1

ORF Insert Sequence:

ATGTCAGACG CAGCCGTAGA CACCAGCTCC GAAATCACCA CCAAGGACTT AAAGGAGAAG 
AAGGAAGTTG TGGAAGAGGC AGAAAATGGA AGAGACGCCC CTGCTAACGG GAATGCTGAG 
AATGAGGAAA ATGGGGAGCA GGAGGCTGAC AATGAGGTAG ACGAAGAAGA GGAAGAAGGT 
GGGGAGGAAG AGGAGGAGGA AGAAGAAGGT GATGGTGAGG AAGAGGATGG AGATGAAGAT 
GAGGAAGCTG AGTCAGCTAC GGGCAAGCGG GCAGCTGAAG ATGATGAGGA TGACGATGTC 
GATACCAAGA AGCAGAAGAC CGACGAGGAT GACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTMA ( XM_011511518.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011509820.1 Homo sapiens prothymosin alpha (PTMA), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu60026
Clone ID Related Accession (Same CDS sequence)	XM_011511518.1
Accession Version	XM_011511518.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	prothymosin alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTAGTA GCCCGAGAGG CGCATCCCCG ACAGTCTCGG ACCTACGCAG CCCGGTGGAC 
TTTGGGGCGA CCTCCCGTGG GACTTGGCCC GCCGAATGCA GACATTCGGG CCTGCCGGGG 
TGGCGGCAGT GGGGCGTCGA GTCGAGAGCC CGGCCGACCG ACGCGCGACC CGCGCGCGTG 
CCACTGCAAG CTCTGCCTGC CGGCCGGGAG TCTCCAAGGC AAGGGACGCA CTCGGCGGCC 
CCGGGCCACG TGCTCCCTGC GCGCGGTGCG TGCCGAGGCC CGCGCGCAAA GCCCGCCGGG 
CGGGGGATGC GCGCCTGCGC GCCGCGACCT CCCTGCCCCC ACTGCTCCCC GGGGCTTCGG 
CCGCCAGGGG GCGAGAGCGG GCGGAGCCGG GGTCCGCGGA GCGGAGCGGG GCGGGCCGGA 
CTGAGAGGGC CGACAGGTGG CCCGGAGCCG CTCGCCGGAC AGCGGCCGAG GGGTTCCCGC 
AGGCCCGGAC GCCGGACCTC TGACTTAAAG GAGAAGAAGG AAGTTGTGGA AGAGGCAGAA 
AATGGAAGAG ACGCCCCTGC TAACGGGAAT GCTGAGAATG AGGAAAATGG GGAGCAGGAG 
GCTGACAATG AGGTAGACGA AGAAGAGGAA GAAGGTGGGG AGGAAGAGGA GGAGGAAGAA 
GAAGGTGATG GTGAGGAAGA GGATGGAGAT GAAGATGAGG AAGCTGAGTC AGCTACGGGC 
AAGCGGGCAG CTGAAGATGA TGAGGATGAC GATGTCGATA CCAAGAAGCA GAAGACCGAC 
GAGGATGACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011509820.1
CDS	457..1248
Translation	MSSSPRGASPTVSDLRSPVDFGATSRGTWPAECRHSGLPGWRQWGVESRARPTDARPARVPLQALPAGRESPRQGTHSAAPGHVLPARGACRGPRAKPAGRGMRACAPRPPCPHCSPGLRPPGGESGRSRGPRSGAGRAGLRGPTGGPEPLAGQRPRGSRRPGRRTSDLKEKKEVVEEAENGRDAPANGNAENEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD

Target ORF information:

RefSeq Version	XM_011511518.1
Organism	Homo sapiens(human)
Definition	Homo sapiens prothymosin alpha (PTMA), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011511518.1

ORF Insert Sequence:

ATGAGTAGTA GCCCGAGAGG CGCATCCCCG ACAGTCTCGG ACCTACGCAG CCCGGTGGAC 
TTTGGGGCGA CCTCCCGTGG GACTTGGCCC GCCGAATGCA GACATTCGGG CCTGCCGGGG 
TGGCGGCAGT GGGGCGTCGA GTCGAGAGCC CGGCCGACCG ACGCGCGACC CGCGCGCGTG 
CCACTGCAAG CTCTGCCTGC CGGCCGGGAG TCTCCAAGGC AAGGGACGCA CTCGGCGGCC 
CCGGGCCACG TGCTCCCTGC GCGCGGTGCG TGCCGAGGCC CGCGCGCAAA GCCCGCCGGG 
CGGGGGATGC GCGCCTGCGC GCCGCGACCT CCCTGCCCCC ACTGCTCCCC GGGGCTTCGG 
CCGCCAGGGG GCGAGAGCGG GCGGAGCCGG GGTCCGCGGA GCGGAGCGGG GCGGGCCGGA 
CTGAGAGGGC CGACAGGTGG CCCGGAGCCG CTCGCCGGAC AGCGGCCGAG GGGTTCCCGC 
AGGCCCGGAC GCCGGACCTC TGACTTAAAG GAGAAGAAGG AAGTTGTGGA AGAGGCAGAA 
AATGGAAGAG ACGCCCCTGC TAACGGGAAT GCTGAGAATG AGGAAAATGG GGAGCAGGAG 
GCTGACAATG AGGTAGACGA AGAAGAGGAA GAAGGTGGGG AGGAAGAGGA GGAGGAAGAA 
GAAGGTGATG GTGAGGAAGA GGATGGAGAT GAAGATGAGG AAGCTGAGTC AGCTACGGGC 
AAGCGGGCAG CTGAAGATGA TGAGGATGAC GATGTCGATA CCAAGAAGCA GAAGACCGAC 
GAGGATGACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTMA ( XM_011511519.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011509821.1 Homo sapiens prothymosin alpha (PTMA), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu60027
Clone ID Related Accession (Same CDS sequence)	XM_011511519.1
Accession Version	XM_011511519.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	prothymosin alpha isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTAGTA GCCCGAGAGG CGCATCCCCG ACAGTCTCGG ACCTACGCAG CCCGGTGGAC 
TTTGGGGCGA CCTCCCGTGG GACTTGGCCC GCCGAATGCA GACATTCGGG CCTGCCGGGG 
TGGCGGCAGT GGGGCGTCGA GTCGAGAGCC CGGCCGACCG ACGCGCGACC CGCGCGCGTG 
CCACTGCAAG CTCTGCCTGC CGGCCGGGAG TCTCCAAGGC AAGGGACGCA CTCGGCGGCC 
CCGGGCCACG TGCTCCCTGC GCGCGGTGCG TGCCGAGGCC CGCGCGCAAA GCCCGCCGGG 
CGGGGGATGC GCGCCTGCGC GCCGCGACCT CCCTGCCCCC ACTGCTCCCC GGGGCTTCGG 
CCGCCAGGGG GCGAGAGCGG GCGGAGCCGG GGTCCGCGGA GCGGAGCGGG GCGGGCCGGA 
CTGAGAGGGC CGACAGGTGG CCCGGAGCCG CTCGCCGGAC AGCGGCCGAG GGGTTCCCGC 
AGGCCCGGAC GCCGGACCTC TGACTTAAAG GAGAAGAAGG AAGTTGTGGA AGAGGCAGAA 
AATGGAAGAG ACGCCCCTGC TAACGGGAAT GCTAATGAGG AAAATGGGGA GCAGGAGGCT 
GACAATGAGG TAGACGAAGA AGAGGAAGAA GGTGGGGAGG AAGAGGAGGA GGAAGAAGAA 
GGTGATGGTG AGGAAGAGGA TGGAGATGAA GATGAGGAAG CTGAGTCAGC TACGGGCAAG 
CGGGCAGCTG AAGATGATGA GGATGACGAT GTCGATACCA AGAAGCAGAA GACCGACGAG 
GATGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011509821.1
CDS	457..1245
Translation	MSSSPRGASPTVSDLRSPVDFGATSRGTWPAECRHSGLPGWRQWGVESRARPTDARPARVPLQALPAGRESPRQGTHSAAPGHVLPARGACRGPRAKPAGRGMRACAPRPPCPHCSPGLRPPGGESGRSRGPRSGAGRAGLRGPTGGPEPLAGQRPRGSRRPGRRTSDLKEKKEVVEEAENGRDAPANGNANEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD

Target ORF information:

RefSeq Version	XM_011511519.1
Organism	Homo sapiens(human)
Definition	Homo sapiens prothymosin alpha (PTMA), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011511519.1

ORF Insert Sequence:

ATGAGTAGTA GCCCGAGAGG CGCATCCCCG ACAGTCTCGG ACCTACGCAG CCCGGTGGAC 
TTTGGGGCGA CCTCCCGTGG GACTTGGCCC GCCGAATGCA GACATTCGGG CCTGCCGGGG 
TGGCGGCAGT GGGGCGTCGA GTCGAGAGCC CGGCCGACCG ACGCGCGACC CGCGCGCGTG 
CCACTGCAAG CTCTGCCTGC CGGCCGGGAG TCTCCAAGGC AAGGGACGCA CTCGGCGGCC 
CCGGGCCACG TGCTCCCTGC GCGCGGTGCG TGCCGAGGCC CGCGCGCAAA GCCCGCCGGG 
CGGGGGATGC GCGCCTGCGC GCCGCGACCT CCCTGCCCCC ACTGCTCCCC GGGGCTTCGG 
CCGCCAGGGG GCGAGAGCGG GCGGAGCCGG GGTCCGCGGA GCGGAGCGGG GCGGGCCGGA 
CTGAGAGGGC CGACAGGTGG CCCGGAGCCG CTCGCCGGAC AGCGGCCGAG GGGTTCCCGC 
AGGCCCGGAC GCCGGACCTC TGACTTAAAG GAGAAGAAGG AAGTTGTGGA AGAGGCAGAA 
AATGGAAGAG ACGCCCCTGC TAACGGGAAT GCTAATGAGG AAAATGGGGA GCAGGAGGCT 
GACAATGAGG TAGACGAAGA AGAGGAAGAA GGTGGGGAGG AAGAGGAGGA GGAAGAAGAA 
GGTGATGGTG AGGAAGAGGA TGGAGATGAA GATGAGGAAG CTGAGTCAGC TACGGGCAAG 
CGGGCAGCTG AAGATGATGA GGATGACGAT GTCGATACCA AGAAGCAGAA GACCGACGAG 
GATGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTMA ( XM_011511520.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011509822.1 Homo sapiens prothymosin alpha (PTMA), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu60028
Clone ID Related Accession (Same CDS sequence)	XM_011511520.1
Accession Version	XM_011511520.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	prothymosin alpha isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGACAT TCGGGCCTGC CGGGGTGGCG GCAGTGGGGC GTCGAGTCGA GAGCCCGGCC 
GACCGACGCG CGACCCGCGC GCGTGCCACT GCAAGCTCTG CCTGCCGGCC GGGAGTCTCC 
AAGGCAAGGG ACGCACTCGG CGGCCCCGGG CCACGTGCTC CCTGCGCGCG GTGCGTGCCG 
AGGCCCGCGC GCAAAGCCCG CCGGGCGGGG GATGCGCGCC TGCGCGCCGC GACCTCCCTG 
CCCCCACTGC TCCCCGGGGC TTCGGCCGCC AGGGGGCGAG AGCGGGCGGA GCCGGGGTCC 
GCGGAGCGGA GCGGGGCGGG CCGGACTGAG AGGGCCGACA GGTGGCCCGG AGCCGCTCGC 
CGGACAGCGG CCGAGGGGTT CCCGCAGGCC CGGACGCCGG ACCTCTGTTG GTATTGGTGG 
CCGTGTCGTG TGGAAAAAGT TACCGGGCGC CCGGGGCCGC GCTGCCTTTT GGATCCCGGG 
CGGAGTCCCA CCCCCGAGGA CTTAAAGGAG AAGAAGGAAG TTGTGGAAGA GGCAGAAAAT 
GGAAGAGACG CCCCTGCTAA CGGGAATGCT GAGAATGAGG AAAATGGGGA GCAGGAGGCT 
GACAATGAGG TAGACGAAGA AGAGGAAGAA GGTGGGGAGG AAGAGGAGGA GGAAGAAGAA 
GGTGATGGTG AGGAAGAGGA TGGAGATGAA GATGAGGAAG CTGAGTCAGC TACGGGCAAG 
CGGGCAGCTG AAGATGATGA GGATGACGAT GTCGATACCA AGAAGCAGAA GACCGACGAG 
GATGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011509822.1
CDS	359..1147
Translation	MQTFGPAGVAAVGRRVESPADRRATRARATASSACRPGVSKARDALGGPGPRAPCARCVPRPARKARRAGDARLRAATSLPPLLPGASAARGRERAEPGSAERSGAGRTERADRWPGAARRTAAEGFPQARTPDLCWYWWPCRVEKVTGRPGPRCLLDPGRSPTPEDLKEKKEVVEEAENGRDAPANGNAENEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD

Target ORF information:

RefSeq Version	XM_011511520.1
Organism	Homo sapiens(human)
Definition	Homo sapiens prothymosin alpha (PTMA), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011511520.1

ORF Insert Sequence:

ATGCAGACAT TCGGGCCTGC CGGGGTGGCG GCAGTGGGGC GTCGAGTCGA GAGCCCGGCC 
GACCGACGCG CGACCCGCGC GCGTGCCACT GCAAGCTCTG CCTGCCGGCC GGGAGTCTCC 
AAGGCAAGGG ACGCACTCGG CGGCCCCGGG CCACGTGCTC CCTGCGCGCG GTGCGTGCCG 
AGGCCCGCGC GCAAAGCCCG CCGGGCGGGG GATGCGCGCC TGCGCGCCGC GACCTCCCTG 
CCCCCACTGC TCCCCGGGGC TTCGGCCGCC AGGGGGCGAG AGCGGGCGGA GCCGGGGTCC 
GCGGAGCGGA GCGGGGCGGG CCGGACTGAG AGGGCCGACA GGTGGCCCGG AGCCGCTCGC 
CGGACAGCGG CCGAGGGGTT CCCGCAGGCC CGGACGCCGG ACCTCTGTTG GTATTGGTGG 
CCGTGTCGTG TGGAAAAAGT TACCGGGCGC CCGGGGCCGC GCTGCCTTTT GGATCCCGGG 
CGGAGTCCCA CCCCCGAGGA CTTAAAGGAG AAGAAGGAAG TTGTGGAAGA GGCAGAAAAT 
GGAAGAGACG CCCCTGCTAA CGGGAATGCT GAGAATGAGG AAAATGGGGA GCAGGAGGCT 
GACAATGAGG TAGACGAAGA AGAGGAAGAA GGTGGGGAGG AAGAGGAGGA GGAAGAAGAA 
GGTGATGGTG AGGAAGAGGA TGGAGATGAA GATGAGGAAG CTGAGTCAGC TACGGGCAAG 
CGGGCAGCTG AAGATGATGA GGATGACGAT GTCGATACCA AGAAGCAGAA GACCGACGAG 
GATGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTMA ( XM_011511521.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011509823.1 Homo sapiens prothymosin alpha (PTMA), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu60029
Clone ID Related Accession (Same CDS sequence)	XM_011511521.1
Accession Version	XM_011511521.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	prothymosin alpha isoform X4
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGACAT TCGGGCCTGC CGGGGTGGCG GCAGTGGGGC GTCGAGTCGA GAGCCCGGCC 
GACCGACGCG CGACCCGCGC GCGTGCCACT GCAAGCTCTG CCTGCCGGCC GGGAGTCTCC 
AAGGCAAGGG ACGCACTCGG CGGCCCCGGG CCACGTGCTC CCTGCGCGCG GTGCGTGCCG 
AGGCCCGCGC GCAAAGCCCG CCGGGCGGGG GATGCGCGCC TGCGCGCCGC GACCTCCCTG 
CCCCCACTGC TCCCCGGGGC TTCGGCCGCC AGGGGGCGAG AGCGGGCGGA GCCGGGGTCC 
GCGGAGCGGA GCGGGGCGGG CCGGACTGAG AGGGCCGACA GGTGGCCCGG AGCCGCTCGC 
CGGACAGCGG CCGAGGGGTT CCCGCAGGCC CGGACGCCGG ACCTCTGTTG GTATTGGTGG 
CCGTGTCGTG TGGAAAAAGT TACCGGGCGC CCGGGGCCGC GCTGCCTTTT GGATCCCGGG 
CGGAGTCCCA CCCCCGAGGA CTTAAAGGAG AAGAAGGAAG TTGTGGAAGA GGCAGAAAAT 
GGAAGAGACG CCCCTGCTAA CGGGAATGCT AATGAGGAAA ATGGGGAGCA GGAGGCTGAC 
AATGAGGTAG ACGAAGAAGA GGAAGAAGGT GGGGAGGAAG AGGAGGAGGA AGAAGAAGGT 
GATGGTGAGG AAGAGGATGG AGATGAAGAT GAGGAAGCTG AGTCAGCTAC GGGCAAGCGG 
GCAGCTGAAG ATGATGAGGA TGACGATGTC GATACCAAGA AGCAGAAGAC CGACGAGGAT 
GACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011509823.1
CDS	359..1144
Translation	MQTFGPAGVAAVGRRVESPADRRATRARATASSACRPGVSKARDALGGPGPRAPCARCVPRPARKARRAGDARLRAATSLPPLLPGASAARGRERAEPGSAERSGAGRTERADRWPGAARRTAAEGFPQARTPDLCWYWWPCRVEKVTGRPGPRCLLDPGRSPTPEDLKEKKEVVEEAENGRDAPANGNANEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD

Target ORF information:

RefSeq Version	XM_011511521.1
Organism	Homo sapiens(human)
Definition	Homo sapiens prothymosin alpha (PTMA), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011511521.1

ORF Insert Sequence:

ATGCAGACAT TCGGGCCTGC CGGGGTGGCG GCAGTGGGGC GTCGAGTCGA GAGCCCGGCC 
GACCGACGCG CGACCCGCGC GCGTGCCACT GCAAGCTCTG CCTGCCGGCC GGGAGTCTCC 
AAGGCAAGGG ACGCACTCGG CGGCCCCGGG CCACGTGCTC CCTGCGCGCG GTGCGTGCCG 
AGGCCCGCGC GCAAAGCCCG CCGGGCGGGG GATGCGCGCC TGCGCGCCGC GACCTCCCTG 
CCCCCACTGC TCCCCGGGGC TTCGGCCGCC AGGGGGCGAG AGCGGGCGGA GCCGGGGTCC 
GCGGAGCGGA GCGGGGCGGG CCGGACTGAG AGGGCCGACA GGTGGCCCGG AGCCGCTCGC 
CGGACAGCGG CCGAGGGGTT CCCGCAGGCC CGGACGCCGG ACCTCTGTTG GTATTGGTGG 
CCGTGTCGTG TGGAAAAAGT TACCGGGCGC CCGGGGCCGC GCTGCCTTTT GGATCCCGGG 
CGGAGTCCCA CCCCCGAGGA CTTAAAGGAG AAGAAGGAAG TTGTGGAAGA GGCAGAAAAT 
GGAAGAGACG CCCCTGCTAA CGGGAATGCT AATGAGGAAA ATGGGGAGCA GGAGGCTGAC 
AATGAGGTAG ACGAAGAAGA GGAAGAAGGT GGGGAGGAAG AGGAGGAGGA AGAAGAAGGT 
GATGGTGAGG AAGAGGATGG AGATGAAGAT GAGGAAGCTG AGTCAGCTAC GGGCAAGCGG 
GCAGCTGAAG ATGATGAGGA TGACGATGTC GATACCAAGA AGCAGAAGAC CGACGAGGAT 
GACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTMA ( XM_011511522.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011509824.1 Homo sapiens prothymosin alpha (PTMA), transcript variant X5, mRNA.

