• English
  • Sign In
    Please Sign In
    Sign In
    New to GenScript?
    Register
  • Contact Us
×
Contact us now: +1-877-436-7274

SCO1 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol SCO1
Entrez Gene ID 6341
Full Name SCO1, cytochrome c oxidase assembly protein
Synonyms SCOD1
General protein information
Preferred Names

SCO1, cytochrome c oxidase assembly protein

Names

protein SCO1 homolog, mitochondrial
SCO cytochrome oxidase deficient homolog 1
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

17

17p13.1
Summary Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. [provided by RefSeq, Jul 2008].
Disorder MIM:

603644

Disorder Html: Mitochondrial complex IV deficiency, 220110 (3)

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_005256751.3 XP_005256808.1 protein SCO1 homolog, mitochondrial isoform X1
NM_004589.3 NP_004580.1 protein SCO1 homolog, mitochondrial
XM_005256751.4 XP_005256808.1 protein SCO1 homolog, mitochondrial isoform X1
NM_004589.4 NP_004580.1 protein SCO1 homolog, mitochondrial

Pathways from BioSystems


Homologies


Canis lupus familiaris (dog) SCO1 XP_546624.3
Bos taurus (cattle) SCO1 NP_001073712.1
Drosophila melanogaster (fruit fly) Scox NP_608884.1
Schizosaccharomyces pombe (fission yeast) sco1 NP_595287.1
Oryza sativa (rice) Os02g0159700 NP_001045964.1
Mus musculus (house mouse) Sco1 NP_001035115.1
Danio rerio (zebrafish) LOC796572 XP_005164365.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP008774 XP_314900.3
Caenorhabditis elegans (roundworm) sco-1 NP_494755.1
Saccharomyces cerevisiae (baker's yeast) SCO1 NP_009593.1
Homo sapiens (human) SCO1 NP_004580.1
Rattus norvegicus (Norway rat) Sco1 NP_001166845.1
Gallus gallus (chicken) SCO1 XP_004946120.1
Xenopus tropicalis (tropical clawed frog) LOC100494754 XP_002937049.2
LOC722074 XP_001118271.1
Magnaporthe oryzae (rice blast fungus) MGG_03006 XP_003720686.1
Neurospora crassa NCU03177 XP_964583.2
Arabidopsis thaliana (thale cress) AT3G08950 NP_566339.1
Pan troglodytes (chimpanzee) SCO1 XP_001164786.1
Kluyveromyces lactis KLLA0D03630g XP_453226.1
Eremothecium gossypii AGOS_AEL191C NP_984670.2

Gene Ontology


Bibliography

Related articles in PubMed

The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.
Lorenzi I, Oeljeklaus S, Aich A, Rons?r C, Callegari S, Dudek J, Warscheid B, Dennerlein S, Rehling P
Biochimica et biophysica acta1865(2)323-333(2018 Feb)

Human mitochondrial cytochrome
Bourens M, Barrientos A
The Journal of biological chemistry292(19)7774-7783(2017 05)

Loop recognition and copper-mediated disulfide reduction underpin metal site assembly of CuA in human cytochrome oxidase.
Morgada MN, Abriata LA, Cefaro C, Gajda K, Banci L, Vila AJ
Proceedings of the National Academy of Sciences of the United States of America112(38)11771-6(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results find that COA6 associates with COX2 and is crucial for its maturation and complex IV biogenesis. Also, COA6 interacts with the copper chaperone SCO1 which indicates that COA6 is intrinsically involved in the copper delivery process for COX2.
Title: COA6 is a mitochondrial complex IV assembly factor critical for biogenesis of mtDNA-encoded COX2.

Sco1 is a metallochaperone that selectively transfers Cu(I) ions based on loop recognition, whereas Sco2 is a copper-dependent thiol reductase of the cysteine ligands in the oxidase.
Title: Loop recognition and copper-mediated disulfide reduction underpin metal site assembly of CuA in human cytochrome oxidase.

COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase.
Title: Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase.

