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CCND1 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol CCND1
Entrez Gene ID 595
Full Name cyclin D1
Synonyms BCL1,D11S287E,PRAD1,U21B31
General protein information
Preferred Names

cyclin D1

Names

G1/S-specific cyclin-D1
B-cell CLL/lymphoma 1
B-cell lymphoma 1 protein
BCL-1 oncogene
PRAD1 oncogene
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

11

11q13.3
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008].
Disorder MIM:

168461

Disorder Html: {Colorectal cancer, susceptibility to}, 114500 (3); {von Hippel-Lindau syndrome, modifier of}, 193300 (3); {Multiple myeloma, susceptibility to}, 254500 (3)

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_053056.3 NP_444284.1 G1/S-specific cyclin-D1
NM_053056.2 NP_444284.1 G1/S-specific cyclin-D1

Pathways from BioSystems


Homologies


Homo sapiens (human) CCND1 NP_444284.1
Bos taurus (cattle) CCND1 NP_001039738.1
Mus musculus (house mouse) Ccnd1 NP_031657.1
Gallus gallus (chicken) CCND1 NP_990712.1
Pan troglodytes (chimpanzee) CCND1 XP_003952008.1
CCND1 XP_001101029.1
Canis lupus familiaris (dog) CCND1 NP_001005757.1
Rattus norvegicus (Norway rat) Ccnd1 NP_741989.3
Danio rerio (zebrafish) ccnd1 NP_571100.1
Xenopus tropicalis (tropical clawed frog) ccnd1 NP_001005452.1

Gene Ontology

The following CCND1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCND1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu17797 NM_053056.3
Latest version!		 Homo sapiens cyclin D1 (CCND1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $99.50-$139.30
$199.00
View Old Accession Versions >>
OHu17797 NM_053056.2 Homo sapiens cyclin D1 (CCND1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $99.50-$139.30
$199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu17797
Clone ID Related Accession (Same CDS sequence) NM_053056.3 , NM_053056.2
Accession Version NM_053056.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 888bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-31
Organism Homo sapiens(human)
Product G1/S-specific cyclin-D1
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM796500.1, BC001501.2, AP001888.4 and X59798.1. On Aug 31, 2019 this sequence version replaced NM_053056.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC023620.2, X59798.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGAACACC AGCTCCTGTG CTGCGAAGTG GAAACCATCC GCCGCGCGTA CCCCGATGCC 
AACCTCCTCA ACGACCGGGT GCTGCGGGCC ATGCTGAAGG CGGAGGAGAC CTGCGCGCCC 
TCGGTGTCCT ACTTCAAATG TGTGCAGAAG GAGGTCCTGC CGTCCATGCG GAAGATCGTC 
GCCACCTGGA TGCTGGAGGT CTGCGAGGAA CAGAAGTGCG AGGAGGAGGT CTTCCCGCTG 
GCCATGAACT ACCTGGACCG CTTCCTGTCG CTGGAGCCCG TGAAAAAGAG CCGCCTGCAG 
CTGCTGGGGG CCACTTGCAT GTTCGTGGCC TCTAAGATGA AGGAGACCAT CCCCCTGACG 
GCCGAGAAGC TGTGCATCTA CACCGACAAC TCCATCCGGC CCGAGGAGCT GCTGCAAATG 
GAGCTGCTCC TGGTGAACAA GCTCAAGTGG AACCTGGCCG CAATGACCCC GCACGATTTC 
ATTGAACACT TCCTCTCCAA AATGCCAGAG GCGGAGGAGA ACAAACAGAT CATCCGCAAA 
CACGCGCAGA CCTTCGTTGC CCTCTGTGCC ACAGATGTGA AGTTCATTTC CAATCCGCCC 
TCCATGGTGG CAGCGGGGAG CGTGGTGGCC GCAGTGCAAG GCCTGAACCT GAGGAGCCCC 
AACAACTTCC TGTCCTACTA CCGCCTCACA CGCTTCCTCT CCAGAGTGAT CAAGTGTGAC 
CCGGACTGCC TCCGGGCCTG CCAGGAGCAG ATCGAAGCCC TGCTGGAGTC AAGCCTGCGC 
CAGGCCCAGC AGAACATGGA CCCCAAGGCC GCCGAGGAGG AGGAAGAGGA GGAGGAGGAG 
GTGGACCTGG CTTGCACACC CACCGACGTG CGGGACGTGG ACATCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_444284.1
CDS159..1046
Translation

