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MAGEE1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol MAGEE1
Entrez Gene ID 57692
Full Name MAGE family member E1
Synonyms DAMAGE,HCA1
General protein information
Preferred Names

MAGE family member E1

Names

melanoma-associated antigen E1
MAGE-E1 antigen
alpha-dystrobrevin-associated MAGE Protein
dystrobrevin-associated MAGE protein
hepatocellular carcinoma-associated HCA1
hepatocellular carcinoma-associated protein 1
melanoma antigen family E, 1
melanoma antigen family E1

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

X

Xq13.3

Summary This gene encodes an alpha-dystrobrevin-associated MAGE (melanoma-associated antigen) protein, which is a member of the MAGE family. The protein contains a nuclear localization signal in the N-terminus, 30 12-amino acid repeats beginning at nt 60 with the consensus sequence ASEGPSTSVLPT, and two MAGE domains in the C-terminus. It may play a signaling role in brain, muscle, and peripheral nerve. This gene is located on X chromosome in a region containing loci linked to mental retardation. [provided by RefSeq, Mar 2010].
Disorder MIM:

300759


mRNA and Protein(s)

mRNA Protein Name
NM_020932.2 NP_065983.1 melanoma-associated antigen E1



Mus musculus (house mouse) Magee1 NP_444431.3
Homo sapiens (human) MAGEE1 NP_065983.1
Pan troglodytes (chimpanzee) MAGEE1 XP_001143922.2
Rattus norvegicus (Norway rat) Magee1 NP_001073360.1


Related articles in PubMed

Naturally occurring HCA1 missense mutations result in loss of function: potential impact on lipid deposition.
Doyle JR, Lane JM, Beinborn M, Kopin AS
Journal of lipid research54(3)823-30(2013 Mar)

MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.
Doyle JM, Gao J, Wang J, Yang M, Potts PR
Molecular cell39(6)963-74(2010 Sep)

Frequent MAGE mutations in human melanoma.
Caballero OL, Zhao Q, Rimoldi D, Stevenson BJ, Svobodová S, Devalle S, Röhrig UF, Pagotto A, Michielin O, Speiser D, Wolchok JD, Liu C, Pejovic T, Odunsi K, Brasseur F, Van den Eynde BJ, Old LJ, Lu X, Cebon J, Strausberg RL, Simpson AJ
PloS one5(9)(2010 Sep)

DAMAGE, a novel alpha-dystrobrevin-associated MAGE protein in dystrophin complexes.
Albrecht DE, Froehner SC
The Journal of biological chemistry279(8)7014-23(2004 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that lipid homeostasis may be altered in carriers of selected HCA1 missense variants.
Title: Naturally occurring HCA1 missense mutations result in loss of function: potential impact on lipid deposition.

Observational study of gene-disease association. (HuGE Navigator)
Title: Frequent MAGE mutations in human melanoma.

a new dystrobrevin-associated protein that may play a signaling role in brain, muscle, and peripheral nerve
Title: DAMAGE, a novel alpha-dystrobrevin-associated MAGE protein in dystrophin complexes.

