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NYX cDNA ORF clone, Homo sapiens(Human)

Gene Symbol NYX
Entrez Gene ID 60506
Full Name nyctalopin
Synonyms CLRP,CSNB1,CSNB1A,CSNB4,NBM1
General protein information
Preferred Names

nyctalopin

Names

nyctalopin
leucine-rich repeat protein

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

X

Xp11.4

Summary The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. [provided by RefSeq, Oct 2008].
Disorder MIM:

300278

Disorder Html: Night blindness, congenital stationary, type 1, 310500 (3)

mRNA and Protein(s)

mRNA Protein Name
XM_005272632.2 XP_005272689.1 nyctalopin isoform X1
XM_017029709.1 XP_016885198.1 nyctalopin isoform X1
NM_022567.2 NP_072089.1 nyctalopin precursor



Macaca mulatta (rhesus monkey) SLRN XP_001087613.1
Danio rerio (zebrafish) nyx NP_001071085.1
Canis lupus familiaris (dog) NYX XP_005641316.1
Bos taurus (cattle) NYX XP_005228361.1
Rattus norvegicus (Norway rat) Nyx NP_001094437.1
Homo sapiens (human) NYX NP_072089.1
Pan troglodytes (chimpanzee) NYX XP_001138632.2
Gallus gallus (chicken) NYX XP_004934667.1
Xenopus tropicalis (tropical clawed frog) nyx XP_002932845.2
Mus musculus (house mouse) Nyx NP_775591.1


Related articles in PubMed

Two Novel NYX Gene Mutations in the Chinese Families with X-linked Congenital Stationary Night Blindness.
Dai S, Ying M, Wang K, Wang L, Han R, Hao P, Li N
Scientific reports512679(2015 Aug)

NYX mutations in four families with high myopia with or without CSNB1.
Zhou L, Li T, Song X, Li Y, Li H, Dan H
Molecular vision21213-23(2015)

Genotype and phenotype of 101 dutch patients with congenital stationary night blindness.
Bijveld MM, Florijn RJ, Bergen AA, van den Born LI, Kamermans M, Prick L, Riemslag FC, van Schooneveld MJ, Kappers AM, van Genderen MM
Ophthalmology120(10)2072-81(2013 Oct)

Electroretinographic findings in a patient with congenital stationary night blindness due to a novel NYX mutation.
McAnany JJ, Alexander KR, Kumar NM, Ying H, Anastasakis A, Fishman GA
Ophthalmic genetics34(3)167-73(2013 Sep)

A novel missense mutation in the NYX gene associated with high myopia.
Yip SP, Li CC, Yiu WC, Hung WH, Lam WW, Lai MC, Ng PW, Fung WY, Chu PH, Jiang B, Chan HH, Yap MK
Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)33(3)346-53(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Two Novel NYX Gene Mutations in the Chinese Families with X-linked Congenital Stationary Night Blindness were described.
Title: Two Novel NYX Gene Mutations in the Chinese Families with X-linked Congenital Stationary Night Blindness.

Four potential pathogenic variations in the NYX gene were found in four families with high myopia with or without CSNB1.
Title: NYX mutations in four families with high myopia with or without CSNB1.

A mutation was identified in NYX in 20 male patients with Congenital Stationary Night Blindness 1.
Title: Genotype and phenotype of 101 dutch patients with congenital stationary night blindness.

Loss of ERG amplitude and apparent ON-pathway dysfunction at high temporal frequencies distinguish this patient with a Trp237Ter NYX mutation from those with other previously reported NYX mutations.
Title: Electroretinographic findings in a patient with congenital stationary night blindness due to a novel NYX mutation.

A missense mutation (c.529_530GC>AT or p.Ala177Met) was identified in one male subject with high myopia, but not in 200 male emmetropes.
Title: A novel missense mutation in the NYX gene associated with high myopia.

The following NYX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NYX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19068 NM_022567.2
Latest version!
Homo sapiens nyctalopin (NYX), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
OHu19068 XM_005272632.2
Latest version!
Homo sapiens nyctalopin (NYX), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
OHu19068 XM_017029709.1
Latest version!
Homo sapiens nyctalopin (NYX), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00

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2-4 Clone 40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19068
Clone ID Related Accession (Same CDS sequence) XM_005272632.2 , XM_017029709.1 , NM_022567.2
Accession Version NM_022567.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1446bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-04
Organism Homo sapiens(Human)
Product nyctalopin precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ278865.1. This sequence is a reference standard in the RefSeqGene project. On Sep 13, 2008 this sequence version replaced NM_022567.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ278865.1, BC112242.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGAAAGGCC GAGGGATGTT GGTCCTGCTT CTGCATGCGG TGGTCCTCGG CCTGCCCAGC 
GCCTGGGCCG TGGGGGCCTG CGCCCGCGCT TGTCCCGCCG CCTGCGCCTG CAGCACCGTG
GAGCGCGGCT GCTCGGTGCG CTGCGACCGC GCGGGCCTCC TGCGGGTGCC GGCCGAGCTC
CCGTGCGAGG CGGTCTCCAT CGACCTGGAC CGGAACGGCC TGCGCTTCCT GGGCGAGCGA
GCCTTCGGCA CGCTGCCGTC CTTGCGCCGC CTGTCGCTGC GCCACAACAA CCTGTCCTTC
ATCACGCCCG GCGCCTTCAA GGGCCTGCCG CGCCTGGCTG AGCTGCGCCT GGCGCACAAC
GGCGACCTGC GCTACCTGCA CGCGCGCACC TTCGCGGCGC TCAGCCGCCT GCGCCGCCTA
GACCTAGCAG CCTGCCGCCT CTTCAGCGTG CCCGAGCGCC TCCTGGCCGA ACTGCCGGCC
CTGCGCGAAC TCGCCGCCTT CGACAACCTG TTCCGCCGCG TGCCGGGCGC GCTGCGCGGC
CTGGCCAACC TGACGCACGC GCACCTGGAG CGCGGCCGCA TCGAGGCGGT GGCCTCCAGC
TCGCTGCAGG GCCTGCGCCG CCTGCGCTCG CTCAGCCTGC AGGCCAACCG CGTCCGTGCC
GTGCACGCTG GCGCCTTCGG GGACTGTGGC GTCCTGGAGC ATCTGCTGCT CAACGACAAC
CTGCTGGCCG AGCTCCCGGC CGACGCCTTC CGCGGCCTGC GGCGCCTGCG CACGCTCAAC
CTGGGTGGCA ACGCGCTGGA CCGCGTGGCG CGCGCCTGGT TCGCTGACCT GGCCGAGCTC
GAGCTGCTCT ACCTGGACCG CAACAGCATC GCCTTCGTGG AGGAGGGCGC CTTCCAGAAC
CTCTCGGGTC TCCTCGCGCT GCACCTCAAC GGCAACCGCC TCACCGTGCT CGCCTGGGTC
GCCTTCCAGC CCGGCTTCTT CCTGGGCCGC CTCTTCCTCT TCCGCAACCC GTGGTGCTGC
GACTGCCGTC TGGAGTGGCT GAGGGACTGG ATGGAGGGCT CCGGACGTGT CACCGACGTG
CCGTGCGCCT CCCCGGGCTC CGTGGCCGGC CTGGACCTCA GCCAGGTGAC CTTCGGGCGC
TCCTCCGATG GCCTCTGTGT GGACCCCGAG GAGCTGAACC TCACCACGTC CAGTCCAGGC
CCGTCCCCAG AACCAGCGGC CACCACCGTG AGCAGGTTCA GCAGCCTCCT CTCCAAGCTG
CTGGCCCCGA GGGTCCCGGT GGAGGAGGCG GCCAACACCA CTGGGGGGCT GGCCAACGCC
TCCCTGTCCG ACAGCCTCTC CTCCCGTGGG GTGGGAGGCG CGGGCCGGCA GCCCTGGTTT
CTCCTCGCCT CTTGTCTCCT GCCCAGCGTG GCCCAGCACG TGGTGTTTGG CCTGCAGATG
GACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_072089.1
CDS431..1876
Misc Feature(1)416..418
Misc Feature(2)617..682
Misc Feature(3)632..691
Misc Feature(4)<647..1381
Misc Feature(5)686..871
Misc Feature(6)689..754
Misc Feature(7)692..763
Misc Feature(8)761..820
Misc Feature(9)764..838
Misc Feature(10)836..907
Misc Feature(11)839..910
Misc Feature(12)908..976
Misc Feature(13)911..979
Misc Feature(14)977..1156
Misc Feature(15)977..1042
Misc Feature(16)980..1051
Misc Feature(17)1049..1114
Misc Feature(18)1052..1123
Misc Feature(19)1121..1186
Misc Feature(20)1124..1300
Misc Feature(21)1124..1195
Misc Feature(22)1193..1258
Misc Feature(23)1196..1267
Misc Feature(24)1265..>1399
Misc Feature(25)1265..1330
Misc Feature(26)1268..1333
Misc Feature(27)1337..1402
Misc Feature(28)1412..1450
Misc Feature(29)1436..>1540
Exon (1)1..467
Exon (2)468..2629
Translation