Target ORF information:

RefSeq Version NM_053056.3
Organism Homo sapiens(human)
Definition Homo sapiens cyclin D1 (CCND1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_053056.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGAACACC AGCTCCTGTG CTGCGAAGTG GAAACCATCC GCCGCGCGTA CCCCGATGCC 
AACCTCCTCA ACGACCGGGT GCTGCGGGCC ATGCTGAAGG CGGAGGAGAC CTGCGCGCCC 
TCGGTGTCCT ACTTCAAATG TGTGCAGAAG GAGGTCCTGC CGTCCATGCG GAAGATCGTC 
GCCACCTGGA TGCTGGAGGT CTGCGAGGAA CAGAAGTGCG AGGAGGAGGT CTTCCCGCTG 
GCCATGAACT ACCTGGACCG CTTCCTGTCG CTGGAGCCCG TGAAAAAGAG CCGCCTGCAG 
CTGCTGGGGG CCACTTGCAT GTTCGTGGCC TCTAAGATGA AGGAGACCAT CCCCCTGACG 
GCCGAGAAGC TGTGCATCTA CACCGACAAC TCCATCCGGC CCGAGGAGCT GCTGCAAATG 
GAGCTGCTCC TGGTGAACAA GCTCAAGTGG AACCTGGCCG CAATGACCCC GCACGATTTC 
ATTGAACACT TCCTCTCCAA AATGCCAGAG GCGGAGGAGA ACAAACAGAT CATCCGCAAA 
CACGCGCAGA CCTTCGTTGC CCTCTGTGCC ACAGATGTGA AGTTCATTTC CAATCCGCCC 
TCCATGGTGG CAGCGGGGAG CGTGGTGGCC GCAGTGCAAG GCCTGAACCT GAGGAGCCCC 
AACAACTTCC TGTCCTACTA CCGCCTCACA CGCTTCCTCT CCAGAGTGAT CAAGTGTGAC 
CCGGACTGCC TCCGGGCCTG CCAGGAGCAG ATCGAAGCCC TGCTGGAGTC AAGCCTGCGC 
CAGGCCCAGC AGAACATGGA CCCCAAGGCC GCCGAGGAGG AGGAAGAGGA GGAGGAGGAG 
GTGGACCTGG CTTGCACACC CACCGACGTG CGGGACGTGG ACATCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17797
Clone ID Related Accession (Same CDS sequence) NM_053056.3 , NM_053056.2
Accession Version NM_053056.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 888bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-06-25
Organism Homo sapiens(human)
Product G1/S-specific cyclin-D1
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM796500.1, BC001501.2, AP001888.4 and X59798.1. This sequence is a reference standard in the RefSeqGene project. On Oct 13, 2005 this sequence version replaced NM_053056.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X59798.1, M73554.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGAACACC AGCTCCTGTG CTGCGAAGTG GAAACCATCC GCCGCGCGTA CCCCGATGCC 
AACCTCCTCA ACGACCGGGT GCTGCGGGCC ATGCTGAAGG CGGAGGAGAC CTGCGCGCCC 
TCGGTGTCCT ACTTCAAATG TGTGCAGAAG GAGGTCCTGC CGTCCATGCG GAAGATCGTC 
GCCACCTGGA TGCTGGAGGT CTGCGAGGAA CAGAAGTGCG AGGAGGAGGT CTTCCCGCTG 
GCCATGAACT ACCTGGACCG CTTCCTGTCG CTGGAGCCCG TGAAAAAGAG CCGCCTGCAG 
CTGCTGGGGG CCACTTGCAT GTTCGTGGCC TCTAAGATGA AGGAGACCAT CCCCCTGACG 
GCCGAGAAGC TGTGCATCTA CACCGACAAC TCCATCCGGC CCGAGGAGCT GCTGCAAATG 
GAGCTGCTCC TGGTGAACAA GCTCAAGTGG AACCTGGCCG CAATGACCCC GCACGATTTC 
ATTGAACACT TCCTCTCCAA AATGCCAGAG GCGGAGGAGA ACAAACAGAT CATCCGCAAA 
CACGCGCAGA CCTTCGTTGC CCTCTGTGCC ACAGATGTGA AGTTCATTTC CAATCCGCCC 
TCCATGGTGG CAGCGGGGAG CGTGGTGGCC GCAGTGCAAG GCCTGAACCT GAGGAGCCCC 
AACAACTTCC TGTCCTACTA CCGCCTCACA CGCTTCCTCT CCAGAGTGAT CAAGTGTGAC 
CCGGACTGCC TCCGGGCCTG CCAGGAGCAG ATCGAAGCCC TGCTGGAGTC AAGCCTGCGC 
CAGGCCCAGC AGAACATGGA CCCCAAGGCC GCCGAGGAGG AGGAAGAGGA GGAGGAGGAG 
GTGGACCTGG CTTGCACACC CACCGACGTG CGGGACGTGG ACATCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_444284.1
CDS210..1097
Translation