COX19 is necessary for the transduction of a SCO1-dependent mitochondrial redox signal that regulates ATP7A-mediated cellular copper efflux.
Title: COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following SCO1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SCO1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu23341 NM_004589.4
Latest version!		 Homo sapiens synthesis of cytochrome C oxidase 1 (SCO1), mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$154.50-$216.30
$309.00
OHu49910 XM_005256751.4
Latest version!		 Homo sapiens SCO1, cytochrome c oxidase assembly protein (SCO1), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 5-7 $69.30
$99.00
View Old Accession Versions >>
OHu49910 XM_005256751.3 Homo sapiens SCO1 cytochrome c oxidase assembly protein (SCO1), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 5-7 $69.30
$99.00
OHu23341 NM_004589.3 Homo sapiens SCO1, cytochrome c oxidase assembly protein (SCO1), mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$154.50-$216.30
$309.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu23341
Clone ID Related Accession (Same CDS sequence) NM_004589.3 , NM_004589.4
Accession Version NM_004589.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 906bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-12-27
Organism Homo sapiens(human)
Product protein SCO1 homolog, mitochondrial
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA571370.1, BC015504.2, KC877631.1, BM981070.1 and BM994602.1. This sequence is a reference standard in the RefSeqGene project. On Jan 17, 2014 this sequence version replaced NM_004589.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.551550.1, SRR1803615.241066.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCGATGC TGGTCCTAGT ACCCGGACGA GTTATGCGGC CTCTGGGTGG CCAACTTTGG 
CGCTTCTTGC CTCGCGGACT CGAGTTTTGG GGCCCAGCCG AGGGGACTGC GAGAGTCTTG 
CTGAGGCAGT TCTGCGCGCG GCAAGCGGAG GCGTGGCGTG CCTCGGGGCG CCCTGGCTAT 
TGCCTGGGAA CCCGGCCCCT CAGCACTGCG AGGCCGCCAC CCCCGTGGTC GCAGAAGGGC 
CCCGGAGACT CCACGCGCCC CTCGAAGCCC GGGCCTGTTT CCTGGAAGTC TTTAGCAATC 
ACATTTGCTA TTGGAGGAGC TTTACTGGCT GGAATGAAGC ACGTCAAGAA AGAAAAGGCA 
GAGAAGTTAG AGAAGGAACG GCAGCGACAC ATCGGCAAGC CTTTACTTGG GGGACCGTTT 
TCCCTCACAA CTCATACTGG GGAGCGTAAA ACTGACAAGG ACTACTTGGG TCAGTGGTTA 
TTGATTTATT TTGGCTTCAC TCATTGCCCT GATGTCTGTC CAGAAGAACT AGAAAAGATG 
ATTCAAGTCG TGGATGAAAT AGATAGCATT ACAACTCTGC CAGATCTAAC TCCACTTTTC 
ATCAGCATTG ACCCAGAGAG GGACACAAAA GAAGCCATCG CAAATTATGT GAAAGAATTT 
TCTCCCAAAC TGGTTGGCTT GACTGGCACG AGAGAAGAGG TCGATCAAGT GGCCAGAGCA 
TACAGAGTGT ATTACAGCCC TGGCCCCAAG GACGAAGATG AAGACTACAT AGTGGATCAC 
ACAATAATAA TGTACTTGAT TGGACCAGAT GGTGAGTTTC TAGATTATTT TGGCCAGAAC 
AAGAGGAAGG GAGAAATAGC TGCTTCAATT GCCACACACA TGAGGCCATA CAGAAAAAAG 
AGCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004580.1
CDS62..967
Translation

Target ORF information:

RefSeq Version NM_004589.3
Organism Homo sapiens(human)
Definition Homo sapiens SCO1, cytochrome c oxidase assembly protein (SCO1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_004589.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCGATGC TGGTCCTAGT ACCCGGACGA GTTATGCGGC CTCTGGGTGG CCAACTTTGG 
CGCTTCTTGC CTCGCGGACT CGAGTTTTGG GGCCCAGCCG AGGGGACTGC GAGAGTCTTG 
CTGAGGCAGT TCTGCGCGCG GCAAGCGGAG GCGTGGCGTG CCTCGGGGCG CCCTGGCTAT 
TGCCTGGGAA CCCGGCCCCT CAGCACTGCG AGGCCGCCAC CCCCGTGGTC GCAGAAGGGC 
CCCGGAGACT CCACGCGCCC CTCGAAGCCC GGGCCTGTTT CCTGGAAGTC TTTAGCAATC 
ACATTTGCTA TTGGAGGAGC TTTACTGGCT GGAATGAAGC ACGTCAAGAA AGAAAAGGCA 
GAGAAGTTAG AGAAGGAACG GCAGCGACAC ATCGGCAAGC CTTTACTTGG GGGACCGTTT 
TCCCTCACAA CTCATACTGG GGAGCGTAAA ACTGACAAGG ACTACTTGGG TCAGTGGTTA 
TTGATTTATT TTGGCTTCAC TCATTGCCCT GATGTCTGTC CAGAAGAACT AGAAAAGATG 
ATTCAAGTCG TGGATGAAAT AGATAGCATT ACAACTCTGC CAGATCTAAC TCCACTTTTC 
ATCAGCATTG ACCCAGAGAG GGACACAAAA GAAGCCATCG CAAATTATGT GAAAGAATTT 
TCTCCCAAAC TGGTTGGCTT GACTGGCACG AGAGAAGAGG TCGATCAAGT GGCCAGAGCA 
TACAGAGTGT ATTACAGCCC TGGCCCCAAG GACGAAGATG AAGACTACAT AGTGGATCAC 
ACAATAATAA TGTACTTGAT TGGACCAGAT GGTGAGTTTC TAGATTATTT TGGCCAGAAC 
AAGAGGAAGG GAGAAATAGC TGCTTCAATT GCCACACACA TGAGGCCATA CAGAAAAAAG 
AGCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23341
Clone ID Related Accession (Same CDS sequence) NM_004589.3 , NM_004589.4
Accession Version NM_004589.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 906bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-05
Organism Homo sapiens(human)
Product protein SCO1 homolog, mitochondrial
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA571370.1, BC015504.2, KC877631.1, BM981070.1, BM994602.1 and AC002347.3. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004589.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.206426.1, SRR1803615.241066.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000255390.10/ ENSP00000255390.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCGATGC TGGTCCTAGT ACCCGGACGA GTTATGCGGC CTCTGGGTGG CCAACTTTGG 
CGCTTCTTGC CTCGCGGACT CGAGTTTTGG GGCCCAGCCG AGGGGACTGC GAGAGTCTTG 
CTGAGGCAGT TCTGCGCGCG GCAAGCGGAG GCGTGGCGTG CCTCGGGGCG CCCTGGCTAT 
TGCCTGGGAA CCCGGCCCCT CAGCACTGCG AGGCCGCCAC CCCCGTGGTC GCAGAAGGGC 
CCCGGAGACT CCACGCGCCC CTCGAAGCCC GGGCCTGTTT CCTGGAAGTC TTTAGCAATC 
ACATTTGCTA TTGGAGGAGC TTTACTGGCT GGAATGAAGC ACGTCAAGAA AGAAAAGGCA 
GAGAAGTTAG AGAAGGAACG GCAGCGACAC ATCGGCAAGC CTTTACTTGG GGGACCGTTT 
TCCCTCACAA CTCATACTGG GGAGCGTAAA ACTGACAAGG ACTACTTGGG TCAGTGGTTA 
TTGATTTATT TTGGCTTCAC TCATTGCCCT GATGTCTGTC CAGAAGAACT AGAAAAGATG 
ATTCAAGTCG TGGATGAAAT AGATAGCATT ACAACTCTGC CAGATCTAAC TCCACTTTTC 
ATCAGCATTG ACCCAGAGAG GGACACAAAA GAAGCCATCG CAAATTATGT GAAAGAATTT 
TCTCCCAAAC TGGTTGGCTT GACTGGCACG AGAGAAGAGG TCGATCAAGT GGCCAGAGCA 
TACAGAGTGT ATTACAGCCC TGGCCCCAAG GACGAAGATG AAGACTACAT AGTGGATCAC 
ACAATAATAA TGTACTTGAT TGGACCAGAT GGTGAGTTTC TAGATTATTT TGGCCAGAAC 
AAGAGGAAGG GAGAAATAGC TGCTTCAATT GCCACACACA TGAGGCCATA CAGAAAAAAG 
AGCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004580.1
CDS27..932
Translation

Target ORF information:

RefSeq Version NM_004589.4
Organism Homo sapiens(human)
Definition Homo sapiens synthesis of cytochrome C oxidase 1 (SCO1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_004589.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCGATGC TGGTCCTAGT ACCCGGACGA GTTATGCGGC CTCTGGGTGG CCAACTTTGG 
CGCTTCTTGC CTCGCGGACT CGAGTTTTGG GGCCCAGCCG AGGGGACTGC GAGAGTCTTG 
CTGAGGCAGT TCTGCGCGCG GCAAGCGGAG GCGTGGCGTG CCTCGGGGCG CCCTGGCTAT 
TGCCTGGGAA CCCGGCCCCT CAGCACTGCG AGGCCGCCAC CCCCGTGGTC GCAGAAGGGC 
CCCGGAGACT CCACGCGCCC CTCGAAGCCC GGGCCTGTTT CCTGGAAGTC TTTAGCAATC 
ACATTTGCTA TTGGAGGAGC TTTACTGGCT GGAATGAAGC ACGTCAAGAA AGAAAAGGCA 
GAGAAGTTAG AGAAGGAACG GCAGCGACAC ATCGGCAAGC CTTTACTTGG GGGACCGTTT 
TCCCTCACAA CTCATACTGG GGAGCGTAAA ACTGACAAGG ACTACTTGGG TCAGTGGTTA 
TTGATTTATT TTGGCTTCAC TCATTGCCCT GATGTCTGTC CAGAAGAACT AGAAAAGATG 
ATTCAAGTCG TGGATGAAAT AGATAGCATT ACAACTCTGC CAGATCTAAC TCCACTTTTC 
ATCAGCATTG ACCCAGAGAG GGACACAAAA GAAGCCATCG CAAATTATGT GAAAGAATTT 
TCTCCCAAAC TGGTTGGCTT GACTGGCACG AGAGAAGAGG TCGATCAAGT GGCCAGAGCA 
TACAGAGTGT ATTACAGCCC TGGCCCCAAG GACGAAGATG AAGACTACAT AGTGGATCAC 
ACAATAATAA TGTACTTGAT TGGACCAGAT GGTGAGTTTC TAGATTATTT TGGCCAGAAC 
AAGAGGAAGG GAGAAATAGC TGCTTCAATT GCCACACACA TGAGGCCATA CAGAAAAAAG 
AGCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu49910
Clone ID Related Accession (Same CDS sequence) XM_005256751.3 , XM_005256751.4
Accession Version XM_005256751.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 573bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product protein SCO1 homolog, mitochondrial isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005256751.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
ATGAAGCACG TCAAGAAAGA AAAGGCAGAG AAGTTAGAGA AGGAACGGCA GCGACACATC 
GGCAAGCCTT TACTTGGGGG ACCGTTTTCC CTCACAACTC ATACTGGGGA GCGTAAAACT 
GACAAGGACT ACTTGGGTCA GTGGTTATTG ATTTATTTTG GCTTCACTCA TTGCCCTGAT 
GTCTGTCCAG AAGAACTAGA AAAGATGATT CAAGTCGTGG ATGAAATAGA TAGCATTACA 
ACTCTGCCAG ATCTAACTCC ACTTTTCATC AGCATTGACC CAGAGAGGGA CACAAAAGAA 
GCCATCGCAA ATTATGTGAA AGAATTTTCT CCCAAACTGG TTGGCTTGAC TGGCACGAGA 
GAAGAGGTCG ATCAAGTGGC CAGAGCATAC AGAGTGTATT ACAGCCCTGG CCCCAAGGAC 
GAAGATGAAG ACTACATAGT GGATCACACA ATAATAATGT ACTTGATTGG ACCAGATGGT 
GAGTTTCTAG ATTATTTTGG CCAGAACAAG AGGAAGGGAG AAATAGCTGC TTCAATTGCC 
ACACACATGA GGCCATACAG AAAAAAGAGC TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005256808.1
CDS362..934
Translation

Target ORF information:

RefSeq Version XM_005256751.3
Organism Homo sapiens(human)
Definition Homo sapiens SCO1 cytochrome c oxidase assembly protein (SCO1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_005256751.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGAAGCACG TCAAGAAAGA AAAGGCAGAG AAGTTAGAGA AGGAACGGCA GCGACACATC 
GGCAAGCCTT TACTTGGGGG ACCGTTTTCC CTCACAACTC ATACTGGGGA GCGTAAAACT 
GACAAGGACT ACTTGGGTCA GTGGTTATTG ATTTATTTTG GCTTCACTCA TTGCCCTGAT 
GTCTGTCCAG AAGAACTAGA AAAGATGATT CAAGTCGTGG ATGAAATAGA TAGCATTACA 
ACTCTGCCAG ATCTAACTCC ACTTTTCATC AGCATTGACC CAGAGAGGGA CACAAAAGAA 
GCCATCGCAA ATTATGTGAA AGAATTTTCT CCCAAACTGG TTGGCTTGAC TGGCACGAGA 
GAAGAGGTCG ATCAAGTGGC CAGAGCATAC AGAGTGTATT ACAGCCCTGG CCCCAAGGAC 
GAAGATGAAG ACTACATAGT GGATCACACA ATAATAATGT ACTTGATTGG ACCAGATGGT 
GAGTTTCTAG ATTATTTTGG CCAGAACAAG AGGAAGGGAG AAATAGCTGC TTCAATTGCC 
ACACACATGA GGCCATACAG AAAAAAGAGC TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu49910
Clone ID Related Accession (Same CDS sequence) XM_005256751.3 , XM_005256751.4
Accession Version XM_005256751.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 573bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-03-25
Organism Homo sapiens(human)
Product protein SCO1 homolog, mitochondrial isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005256751.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
ATGAAGCACG TCAAGAAAGA AAAGGCAGAG AAGTTAGAGA AGGAACGGCA GCGACACATC 
GGCAAGCCTT TACTTGGGGG ACCGTTTTCC CTCACAACTC ATACTGGGGA GCGTAAAACT 
GACAAGGACT ACTTGGGTCA GTGGTTATTG ATTTATTTTG GCTTCACTCA TTGCCCTGAT 
GTCTGTCCAG AAGAACTAGA AAAGATGATT CAAGTCGTGG ATGAAATAGA TAGCATTACA 
ACTCTGCCAG ATCTAACTCC ACTTTTCATC AGCATTGACC CAGAGAGGGA CACAAAAGAA 
GCCATCGCAA ATTATGTGAA AGAATTTTCT CCCAAACTGG TTGGCTTGAC TGGCACGAGA 
GAAGAGGTCG ATCAAGTGGC CAGAGCATAC AGAGTGTATT ACAGCCCTGG CCCCAAGGAC 
GAAGATGAAG ACTACATAGT GGATCACACA ATAATAATGT ACTTGATTGG ACCAGATGGT 
GAGTTTCTAG ATTATTTTGG CCAGAACAAG AGGAAGGGAG AAATAGCTGC TTCAATTGCC 
ACACACATGA GGCCATACAG AAAAAAGAGC TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005256808.1
CDS362..934
Translation

Target ORF information:

RefSeq Version XM_005256751.4
Organism Homo sapiens(human)
Definition Homo sapiens SCO1, cytochrome c oxidase assembly protein (SCO1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_005256751.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGAAGCACG TCAAGAAAGA AAAGGCAGAG AAGTTAGAGA AGGAACGGCA GCGACACATC 
GGCAAGCCTT TACTTGGGGG ACCGTTTTCC CTCACAACTC ATACTGGGGA GCGTAAAACT 
GACAAGGACT ACTTGGGTCA GTGGTTATTG ATTTATTTTG GCTTCACTCA TTGCCCTGAT 
GTCTGTCCAG AAGAACTAGA AAAGATGATT CAAGTCGTGG ATGAAATAGA TAGCATTACA 
ACTCTGCCAG ATCTAACTCC ACTTTTCATC AGCATTGACC CAGAGAGGGA CACAAAAGAA 
GCCATCGCAA ATTATGTGAA AGAATTTTCT CCCAAACTGG TTGGCTTGAC TGGCACGAGA 
GAAGAGGTCG ATCAAGTGGC CAGAGCATAC AGAGTGTATT ACAGCCCTGG CCCCAAGGAC 
GAAGATGAAG ACTACATAGT GGATCACACA ATAATAATGT ACTTGATTGG ACCAGATGGT 
GAGTTTCTAG ATTATTTTGG CCAGAACAAG AGGAAGGGAG AAATAGCTGC TTCAATTGCC 
ACACACATGA GGCCATACAG AAAAAAGAGC TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.
Biochimica et biophysica acta1865(2)323-333(2018 Feb)
Lorenzi I,Oeljeklaus S,Aich A,Rons?r C,Callegari S,Dudek J,Warscheid B,Dennerlein S,Rehling P


book

Human mitochondrial cytochrome
The Journal of biological chemistry292(19)7774-7783(2017 05)
Bourens M,Barrientos A


book

Loop recognition and copper-mediated disulfide reduction underpin metal site assembly of CuA in human cytochrome oxidase.
Proceedings of the National Academy of Sciences of the United States of America112(38)11771-6(2015 Sep)
Morgada MN,Abriata LA,Cefaro C,Gajda K,Banci L,Vila AJ