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SCNN1G cDNA ORF clone, Homo sapiens(Human)

Gene Symbol SCNN1G
Entrez Gene ID 6340
Full Name sodium channel epithelial 1 gamma subunit
Synonyms BESC3,ENaCg,ENaCgamma,PHA1,SCNEG
General protein information
Preferred Names

sodium channel epithelial 1 gamma subunit

Names

amiloride-sensitive sodium channel subunit gamma
ENaC gamma subunit
amiloride-sensitive epithelial sodium channel gamma subunit
amiloride-sensitive sodium channel gamma-subunit
epithelial Na(+) channel subunit gamma
gamma-ENaC
gamma-NaCH
nonvoltage-gated sodium channel 1 subunit gamma
sodium channe epithelial 1 gamma subunit
sodium channel, non-voltage-gated 1, gamma subunit
sodium channel, nonvoltage-gated 1, gamma

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

16

16p12.2

Summary Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009].
Disorder MIM:

600761

Disorder Html: Liddle syndrome, 177200 (3); Pseudohypoaldosteronism, type I, 264350

mRNA and Protein(s)

mRNA Protein Name
NM_001039.3 NP_001030.2 amiloride-sensitive sodium channel subunit gamma



Mus musculus (house mouse) Scnn1g NP_035456.1
Caenorhabditis elegans (roundworm) asic-1 NP_491214.3
Caenorhabditis elegans (roundworm) mec-4 NP_510712.2
Caenorhabditis elegans (roundworm) del-1 NP_510380.1
Caenorhabditis elegans (roundworm) unc-8 NP_501138.1
Xenopus tropicalis (tropical clawed frog) scnn1g XP_004918046.1
Macaca mulatta (rhesus monkey) SCNN1G XP_001093466.1
Pan troglodytes (chimpanzee) SCNN1G XP_003315070.1
Caenorhabditis elegans (roundworm) unc-105 NP_001254142.1
Caenorhabditis elegans (roundworm) asic-2 NP_492099.1
Caenorhabditis elegans (roundworm) mec-10 NP_509438.1
Bos taurus (cattle) SCNN1G NP_001180103.1
Gallus gallus (chicken) SCNN1G XP_414880.2
Homo sapiens (human) SCNN1G NP_001030.2
Rattus norvegicus (Norway rat) Scnn1g NP_058742.1
Canis lupus familiaris (dog) SCNN1G XP_547093.2
Caenorhabditis elegans (roundworm) deg-1 NP_509311.1
Caenorhabditis elegans (roundworm) del-4 NP_492230.2


Related articles in PubMed

Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.
Hanukoglu I, Hanukoglu A
Gene579(2)95-132(2016 Apr)

Assessment of epithelial sodium channel variants in nonwhite cystic fibrosis patients with non-diagnostic CFTR genotypes.
Brennan ML, Pique LM, Schrijver I
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society15(1)52-9(2016 Jan)

Expression and distribution of epithelial sodium channel in nasal polyp and nasal mucosa.
Jiang Y, Xu J, Chen Y, Shi J, Zhang C, Li J
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery272(11)3361-6(2015 Nov)

A potential role for interleukin-33 and γ-epithelium sodium channel in the pathogenesis of human malaria associated lung injury.
Ampawong S, Chaisri U, Viriyavejakul P, Prapansilp P, Grau GE, Turner GD, Pongponratn E
Malaria journal14389(2015 Oct)

Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease.
Azad AK, Rauh R, Vermeulen F, Jaspers M, Korbmacher J, Boissier B, Bassinet L, Fichou Y, des Georges M, Stanke F, De Boeck K, Dupont L, Balascáková M, Hjelte L, Lebecque P, Radojkovic D, Castellani C, Schwartz M, Stuhrmann M, Schwarz M, Skalicka V, de Monestrol I, Girodon E, Férec C, Claustres M, Tümmler B, Cassiman JJ, Korbmacher C, Cuppens H
Human mutation30(7)1093-103(2009 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells.
Title: Derlin-1 promotes ubiquitylation and degradation of the epithelial Na

deltabetagamma-ENaC is inhibited by CFTR but activated by cyclic AMP.
Title: δβγ-ENaC is inhibited by CFTR but stimulated by cAMP in

hENaC incorporating the Liddle-mutated beta-subunit lacks one or more PKC phosphorylation sites, thereby significantly reducing the inhibitory effect of PKC on Na(+) channel activity, whereas hENaC incorporating Liddle-mutated gamma-subunits remains as susceptible to PKC as wild-type hENaC.
Title: Liddle-Mutation of the β-Subunit, but not the γ-Subunit, Attenuates Protein Kinase C-Mediated Inhibition of Human Epithelial Sodium Channels (hENaC).