The following MAGEE1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAGEE1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19574 NM_020932.2
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Homo sapiens MAGE family member E1 (MAGEE1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $475.30
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19574
Clone ID Related Accession (Same CDS sequence) NM_020932.2
Accession Version NM_020932.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2874bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-11-15
Organism Homo sapiens(Human)
Product melanoma-associated antigen E1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA411859.1, AB046807.1 and BC050588.1. This sequence is a reference standard in the RefSeqGene project. On Mar 13, 2010 this sequence version replaced NM_020932.1.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
ATGTCTCTGG TAAGCCAGAA TTCGCGCCGC CGCCGCCGCC GCGTTGCAAA GGCTACTGCG 
CACAACAGCA GCTGGGGCGA AATGCAGGCC CCTAATGCCC CCGGTCTCCC CGCTGATGTG
CCAGGCTCAG ACGTCCCCCA GGGTCCCAGC GATTCCCAGA TCCTCCAGGG CCTCTGCGCC
TCTGAGGGCC CAAGCACCTC CGTTCTGCCC ACCTCCGCTG AGGGCCCAAG CACCTTTGTG
CCGCCCACCA TCTCTGAGGC CTCAAGCGCC TCCGGGCAGC CCACCATCTC TGAGGGACCT
GGCACCTCCG TGCTGCCCAC CCCCAGTGAG GGCCTAAGCA CCTCCGGGCC TCCCACCATC
TCTAAGGGGC TGTGCACCTC TGTGACGCTT GCCGCCTCTG AGGGCCGGAA CACCTCCAGG
CCGCCCACTT CCTCTGAGGA ACCTAGCACC TCCGTGCCGC CCACCGCCTC TGAGGTACCG
AGCACCTCCC TGCCGCCCAC CCCTGGTGAG GGAACGAGCA CCTCCGTGCC GCCCACAGCC
TATGAGGGAC CAAGCACCTC CGTGGTGCCC ACCCCTGATG AGGGACCAAG CACCTCCGTG
CTGCCTACAC CTGGTGAGGG ACCAGGCACC TCCGTGCCGC TCGCCGCCAC TGAGGGCCTG
AGCACCTCCG TGCAGGCCAC TCCTGATGAG GGACCGAGCA CCTCCGTGCC GCCCACCGCC
ACTGAGGGCC TAAGCACCCC CGTGCCACCC ACCCGTGATG AGGGACCGAG CACCTCCGTG
CCGGCCACTC CTGGTGAGGG ACCGAGCACC TCCGTGCTGC CCGCCGCCTC TGACGGACAA
AGCATCTCCT TGGTGCCCAC CCGCGGTAAG GGATCAAGCA CCTCCGTGCC CCCCACCGCC
ACCGAGGGCC TGAGCACCTC CGTGCAGCCC ACTGCTGGTG AGGGATCGAG CACCTCCGTG
CCGCCCACCC CTGGTGGGGG ACTGAGCACC TCCGTGCCGC CCACCGCCAC TGAGGAGTTG
AGCACCTCCG TGCCGCCCAC TCCCGGTGAG GGACCAAGCA CTTCCGTACT GCCAATCCCC
GGTGAGGGAC TGAGCACCTC TGTGCCGCCC ACCGCCTCTG ATGGATCGGA CACCTCCGTG
CCGCCCACTC CTGGTGAGGG CGCAAGCACC TTAGTGCAGC CCACCGCCCC TGACGGACCG
GGAAGCTCCG TGCTGCCTAA CCCTGGTGAG GGCCCGAGCA CATTGTTTAG CTCTAGTGCT
TCTGTGGACC GGAACCCCTC CAAGTGTTCC CTTGTTTTGC CAAGCCCTAG GGTAACCAAG
GCCTCCGTGG ACTCAGATTC TGAGGGTCCT AAGGGTGCAG AAGGCCCTAT AGAATTCGAG
GTCCTGAGAG ACTGTGAGAG CCCCAACTCC ATTAGTATTA TGGGCCTCAA TACTTCCCGG
GTTGCAATTA CCCTGAAGCC CCAAGACCCT ATGGAACAGA ACGTAGCTGA GCTGTTGCAG
TTCCTGCTGG TGAAGGATCA GAGCAAGTAC CCTATCCGGG AGTCTGAAAT GCGGGAATAT
ATTGTTAAAG AATATCGCAA CCAGTTTCCT GAGATACTCA GGCGAGCAGC AGCCCACCTG
GAGTGCATTT TTAGGTTTGA ATTGAGAGAA CTTGACCCTG AGGCACACAC CTACATTCTG
TTAAACAAAC TGGGACCTGT GCCCTTTGAA GGGTTAGAAG AGAGCCCAAA TGGGCCAAAG
ATGGGCCTCC TGATGATGAT TCTAGGCCAA ATATTCCTGA ATGGCAACCA AGCCAAGGAG
GCTGAGATTT GGGAAATGCT CTGGAGGATG GGGGTGCAGC GGGAAAGGAG GCTTTCCATT
TTTGGGAACC CAAAGAGACT TCTGTCTGTG GAGTTTGTAT GGCAGCGTTA CTTAGACTAC
AGGCCAGTAA CTGACTGTAA ACCAGTGGAG TATGAGTTTT TCTGGGGCCC AAGATCCCAC
CTAGAAACCA CCAAGATGAA AATTCTGAAG TTCATGGCGA AAATATATAA CAAAGATCCT
ATGGATTGGC CAGAGAAATA CAACGAAGCT CTGGAAGAAG ATGCTGCCAG AGCCTTTGCT
GAGGGTTGGC AGGCTCTCCC TCACTTTAGG AGGCCCTTTT TTGAGGAAGC TGCTGCAGAG
GTACCATCCC CTGATTCAGA GGTTTCCAGC TATTCCTCAA AATATGCCCC ACATTCATGG
CCTGAGTCAA GATTGGAGAG CAAGGCAAGG AAGCTGGTGC AGTTATTTCT GCTTATGGAT
TCAACTAAGC TGCCTATACC AAAGAAAGGA ATTCTGTACT ACATTGGCCG AGAGTGCAGC
AAAGTGTTCC CTGACCTCCT GAATCGTGCT GCCCGCACCC TGAACCATGT CTATGGGACA
GAACTAGTGG TACTTGATCC CAGGAATCAC TCCTATACTC TGTACAACCG AAGGGAGATG
GAAGAAACTG AGGAGATCGT AGACAGTCCA AACAGGCCTG GCAACAACTT TTTGATGCAG
GTCCTAAGCT TCATCTTTAT TATGGGCAAC CATGCCAGGG AGTCTGCAGT CTGGGCCTTT
CTGCGGGGCT TAGGGGTTCA AGCTGGGAGA AAGCATGTGA TTACCTGCAG ATACTTGAGT
CAGCGCTATA TAGACAGTTT ACGGGTTCCT GACAGTGATC CAGTGCAATA TGAGTTTGTA
TGGGGTCCTA GAGCCCGTTT GGAAACCTCT AAGATGAAAG CCTTGCGATA TGTGGCCAGA
ATCCACAGAA AGGAACCACA GGACTGGCCA CAGCAGTACA GGGAGGCAAT GGAAGATGAG
GCCAATAGAG CTGATGTTGG GCACAGGCAA ATCTTTGTTC ACAACTTCAG GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_065983.1
CDS279..3152
Misc Feature(1)174..176
Misc Feature(2)<705..1076
Misc Feature(3)1770..2276
Misc Feature(4)2505..3149
Misc Feature(5)2532..3014
Exon (1)1..3701
Translation

