×

CX3CL1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol CX3CL1
Entrez Gene ID 6376
Full Name C-X3-C motif chemokine ligand 1
Synonyms ABCD-3,C3Xkine,CXC3,CXC3C,NTN,NTT,SCYD1,fractalkine,neurotactin
General protein information
Preferred Names

C-X3-C motif chemokine ligand 1

Names

fractalkine
C-X3-C motif chemokine 1
CX3C membrane-anchored chemokine
chemokine (C-X3-C motif) ligand 1
small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin)
small inducible cytokine subfamily D (Cys-X3-Cys), member-1
small-inducible cytokine D1

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

16

16q21

Disorder MIM:

601880


mRNA and Protein(s)

mRNA Protein Name
NM_002996.4 NP_002987.1 fractalkine isoform 1 precursor
NM_001304392.1 NP_001291321.1 fractalkine isoform 2



Macaca mulatta (rhesus monkey) CX3CL1 NP_001028053.1
Rattus norvegicus (Norway rat) Cx3cl1 NP_604450.1
Mus musculus (house mouse) Cx3cl1 NP_033168.2
Canis lupus familiaris (dog) CX3CL1 XP_005617579.1
Homo sapiens (human) CX3CL1 NP_002987.1
Pan troglodytes (chimpanzee) CX3CL1 XP_510989.2
Bos taurus (cattle) CX3CL1 XP_002694931.1


Related articles in PubMed

CX3CL1--a macrophage chemoattractant induced by a single bout of exercise in human skeletal muscle.
Strömberg A, Olsson K, Dijksterhuis JP, Rullman E, Schulte G, Gustafsson T
American journal of physiology. Regulatory, integrative and comparative physiology310(3)R297-304(2016 Feb)

Upregulation of fractalkine contributes to the proliferative response of prostate cancer cells to hypoxia via promoting the G1/S phase transition.
Tang J, Chen Y, Cui R, Li D, Xiao L, Lin P, Du Y, Sun H, Yu X, Zheng X
Molecular medicine reports12(6)7907-14(2015 Dec)

Fractalkine Signaling Regulates Macrophage Recruitment into the Cochlea and Promotes the Survival of Spiral Ganglion Neurons after Selective Hair Cell Lesion.
Kaur T, Zamani D, Tong L, Rubel EW, Ohlemiller KK, Hirose K, Warchol ME
The Journal of neuroscience : the official journal of the Society for Neuroscience35(45)15050-61(2015 Nov)

T lymphocytes and fractalkine contribute to myocardial ischemia/reperfusion injury in patients.
Boag SE, Das R, Shmeleva EV, Bagnall A, Egred M, Howard N, Bennaceur K, Zaman A, Keavney B, Spyridopoulos I
The Journal of clinical investigation125(8)3063-76(2015 Aug)

Gene-gene interactions among CX3CL1, LEPR and IL-6 related to coronary artery disease in Chinese Han population.
Jin SG, Chen GL, Yang SL, Zhao MY
International journal of clinical and experimental pathology8(5)5968-73(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

changes in GSK-3beta activity and/or levels regulate the production and subsequent secretion of fractalkine, a chemokine involved in the immune response that has been linked to AD and to other different neurological disorders.
Title: Glycogen synthase kinase-3β regulates fractalkine production by altering its trafficking from Golgi to plasma membrane: implications for Alzheimer's disease.

Serum FKN may serve as a novel biomarker for assessing disease progression and a new potential therapeutic target for anti-resorptive treatment in osteoporosis patients.
Title: Serum CX3CL1/fractalkine concentrations are positively associated with disease severity in postmenopausal osteoporotic patients.

XCL2 and CX3CL1 expression in lung cancers and adjacent non-cancerous tissues was detected by quantitative PCR and ELISA. The expression of XCL2 and CX3CL1 increases with increasing degree of malignancy, indicating that both chemokines might be important targets in gene therapy for lung cancer.
Title: Expression of Chemokine XCL2 and CX3CL1 in Lung Cancer.

In conclusion, leukoplakia-associated fibroblasts produced and secreted less CX3CL1 by inhibiting the ERK signaling pathway, thereby contributing to impaired cell resistance to Candida albicans.
Title: Reduced CX3CL1 Secretion Contributes to the Susceptibility of Oral Leukoplakia-Associated Fibroblasts to

Fractalkine-CX3CR1 signaling has been shown to protect neurons.
Title: Progesterone Attenuates Microglial-Driven Retinal Degeneration and Stimulates Protective Fractalkine-CX3CR1 Signaling.