One nonsynonymous amino acid variants in SCNN1G in nonwhite Cystic fibrosis patients with non-diagnostic CFTR genotypes was identified.
Title: Assessment of epithelial sodium channel variants in nonwhite cystic fibrosis patients with non-diagnostic CFTR genotypes.

Both vascular smooth muscle cell and bronchial gamma-ENaC downregulation may explain pulmonary fluid disturbances and participate in pulmonary edema pathogenesis.
Title: A potential role for interleukin-33 and γ-epithelium sodium channel in the pathogenesis of human malaria associated lung injury.

The following SCNN1G gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SCNN1G cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu17893 NM_001039.3
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Homo sapiens sodium channel epithelial 1 gamma subunit (SCNN1G), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $265.30
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu17893
Clone ID Related Accession (Same CDS sequence) NM_001039.3
Accession Version NM_001039.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1950bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-30
Organism Homo sapiens(Human)
Product amiloride-sensitive sodium channel subunit gamma
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC059391.1 and X87160.1. This sequence is a reference standard in the RefSeqGene project. On Jun 15, 2007 this sequence version replaced NM_001039.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC059391.1, SRR1660805.207998.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
ATGGCACCCG GAGAGAAGAT CAAAGCCAAA ATCAAGAAGA ATCTGCCCGT GACGGGCCCT 
CAGGCGCCGA CCATTAAAGA GCTGATGCGG TGGTACTGCC TCAACACCAA CACCCATGGC
TGTCGCCGCA TCGTGGTGTC CCGCGGCCGT CTGCGCCGCC TCCTCTGGAT CGGGTTCACA
CTGACTGCCG TGGCCCTCAT CCTCTGGCAG TGCGCCCTCC TCGTCTTCTC CTTCTATACT
GTCTCAGTTT CCATCAAAGT CCACTTCCGG AAGCTGGATT TTCCTGCAGT CACCATCTGC
AACATCAACC CCTACAAGTA CAGCACCGTT CGCCACCTTC TAGCTGACTT GGAACAGGAG
ACCAGAGAGG CCCTGAAGTC CCTGTATGGC TTTCCAGAGT CCCGGAAGCG CCGAGAGGCG
GAGTCCTGGA ACTCCGTCTC AGAGGGAAAG CAGCCTAGAT TCTCCCACCG GATTCCGCTG
CTGATCTTTG ATCAGGATGA GAAGGGCAAG GCCAGGGACT TCTTCACAGG GAGGAAGCGG