Target ORF information:

RefSeq Version NM_022567.2
Organism Homo sapiens(Human)
Definition Homo sapiens nyctalopin (NYX), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_022567.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGAAAGGCC GAGGGATGTT GGTCCTGCTT CTGCATGCGG TGGTCCTCGG CCTGCCCAGC 
GCCTGGGCCG TGGGGGCCTG CGCCCGCGCT TGTCCCGCCG CCTGCGCCTG CAGCACCGTG
GAGCGCGGCT GCTCGGTGCG CTGCGACCGC GCGGGCCTCC TGCGGGTGCC GGCCGAGCTC
CCGTGCGAGG CGGTCTCCAT CGACCTGGAC CGGAACGGCC TGCGCTTCCT GGGCGAGCGA
GCCTTCGGCA CGCTGCCGTC CTTGCGCCGC CTGTCGCTGC GCCACAACAA CCTGTCCTTC
ATCACGCCCG GCGCCTTCAA GGGCCTGCCG CGCCTGGCTG AGCTGCGCCT GGCGCACAAC
GGCGACCTGC GCTACCTGCA CGCGCGCACC TTCGCGGCGC TCAGCCGCCT GCGCCGCCTA
GACCTAGCAG CCTGCCGCCT CTTCAGCGTG CCCGAGCGCC TCCTGGCCGA ACTGCCGGCC
CTGCGCGAAC TCGCCGCCTT CGACAACCTG TTCCGCCGCG TGCCGGGCGC GCTGCGCGGC
CTGGCCAACC TGACGCACGC GCACCTGGAG CGCGGCCGCA TCGAGGCGGT GGCCTCCAGC
TCGCTGCAGG GCCTGCGCCG CCTGCGCTCG CTCAGCCTGC AGGCCAACCG CGTCCGTGCC
GTGCACGCTG GCGCCTTCGG GGACTGTGGC GTCCTGGAGC ATCTGCTGCT CAACGACAAC
CTGCTGGCCG AGCTCCCGGC CGACGCCTTC CGCGGCCTGC GGCGCCTGCG CACGCTCAAC
CTGGGTGGCA ACGCGCTGGA CCGCGTGGCG CGCGCCTGGT TCGCTGACCT GGCCGAGCTC
GAGCTGCTCT ACCTGGACCG CAACAGCATC GCCTTCGTGG AGGAGGGCGC CTTCCAGAAC
CTCTCGGGTC TCCTCGCGCT GCACCTCAAC GGCAACCGCC TCACCGTGCT CGCCTGGGTC
GCCTTCCAGC CCGGCTTCTT CCTGGGCCGC CTCTTCCTCT TCCGCAACCC GTGGTGCTGC
GACTGCCGTC TGGAGTGGCT GAGGGACTGG ATGGAGGGCT CCGGACGTGT CACCGACGTG
CCGTGCGCCT CCCCGGGCTC CGTGGCCGGC CTGGACCTCA GCCAGGTGAC CTTCGGGCGC
TCCTCCGATG GCCTCTGTGT GGACCCCGAG GAGCTGAACC TCACCACGTC CAGTCCAGGC
CCGTCCCCAG AACCAGCGGC CACCACCGTG AGCAGGTTCA GCAGCCTCCT CTCCAAGCTG
CTGGCCCCGA GGGTCCCGGT GGAGGAGGCG GCCAACACCA CTGGGGGGCT GGCCAACGCC
TCCCTGTCCG ACAGCCTCTC CTCCCGTGGG GTGGGAGGCG CGGGCCGGCA GCCCTGGTTT
CTCCTCGCCT CTTGTCTCCT GCCCAGCGTG GCCCAGCACG TGGTGTTTGG CCTGCAGATG
GACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19068
Clone ID Related Accession (Same CDS sequence) XM_005272632.2 , XM_017029709.1 , NM_022567.2
Accession Version XM_005272632.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1446bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-12
Organism Homo sapiens(Human)
Product nyctalopin isoform X1
Comment

