METTL17 cDNA ORF clone, Homo sapiens(human)
Gene Symbol | METTL17 |
Entrez Gene ID | 64745 |
Full Name | methyltransferase like 17 |
Synonyms | METT11D1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_001029991.1 | NP_001025162.1 | methyltransferase-like protein 17, mitochondrial isoform 1 precursor |
NM_022734.2 | NP_073571.1 | methyltransferase-like protein 17, mitochondrial isoform 2 precursor |
NM_022734.3 | NP_073571.1 | methyltransferase-like protein 17, mitochondrial isoform 2 precursor |
XM_017021601.2 | XP_016877090.1 | methyltransferase-like protein 17, mitochondrial isoform X2 |
XM_017021601.1 | XP_016877090.1 | methyltransferase-like protein 17, mitochondrial isoform X2 |
NM_001029991.2 | NP_001025162.1 | methyltransferase-like protein 17, mitochondrial isoform 1 precursor |
XM_006720236.3 | XP_006720299.1 | methyltransferase-like protein 17, mitochondrial isoform X1 |
XM_006720236.2 | XP_006720299.1 | methyltransferase-like protein 17, mitochondrial isoform X1 |

Homo sapiens (human) | METTL17 | NP_073571.1 |
Canis lupus familiaris (dog) | METTL17 | XP_005629480.1 |
Bos taurus (cattle) | METTL17 | NP_001033631.1 |
Rattus norvegicus (Norway rat) | Mettl17 | XP_223974.4 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002734 | XP_312193.4 |
Pan troglodytes (chimpanzee) | METTL17 | XP_001142880.1 |
Mus musculus (house mouse) | Mettl17 | NP_001025161.1 |
Danio rerio (zebrafish) | mettl17 | XP_005171396.1 |
Caenorhabditis elegans (roundworm) | CELE_F32A7.4 | NP_493592.1 |
Xenopus tropicalis (tropical clawed frog) | mettl17 | NP_001120620.1 |
METTL17 | XP_001093161.1 | |
Drosophila melanogaster (fruit fly) | CG13126 | NP_609330.1 |

Related articles in PubMed
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)
Methyltransferase-like 17 physically and functionally interacts with estrogen receptors.
Du P, Yuan B, Cao J, Zhao J, Ding L, Chen L, Ying S, Jiang L, Lin J, Xu X, Cheng L, Ye Q
IUBMB life67(11)861-8(2015 Nov)
Next-generation sequencing to generate interactome datasets.
Yu H, Tardivo L, Tam S, Weiner E, Gebreab F, Fan C, Svrzikapa N, Hirozane-Kishikawa T, Rietman E, Yang X, Sahalie J, Salehi-Ashtiani K, Hao T, Cusick ME, Hill DE, Roth FP, Braun P, Vidal M
Nature methods8(6)478-80(2011 Jun)
Sequence variants in four candidate genes (NIPSNAP1, GBAS, CHCHD1 and METT11D1) in patients with combined oxidative phosphorylation system deficiencies.
Smits P, Rodenburg RJ, Smeitink JA, van den Heuvel LP
Journal of inherited metabolic disease33 Suppl 3S13-9(2010 Dec)
Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
METTL17 is a novel coactivator of estrogen receptors and may play a role in breast tumorigenesis.
Title: Methyltransferase-like 17 physically and functionally interacts with estrogen receptors.
METT11D1 mutations could not explain phenotype of patients with combined oxidative phosphorylation system deficiencies.
Title: Sequence variants in four candidate genes (NIPSNAP1, GBAS, CHCHD1 and METT11D1) in patients with combined oxidative phosphorylation system deficiencies.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Possible component of the small subunit of the mitochondrial ribosome, has similarity to yeast Rsm22 (Ykl155c) mitochondrial ribosomal protein.
Title: Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues.