AAAGTCGGCG GTAGCATCAT TCACAAGGCT TCAAATGTCA TGCACATCGA GTCCAAGCAA
GTGGTGGGAT TCCAACTGTG CTCAAATGAC ACCTCCGACT GTGCCACCTA CACCTTCAGC
TCGGGAATCA ATGCCATTCA GGAGTGGTAT AAGCTACACT ACATGAACAT CATGGCACAG
GTGCCTCTGG AGAAGAAAAT CAACATGAGC TATTCTGCTG AGGAGCTGCT GGTGACCTGC
TTCTTTGATG GAGTGTCCTG TGATGCCAGG AATTTCACGC TTTTCCACCA CCCGATGCAT
GGGAATTGCT ATACTTTCAA CAACAGAGAA AATGAGACCA TTCTCAGCAC CTCCATGGGG
GGCAGCGAAT ATGGGCTGCA AGTCATTTTG TACATAAACG AAGAGGAATA CAACCCATTC
CTCGTGTCCT CCACTGGAGC TAAGGTGATC ATCCATCGGC AGGATGAGTA TCCCTTCGTC
GAAGATGTGG GAACAGAGAT TGAGACAGCA ATGGTCACCT CTATAGGAAT GCACCTGACA
GAGTCCTTCA AGCTGAGTGA GCCCTACAGT CAGTGCACGG AGGACGGGAG TGACGTGCCA
ATCAGGAACA TCTACAACGC TGCCTACTCG CTCCAGATCT GCCTTCATTC ATGCTTCCAG
ACAAAGATGG TGGAGAAATG TGGGTGTGCC CAGTACAGCC AGCCTCTACC TCCTGCAGCC
AACTACTGCA ACTACCAGCA GCACCCCAAC TGGATGTATT GTTACTACCA ACTGCATCGA
GCCTTTGTCC AGGAAGAGCT GGGCTGCCAG TCTGTGTGCA AGGAAGCCTG CAGCTTTAAA
GAGTGGACAC TAACCACAAG CCTGGCACAA TGGCCATCTG TGGTTTCGGA GAAGTGGTTG
CTGCCTGTTC TCACTTGGGA CCAAGGCCGG CAAGTAAACA AAAAGCTCAA CAAGACAGAC
TTGGCCAAAC TCTTGATATT CTACAAAGAC CTGAACCAGA GATCCATCAT GGAGAGCCCA
GCCAACAGTA TTGAGATGCT TCTGTCCAAC TTCGGTGGCC AGCTGGGCCT GTGGATGAGC
TGCTCTGTTG TCTGCGTCAT CGAGATCATC GAGGTCTTCT TCATTGACTT CTTCTCTATC
ATTGCCCGCC GCCAGTGGCA GAAAGCCAAG GAGTGGTGGG CCTGGAAACA GGCTCCCCCA
TGTCCAGAAG CTCCCCGTAG CCCACAGGGC CAGGACAATC CAGCCCTGGA TATAGACGAT
GACCTACCCA CTTTCAACTC TGCTTTGCAC CTGCCTCCAG CCCTAGGAAC CCAAGTGCCC
GGCACACCGC CCCCCAAATA CAATACCTTG CGCTTGGAGA GGGCCTTTTC CAACCAGCTC
ACAGATACCC AGATGCTGGA TGAGCTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001030.2
CDS140..2089
Misc Feature(1)32..34
Misc Feature(2)155..157
Misc Feature(3)161..163
Misc Feature(4)167..169
Misc Feature(5)173..175
Misc Feature(6)176..178
Misc Feature(7)209..2029
Misc Feature(8)215..217
Misc Feature(9)233..1792
Misc Feature(10)305..367
Misc Feature(11)1763..1825
Misc Feature(12)2003..2005
Exon (1)1..95
Exon (2)96..456
Exon (3)457..757
Exon (4)758..948
Exon (5)949..1052
Exon (6)1053..1216
Exon (7)1217..1315
Exon (8)1316..1433
Exon (9)1434..1512
Exon (10)1513..1570
Exon (11)1571..1632
Exon (12)1633..1708
Exon (13)1709..3499
Translation