The following CX3CL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CX3CL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu23577 NM_002996.4
Latest version!
Homo sapiens C-X3-C motif chemokine ligand 1 (CX3CL1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu60433 NM_001304392.1
Latest version!
Homo sapiens C-X3-C motif chemokine ligand 1 (CX3CL1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $139.30
$199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23577
Clone ID Related Accession (Same CDS sequence) NM_002996.4
Accession Version NM_002996.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1194bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-10-08
Organism Homo sapiens(Human)
Product fractalkine isoform 1 precursor
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY114023.1, BC001163.1, AC009052.8 and GU047346.1. On Jan 22, 2015 this sequence version replaced NM_002996.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HY114023.1, BC001163.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGGCTCCGA TATCTCTGTC GTGGCTGCTC CGCTTGGCCA CCTTCTGCCA TCTGACTGTC 
CTGCTGGCTG GACAGCACCA CGGTGTGACG AAATGCAACA TCACGTGCAG CAAGATGACA
TCAAAGATAC CTGTAGCTTT GCTCATCCAC TATCAACAGA ACCAGGCATC ATGCGGCAAA
CGCGCAATCA TCTTGGAGAC GAGACAGCAC AGGCTGTTCT GTGCCGACCC GAAGGAGCAA
TGGGTCAAGG ACGCGATGCA GCATCTGGAC CGCCAGGCTG CTGCCCTAAC TCGAAATGGC
GGCACCTTCG AGAAGCAGAT CGGCGAGGTG AAGCCCAGGA CCACCCCTGC CGCCGGGGGA
ATGGACGAGT CTGTGGTCCT GGAGCCCGAA GCCACAGGCG AAAGCAGTAG CCTGGAGCCG
ACTCCTTCTT CCCAGGAAGC ACAGAGGGCC CTGGGGACCT CCCCAGAGCT GCCGACGGGC
GTGACTGGTT CCTCAGGGAC CAGGCTCCCC CCGACGCCAA AGGCTCAGGA TGGAGGGCCT
GTGGGCACGG AGCTTTTCCG AGTGCCTCCC GTCTCCACTG CCGCCACGTG GCAGAGTTCT
GCTCCCCACC AACCTGGGCC CAGCCTCTGG GCTGAGGCAA AGACCTCTGA GGCCCCGTCC
ACCCAGGACC CCTCCACCCA GGCCTCCACT GCGTCCTCCC CAGCCCCAGA GGAGAATGCT
CCGTCTGAAG GCCAGCGTGT GTGGGGTCAG GGACAGAGCC CCAGGCCAGA GAACTCTCTG
GAGCGGGAGG AGATGGGTCC CGTGCCAGCG CACACGGATG CCTTCCAGGA CTGGGGGCCT
GGCAGCATGG CCCACGTCTC TGTGGTCCCT GTCTCCTCAG AAGGGACCCC CAGCAGGGAG
CCAGTGGCTT CAGGCAGCTG GACCCCTAAG GCTGAGGAAC CCATCCATGC CACCATGGAC
CCCCAGAGGC TGGGCGTCCT TATCACTCCT GTCCCTGACG CCCAGGCTGC CACCCGGAGG
CAGGCGGTGG GGCTGCTGGC CTTCCTTGGC CTCCTCTTCT GCCTGGGGGT GGCCATGTTC
ACCTACCAGA GCCTCCAGGG CTGCCCTCGA AAGATGGCAG GAGAGATGGC GGAGGGCCTT
CGCTACATCC CCCGGAGCTG TGGTAGTAAT TCATATGTCC TGGTGCCCGT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002987.1
CDS109..1302
Misc Feature(1)43..45
Misc Feature(2)181..408
Misc Feature(3)181..408
Misc Feature(4)order(181..252,268..294,349..378)
Misc Feature(5)order(202..222,256..264,316..324)
Misc Feature(6)205..252
Misc Feature(7)205..213
Misc Feature(8)order(220..222,232..234,310..312,319..321,400..402)
Misc Feature(9)268..294
Misc Feature(10)order(286..291,340..342,355..357,379..381)
Misc Feature(11)307..321
Misc Feature(12)409..1131
Misc Feature(13)1123..1128
Misc Feature(14)1132..1194
Exon (1)1..178
Exon (2)179..299
Exon (3)300..3318
Translation

Target ORF information:

RefSeq Version NM_002996.4
Organism Homo sapiens(Human)
Definition Homo sapiens C-X3-C motif chemokine ligand 1 (CX3CL1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002996.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGGCTCCGA TATCTCTGTC GTGGCTGCTC CGCTTGGCCA CCTTCTGCCA TCTGACTGTC 
CTGCTGGCTG GACAGCACCA CGGTGTGACG AAATGCAACA TCACGTGCAG CAAGATGACA
TCAAAGATAC CTGTAGCTTT GCTCATCCAC TATCAACAGA ACCAGGCATC ATGCGGCAAA
CGCGCAATCA TCTTGGAGAC GAGACAGCAC AGGCTGTTCT GTGCCGACCC GAAGGAGCAA
TGGGTCAAGG ACGCGATGCA GCATCTGGAC CGCCAGGCTG CTGCCCTAAC TCGAAATGGC
GGCACCTTCG AGAAGCAGAT CGGCGAGGTG AAGCCCAGGA CCACCCCTGC CGCCGGGGGA
ATGGACGAGT CTGTGGTCCT GGAGCCCGAA GCCACAGGCG AAAGCAGTAG CCTGGAGCCG
ACTCCTTCTT CCCAGGAAGC ACAGAGGGCC CTGGGGACCT CCCCAGAGCT GCCGACGGGC
GTGACTGGTT CCTCAGGGAC CAGGCTCCCC CCGACGCCAA AGGCTCAGGA TGGAGGGCCT
GTGGGCACGG AGCTTTTCCG AGTGCCTCCC GTCTCCACTG CCGCCACGTG GCAGAGTTCT
GCTCCCCACC AACCTGGGCC CAGCCTCTGG GCTGAGGCAA AGACCTCTGA GGCCCCGTCC
ACCCAGGACC CCTCCACCCA GGCCTCCACT GCGTCCTCCC CAGCCCCAGA GGAGAATGCT
CCGTCTGAAG GCCAGCGTGT GTGGGGTCAG GGACAGAGCC CCAGGCCAGA GAACTCTCTG
GAGCGGGAGG AGATGGGTCC CGTGCCAGCG CACACGGATG CCTTCCAGGA CTGGGGGCCT
GGCAGCATGG CCCACGTCTC TGTGGTCCCT GTCTCCTCAG AAGGGACCCC CAGCAGGGAG
CCAGTGGCTT CAGGCAGCTG GACCCCTAAG GCTGAGGAAC CCATCCATGC CACCATGGAC
CCCCAGAGGC TGGGCGTCCT TATCACTCCT GTCCCTGACG CCCAGGCTGC CACCCGGAGG
CAGGCGGTGG GGCTGCTGGC CTTCCTTGGC CTCCTCTTCT GCCTGGGGGT GGCCATGTTC
ACCTACCAGA GCCTCCAGGG CTGCCCTCGA AAGATGGCAG GAGAGATGGC GGAGGGCCTT
CGCTACATCC CCCGGAGCTG TGGTAGTAAT TCATATGTCC TGGTGCCCGT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu60433
Clone ID Related Accession (Same CDS sequence) NM_001304392.1
Accession Version NM_001304392.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 939bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-10-08
Organism Homo sapiens(Human)
Product fractalkine isoform 2
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY114023.1, CA396869.1, BC001163.1, AC009052.8 and GU047346.1. Transcript Variant: This variant (2) lacks an alternate exon in the 5' end and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA396869.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGCAGCATC TGGACCGCCA GGCTGCTGCC CTAACTCGAA ATGGCGGCAC CTTCGAGAAG 
CAGATCGGCG AGGTGAAGCC CAGGACCACC CCTGCCGCCG GGGGAATGGA CGAGTCTGTG
GTCCTGGAGC CCGAAGCCAC AGGCGAAAGC AGTAGCCTGG AGCCGACTCC TTCTTCCCAG
GAAGCACAGA GGGCCCTGGG GACCTCCCCA GAGCTGCCGA CGGGCGTGAC TGGTTCCTCA
GGGACCAGGC TCCCCCCGAC GCCAAAGGCT CAGGATGGAG GGCCTGTGGG CACGGAGCTT
TTCCGAGTGC CTCCCGTCTC CACTGCCGCC ACGTGGCAGA GTTCTGCTCC CCACCAACCT
GGGCCCAGCC TCTGGGCTGA GGCAAAGACC TCTGAGGCCC CGTCCACCCA GGACCCCTCC
ACCCAGGCCT CCACTGCGTC CTCCCCAGCC CCAGAGGAGA ATGCTCCGTC TGAAGGCCAG
CGTGTGTGGG GTCAGGGACA GAGCCCCAGG CCAGAGAACT CTCTGGAGCG GGAGGAGATG
GGTCCCGTGC CAGCGCACAC GGATGCCTTC CAGGACTGGG GGCCTGGCAG CATGGCCCAC
GTCTCTGTGG TCCCTGTCTC CTCAGAAGGG ACCCCCAGCA GGGAGCCAGT GGCTTCAGGC
AGCTGGACCC CTAAGGCTGA GGAACCCATC CATGCCACCA TGGACCCCCA GAGGCTGGGC
GTCCTTATCA CTCCTGTCCC TGACGCCCAG GCTGCCACCC GGAGGCAGGC GGTGGGGCTG
CTGGCCTTCC TTGGCCTCCT CTTCTGCCTG GGGGTGGCCA TGTTCACCTA CCAGAGCCTC
CAGGGCTGCC CTCGAAAGAT GGCAGGAGAG ATGGCGGAGG GCCTTCGCTA CATCCCCCGG
AGCTGTGGTA GTAATTCATA TGTCCTGGTG CCCGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001291321.1
CDS243..1181
Misc Feature(1)63..65
Misc Feature(2)<243..287
Exon (1)1..178
Exon (2)179..3197
Translation