Price & Availability↑

CloneID	OHu60030
Clone ID Related Accession (Same CDS sequence)	XM_011511522.2
Accession Version	XM_011511522.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	prothymosin alpha isoform X5
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011511522.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTAGTA GCCCGAGAGG CGCATCCCCG ACAGTCTCGG ACCTACGCAG CCCGGTGGAC 
TTTGGGGCGA CCTCCCGTGG GACTTGGCCC GCCGAATGCA GACATTCGGG CCTGCCGGGG 
TGGCGGCAGT GGGGCGTCGA GTCGAGAGCC CGGCCGACCG ACGCGCGACC CGCGCGCGTG 
CCACTGCAAG CTCTGCCTGC CGGCCGGGAG TCTCCAAGGC AAGGGACGCA CTCGGCGGCC 
CCGGGCCACG TGCTCCCTGC GCGCGGTGCG TGCCGAGGCC CGCGCGCAAA GCCCGCCGGG 
CGGGGGATGC GCGCCTGCGC GCCGCGACCT CCCTGCCCCC ACTGCTCCCC GGGGCTTCGG 
CCGCCAGGGG GCGAGAGCGG GCGGAGCCGG GGTCCGCGGA GCGGAGCGGG GCGGGCCGGA 
CTGAGAGGGC CGACAGGTGG CCCGGAGCCG CTCGCCGGAC AGCGGCCGAG GGGTTCCCGC 
AGGCCCGGAC GCCGGACCTC TGACTTAAAG GAGAAGAAGG AAGTTGTGGA AGAGGCAGAA 
AATGGAAGAG ACGCCCCTGC TAACGGGAAT GCTGTGAGGA AGAGGATGGA GATGAAGATG 
AGGAAGCTGA GTCAGCTACG GGCAAGCGGG CAGCTGAAGA TGATGAGGAT GACGATGTCG 
ATACCAAGAA GCAGAAGACC GACGAGGATG ACTAGACAGC AAAAAAGGAA AAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011509824.1
CDS	1314..2030
Translation	MSSSPRGASPTVSDLRSPVDFGATSRGTWPAECRHSGLPGWRQWGVESRARPTDARPARVPLQALPAGRESPRQGTHSAAPGHVLPARGACRGPRAKPAGRGMRACAPRPPCPHCSPGLRPPGGESGRSRGPRSGAGRAGLRGPTGGPEPLAGQRPRGSRRPGRRTSDLKEKKEVVEEAENGRDAPANGNAVRKRMEMKMRKLSQLRASGQLKMMRMTMSIPRSRRPTRMTRQQKRKS

Target ORF information:

RefSeq Version	XM_011511522.2
Organism	Homo sapiens(human)
Definition	Homo sapiens prothymosin alpha (PTMA), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011511522.2

ORF Insert Sequence:

ATGAGTAGTA GCCCGAGAGG CGCATCCCCG ACAGTCTCGG ACCTACGCAG CCCGGTGGAC 
TTTGGGGCGA CCTCCCGTGG GACTTGGCCC GCCGAATGCA GACATTCGGG CCTGCCGGGG 
TGGCGGCAGT GGGGCGTCGA GTCGAGAGCC CGGCCGACCG ACGCGCGACC CGCGCGCGTG 
CCACTGCAAG CTCTGCCTGC CGGCCGGGAG TCTCCAAGGC AAGGGACGCA CTCGGCGGCC 
CCGGGCCACG TGCTCCCTGC GCGCGGTGCG TGCCGAGGCC CGCGCGCAAA GCCCGCCGGG 
CGGGGGATGC GCGCCTGCGC GCCGCGACCT CCCTGCCCCC ACTGCTCCCC GGGGCTTCGG 
CCGCCAGGGG GCGAGAGCGG GCGGAGCCGG GGTCCGCGGA GCGGAGCGGG GCGGGCCGGA 
CTGAGAGGGC CGACAGGTGG CCCGGAGCCG CTCGCCGGAC AGCGGCCGAG GGGTTCCCGC 
AGGCCCGGAC GCCGGACCTC TGACTTAAAG GAGAAGAAGG AAGTTGTGGA AGAGGCAGAA 
AATGGAAGAG ACGCCCCTGC TAACGGGAAT GCTGTGAGGA AGAGGATGGA GATGAAGATG 
AGGAAGCTGA GTCAGCTACG GGCAAGCGGG CAGCTGAAGA TGATGAGGAT GACGATGTCG 
ATACCAAGAA GCAGAAGACC GACGAGGATG ACTAGACAGC AAAAAAGGAA AAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prothymosin ? interacts with SET, ANP32A and ANP32B and other cytoplasmic and mitochondrial proteins in proliferating cells.
Archives of biochemistry and biophysics63574-86(2017 Dec)
Barbeito P,Sarandeses CS,D?az-Jullien C,Muras J,Covelo G,Moreira D,Freire-Cobo C,Freire M

Prothymosin-? Variants Elicit Anti-HIV-1 Response via TLR4 Dependent and Independent Pathways.
PloS one11(6)e0156486(2016)
Gusella GL,Teixeira A,Aberg J,Uversky VN,Mosoian A

Prothymosin-? Overexpression Contributes to the Development of Insulin Resistance.
The Journal of clinical endocrinology and metabolism100(11)4114-23(2015 Nov)
Su YC,Ou HY,Wu HT,Wu P,Chen YC,Su BH,Shiau AL,Chang CJ,Wu CL

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PTMA cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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