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGAAAGGCC GAGGGATGTT GGTCCTGCTT CTGCATGCGG TGGTCCTCGG CCTGCCCAGC 
GCCTGGGCCG TGGGGGCCTG CGCCCGCGCT TGTCCCGCCG CCTGCGCCTG CAGCACCGTG
GAGCGCGGCT GCTCGGTGCG CTGCGACCGC GCGGGCCTCC TGCGGGTGCC GGCCGAGCTC
CCGTGCGAGG CGGTCTCCAT CGACCTGGAC CGGAACGGCC TGCGCTTCCT GGGCGAGCGA
GCCTTCGGCA CGCTGCCGTC CTTGCGCCGC CTGTCGCTGC GCCACAACAA CCTGTCCTTC
ATCACGCCCG GCGCCTTCAA GGGCCTGCCG CGCCTGGCTG AGCTGCGCCT GGCGCACAAC
GGCGACCTGC GCTACCTGCA CGCGCGCACC TTCGCGGCGC TCAGCCGCCT GCGCCGCCTA
GACCTAGCAG CCTGCCGCCT CTTCAGCGTG CCCGAGCGCC TCCTGGCCGA ACTGCCGGCC
CTGCGCGAAC TCGCCGCCTT CGACAACCTG TTCCGCCGCG TGCCGGGCGC GCTGCGCGGC
CTGGCCAACC TGACGCACGC GCACCTGGAG CGCGGCCGCA TCGAGGCGGT GGCCTCCAGC
TCGCTGCAGG GCCTGCGCCG CCTGCGCTCG CTCAGCCTGC AGGCCAACCG CGTCCGTGCC
GTGCACGCTG GCGCCTTCGG GGACTGTGGC GTCCTGGAGC ATCTGCTGCT CAACGACAAC
CTGCTGGCCG AGCTCCCGGC CGACGCCTTC CGCGGCCTGC GGCGCCTGCG CACGCTCAAC
CTGGGTGGCA ACGCGCTGGA CCGCGTGGCG CGCGCCTGGT TCGCTGACCT GGCCGAGCTC
GAGCTGCTCT ACCTGGACCG CAACAGCATC GCCTTCGTGG AGGAGGGCGC CTTCCAGAAC
CTCTCGGGTC TCCTCGCGCT GCACCTCAAC GGCAACCGCC TCACCGTGCT CGCCTGGGTC
GCCTTCCAGC CCGGCTTCTT CCTGGGCCGC CTCTTCCTCT TCCGCAACCC GTGGTGCTGC
GACTGCCGTC TGGAGTGGCT GAGGGACTGG ATGGAGGGCT CCGGACGTGT CACCGACGTG
CCGTGCGCCT CCCCGGGCTC CGTGGCCGGC CTGGACCTCA GCCAGGTGAC CTTCGGGCGC
TCCTCCGATG GCCTCTGTGT GGACCCCGAG GAGCTGAACC TCACCACGTC CAGTCCAGGC
CCGTCCCCAG AACCAGCGGC CACCACCGTG AGCAGGTTCA GCAGCCTCCT CTCCAAGCTG
CTGGCCCCGA GGGTCCCGGT GGAGGAGGCG GCCAACACCA CTGGGGGGCT GGCCAACGCC
TCCCTGTCCG ACAGCCTCTC CTCCCGTGGG GTGGGAGGCG CGGGCCGGCA GCCCTGGTTT
CTCCTCGCCT CTTGTCTCCT GCCCAGCGTG GCCCAGCACG TGGTGTTTGG CCTGCAGATG
GACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005272689.1
Translation

Target ORF information:

RefSeq Version XM_005272632.2
Organism Homo sapiens(Human)
Definition Homo sapiens nyctalopin (NYX), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005272632.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGAAAGGCC GAGGGATGTT GGTCCTGCTT CTGCATGCGG TGGTCCTCGG CCTGCCCAGC 
GCCTGGGCCG TGGGGGCCTG CGCCCGCGCT TGTCCCGCCG CCTGCGCCTG CAGCACCGTG
GAGCGCGGCT GCTCGGTGCG CTGCGACCGC GCGGGCCTCC TGCGGGTGCC GGCCGAGCTC
CCGTGCGAGG CGGTCTCCAT CGACCTGGAC CGGAACGGCC TGCGCTTCCT GGGCGAGCGA
GCCTTCGGCA CGCTGCCGTC CTTGCGCCGC CTGTCGCTGC GCCACAACAA CCTGTCCTTC
ATCACGCCCG GCGCCTTCAA GGGCCTGCCG CGCCTGGCTG AGCTGCGCCT GGCGCACAAC
GGCGACCTGC GCTACCTGCA CGCGCGCACC TTCGCGGCGC TCAGCCGCCT GCGCCGCCTA
GACCTAGCAG CCTGCCGCCT CTTCAGCGTG CCCGAGCGCC TCCTGGCCGA ACTGCCGGCC
CTGCGCGAAC TCGCCGCCTT CGACAACCTG TTCCGCCGCG TGCCGGGCGC GCTGCGCGGC
CTGGCCAACC TGACGCACGC GCACCTGGAG CGCGGCCGCA TCGAGGCGGT GGCCTCCAGC
TCGCTGCAGG GCCTGCGCCG CCTGCGCTCG CTCAGCCTGC AGGCCAACCG CGTCCGTGCC
GTGCACGCTG GCGCCTTCGG GGACTGTGGC GTCCTGGAGC ATCTGCTGCT CAACGACAAC
CTGCTGGCCG AGCTCCCGGC CGACGCCTTC CGCGGCCTGC GGCGCCTGCG CACGCTCAAC
CTGGGTGGCA ACGCGCTGGA CCGCGTGGCG CGCGCCTGGT TCGCTGACCT GGCCGAGCTC
GAGCTGCTCT ACCTGGACCG CAACAGCATC GCCTTCGTGG AGGAGGGCGC CTTCCAGAAC
CTCTCGGGTC TCCTCGCGCT GCACCTCAAC GGCAACCGCC TCACCGTGCT CGCCTGGGTC
GCCTTCCAGC CCGGCTTCTT CCTGGGCCGC CTCTTCCTCT TCCGCAACCC GTGGTGCTGC
GACTGCCGTC TGGAGTGGCT GAGGGACTGG ATGGAGGGCT CCGGACGTGT CACCGACGTG
CCGTGCGCCT CCCCGGGCTC CGTGGCCGGC CTGGACCTCA GCCAGGTGAC CTTCGGGCGC
TCCTCCGATG GCCTCTGTGT GGACCCCGAG GAGCTGAACC TCACCACGTC CAGTCCAGGC
CCGTCCCCAG AACCAGCGGC CACCACCGTG AGCAGGTTCA GCAGCCTCCT CTCCAAGCTG
CTGGCCCCGA GGGTCCCGGT GGAGGAGGCG GCCAACACCA CTGGGGGGCT GGCCAACGCC
TCCCTGTCCG ACAGCCTCTC CTCCCGTGGG GTGGGAGGCG CGGGCCGGCA GCCCTGGTTT
CTCCTCGCCT CTTGTCTCCT GCCCAGCGTG GCCCAGCACG TGGTGTTTGG CCTGCAGATG
GACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19068
Clone ID Related Accession (Same CDS sequence) XM_005272632.2 , XM_017029709.1 , NM_022567.2
Accession Version XM_017029709.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1446bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product nyctalopin isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGAAAGGCC GAGGGATGTT GGTCCTGCTT CTGCATGCGG TGGTCCTCGG CCTGCCCAGC 
