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SGCB cDNA ORF clone, Homo sapiens(Human)

Gene Symbol SGCB
Entrez Gene ID 6443
Full Name sarcoglycan beta
Synonyms A3b,LGMD2E,SGC
General protein information
Preferred Names

sarcoglycan beta

Names

beta-sarcoglycan
43 kDa dystrophin-associated glycoprotein
43DAG
beta-SG
beta-sarcoglycan(43kD dystrophin-associated glycoprotein)
limb girdle muscular dystrophy 2E (non-linked families)
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

4

4q12

Summary This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008].
Disorder MIM:

600900

Disorder Html: Muscular dystrophy, limb-girdle, type 2E, 604286 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_000232.4 NP_000223.1 beta-sarcoglycan



Rattus norvegicus (Norway rat) Sgcb NP_001177997.1
Gallus gallus (chicken) SGCB NP_001026326.1
Homo sapiens (human) SGCB NP_000223.1
Pan troglodytes (chimpanzee) SGCB XP_517299.2
Canis lupus familiaris (dog) SGCB XP_853790.1
Xenopus tropicalis (tropical clawed frog) sgcb NP_001135484.1
Bos taurus (cattle) SGCB NP_001095658.1
Danio rerio (zebrafish) sgcb NP_001030145.1
Mus musculus (house mouse) Sgcb NP_036020.1
Macaca mulatta (rhesus monkey) SGCB XP_001090970.1


Related articles in PubMed

Sarcoglycanopathies: can muscle immunoanalysis predict the genotype?
Klinge L, Dekomien G, Aboumousa A, Charlton R, Epplen JT, Barresi R, Bushby K, Straub V
Neuromuscular disorders : NMD18(12)934-41(2008 Dec)

Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation.
Sharma P, Tran T, Stelmack GL, McNeill K, Gosens R, Mutawe MM, Unruh H, Gerthoffer WT, Halayko AJ
American journal of physiology. Lung cellular and molecular physiology294(1)L57-68(2008 Jan)

The beta-delta-core of sarcoglycan is essential for deposition at the plasma membrane.
Draviam RA, Shand SH, Watkins SC
Muscle & nerve34(6)691-701(2006 Dec)

Muscle protein analysis in the detection of heterozygotes for recessive limb girdle muscular dystrophy type 2B and 2E.
Fanin M, Nascimbeni AC, Angelini C
Neuromuscular disorders : NMD16(11)792-9(2006 Nov)

Homozygous microdeletion of chromosome 4q11-q12 causes severe limb-girdle muscular dystrophy type 2E with joint hyperlaxity and contractures.
Kaindl AM, Jakubiczka S, Lücke T, Bartsch O, Weis J, Stoltenburg-Didinger G, Aksu F, Oexle K, Koehler K, Huebner A
Human mutation26(3)279-80(2005 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clinical severity of limb-girdle muscular dystrophy type 2Emay be predicted by SGCB gene mutation and sarcoglycan protein expression.
Title: Clinical and genetic spectrum in limb-girdle muscular dystrophy type 2E.

The limb-girdle muscular dystrophy patients with beta-sarcoglycan deficient LGMD2E do not enable an accurate prediction of the genotype.
Title: Sarcoglycanopathies: can muscle immunoanalysis predict the genotype?

These data suggest that formation of the beta-delta-core may promote the export and deposition of sarcoglycan subcomplexes at the plasma membrane, and therefore identifies a mechanism for sarcoglycan transport.
Title: The beta-delta-core of sarcoglycan is essential for deposition at the plasma membrane.

While the quantity of beta-sarcoglycan was nearly normal in the limb girdle muscular dystrophy (LGMD)2E carrier, the levels of dysferlin protein were reduced to 50% of controls in the carriers of LGMD2B.
Title: Muscle protein analysis in the detection of heterozygotes for recessive limb girdle muscular dystrophy type 2B and 2E.

beta-sarcoglycan and SPATA18 may have a role in limb-girdle muscular dystrophy type 2E
Title: Homozygous microdeletion of chromosome 4q11-q12 causes severe limb-girdle muscular dystrophy type 2E with joint hyperlaxity and contractures.

The following SGCB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SGCB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu21735 NM_000232.4
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Homo sapiens sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (SGCB), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu21735
Clone ID Related Accession (Same CDS sequence) NM_000232.4
Accession Version NM_000232.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 957bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-04-23
Organism Homo sapiens(Human)
Product beta-sarcoglycan
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN483961.1, BC020709.1, AC093858.2, AK094731.1 and CA449352.1. This sequence is a reference standard in the RefSeqGene project. On Oct 17, 2008 this sequence version replaced NM_000232.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC020709.1, AK289892.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCGGCAG CGGCGGCGGC GGCTGCAGAA CAGCAAAGTT CCAATGGTCC TGTAAAGAAG 
TCCATGCGTG AGAAGGCTGT TGAGAGAAGG AGTGTCAATA AAGAGCACAA CAGTAACTTT
AAAGCTGGAT ACATTCCGAT TGATGAAGAT CGTCTCCACA AAACAGGGTT GAGAGGAAGA
AAGGGCAATT TAGCCATCTG TGTGATTATC CTCTTGTTTA TCCTGGCTGT CATCAATTTA
ATAATAACAC TTGTTATTTG GGCCGTGATT CGCATTGGAC CAAATGGCTG TGATAGTATG
GAGTTTCATG AAAGTGGCCT GCTTCGATTT AAGCAAGTAT CTGACATGGG AGTGATCCAC
CCTCTTTATA AAAGCACAGT AGGAGGAAGG CGAAATGAAA ATTTGGTCAT CACTGGCAAC
AACCAGCCTA TTGTTTTTCA GCAAGGGACA ACAAAGCTCA GTGTAGAAAA CAACAAAACT
TCTATTACAA GTGACATCGG CATGCAGTTT TTTGACCCGA GGACTCAAAA TATCTTATTC
AGCACAGACT ATGAAACTCA TGAGTTTCAT TTGCCAAGTG GAGTGAAAAG TTTGAATGTT
CAAAAGGCAT CTACTGAAAG GATTACCAGC AATGCTACCA GTGATTTAAA TATAAAAGTT
GATGGGCGTG CTATTGTGCG TGGAAATGAA GGTGTATTCA TTATGGGCAA AACCATTGAA
TTTCACATGG GTGGTAATAT GGAGTTAAAG GCGGAAAACA GTATCATCCT AAATGGATCT
GTGATGGTCA GCACCACCCG CCTACCCAGT TCCTCCAGTG GAGACCAGTT GGGTAGTGGT
GACTGGGTAC GCTACAAGCT CTGCATGTGT GCTGATGGGA CGCTCTTCAA GGTGCAAGTA
ACCAGCCAGA ACATGGGCTG CCAAATCTCA GACAACCCCT GTGGAAACAC TCATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000223.1
CDS61..1017
Misc Feature(1)235..966
Misc Feature(2)256..318
Exon (1)1..93
Exon (2)94..303
Exon (3)304..489
Exon (4)490..681
Exon (5)682..813
Exon (6)814..4279
Translation

Target ORF information:

RefSeq Version NM_000232.4
Organism Homo sapiens(Human)
Definition Homo sapiens sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (SGCB), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000232.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCGGCAG CGGCGGCGGC GGCTGCAGAA CAGCAAAGTT CCAATGGTCC TGTAAAGAAG 
TCCATGCGTG AGAAGGCTGT TGAGAGAAGG AGTGTCAATA AAGAGCACAA CAGTAACTTT
AAAGCTGGAT ACATTCCGAT TGATGAAGAT CGTCTCCACA AAACAGGGTT GAGAGGAAGA
AAGGGCAATT TAGCCATCTG TGTGATTATC CTCTTGTTTA TCCTGGCTGT CATCAATTTA
ATAATAACAC TTGTTATTTG GGCCGTGATT CGCATTGGAC CAAATGGCTG TGATAGTATG
GAGTTTCATG AAAGTGGCCT GCTTCGATTT AAGCAAGTAT CTGACATGGG AGTGATCCAC
CCTCTTTATA AAAGCACAGT AGGAGGAAGG CGAAATGAAA ATTTGGTCAT CACTGGCAAC
AACCAGCCTA TTGTTTTTCA GCAAGGGACA ACAAAGCTCA GTGTAGAAAA CAACAAAACT
TCTATTACAA GTGACATCGG CATGCAGTTT TTTGACCCGA GGACTCAAAA TATCTTATTC
AGCACAGACT ATGAAACTCA TGAGTTTCAT TTGCCAAGTG GAGTGAAAAG TTTGAATGTT
CAAAAGGCAT CTACTGAAAG GATTACCAGC AATGCTACCA GTGATTTAAA TATAAAAGTT
GATGGGCGTG CTATTGTGCG TGGAAATGAA GGTGTATTCA TTATGGGCAA AACCATTGAA
TTTCACATGG GTGGTAATAT GGAGTTAAAG GCGGAAAACA GTATCATCCT AAATGGATCT
GTGATGGTCA GCACCACCCG CCTACCCAGT TCCTCCAGTG GAGACCAGTT GGGTAGTGGT
GACTGGGTAC GCTACAAGCT CTGCATGTGT GCTGATGGGA CGCTCTTCAA GGTGCAAGTA
ACCAGCCAGA ACATGGGCTG CCAAATCTCA GACAACCCCT GTGGAAACAC TCATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Sarcoglycanopathies: can muscle immunoanalysis predict the genotype?
Neuromuscular disorders : NMD18(12)934-41(2008 Dec)
Klinge L,Dekomien G,Aboumousa A,Charlton R,Epplen JT,Barresi R,Bushby K,Straub V


book

Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation.
American journal of physiology. Lung cellular and molecular physiology294(1)L57-68(2008 Jan)
Sharma P,Tran T,Stelmack GL,McNeill K,Gosens R,Mutawe MM,Unruh H,Gerthoffer WT,Halayko AJ


book

The beta-delta-core of sarcoglycan is essential for deposition at the plasma membrane.
Muscle & nerve34(6)691-701(2006 Dec)
Draviam RA,Shand SH,Watkins SC


book

Muscle protein analysis in the detection of heterozygotes for recessive limb girdle muscular dystrophy type 2B and 2E.
Neuromuscular disorders : NMD16(11)792-9(2006 Nov)
Fanin M,Nascimbeni AC,Angelini C


book

Homozygous microdeletion of chromosome 4q11-q12 causes severe limb-girdle muscular dystrophy type 2E with joint hyperlaxity and contractures.
Human mutation26(3)279-80(2005 Sep)
Kaindl AM,Jakubiczka S,Lücke T,Bartsch O,Weis J,Stoltenburg-Didinger G,Aksu F,Oexle K,Koehler K,Huebner A


 
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