Target ORF information:

RefSeq Version NM_053056.2
Organism Homo sapiens(human)
Definition Homo sapiens cyclin D1 (CCND1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_053056.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGAACACC AGCTCCTGTG CTGCGAAGTG GAAACCATCC GCCGCGCGTA CCCCGATGCC 
AACCTCCTCA ACGACCGGGT GCTGCGGGCC ATGCTGAAGG CGGAGGAGAC CTGCGCGCCC 
TCGGTGTCCT ACTTCAAATG TGTGCAGAAG GAGGTCCTGC CGTCCATGCG GAAGATCGTC 
GCCACCTGGA TGCTGGAGGT CTGCGAGGAA CAGAAGTGCG AGGAGGAGGT CTTCCCGCTG 
GCCATGAACT ACCTGGACCG CTTCCTGTCG CTGGAGCCCG TGAAAAAGAG CCGCCTGCAG 
CTGCTGGGGG CCACTTGCAT GTTCGTGGCC TCTAAGATGA AGGAGACCAT CCCCCTGACG 
GCCGAGAAGC TGTGCATCTA CACCGACAAC TCCATCCGGC CCGAGGAGCT GCTGCAAATG 
GAGCTGCTCC TGGTGAACAA GCTCAAGTGG AACCTGGCCG CAATGACCCC GCACGATTTC 
ATTGAACACT TCCTCTCCAA AATGCCAGAG GCGGAGGAGA ACAAACAGAT CATCCGCAAA 
CACGCGCAGA CCTTCGTTGC CCTCTGTGCC ACAGATGTGA AGTTCATTTC CAATCCGCCC 
TCCATGGTGG CAGCGGGGAG CGTGGTGGCC GCAGTGCAAG GCCTGAACCT GAGGAGCCCC 
AACAACTTCC TGTCCTACTA CCGCCTCACA CGCTTCCTCT CCAGAGTGAT CAAGTGTGAC 
CCGGACTGCC TCCGGGCCTG CCAGGAGCAG ATCGAAGCCC TGCTGGAGTC AAGCCTGCGC 
CAGGCCCAGC AGAACATGGA CCCCAAGGCC GCCGAGGAGG AGGAAGAGGA GGAGGAGGAG 
GTGGACCTGG CTTGCACACC CACCGACGTG CGGGACGTGG ACATCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed