CCND1 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | CCND1 |
| Entrez Gene ID | 595 |
| Full Name | cyclin D1 |
| Synonyms | BCL1,D11S287E,PRAD1,U21B31 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: | |
| Disorder Html: | {Colorectal cancer, susceptibility to}, 114500 (3); {von Hippel-Lindau syndrome, modifier of}, 193300 (3); {Multiple myeloma, susceptibility to}, 254500 (3) |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_053056.2 | NP_444284.1 | G1/S-specific cyclin-D1 |
| Homo sapiens (human) | CCND1 | NP_444284.1 |
| Bos taurus (cattle) | CCND1 | NP_001039738.1 |
| Mus musculus (house mouse) | Ccnd1 | NP_031657.1 |
| Gallus gallus (chicken) | CCND1 | NP_990712.1 |
| Pan troglodytes (chimpanzee) | CCND1 | XP_003952008.1 |
| CCND1 | XP_001101029.1 | |
| Canis lupus familiaris (dog) | CCND1 | NP_001005757.1 |
| Rattus norvegicus (Norway rat) | Ccnd1 | NP_741989.3 |
| Danio rerio (zebrafish) | ccnd1 | NP_571100.1 |
| Xenopus tropicalis (tropical clawed frog) | ccnd1 | NP_001005452.1 |
The following CCND1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCND1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu17797 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_053056.2 | |
| Accession Version | NM_053056.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-06-25 | |
| Organism | Homo sapiens(human) | |
| Product | G1/S-specific cyclin-D1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM796500.1, BC001501.2, AP001888.4 and X59798.1. This sequence is a reference standard in the RefSeqGene project. On Oct 13, 2005 this sequence version replaced NM_053056.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X59798.1, M73554.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGGAACACC AGCTCCTGTG CTGCGAAGTG GAAACCATCC GCCGCGCGTA CCCCGATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_444284.1 |
| CDS | 210..1097 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_053056.2 |
ORF Insert Sequence:
1 | ATGGAACACC AGCTCCTGTG CTGCGAAGTG GAAACCATCC GCCGCGCGTA CCCCGATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.