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SAA1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol SAA1
Entrez Gene ID 6288
Full Name serum amyloid A1
Synonyms PIG4,SAA,SAA2,TP53I4
General protein information
Preferred Names

serum amyloid A1

Names

serum amyloid A-1 protein
serum amyloid A protein
tumor protein p53 inducible protein 4

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

11

11p15.1

Summary This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. [provided by RefSeq, Feb 2016].
Disorder MIM:

104750


mRNA and Protein(s)

mRNA Protein Name
NM_199161.4 NP_954630.1 serum amyloid A-1 protein preproprotein
NM_000331.4 NP_000322.2 serum amyloid A-1 protein preproprotein
NM_001178006.2 NP_001171477.1 serum amyloid A-1 protein preproprotein
NM_000331.5 NP_000322.2 serum amyloid A-1 protein preproprotein
NM_199161.3 NP_954630.1 serum amyloid A-1 protein preproprotein
NM_001178006.1 NP_001171477.1 serum amyloid A-1 protein preproprotein



Homo sapiens (human) SAA1 NP_000322.2
Bos taurus (cattle) SAA3 NP_851359.2
Canis lupus familiaris (dog) LOC100684663 XP_003432981.1
Mus musculus (house mouse) Saa2 NP_035444.1
Canis lupus familiaris (dog) LOC476879 XP_534081.1
Bos taurus (cattle) SAA2 NP_001068728.1
Bos taurus (cattle) M-SAA3.2 NP_001229502.1
Mus musculus (house mouse) Saa1 NP_033143.1
Danio rerio (zebrafish) saa NP_001005599.1
Pan troglodytes (chimpanzee) SAA1 XP_003951896.1
Macaca mulatta (rhesus monkey) SAA1 XP_001086366.1
Canis lupus familiaris (dog) LOC102155886 XP_005633785.1
Macaca mulatta (rhesus monkey) LOC694944 XP_001086477.1


Related articles in PubMed

Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo.
Baranova IN, Souza ACP, Bocharov AV, Vishnyakova TG, Hu X, Vaisman BL, Amar MJ, Chen Z, Remaley AT, Patterson AP, Yuen PST, Star RA, Eggerman TL
PloS one12(4)e0175824(2017)

MEFV and SAA1 genotype associations with clinical features of familial Mediterranean fever and amyloidosis in Armenia.
Atoyan S, Hayrapetyan H, Sarkisian T, Ben-Chetrit E
Clinical and experimental rheumatology34(6 Suppl 102)72-76(2016 Sep-Oct)

Detection of AA76, a Common Form of Amyloid A Protein, as a Way of Diagnosing AA Amyloidosis.
Sato J, Okuda Y, Kuroda T, Yamada T
Annals of clinical and laboratory science46(2)147-53(2016)

Serum Amyloid a Promotes Visfatin Expression in Macrophages.
Wang S, Zhang X, Tan L
BioMed research international20164819327(2016)

Human serum amyloid A (SAA): biosynthesis and postsynthetic processing of preSAA and structural variants defined by complementary DNA.
Sipe JD, Colten HR, Goldberger G, Edge MD, Tack BF, Cohen AS, Whitehead AS
Biochemistry24(12)2931-6(1985 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SR-A1 suppresses lung cancer metastasis by downregulating SAA1 production in tumor-associated macrophages (TAM).
Title: Scavenger Receptor A1 Prevents Metastasis of Non-Small Cell Lung Cancer via Suppression of Macrophage Serum Amyloid A1.

Serum amyloid A could represent a novel marker of primary unexplained recurrent early pregnancy loss because affected women exhibited elevated levels of this protein.
Title: Maternal serum amyloid A level as a novel marker of primary unexplained recurrent early pregnancy loss.

SAA, PROZ, and C4BPB may serve as new potential biomarkers for TB
Title: Serum amyloid A, protein Z, and C4b-binding protein β chain as new potential biomarkers for pulmonary tuberculosis.

The findings identify SR-BII as a functional SAA receptor that mediates SAA uptake and contributes to its proinflammatory signaling via the MAPK-mediated signaling pathways.
Title: Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo.

Correlate MEFV genotype and the SAA1 polymorphisms with the clinical manifestations of familial Mediterranean fever and the occurrence of amyloidosis in a large cohort of Armenian patients.
Title: MEFV and SAA1 genotype associations with clinical features of familial Mediterranean fever and amyloidosis in Armenia.

The following SAA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SAA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu20486 NM_000331.5
Latest version!
Homo sapiens serum amyloid A1 (SAA1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu20486 NM_001178006.2
Latest version!
Homo sapiens serum amyloid A1 (SAA1), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu20486 NM_199161.4
Latest version!
Homo sapiens serum amyloid A1 (SAA1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
View Old Accession Versions >>
OHu20486 NM_000331.4 Homo sapiens serum amyloid A1 (SAA1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu20486 NM_199161.3 Homo sapiens serum amyloid A1 (SAA1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu20486 NM_001178006.1 Homo sapiens serum amyloid A1 (SAA1), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu20486
Clone ID Related Accession (Same CDS sequence) NM_199161.4 , NM_000331.4 , NM_001178006.2 , NM_000331.5 , NM_199161.3 , NM_001178006.1
Accession Version NM_199161.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 369bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product serum amyloid A-1 protein preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG562565.1, BC007022.1, BX102362.1 and BE964588.2. On Feb 12, 2016 this sequence version replaced NM_199161.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG618566.1, BG562565.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_954630.1
CDS77..445
Misc Feature(1)11..13
Misc Feature(2)131..211
Misc Feature(3)143..442
Misc Feature(4)377..379
Exon (1)1..72
Exon (2)73..167
Exon (3)168..306
Exon (4)307..567
Translation

