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SCNN1G cDNA ORF clone, Homo sapiens (human)

Gene Symbol SCNN1G
Entrez Gene ID 6340
Full Name sodium channel, non voltage gated 1 gamma subunit
Synonyms BESC3, ENaCg, ENaCgamma, PHA1, SCNEG
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16p12

Summary Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009]. lac of sum
Disorder MIM:

600761

Disorder Html: Liddle syndrome, 177200 (3); Pseudohypoaldosteronism, type I, 264350

mRNA and Protein(s)

mRNA Protein Name
NM_001039 NP_001030 amiloride-sensitive sodium channel subunit gamma



Homo sapiens (human) SCNN1G NP_001030.2
Pan troglodytes (chimpanzee) SCNN1G XP_003315070.1
Macaca mulatta (Rhesus monkey) SCNN1G XP_001093466.1
Canis lupus familiaris (dog) SCNN1G XP_547093.2
Bos taurus (cattle) SCNN1G NP_001180103.1
Mus musculus (house mouse) Scnn1g NP_035456.1
Rattus norvegicus (Norway rat) Scnn1g NP_058742.1
Gallus gallus (chicken) SCNN1G XP_414880.2
Caenorhabditis elegans deg-1 NP_509311.1
Caenorhabditis elegans unc-105 NP_001254142.1
Caenorhabditis elegans asic-1 NP_491214.3
Caenorhabditis elegans mec-4 NP_510712.2
Caenorhabditis elegans del-4 NP_492230.2
Caenorhabditis elegans del-1 NP_510380.1
Caenorhabditis elegans asic-2 NP_492099.1
Caenorhabditis elegans unc-8 NP_501138.1
Caenorhabditis elegans mec-10 NP_509438.1
Xenopus (Silurana) tropicalis (western clawed frog) scnn1g XP_004918046.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SCNN1G gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SCNN1G cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu17893 NM_001039 Homo sapiens sodium channel, non voltage gated 1 gamma subunit (SCNN1G), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $265.30
$379.00
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu17893
Clone ID Related Accession (Same CDS sequence) NM_001039
Accession Version NM_001039.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1950bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product amiloride-sensitive sodium channel subunit gamma
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC059391.1 and X87160.1. This sequence is a reference standard in the RefSeqGene project. On Jun 15, 2007 this sequence version replaced gi:42476332. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC059391.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
ATGGCACCCG GAGAGAAGAT CAAAGCCAAA ATCAAGAAGA ATCTGCCCGT GACGGGCCCT 
CAGGCGCCGA CCATTAAAGA GCTGATGCGG TGGTACTGCC TCAACACCAA CACCCATGGC
TGTCGCCGCA TCGTGGTGTC CCGCGGCCGT CTGCGCCGCC TCCTCTGGAT CGGGTTCACA
CTGACTGCCG TGGCCCTCAT CCTCTGGCAG TGCGCCCTCC TCGTCTTCTC CTTCTATACT
GTCTCAGTTT CCATCAAAGT CCACTTCCGG AAGCTGGATT TTCCTGCAGT CACCATCTGC
AACATCAACC CCTACAAGTA CAGCACCGTT CGCCACCTTC TAGCTGACTT GGAACAGGAG
ACCAGAGAGG CCCTGAAGTC CCTGTATGGC TTTCCAGAGT CCCGGAAGCG CCGAGAGGCG