GCCTGGGCCG TGGGGGCCTG CGCCCGCGCT TGTCCCGCCG CCTGCGCCTG CAGCACCGTG
GAGCGCGGCT GCTCGGTGCG CTGCGACCGC GCGGGCCTCC TGCGGGTGCC GGCCGAGCTC
CCGTGCGAGG CGGTCTCCAT CGACCTGGAC CGGAACGGCC TGCGCTTCCT GGGCGAGCGA
GCCTTCGGCA CGCTGCCGTC CTTGCGCCGC CTGTCGCTGC GCCACAACAA CCTGTCCTTC
ATCACGCCCG GCGCCTTCAA GGGCCTGCCG CGCCTGGCTG AGCTGCGCCT GGCGCACAAC
GGCGACCTGC GCTACCTGCA CGCGCGCACC TTCGCGGCGC TCAGCCGCCT GCGCCGCCTA
GACCTAGCAG CCTGCCGCCT CTTCAGCGTG CCCGAGCGCC TCCTGGCCGA ACTGCCGGCC
CTGCGCGAAC TCGCCGCCTT CGACAACCTG TTCCGCCGCG TGCCGGGCGC GCTGCGCGGC
CTGGCCAACC TGACGCACGC GCACCTGGAG CGCGGCCGCA TCGAGGCGGT GGCCTCCAGC
TCGCTGCAGG GCCTGCGCCG CCTGCGCTCG CTCAGCCTGC AGGCCAACCG CGTCCGTGCC
GTGCACGCTG GCGCCTTCGG GGACTGTGGC GTCCTGGAGC ATCTGCTGCT CAACGACAAC
CTGCTGGCCG AGCTCCCGGC CGACGCCTTC CGCGGCCTGC GGCGCCTGCG CACGCTCAAC
CTGGGTGGCA ACGCGCTGGA CCGCGTGGCG CGCGCCTGGT TCGCTGACCT GGCCGAGCTC
GAGCTGCTCT ACCTGGACCG CAACAGCATC GCCTTCGTGG AGGAGGGCGC CTTCCAGAAC
CTCTCGGGTC TCCTCGCGCT GCACCTCAAC GGCAACCGCC TCACCGTGCT CGCCTGGGTC
GCCTTCCAGC CCGGCTTCTT CCTGGGCCGC CTCTTCCTCT TCCGCAACCC GTGGTGCTGC
GACTGCCGTC TGGAGTGGCT GAGGGACTGG ATGGAGGGCT CCGGACGTGT CACCGACGTG
CCGTGCGCCT CCCCGGGCTC CGTGGCCGGC CTGGACCTCA GCCAGGTGAC CTTCGGGCGC
TCCTCCGATG GCCTCTGTGT GGACCCCGAG GAGCTGAACC TCACCACGTC CAGTCCAGGC
CCGTCCCCAG AACCAGCGGC CACCACCGTG AGCAGGTTCA GCAGCCTCCT CTCCAAGCTG
CTGGCCCCGA GGGTCCCGGT GGAGGAGGCG GCCAACACCA CTGGGGGGCT GGCCAACGCC
TCCCTGTCCG ACAGCCTCTC CTCCCGTGGG GTGGGAGGCG CGGGCCGGCA GCCCTGGTTT
CTCCTCGCCT CTTGTCTCCT GCCCAGCGTG GCCCAGCACG TGGTGTTTGG CCTGCAGATG
GACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016885198.1
CDS99..1544
Misc Feature(1)300..359
Misc Feature(2)<315..1049
Misc Feature(3)354..539
Misc Feature(4)360..431
Misc Feature(5)432..506
Misc Feature(6)507..578
Misc Feature(7)579..647
Misc Feature(8)645..824
Misc Feature(9)648..719
Misc Feature(10)720..791
Misc Feature(11)792..968
Misc Feature(12)792..863
Misc Feature(13)864..935
Misc Feature(14)933..>1067
Misc Feature(15)936..1001
Misc Feature(16)1080..1118
Misc Feature(17)1104..>1208
Translation

