Gene Symbol | SH3BGR |
Entrez Gene ID | 6450 |
Full Name | SH3 domain binding glutamate rich protein |
Synonyms | 21-GARP |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » SH3BGR cDNA ORF clone
Gene Symbol | SH3BGR |
Entrez Gene ID | 6450 |
Full Name | SH3 domain binding glutamate rich protein |
Synonyms | 21-GARP |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_006724041.2 | XP_006724104.1 | SH3 domain-binding glutamic acid-rich protein isoform X1 |
XM_005261024.1 | XP_005261081.1 | SH3 domain-binding glutamic acid-rich protein isoform X1 |
NM_001317742.1 | NP_001304671.1 | SH3 domain-binding glutamic acid-rich protein isoform b |
NM_001317741.1 | NP_001304670.1 | SH3 domain-binding glutamic acid-rich protein isoform d |
NM_007341.2 | NP_031367.1 | SH3 domain-binding glutamic acid-rich protein isoform a |
XM_006724042.2 | XP_006724105.1 | SH3 domain-binding glutamic acid-rich protein isoform X1 |
NM_001001713.1 | NP_001001713.1 | SH3 domain-binding glutamic acid-rich protein isoform b |
XM_005261025.3 | XP_005261082.1 | SH3 domain-binding glutamic acid-rich protein isoform X1 |
NM_001317740.1 | NP_001304669.1 | SH3 domain-binding glutamic acid-rich protein isoform c |
Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.
Alves da Silva AF, Machado FB, Pavarino ?C, Biselli-P?rico JM, Zampieri BL, da Silva Francisco Junior R, Mozer Rodrigues PT, Terra Machado D, Santos-Rebou?as CB, Gomes Fernandes M, Chuva de Sousa Lopes SM, Lopes Rios ?F, Medina-Acosta E
PloS one11(4)e0154108(2016)
Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.
Naukkarinen J, Surakka I, Pietil?inen KH, Rissanen A, Salomaa V, Ripatti S, Yki-J?rvinen H, van Duijn CM, Wichmann HE, Kaprio J, Taskinen MR, Peltonen L,
PLoS genetics6(6)e1000976(2010 Jun)
Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.
Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem P, Lehrach H, Yaspo ML, Janitz M
BMC genomics7155(2006 Jun)
Heart morphogenesis is not affected by overexpression of the Sh3bgr gene mapping to the Down syndrome heart critical region.
Sandri C, Di Lisi R, Picard A, Argentini C, Calabria E, Myklak K, Scartezzini P, Schiaffino S
Human genetics114(5)517-9(2004 Apr)
Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system.
Jiang LQ, Wen SJ, Wang HY, Chen LY
Hypertension research : official journal of the Japanese Society of Hypertension25(4)647-52(2002 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
RNA-seq evidence of biallelic expression of SH3BGR and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of SH3BGR is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals.
Title: Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.
The following SH3BGR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SH3BGR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu01911 | |
Clone ID Related Accession (Same CDS sequence) | XM_006724041.2 , XM_005261024.1 , NM_001317742.1 , XM_006724042.2 , NM_001001713.1 , XM_005261025.3 | |
Accession Version | NM_001317742.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-15 | |
Organism | Homo sapiens(human) | |
Product | SH3 domain-binding glutamic acid-rich protein isoform b | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF121781.1, BI819819.1, AF121897.4 and BQ574343.1. On Dec 8, 2015 this sequence version replaced XM_006724041.2. Transcript Variant: This variant (5) uses an alternate 5' most exon and lacks a portion of the 5' coding region compared to variant 1. These differences result in the use of alternate start codon compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus compared to isoform a. Variants 2 and 5 encode the same isoform (b). ##Evidence-Data-START## Transcript exon combination :: BI819819.1, ERR279864.1524.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAGAGAGA ATGTTCCTGG AGAGAAAAAA CCTCAAAATG GGATTCCTTT GCCTCCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001304671.1 |
CDS | 128..514 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001317742.1 |
1 | ATGAGAGAGA ATGTTCCTGG AGAGAAAAAA CCTCAAAATG GGATTCCTTT GCCTCCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01911 | |
Clone ID Related Accession (Same CDS sequence) | XM_006724041.2 , XM_005261024.1 , NM_001317742.1 , XM_006724042.2 , NM_001001713.1 , XM_005261025.3 | |
Accession Version | NM_001001713.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-14 | |
Organism | Homo sapiens(human) | |
Product | SH3 domain-binding glutamic acid-rich protein isoform b | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM474020.1, BC006371.2, AI338732.1 and X93498.1. Transcript Variant: This variant (2) uses an alternate 5' exon compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 5 encode the same isoform (b). ##Evidence-Data-START## Transcript exon combination :: BM474020.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGAGAGA ATGTTCCTGG AGAGAAAAAA CCTCAAAATG GGATTCCTTT GCCTCCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001001713.1 |
CDS | 159..545 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001001713.1 |
1 | ATGAGAGAGA ATGTTCCTGG AGAGAAAAAA CCTCAAAATG GGATTCCTTT GCCTCCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01911 | |
Clone ID Related Accession (Same CDS sequence) | XM_006724041.2 , XM_005261024.1 , NM_001317742.1 , XM_006724042.2 , NM_001001713.1 , XM_005261025.3 | |
Accession Version | XM_006724041.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | SH3 domain-binding glutamic acid-rich protein isoform X1 | |
Comment |