GAGTCCTGGA ACTCCGTCTC AGAGGGAAAG CAGCCTAGAT TCTCCCACCG GATTCCGCTG
CTGATCTTTG ATCAGGATGA GAAGGGCAAG GCCAGGGACT TCTTCACAGG GAGGAAGCGG
AAAGTCGGCG GTAGCATCAT TCACAAGGCT TCAAATGTCA TGCACATCGA GTCCAAGCAA
GTGGTGGGAT TCCAACTGTG CTCAAATGAC ACCTCCGACT GTGCCACCTA CACCTTCAGC
TCGGGAATCA ATGCCATTCA GGAGTGGTAT AAGCTACACT ACATGAACAT CATGGCACAG
GTGCCTCTGG AGAAGAAAAT CAACATGAGC TATTCTGCTG AGGAGCTGCT GGTGACCTGC
TTCTTTGATG GAGTGTCCTG TGATGCCAGG AATTTCACGC TTTTCCACCA CCCGATGCAT
GGGAATTGCT ATACTTTCAA CAACAGAGAA AATGAGACCA TTCTCAGCAC CTCCATGGGG
GGCAGCGAAT ATGGGCTGCA AGTCATTTTG TACATAAACG AAGAGGAATA CAACCCATTC
CTCGTGTCCT CCACTGGAGC TAAGGTGATC ATCCATCGGC AGGATGAGTA TCCCTTCGTC
GAAGATGTGG GAACAGAGAT TGAGACAGCA ATGGTCACCT CTATAGGAAT GCACCTGACA
GAGTCCTTCA AGCTGAGTGA GCCCTACAGT CAGTGCACGG AGGACGGGAG TGACGTGCCA
ATCAGGAACA TCTACAACGC TGCCTACTCG CTCCAGATCT GCCTTCATTC ATGCTTCCAG
ACAAAGATGG TGGAGAAATG TGGGTGTGCC CAGTACAGCC AGCCTCTACC TCCTGCAGCC
AACTACTGCA ACTACCAGCA GCACCCCAAC TGGATGTATT GTTACTACCA ACTGCATCGA
GCCTTTGTCC AGGAAGAGCT GGGCTGCCAG TCTGTGTGCA AGGAAGCCTG CAGCTTTAAA
GAGTGGACAC TAACCACAAG CCTGGCACAA TGGCCATCTG TGGTTTCGGA GAAGTGGTTG
CTGCCTGTTC TCACTTGGGA CCAAGGCCGG CAAGTAAACA AAAAGCTCAA CAAGACAGAC
TTGGCCAAAC TCTTGATATT CTACAAAGAC CTGAACCAGA GATCCATCAT GGAGAGCCCA
GCCAACAGTA TTGAGATGCT TCTGTCCAAC TTCGGTGGCC AGCTGGGCCT GTGGATGAGC
TGCTCTGTTG TCTGCGTCAT CGAGATCATC GAGGTCTTCT TCATTGACTT CTTCTCTATC
ATTGCCCGCC GCCAGTGGCA GAAAGCCAAG GAGTGGTGGG CCTGGAAACA GGCTCCCCCA
TGTCCAGAAG CTCCCCGTAG CCCACAGGGC CAGGACAATC CAGCCCTGGA TATAGACGAT
GACCTACCCA CTTTCAACTC TGCTTTGCAC CTGCCTCCAG CCCTAGGAAC CCAAGTGCCC
GGCACACCGC CCCCCAAATA CAATACCTTG CGCTTGGAGA GGGCCTTTTC CAACCAGCTC
ACAGATACCC AGATGCTGGA TGAGCTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001030.2
CDS140..2089
Misc Feature(1)32..34(+)
Misc Feature(2)155..157(+)
Misc Feature(3)161..163(+)
Misc Feature(4)167..169(+)
Misc Feature(5)173..175(+)
Misc Feature(6)176..178(+)
Misc Feature(7)209..2029(+)
Misc Feature(8)215..217(+)
Misc Feature(9)233..1792(+)
Misc Feature(10)305..376(+)
Misc Feature(11)1709..1804(+)
Misc Feature(12)2003..2005(+)
Exon (1)1..95
Gene:SCNN1G
Gene Synonym:
Exon (2)96..456
Gene:SCNN1G
Gene Synonym:
Exon (3)457..757
Gene:SCNN1G
Gene Synonym:
Exon (4)758..948
Gene:SCNN1G
Gene Synonym:
Exon (5)949..1052
Gene:SCNN1G
Gene Synonym:
Exon (6)1053..1216
Gene:SCNN1G
Gene Synonym:
Exon (7)1217..1315
Gene:SCNN1G
Gene Synonym:
Exon (8)1316..1433
Gene:SCNN1G
Gene Synonym:
Exon (9)1434..1512
Gene:SCNN1G
Gene Synonym:
Exon (10)1513..1570
Gene:SCNN1G
Gene Synonym:
Exon (11)1571..1632
Gene:SCNN1G
Gene Synonym:
Exon (12)1633..1708
Gene:SCNN1G
Gene Synonym:
Exon (13)1709..3499
Gene:SCNN1G
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001039
Organism Homo sapiens (human)
Definition Homo sapiens sodium channel, non voltage gated 1 gamma subunit (SCNN1G), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001039

