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CCL20 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CCL20
Entrez Gene ID 6364
Full Name chemokine (C-C motif) ligand 20
Synonyms CKb4, Exodus, LARC, MIP-3-alpha, MIP-3a, MIP3A, SCYA20, ST38
General protein information
Preferred Names
C-C motif chemokine 20
Names
C-C motif chemokine 20
CC chemokine LARC
beta chemokine exodus-1
small-inducible cytokine A20
macrophage inflammatory protein 3 alpha
liver and activation-regulated chemokine
small inducible cytokine subfamily A (Cys-Cys), member 20
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q36.3

Summary This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]. lac of sum
Disorder MIM:

601960


mRNA and Protein(s)

mRNA Protein Name
NM_004591 NP_004582 C-C motif chemokine 20 isoform 1 precursor
NM_001130046 NP_001123518 C-C motif chemokine 20 isoform 2 precursor



Homo sapiens (human) CCL20 NP_001123518.1
Pan troglodytes (chimpanzee) CCL20 XP_516133.2
Macaca mulatta (Rhesus monkey) CCL20 NP_001028026.1
Canis lupus familiaris (dog) CCL20 NP_001005254.1
Bos taurus (cattle) CCL20 NP_776688.1
Mus musculus (house mouse) Ccl20 NP_058656.1
Rattus norvegicus (Norway rat) Ccl20 NP_062106.1
Gallus gallus (chicken) CCL20 NP_989769.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CCL20 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL20 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu09144
NM_004591 Homo sapiens chemokine (C-C motif) ligand 20 (CCL20), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu09153
NM_001130046 Homo sapiens chemokine (C-C motif) ligand 20 (CCL20), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu09144
Clone ID Related Accession (Same CDS sequence) NM_004591
Accession Version NM_004591.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 291bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product C-C motif chemokine 20 isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D17012.1, D86955.1, U77035.1 and U64197.1. On Jul 12, 2008 this sequence version replaced gi:4759075. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: CD523297.1, D86955.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
ATGTGCTGTA CCAAGAGTTT GCTCCTGGCT GCTTTGATGT CAGTGCTGCT ACTCCACCTC 
TGCGGCGAAT CAGAAGCAGC AAGCAACTTT GACTGCTGTC TTGGATACAC AGACCGTATT
CTTCATCCTA AATTTATTGT GGGCTTCACA CGGCAGCTGG CCAATGAAGG CTGTGACATC
AATGCTATCA TCTTTCACAC AAAGAAAAAG TTGTCTGTGT GCGCAAATCC AAAACAGACT
TGGGTGAAAT ATATTGTGCG TCTCCTCAGT AAAAAAGTCA AGAACATGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004582.1
CDS71..361
Misc Feature(1)41..43(+)
Misc Feature(2)158..340(+)
Misc Feature(3)161..172(+)
Misc Feature(4)164..340(+)
Misc Feature(5)170..340(+)
Misc Feature(6)170..292(+)
Misc Feature(7)170..289(+)
Misc Feature(8)170..205(+)
Misc Feature(9)176..340(+)
Misc Feature(10)182..283(+)
Misc Feature(11)221..331(+)
Misc Feature(12)239..244(+)
Misc Feature(13)269..277(+)
Exon (1)1..146
Gene:CCL20
Gene Synonym:
Exon (2)147..261
Gene:CCL20
Gene Synonym:
Exon (3)262..339
Gene:CCL20
Gene Synonym:
Exon (4)340..842
Gene:CCL20
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_004591
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-C motif) ligand 20 (CCL20), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004591

ORF Insert Sequence:

1
61
121
181
241
ATGTGCTGTA CCAAGAGTTT GCTCCTGGCT GCTTTGATGT CAGTGCTGCT ACTCCACCTC 
TGCGGCGAAT CAGAAGCAGC AAGCAACTTT GACTGCTGTC TTGGATACAC AGACCGTATT
CTTCATCCTA AATTTATTGT GGGCTTCACA CGGCAGCTGG CCAATGAAGG CTGTGACATC
AATGCTATCA TCTTTCACAC AAAGAAAAAG TTGTCTGTGT GCGCAAATCC AAAACAGACT
TGGGTGAAAT ATATTGTGCG TCTCCTCAGT AAAAAAGTCA AGAACATGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu09153
Clone ID Related Accession (Same CDS sequence) NM_001130046
Accession Version NM_001130046.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 288bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product C-C motif chemokine 20 isoform 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC020698.1, U77035.1 and U64197.1. Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: BC020698.1, BG534134.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
ATGTGCTGTA CCAAGAGTTT GCTCCTGGCT GCTTTGATGT CAGTGCTGCT ACTCCACCTC 
TGCGGCGAAT CAGAAGCAAG CAACTTTGAC TGCTGTCTTG GATACACAGA CCGTATTCTT
CATCCTAAAT TTATTGTGGG CTTCACACGG CAGCTGGCCA ATGAAGGCTG TGACATCAAT
GCTATCATCT TTCACACAAA GAAAAAGTTG TCTGTGTGCG CAAATCCAAA ACAGACTTGG
GTGAAATATA TTGTGCGTCT CCTCAGTAAA AAAGTCAAGA ACATGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001123518.1
CDS71..358
Misc Feature(1)41..43(+)
Misc Feature(2)155..337(+)
Misc Feature(3)158..169(+)
Misc Feature(4)161..337(+)
Misc Feature(5)167..337(+)
Misc Feature(6)167..289(+)
Misc Feature(7)167..286(+)
Misc Feature(8)167..202(+)
Misc Feature(9)173..337(+)
Misc Feature(10)179..280(+)
Misc Feature(11)218..328(+)
Misc Feature(12)236..241(+)
Misc Feature(13)266..274(+)
Exon (1)1..146
Gene:CCL20
Gene Synonym:
Exon (2)147..258
Gene:CCL20
Gene Synonym:
Exon (3)259..336
Gene:CCL20
Gene Synonym:
Exon (4)337..839
Gene:CCL20
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001130046
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-C motif) ligand 20 (CCL20), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001130046