Target ORF information:

RefSeq Version XM_017029709.1
Organism Homo sapiens(Human)
Definition Homo sapiens nyctalopin (NYX), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_017029709.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGAAAGGCC GAGGGATGTT GGTCCTGCTT CTGCATGCGG TGGTCCTCGG CCTGCCCAGC 
GCCTGGGCCG TGGGGGCCTG CGCCCGCGCT TGTCCCGCCG CCTGCGCCTG CAGCACCGTG
GAGCGCGGCT GCTCGGTGCG CTGCGACCGC GCGGGCCTCC TGCGGGTGCC GGCCGAGCTC
CCGTGCGAGG CGGTCTCCAT CGACCTGGAC CGGAACGGCC TGCGCTTCCT GGGCGAGCGA
GCCTTCGGCA CGCTGCCGTC CTTGCGCCGC CTGTCGCTGC GCCACAACAA CCTGTCCTTC
ATCACGCCCG GCGCCTTCAA GGGCCTGCCG CGCCTGGCTG AGCTGCGCCT GGCGCACAAC
GGCGACCTGC GCTACCTGCA CGCGCGCACC TTCGCGGCGC TCAGCCGCCT GCGCCGCCTA
GACCTAGCAG CCTGCCGCCT CTTCAGCGTG CCCGAGCGCC TCCTGGCCGA ACTGCCGGCC
CTGCGCGAAC TCGCCGCCTT CGACAACCTG TTCCGCCGCG TGCCGGGCGC GCTGCGCGGC
CTGGCCAACC TGACGCACGC GCACCTGGAG CGCGGCCGCA TCGAGGCGGT GGCCTCCAGC
TCGCTGCAGG GCCTGCGCCG CCTGCGCTCG CTCAGCCTGC AGGCCAACCG CGTCCGTGCC
GTGCACGCTG GCGCCTTCGG GGACTGTGGC GTCCTGGAGC ATCTGCTGCT CAACGACAAC
CTGCTGGCCG AGCTCCCGGC CGACGCCTTC CGCGGCCTGC GGCGCCTGCG CACGCTCAAC
CTGGGTGGCA ACGCGCTGGA CCGCGTGGCG CGCGCCTGGT TCGCTGACCT GGCCGAGCTC
GAGCTGCTCT ACCTGGACCG CAACAGCATC GCCTTCGTGG AGGAGGGCGC CTTCCAGAAC
CTCTCGGGTC TCCTCGCGCT GCACCTCAAC GGCAACCGCC TCACCGTGCT CGCCTGGGTC
GCCTTCCAGC CCGGCTTCTT CCTGGGCCGC CTCTTCCTCT TCCGCAACCC GTGGTGCTGC
GACTGCCGTC TGGAGTGGCT GAGGGACTGG ATGGAGGGCT CCGGACGTGT CACCGACGTG
CCGTGCGCCT CCCCGGGCTC CGTGGCCGGC CTGGACCTCA GCCAGGTGAC CTTCGGGCGC
TCCTCCGATG GCCTCTGTGT GGACCCCGAG GAGCTGAACC TCACCACGTC CAGTCCAGGC
CCGTCCCCAG AACCAGCGGC CACCACCGTG AGCAGGTTCA GCAGCCTCCT CTCCAAGCTG
CTGGCCCCGA GGGTCCCGGT GGAGGAGGCG GCCAACACCA CTGGGGGGCT GGCCAACGCC
TCCCTGTCCG ACAGCCTCTC CTCCCGTGGG GTGGGAGGCG CGGGCCGGCA GCCCTGGTTT
CTCCTCGCCT CTTGTCTCCT GCCCAGCGTG GCCCAGCACG TGGTGTTTGG CCTGCAGATG
GACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Two Novel NYX Gene Mutations in the Chinese Families with X-linked Congenital Stationary Night Blindness.
Scientific reports512679(2015 Aug)
Dai S,Ying M,Wang K,Wang L,Han R,Hao P,Li N


book

NYX mutations in four families with high myopia with or without CSNB1.
Molecular vision21213-23(2015)
Zhou L,Li T,Song X,Li Y,Li H,Dan H


book

Genotype and phenotype of 101 dutch patients with congenital stationary night blindness.
Ophthalmology120(10)2072-81(2013 Oct)
Bijveld MM,Florijn RJ,Bergen AA,van den Born LI,Kamermans M,Prick L,Riemslag FC,van Schooneveld MJ,Kappers AM,van Genderen MM


book

Electroretinographic findings in a patient with congenital stationary night blindness due to a novel NYX mutation.
Ophthalmic genetics34(3)167-73(2013 Sep)
McAnany JJ,Alexander KR,Kumar NM,Ying H,Anastasakis A,Fishman GA


book

A novel missense mutation in the NYX gene associated with high myopia.
Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)33(3)346-53(2013 May)
Yip SP,Li CC,Yiu WC,Hung WH,Lam WW,Lai MC,Ng PW,Fung WY,Chu PH,Jiang B,Chan HH,Yap MK


 
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