Target ORF information:

RefSeq Version NM_199161.4
Organism Homo sapiens(Human)
Definition Homo sapiens serum amyloid A1 (SAA1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_199161.4

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20486
Clone ID Related Accession (Same CDS sequence) NM_199161.4 , NM_000331.4 , NM_001178006.2 , NM_000331.5 , NM_199161.3 , NM_001178006.1
Accession Version NM_000331.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 369bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-15
Organism Homo sapiens(Human)
Product serum amyloid A-1 protein preproprotein
Comment

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000322.2
Translation

Target ORF information:

RefSeq Version NM_000331.4
Organism Homo sapiens(Human)
Definition Homo sapiens serum amyloid A1 (SAA1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000331.4

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20486
Clone ID Related Accession (Same CDS sequence) NM_199161.4 , NM_000331.4 , NM_001178006.2 , NM_000331.5 , NM_199161.3 , NM_001178006.1
Accession Version NM_001178006.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 369bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product serum amyloid A-1 protein preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG562565.1, BC105796.1, BX102362.1 and BE964588.2. On Feb 12, 2016 this sequence version replaced NM_001178006.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC105796.1, BG566837.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001171477.1
CDS138..506
Misc Feature(1)102..104
Misc Feature(2)192..272
Misc Feature(3)204..503
Misc Feature(4)438..440
Exon (1)1..72
Exon (2)73..133
Exon (3)134..228
Exon (4)229..367
Exon (5)368..628
Translation

Target ORF information:

RefSeq Version NM_001178006.2
Organism Homo sapiens(Human)
Definition Homo sapiens serum amyloid A1 (SAA1), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001178006.2

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20486
Clone ID Related Accession (Same CDS sequence) NM_199161.4 , NM_000331.4 , NM_001178006.2 , NM_000331.5 , NM_199161.3 , NM_001178006.1
Accession Version NM_000331.5 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 369bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product serum amyloid A-1 protein preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG562565.1, BG565078.1, BX102362.1 and BE964588.2. This sequence is a reference standard in the RefSeqGene project. On Feb 12, 2016 this sequence version replaced NM_000331.4. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279832.1754.1, BG567754.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000322.2
CDS224..592
Misc Feature(1)188..190
Misc Feature(2)278..358
Misc Feature(3)290..589
Misc Feature(4)524..526
Exon (1)1..219
Exon (2)220..314
Exon (3)315..453
Exon (4)454..714
Translation

Target ORF information:

RefSeq Version NM_000331.5
Organism Homo sapiens(Human)
Definition Homo sapiens serum amyloid A1 (SAA1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000331.5

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20486
Clone ID Related Accession (Same CDS sequence) NM_199161.4 , NM_000331.4 , NM_001178006.2 , NM_000331.5 , NM_199161.3 , NM_001178006.1
Accession Version NM_199161.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 369bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-15
Organism Homo sapiens(Human)
Product serum amyloid A-1 protein preproprotein
Comment

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_954630.1
Translation

Target ORF information:

RefSeq Version NM_199161.3
Organism Homo sapiens(Human)
Definition Homo sapiens serum amyloid A1 (SAA1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_199161.3

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20486
Clone ID Related Accession (Same CDS sequence) NM_199161.4 , NM_000331.4 , NM_001178006.2 , NM_000331.5 , NM_199161.3 , NM_001178006.1
Accession Version NM_001178006.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 369bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-15
Organism Homo sapiens(Human)
Product serum amyloid A-1 protein preproprotein
Comment

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001171477.1
Translation

Target ORF information:

RefSeq Version NM_001178006.1
Organism Homo sapiens(Human)
Definition Homo sapiens serum amyloid A1 (SAA1), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001178006.1

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo.
PloS one12(4)e0175824(2017)
Baranova IN,Souza ACP,Bocharov AV,Vishnyakova TG,Hu X,Vaisman BL,Amar MJ,Chen Z,Remaley AT,Patterson AP,Yuen PST,Star RA,Eggerman TL


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MEFV and SAA1 genotype associations with clinical features of familial Mediterranean fever and amyloidosis in Armenia.
Clinical and experimental rheumatology34(6 Suppl 102)72-76(2016 Sep-Oct)
Atoyan S,Hayrapetyan H,Sarkisian T,Ben-Chetrit E


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Detection of AA76, a Common Form of Amyloid A Protein, as a Way of Diagnosing AA Amyloidosis.
Annals of clinical and laboratory science46(2)147-53(2016)
Sato J,Okuda Y,Kuroda T,Yamada T


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Serum Amyloid a Promotes Visfatin Expression in Macrophages.
BioMed research international20164819327(2016)
Wang S,Zhang X,Tan L


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Human serum amyloid A (SAA): biosynthesis and postsynthetic processing of preSAA and structural variants defined by complementary DNA.
Biochemistry24(12)2931-6(1985 Jun)
Sipe JD,Colten HR,Goldberger G,Edge MD,Tack BF,Cohen AS,Whitehead AS


 
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