ORF Insert Sequence:

1
61
121
181
241
ATGTGCTGTA CCAAGAGTTT GCTCCTGGCT GCTTTGATGT CAGTGCTGCT ACTCCACCTC 
TGCGGCGAAT CAGAAGCAAG CAACTTTGAC TGCTGTCTTG GATACACAGA CCGTATTCTT
CATCCTAAAT TTATTGTGGG CTTCACACGG CAGCTGGCCA ATGAAGGCTG TGACATCAAT
GCTATCATCT TTCACACAAA GAAAAAGTTG TCTGTGTGCG CAAATCCAAA ACAGACTTGG
GTGAAATATA TTGTGCGTCT CCTCAGTAAA AAAGTCAAGA ACATGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

CCL20 and CXCL8 synergize to promote progression and poor survival outcome in patients with colorectal cancer by collaborative induction of the epithelial-mesenchymal transition
Cancer Lett. 348 (1-2), 77-87 (2014)
Cheng XS, Li YF, Tan J, Sun B, Xiao YC, Fang XB, Zhang XF, Li Q, Dong JH, Li M, Qian HH, Yin ZF and Yang ZB.


book

Dermal clusters of mature dendritic cells and T cells are associated with the CCL20/CCR6 chemokine system in chronic psoriasis
J. Invest. Dermatol. 134 (5), 1462-1465 (2014)
Kim TG, Jee H, Fuentes-Duculan J, Wu WH, Byamba D, Kim DS, Kim DY, Lew DH, Yang WI, Krueger JG and Lee MG.


book

miR-21 and its target gene CCL20 are both highly overexpressed in the microenvironment of colorectal tumors: significance of their regulation
Oncol. Rep. 30 (3), 1285-1292 (2013)
Vicinus B, Rubie C, Stegmaier N, Frick VO, Kolsch K, Kauffels A, Ghadjar P, Wagner M and Glanemann M.


book

CCR6/CCL20 chemokine expression profile in distinct colorectal malignancies
Scand. J. Immunol. 78 (3), 298-305 (2013)
Frick VO, Rubie C, Kolsch K, Wagner M, Ghadjar P, Graeber S and Glanemann M.


book

Chemokine (C-C motif) ligand 20, a potential biomarker for Graves' disease, is regulated by osteopontin
PLoS ONE 8 (5), E64277 (2013)
Li X, Qi Y, Ma X, Huang F, Guo H, Jiang X, Hong J, Lin D, Cui B, Ning G, Xu L and Wang S.


book

Many chemokines including CCL20/MIP-3alpha display antimicrobial activity
J. Leukoc. Biol. 74 (3), 448-455 (2003)
Yang D, Chen Q, Hoover DM, Staley P, Tucker KD, Lubkowski J and Oppenheim JJ.


book

Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC
J. Biol. Chem. 272 (23), 14893-14898 (1997)
Baba M, Imai T, Nishimura M, Kakizaki M, Takagi S, Hieshima K, Nomiyama H and Yoshie O.


book

Cloning and characterization of exodus, a novel beta-chemokine
Blood 89 (9), 3315-3322 (1997)
Hromas R, Gray PW, Chantry D, Godiska R, Krathwohl M, Fife K, Bell GI, Takeda J, Aronica S, Gordon M, Cooper S, Broxmeyer HE and Klemsz MJ.


book

Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2
J. Biol. Chem. 272 (9), 5846-5853 (1997)
Hieshima K, Imai T, Opdenakker G, Van Damme J, Kusuda J, Tei H, Sakaki Y, Takatsuki K, Miura R, Yoshie O and Nomiyama H.


book

Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta
J. Immunol. 158 (3), 1033-1036 (1997)
Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK and Zlotnik A.


 
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