1 | ATGAGAGAGA ATGTTCCTGG AGAGAAAAAA CCTCAAAATG GGATTCCTTT GCCTCCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006724104.1 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006724041.2 |
1 | ATGAGAGAGA ATGTTCCTGG AGAGAAAAAA CCTCAAAATG GGATTCCTTT GCCTCCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01911 | |
Clone ID Related Accession (Same CDS sequence) | XM_006724041.2 , XM_005261024.1 , NM_001317742.1 , XM_006724042.2 , NM_001001713.1 , XM_005261025.3 | |
Accession Version | XM_005261024.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | SH3 domain-binding glutamic acid-rich protein isoform X1 | |
Comment |
1 | ATGAGAGAGA ATGTTCCTGG AGAGAAAAAA CCTCAAAATG GGATTCCTTT GCCTCCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005261081.1 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005261024.1 |
1 | ATGAGAGAGA ATGTTCCTGG AGAGAAAAAA CCTCAAAATG GGATTCCTTT GCCTCCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01911 | |
Clone ID Related Accession (Same CDS sequence) | XM_006724041.2 , XM_005261024.1 , NM_001317742.1 , XM_006724042.2 , NM_001001713.1 , XM_005261025.3 | |
Accession Version | XM_006724042.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | SH3 domain-binding glutamic acid-rich protein isoform X1 | |
Comment |
1 | ATGAGAGAGA ATGTTCCTGG AGAGAAAAAA CCTCAAAATG GGATTCCTTT GCCTCCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006724105.1 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006724042.2 |
1 | ATGAGAGAGA ATGTTCCTGG AGAGAAAAAA CCTCAAAATG GGATTCCTTT GCCTCCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01911 | |
Clone ID Related Accession (Same CDS sequence) | XM_006724041.2 , XM_005261024.1 , NM_001317742.1 , XM_006724042.2 , NM_001001713.1 , XM_005261025.3 | |
Accession Version | XM_005261025.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | SH3 domain-binding glutamic acid-rich protein isoform X1 | |
Comment |
1 | ATGAGAGAGA ATGTTCCTGG AGAGAAAAAA CCTCAAAATG GGATTCCTTT GCCTCCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005261082.1 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005261025.3 |
1 | ATGAGAGAGA ATGTTCCTGG AGAGAAAAAA CCTCAAAATG GGATTCCTTT GCCTCCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu04966 | |
Clone ID Related Accession (Same CDS sequence) | NM_007341.2 | |
Accession Version | NM_007341.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 720bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-14 | |
Organism | Homo sapiens(human) | |
Product | SH3 domain-binding glutamic acid-rich protein isoform a | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM697281.1, X93498.1, BC006371.2 and AI338732.1. On Jun 16, 2004 this sequence version replaced NM_007341.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). ##Evidence-Data-START## Transcript exon combination :: BC006371.2, ERR279862.2700.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCTCTGC TGCTCCTTGG AGAGACAGAG CCTCTTAAGT TGGAGCGGGA CTGCCGGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_031367.1 |
CDS | 55..774 |
Translation |
Target ORF information:
Target ORF information:
|
NM_007341.2 |
1 | ATGCCTCTGC TGCTCCTTGG AGAGACAGAG CCTCTTAAGT TGGAGCGGGA CTGCCGGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu101159 | |
Clone ID Related Accession (Same CDS sequence) | NM_001317741.1 | |
Accession Version | NM_001317741.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-15 | |
Organism | Homo sapiens(human) | |
Product | SH3 domain-binding glutamic acid-rich protein isoform d | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG742101.1 and BQ574343.1. Transcript Variant: This variant (4) uses an alternate 5' most exon and lacks an exon in the central coding region compared to variant 1. These differences result in the use of alternate start codon compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: BG742101.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGAGAGAGA ATGTTCCTGG AGAGAAAAAA CCTCAAAATG GGATTCCTTT GCCTCCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001304670.1 |
CDS | 302..595 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001317741.1 |
1 | ATGAGAGAGA ATGTTCCTGG AGAGAAAAAA CCTCAAAATG GGATTCCTTT GCCTCCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu101173 | |
Clone ID Related Accession (Same CDS sequence) | NM_001317740.1 | |
Accession Version | NM_001317740.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-15 | |
Organism | Homo sapiens(human) | |
Product | SH3 domain-binding glutamic acid-rich protein isoform c | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM701533.1, AW962501.1, AF121897.4 and BQ574343.1. Transcript Variant: This variant (3) lacks an exon compared to variant 1. The encoded isoform (c) is shorter than isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AW962501.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCCTCTGC TGCTCCTTGG AGAGACAGAG CCTCTTAAGT TGGAGCGGGA CTGCCGGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001304669.1 |
CDS | 79..705 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001317740.1 |
1 | ATGCCTCTGC TGCTCCTTGG AGAGACAGAG CCTCTTAAGT TGGAGCGGGA CTGCCGGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners. |
Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. |
Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. |
Heart morphogenesis is not affected by overexpression of the Sh3bgr gene mapping to the Down syndrome heart critical region. |
Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system. |