Target ORF information:

RefSeq Version NM_001039.3
Organism Homo sapiens(Human)
Definition Homo sapiens sodium channel epithelial 1 gamma subunit (SCNN1G), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001039.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
ATGGCACCCG GAGAGAAGAT CAAAGCCAAA ATCAAGAAGA ATCTGCCCGT GACGGGCCCT 
CAGGCGCCGA CCATTAAAGA GCTGATGCGG TGGTACTGCC TCAACACCAA CACCCATGGC
TGTCGCCGCA TCGTGGTGTC CCGCGGCCGT CTGCGCCGCC TCCTCTGGAT CGGGTTCACA
CTGACTGCCG TGGCCCTCAT CCTCTGGCAG TGCGCCCTCC TCGTCTTCTC CTTCTATACT
GTCTCAGTTT CCATCAAAGT CCACTTCCGG AAGCTGGATT TTCCTGCAGT CACCATCTGC
AACATCAACC CCTACAAGTA CAGCACCGTT CGCCACCTTC TAGCTGACTT GGAACAGGAG
ACCAGAGAGG CCCTGAAGTC CCTGTATGGC TTTCCAGAGT CCCGGAAGCG CCGAGAGGCG
GAGTCCTGGA ACTCCGTCTC AGAGGGAAAG CAGCCTAGAT TCTCCCACCG GATTCCGCTG
CTGATCTTTG ATCAGGATGA GAAGGGCAAG GCCAGGGACT TCTTCACAGG GAGGAAGCGG
AAAGTCGGCG GTAGCATCAT TCACAAGGCT TCAAATGTCA TGCACATCGA GTCCAAGCAA
GTGGTGGGAT TCCAACTGTG CTCAAATGAC ACCTCCGACT GTGCCACCTA CACCTTCAGC
TCGGGAATCA ATGCCATTCA GGAGTGGTAT AAGCTACACT ACATGAACAT CATGGCACAG
GTGCCTCTGG AGAAGAAAAT CAACATGAGC TATTCTGCTG AGGAGCTGCT GGTGACCTGC
TTCTTTGATG GAGTGTCCTG TGATGCCAGG AATTTCACGC TTTTCCACCA CCCGATGCAT
GGGAATTGCT ATACTTTCAA CAACAGAGAA AATGAGACCA TTCTCAGCAC CTCCATGGGG
GGCAGCGAAT ATGGGCTGCA AGTCATTTTG TACATAAACG AAGAGGAATA CAACCCATTC
CTCGTGTCCT CCACTGGAGC TAAGGTGATC ATCCATCGGC AGGATGAGTA TCCCTTCGTC
GAAGATGTGG GAACAGAGAT TGAGACAGCA ATGGTCACCT CTATAGGAAT GCACCTGACA
GAGTCCTTCA AGCTGAGTGA GCCCTACAGT CAGTGCACGG AGGACGGGAG TGACGTGCCA
ATCAGGAACA TCTACAACGC TGCCTACTCG CTCCAGATCT GCCTTCATTC ATGCTTCCAG
ACAAAGATGG TGGAGAAATG TGGGTGTGCC CAGTACAGCC AGCCTCTACC TCCTGCAGCC
AACTACTGCA ACTACCAGCA GCACCCCAAC TGGATGTATT GTTACTACCA ACTGCATCGA
GCCTTTGTCC AGGAAGAGCT GGGCTGCCAG TCTGTGTGCA AGGAAGCCTG CAGCTTTAAA
GAGTGGACAC TAACCACAAG CCTGGCACAA TGGCCATCTG TGGTTTCGGA GAAGTGGTTG
CTGCCTGTTC TCACTTGGGA CCAAGGCCGG CAAGTAAACA AAAAGCTCAA CAAGACAGAC
TTGGCCAAAC TCTTGATATT CTACAAAGAC CTGAACCAGA GATCCATCAT GGAGAGCCCA
GCCAACAGTA TTGAGATGCT TCTGTCCAAC TTCGGTGGCC AGCTGGGCCT GTGGATGAGC
TGCTCTGTTG TCTGCGTCAT CGAGATCATC GAGGTCTTCT TCATTGACTT CTTCTCTATC
ATTGCCCGCC GCCAGTGGCA GAAAGCCAAG GAGTGGTGGG CCTGGAAACA GGCTCCCCCA
TGTCCAGAAG CTCCCCGTAG CCCACAGGGC CAGGACAATC CAGCCCTGGA TATAGACGAT
GACCTACCCA CTTTCAACTC TGCTTTGCAC CTGCCTCCAG CCCTAGGAAC CCAAGTGCCC
GGCACACCGC CCCCCAAATA CAATACCTTG CGCTTGGAGA GGGCCTTTTC CAACCAGCTC
ACAGATACCC AGATGCTGGA TGAGCTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.
Gene579(2)95-132(2016 Apr)
Hanukoglu I,Hanukoglu A


book

Assessment of epithelial sodium channel variants in nonwhite cystic fibrosis patients with non-diagnostic CFTR genotypes.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society15(1)52-9(2016 Jan)
Brennan ML,Pique LM,Schrijver I


book

Expression and distribution of epithelial sodium channel in nasal polyp and nasal mucosa.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery272(11)3361-6(2015 Nov)
Jiang Y,Xu J,Chen Y,Shi J,Zhang C,Li J


book

A potential role for interleukin-33 and γ-epithelium sodium channel in the pathogenesis of human malaria associated lung injury.
Malaria journal14389(2015 Oct)
Ampawong S,Chaisri U,Viriyavejakul P,Prapansilp P,Grau GE,Turner GD,Pongponratn E


book

Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease.
Human mutation30(7)1093-103(2009 Jul)
Azad AK,Rauh R,Vermeulen F,Jaspers M,Korbmacher J,Boissier B,Bassinet L,Fichou Y,des Georges M,Stanke F,De Boeck K,Dupont L,Balascáková M,Hjelte L,Lebecque P,Radojkovic D,Castellani C,Schwartz M,Stuhrmann M,Schwarz M,Skalicka V,de Monestrol I,Girodon E,Férec C,Claustres M,Tümmler B,Cassiman JJ,Korbmacher C,Cuppens H


 
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