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
ATGGCACCCG GAGAGAAGAT CAAAGCCAAA ATCAAGAAGA ATCTGCCCGT GACGGGCCCT 
CAGGCGCCGA CCATTAAAGA GCTGATGCGG TGGTACTGCC TCAACACCAA CACCCATGGC
TGTCGCCGCA TCGTGGTGTC CCGCGGCCGT CTGCGCCGCC TCCTCTGGAT CGGGTTCACA
CTGACTGCCG TGGCCCTCAT CCTCTGGCAG TGCGCCCTCC TCGTCTTCTC CTTCTATACT
GTCTCAGTTT CCATCAAAGT CCACTTCCGG AAGCTGGATT TTCCTGCAGT CACCATCTGC
AACATCAACC CCTACAAGTA CAGCACCGTT CGCCACCTTC TAGCTGACTT GGAACAGGAG
ACCAGAGAGG CCCTGAAGTC CCTGTATGGC TTTCCAGAGT CCCGGAAGCG CCGAGAGGCG
GAGTCCTGGA ACTCCGTCTC AGAGGGAAAG CAGCCTAGAT TCTCCCACCG GATTCCGCTG
CTGATCTTTG ATCAGGATGA GAAGGGCAAG GCCAGGGACT TCTTCACAGG GAGGAAGCGG
AAAGTCGGCG GTAGCATCAT TCACAAGGCT TCAAATGTCA TGCACATCGA GTCCAAGCAA
GTGGTGGGAT TCCAACTGTG CTCAAATGAC ACCTCCGACT GTGCCACCTA CACCTTCAGC
TCGGGAATCA ATGCCATTCA GGAGTGGTAT AAGCTACACT ACATGAACAT CATGGCACAG
GTGCCTCTGG AGAAGAAAAT CAACATGAGC TATTCTGCTG AGGAGCTGCT GGTGACCTGC
TTCTTTGATG GAGTGTCCTG TGATGCCAGG AATTTCACGC TTTTCCACCA CCCGATGCAT
GGGAATTGCT ATACTTTCAA CAACAGAGAA AATGAGACCA TTCTCAGCAC CTCCATGGGG
GGCAGCGAAT ATGGGCTGCA AGTCATTTTG TACATAAACG AAGAGGAATA CAACCCATTC
CTCGTGTCCT CCACTGGAGC TAAGGTGATC ATCCATCGGC AGGATGAGTA TCCCTTCGTC
GAAGATGTGG GAACAGAGAT TGAGACAGCA ATGGTCACCT CTATAGGAAT GCACCTGACA
GAGTCCTTCA AGCTGAGTGA GCCCTACAGT CAGTGCACGG AGGACGGGAG TGACGTGCCA
ATCAGGAACA TCTACAACGC TGCCTACTCG CTCCAGATCT GCCTTCATTC ATGCTTCCAG
ACAAAGATGG TGGAGAAATG TGGGTGTGCC CAGTACAGCC AGCCTCTACC TCCTGCAGCC
AACTACTGCA ACTACCAGCA GCACCCCAAC TGGATGTATT GTTACTACCA ACTGCATCGA
GCCTTTGTCC AGGAAGAGCT GGGCTGCCAG TCTGTGTGCA AGGAAGCCTG CAGCTTTAAA
GAGTGGACAC TAACCACAAG CCTGGCACAA TGGCCATCTG TGGTTTCGGA GAAGTGGTTG
CTGCCTGTTC TCACTTGGGA CCAAGGCCGG CAAGTAAACA AAAAGCTCAA CAAGACAGAC
TTGGCCAAAC TCTTGATATT CTACAAAGAC CTGAACCAGA GATCCATCAT GGAGAGCCCA
GCCAACAGTA TTGAGATGCT TCTGTCCAAC TTCGGTGGCC AGCTGGGCCT GTGGATGAGC
TGCTCTGTTG TCTGCGTCAT CGAGATCATC GAGGTCTTCT TCATTGACTT CTTCTCTATC
ATTGCCCGCC GCCAGTGGCA GAAAGCCAAG GAGTGGTGGG CCTGGAAACA GGCTCCCCCA
TGTCCAGAAG CTCCCCGTAG CCCACAGGGC CAGGACAATC CAGCCCTGGA TATAGACGAT
GACCTACCCA CTTTCAACTC TGCTTTGCAC CTGCCTCCAG CCCTAGGAAC CCAAGTGCCC
GGCACACCGC CCCCCAAATA CAATACCTTG CGCTTGGAGA GGGCCTTTTC CAACCAGCTC
ACAGATACCC AGATGCTGGA TGAGCTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Cysteine palmitoylation of the gamma subunit has a dominant role in modulating activity of the epithelial sodium channel
J. Biol. Chem. 289 (20), 14351-14359 (2014)
Mukherjee A, Mueller GM, Kinlough CL, Sheng N, Wang Z, Mustafa SA, Kashlan OB, Kleyman TR and Hughey RP.