The following METTL17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the METTL17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu15799 | |
Clone ID Related Accession (Same CDS sequence) | NM_022734.2 , NM_022734.3 | |
Accession Version | NM_022734.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1371bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-06-22 | |
Organism | Homo sapiens(human) | |
Product | methyltransferase-like protein 17, mitochondrial isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG437086.1, AL355922.4, BC005053.1 and AK024512.1. On Aug 9, 2005 this sequence version replaced NM_022734.1. Transcript Variant: This variant (2) lacks a segment in the 3' coding region, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK024512.1, SRR1163657.377267.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCGG CACTGAAGTG TCTACTGACA TTAGGAAGAT GGTGCCCCGG CCTTGGAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_073571.1 |
CDS | 198..1568 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGGCGG CACTGAAGTG TCTACTGACA TTAGGAAGAT GGTGCCCCGG CCTTGGAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu15799 | |
Clone ID Related Accession (Same CDS sequence) | NM_022734.2 , NM_022734.3 | |
Accession Version | NM_022734.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1371bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-28 | |
Organism | Homo sapiens(human) | |
Product | methyltransferase-like protein 17, mitochondrial isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL355922.4, BC005053.1 and AK024512.1. On Jun 2, 2019 this sequence version replaced NM_022734.2. Transcript Variant: This variant (2) lacks a segment in the 3' coding region, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK024512.1, SRR3476690.211343.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCGG CACTGAAGTG TCTACTGACA TTAGGAAGAT GGTGCCCCGG CCTTGGAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_073571.1 |
CDS | 24..1394 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGGCGG CACTGAAGTG TCTACTGACA TTAGGAAGAT GGTGCCCCGG CCTTGGAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu15948 | |
Clone ID Related Accession (Same CDS sequence) | NM_001029991.1 , NM_001029991.2 | |
Accession Version | NM_001029991.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-06-22 | |
Organism | Homo sapiens(human) | |
Product | methyltransferase-like protein 17, mitochondrial isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG437086.1, AL355922.4 and AK024512.1. Transcript Variant: This variant (1) encodes the longer protein (isoform 1). ##Evidence-Data-START## Transcript exon combination :: SRR1163655.95172.1, SRR1163658.524724.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCGG CACTGAAGTG TCTACTGACA TTAGGAAGAT GGTGCCCCGG CCTTGGAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001025162.1 |
CDS | 198..1634 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGGCGG CACTGAAGTG TCTACTGACA TTAGGAAGAT GGTGCCCCGG CCTTGGAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu15948 | |
Clone ID Related Accession (Same CDS sequence) | NM_001029991.1 , NM_001029991.2 | |
Accession Version | NM_001029991.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-28 | |
Organism | Homo sapiens(human) | |
Product | methyltransferase-like protein 17, mitochondrial isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL355922.4 and AK024512.1. On Jun 2, 2019 this sequence version replaced NM_001029991.1. Transcript Variant: This variant (1) encodes the longer protein (isoform 1). ##Evidence-Data-START## Transcript exon combination :: AF321002.1, SRR5189658.136151.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCGG CACTGAAGTG TCTACTGACA TTAGGAAGAT GGTGCCCCGG CCTTGGAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001025162.1 |
CDS | 24..1460 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGGCGG CACTGAAGTG TCTACTGACA TTAGGAAGAT GGTGCCCCGG CCTTGGAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu47868 | |
Clone ID Related Accession (Same CDS sequence) | XM_006720236.3 , XM_006720236.2 | |
Accession Version | XM_006720236.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | methyltransferase-like protein 17, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006720236.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGCAA GACTGGATGG TGGCTTTGCA GCAGTCTCCA GAGCATTCCA TGAGATCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006720299.1 |
CDS | 530..1492 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCAGCAA GACTGGATGG TGGCTTTGCA GCAGTCTCCA GAGCATTCCA TGAGATCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu47868 | |
Clone ID Related Accession (Same CDS sequence) | XM_006720236.3 , XM_006720236.2 | |
Accession Version | XM_006720236.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | methyltransferase-like protein 17, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006720236.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGCAA GACTGGATGG TGGCTTTGCA GCAGTCTCCA GAGCATTCCA TGAGATCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006720299.1 |
CDS | 432..1394 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCAGCAA GACTGGATGG TGGCTTTGCA GCAGTCTCCA GAGCATTCCA TGAGATCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu85080 | |
Clone ID Related Accession (Same CDS sequence) | XM_017021601.2 , XM_017021601.1 | |
Accession Version | XM_017021601.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | methyltransferase-like protein 17, mitochondrial isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017021601.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGCAA GACTGGATGG TGGCTTTGCA GCAGTCTCCA GAGCATTCCA TGAGATCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016877090.1 |
CDS | 530..1426 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCAGCAA GACTGGATGG TGGCTTTGCA GCAGTCTCCA GAGCATTCCA TGAGATCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu85080 | |
Clone ID Related Accession (Same CDS sequence) | XM_017021601.2 , XM_017021601.1 | |
Accession Version | XM_017021601.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | methyltransferase-like protein 17, mitochondrial isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGCAA GACTGGATGG TGGCTTTGCA GCAGTCTCCA GAGCATTCCA TGAGATCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016877090.1 |
CDS | 432..1328 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCAGCAA GACTGGATGG TGGCTTTGCA GCAGTCTCCA GAGCATTCCA TGAGATCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. |
![]() |
Methyltransferase-like 17 physically and functionally interacts with estrogen receptors. |
![]() |
Next-generation sequencing to generate interactome datasets. |
![]() |
Sequence variants in four candidate genes (NIPSNAP1, GBAS, CHCHD1 and METT11D1) in patients with combined oxidative phosphorylation system deficiencies. |
![]() |
Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. |