Target ORF information:

RefSeq Version NM_001304392.1
Organism Homo sapiens(Human)
Definition Homo sapiens C-X3-C motif chemokine ligand 1 (CX3CL1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001304392.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGCAGCATC TGGACCGCCA GGCTGCTGCC CTAACTCGAA ATGGCGGCAC CTTCGAGAAG 
CAGATCGGCG AGGTGAAGCC CAGGACCACC CCTGCCGCCG GGGGAATGGA CGAGTCTGTG
GTCCTGGAGC CCGAAGCCAC AGGCGAAAGC AGTAGCCTGG AGCCGACTCC TTCTTCCCAG
GAAGCACAGA GGGCCCTGGG GACCTCCCCA GAGCTGCCGA CGGGCGTGAC TGGTTCCTCA
GGGACCAGGC TCCCCCCGAC GCCAAAGGCT CAGGATGGAG GGCCTGTGGG CACGGAGCTT
TTCCGAGTGC CTCCCGTCTC CACTGCCGCC ACGTGGCAGA GTTCTGCTCC CCACCAACCT
GGGCCCAGCC TCTGGGCTGA GGCAAAGACC TCTGAGGCCC CGTCCACCCA GGACCCCTCC
ACCCAGGCCT CCACTGCGTC CTCCCCAGCC CCAGAGGAGA ATGCTCCGTC TGAAGGCCAG
CGTGTGTGGG GTCAGGGACA GAGCCCCAGG CCAGAGAACT CTCTGGAGCG GGAGGAGATG
GGTCCCGTGC CAGCGCACAC GGATGCCTTC CAGGACTGGG GGCCTGGCAG CATGGCCCAC
GTCTCTGTGG TCCCTGTCTC CTCAGAAGGG ACCCCCAGCA GGGAGCCAGT GGCTTCAGGC
AGCTGGACCC CTAAGGCTGA GGAACCCATC CATGCCACCA TGGACCCCCA GAGGCTGGGC
GTCCTTATCA CTCCTGTCCC TGACGCCCAG GCTGCCACCC GGAGGCAGGC GGTGGGGCTG
CTGGCCTTCC TTGGCCTCCT CTTCTGCCTG GGGGTGGCCA TGTTCACCTA CCAGAGCCTC
CAGGGCTGCC CTCGAAAGAT GGCAGGAGAG ATGGCGGAGG GCCTTCGCTA CATCCCCCGG
AGCTGTGGTA GTAATTCATA TGTCCTGGTG CCCGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

CX3CL1--a macrophage chemoattractant induced by a single bout of exercise in human skeletal muscle.
American journal of physiology. Regulatory, integrative and comparative physiology310(3)R297-304(2016 Feb)
Strömberg A,Olsson K,Dijksterhuis JP,Rullman E,Schulte G,Gustafsson T


book

Upregulation of fractalkine contributes to the proliferative response of prostate cancer cells to hypoxia via promoting the G1/S phase transition.
Molecular medicine reports12(6)7907-14(2015 Dec)
Tang J,Chen Y,Cui R,Li D,Xiao L,Lin P,Du Y,Sun H,Yu X,Zheng X


book

Fractalkine Signaling Regulates Macrophage Recruitment into the Cochlea and Promotes the Survival of Spiral Ganglion Neurons after Selective Hair Cell Lesion.
The Journal of neuroscience : the official journal of the Society for Neuroscience35(45)15050-61(2015 Nov)
Kaur T,Zamani D,Tong L,Rubel EW,Ohlemiller KK,Hirose K,Warchol ME


book

T lymphocytes and fractalkine contribute to myocardial ischemia/reperfusion injury in patients.
The Journal of clinical investigation125(8)3063-76(2015 Aug)
Boag SE,Das R,Shmeleva EV,Bagnall A,Egred M,Howard N,Bennaceur K,Zaman A,Keavney B,Spyridopoulos I


book

Gene-gene interactions among CX3CL1, LEPR and IL-6 related to coronary artery disease in Chinese Han population.
International journal of clinical and experimental pathology8(5)5968-73(2015)
Jin SG,Chen GL,Yang SL,Zhao MY


 
*
*
*
*