Target ORF information:

RefSeq Version NM_020932.2
Organism Homo sapiens(Human)
Definition Homo sapiens MAGE family member E1 (MAGEE1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_020932.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
ATGTCTCTGG TAAGCCAGAA TTCGCGCCGC CGCCGCCGCC GCGTTGCAAA GGCTACTGCG 
CACAACAGCA GCTGGGGCGA AATGCAGGCC CCTAATGCCC CCGGTCTCCC CGCTGATGTG
CCAGGCTCAG ACGTCCCCCA GGGTCCCAGC GATTCCCAGA TCCTCCAGGG CCTCTGCGCC
TCTGAGGGCC CAAGCACCTC CGTTCTGCCC ACCTCCGCTG AGGGCCCAAG CACCTTTGTG
CCGCCCACCA TCTCTGAGGC CTCAAGCGCC TCCGGGCAGC CCACCATCTC TGAGGGACCT
GGCACCTCCG TGCTGCCCAC CCCCAGTGAG GGCCTAAGCA CCTCCGGGCC TCCCACCATC
TCTAAGGGGC TGTGCACCTC TGTGACGCTT GCCGCCTCTG AGGGCCGGAA CACCTCCAGG
CCGCCCACTT CCTCTGAGGA ACCTAGCACC TCCGTGCCGC CCACCGCCTC TGAGGTACCG
AGCACCTCCC TGCCGCCCAC CCCTGGTGAG GGAACGAGCA CCTCCGTGCC GCCCACAGCC
TATGAGGGAC CAAGCACCTC CGTGGTGCCC ACCCCTGATG AGGGACCAAG CACCTCCGTG
CTGCCTACAC CTGGTGAGGG ACCAGGCACC TCCGTGCCGC TCGCCGCCAC TGAGGGCCTG
AGCACCTCCG TGCAGGCCAC TCCTGATGAG GGACCGAGCA CCTCCGTGCC GCCCACCGCC
ACTGAGGGCC TAAGCACCCC CGTGCCACCC ACCCGTGATG AGGGACCGAG CACCTCCGTG
CCGGCCACTC CTGGTGAGGG ACCGAGCACC TCCGTGCTGC CCGCCGCCTC TGACGGACAA
AGCATCTCCT TGGTGCCCAC CCGCGGTAAG GGATCAAGCA CCTCCGTGCC CCCCACCGCC
ACCGAGGGCC TGAGCACCTC CGTGCAGCCC ACTGCTGGTG AGGGATCGAG CACCTCCGTG
CCGCCCACCC CTGGTGGGGG ACTGAGCACC TCCGTGCCGC CCACCGCCAC TGAGGAGTTG
AGCACCTCCG TGCCGCCCAC TCCCGGTGAG GGACCAAGCA CTTCCGTACT GCCAATCCCC
GGTGAGGGAC TGAGCACCTC TGTGCCGCCC ACCGCCTCTG ATGGATCGGA CACCTCCGTG
CCGCCCACTC CTGGTGAGGG CGCAAGCACC TTAGTGCAGC CCACCGCCCC TGACGGACCG
GGAAGCTCCG TGCTGCCTAA CCCTGGTGAG GGCCCGAGCA CATTGTTTAG CTCTAGTGCT
TCTGTGGACC GGAACCCCTC CAAGTGTTCC CTTGTTTTGC CAAGCCCTAG GGTAACCAAG
GCCTCCGTGG ACTCAGATTC TGAGGGTCCT AAGGGTGCAG AAGGCCCTAT AGAATTCGAG
GTCCTGAGAG ACTGTGAGAG CCCCAACTCC ATTAGTATTA TGGGCCTCAA TACTTCCCGG
GTTGCAATTA CCCTGAAGCC CCAAGACCCT ATGGAACAGA ACGTAGCTGA GCTGTTGCAG
TTCCTGCTGG TGAAGGATCA GAGCAAGTAC CCTATCCGGG AGTCTGAAAT GCGGGAATAT
ATTGTTAAAG AATATCGCAA CCAGTTTCCT GAGATACTCA GGCGAGCAGC AGCCCACCTG
GAGTGCATTT TTAGGTTTGA ATTGAGAGAA CTTGACCCTG AGGCACACAC CTACATTCTG
TTAAACAAAC TGGGACCTGT GCCCTTTGAA GGGTTAGAAG AGAGCCCAAA TGGGCCAAAG
ATGGGCCTCC TGATGATGAT TCTAGGCCAA ATATTCCTGA ATGGCAACCA AGCCAAGGAG
GCTGAGATTT GGGAAATGCT CTGGAGGATG GGGGTGCAGC GGGAAAGGAG GCTTTCCATT
TTTGGGAACC CAAAGAGACT TCTGTCTGTG GAGTTTGTAT GGCAGCGTTA CTTAGACTAC
AGGCCAGTAA CTGACTGTAA ACCAGTGGAG TATGAGTTTT TCTGGGGCCC AAGATCCCAC
CTAGAAACCA CCAAGATGAA AATTCTGAAG TTCATGGCGA AAATATATAA CAAAGATCCT
ATGGATTGGC CAGAGAAATA CAACGAAGCT CTGGAAGAAG ATGCTGCCAG AGCCTTTGCT
GAGGGTTGGC AGGCTCTCCC TCACTTTAGG AGGCCCTTTT TTGAGGAAGC TGCTGCAGAG
GTACCATCCC CTGATTCAGA GGTTTCCAGC TATTCCTCAA AATATGCCCC ACATTCATGG
CCTGAGTCAA GATTGGAGAG CAAGGCAAGG AAGCTGGTGC AGTTATTTCT GCTTATGGAT
TCAACTAAGC TGCCTATACC AAAGAAAGGA ATTCTGTACT ACATTGGCCG AGAGTGCAGC
AAAGTGTTCC CTGACCTCCT GAATCGTGCT GCCCGCACCC TGAACCATGT CTATGGGACA
GAACTAGTGG TACTTGATCC CAGGAATCAC TCCTATACTC TGTACAACCG AAGGGAGATG
GAAGAAACTG AGGAGATCGT AGACAGTCCA AACAGGCCTG GCAACAACTT TTTGATGCAG
GTCCTAAGCT TCATCTTTAT TATGGGCAAC CATGCCAGGG AGTCTGCAGT CTGGGCCTTT
CTGCGGGGCT TAGGGGTTCA AGCTGGGAGA AAGCATGTGA TTACCTGCAG ATACTTGAGT
CAGCGCTATA TAGACAGTTT ACGGGTTCCT GACAGTGATC CAGTGCAATA TGAGTTTGTA
TGGGGTCCTA GAGCCCGTTT GGAAACCTCT AAGATGAAAG CCTTGCGATA TGTGGCCAGA
ATCCACAGAA AGGAACCACA GGACTGGCCA CAGCAGTACA GGGAGGCAAT GGAAGATGAG
GCCAATAGAG CTGATGTTGG GCACAGGCAA ATCTTTGTTC ACAACTTCAG GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Naturally occurring HCA1 missense mutations result in loss of function: potential impact on lipid deposition.
Journal of lipid research54(3)823-30(2013 Mar)
Doyle JR,Lane JM,Beinborn M,Kopin AS


book

MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.
Molecular cell39(6)963-74(2010 Sep)
Doyle JM,Gao J,Wang J,Yang M,Potts PR


book

Frequent MAGE mutations in human melanoma.
PloS one5(9)(2010 Sep)
Caballero OL,Zhao Q,Rimoldi D,Stevenson BJ,Svobodová S,Devalle S,Röhrig UF,Pagotto A,Michielin O,Speiser D,Wolchok JD,Liu C,Pejovic T,Odunsi K,Brasseur F,Van den Eynde BJ,Old LJ,Lu X,Cebon J,Strausberg RL,Simpson AJ


book

DAMAGE, a novel alpha-dystrobrevin-associated MAGE protein in dystrophin complexes.
The Journal of biological chemistry279(8)7014-23(2004 Feb)
Albrecht DE,Froehner SC


 
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