book

Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures
Am. J. Physiol. Lung Cell Mol. Physiol. 305 (12), L990-L1001 (2013)
Hobbs CA, Blanchard MG, Alijevic O, Tan CD, Kellenberger S, Bencharit S, Cao R, Kesimer M, Walton WG, Henderson AG, Redinbo MR, Stutts MJ and Tarran R.


book

WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination
Am. J. Physiol. Renal Physiol. 305 (1), F31-F41 (2013)
Yu L, Cai H, Yue Q, Alli AA, Wang D, Al-Khalili O, Bao HF and Eaton DC.


book

Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta
Placenta 34 (2), 197-200 (2013)
Marino GI and Kotsias BA.


book

Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease
Hum. Mutat. 30 (7), 1093-1103 (2009)
Azad AK, Rauh R, Vermeulen F, Jaspers M, Korbmacher J, Boissier B, Bassinet L, Fichou Y, des Georges M, Stanke F, De Boeck K, Dupont L, Balascakova M, Hjelte L, Lebecque P, Radojkovic D, Castellani C, Schwartz M, Stuhrmann M, Schwarz M, Skalicka V, de Monestrol I, Girodon E, Ferec C, Claustres M, Tummler B, Cassiman JJ, Korbmacher C and Cuppens H.


book

Novel mutations responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel alpha-, beta-, and gamma-subunit genes
J. Clin. Endocrinol. Metab. 87 (7), 3344-3350 (2002)
Saxena A, Hanukoglu I, Saxena D, Thompson RJ, Gardiner RM and Hanukoglu A.


book

Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel
J. Biol. Chem. 270 (46), 27411-27414 (1995)
Waldmann R, Champigny G, Bassilana F, Voilley N and Lazdunski M.


book

Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome
Nat. Genet. 11 (1), 76-82 (1995)
Hansson JH, Nelson-Williams C, Suzuki H, Schild L, Shimkets R, Lu Y, Canessa C, Iwasaki T, Rossier B and Lifton RP.


book

Cloning, chromosomal localization, and physical linkage of the beta and gamma subunits (SCNN1B and SCNN1G) of the human epithelial amiloride-sensitive sodium channel
Genomics 28 (3), 560-565 (1995)
Voilley N, Bassilana F, Mignon C, Merscher S, Mattei MG, Carle GF, Lazdunski M and Barbry P.


book

Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel
Am. J. Physiol. 268 (5 PT 1), C1157-C1163 (1995)
McDonald FJ, Price MP, Snyder PM and Welsh MJ.


 
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