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ARV1 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol ARV1
Entrez Gene ID 64801
Full Name ARV1 homolog, fatty acid homeostasis modulator
Synonyms EIEE38
General protein information
Preferred Names

ARV1 homolog, fatty acid homeostasis modulator

Names

protein ARV1
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

1

1q42.2
Summary this gene encodes a transmembrane protein that contains a conserved zinc ribbon motif at the N- terminus. A similar protein in mouse is thought to function in fatty acid homeostasis. Mutations in this gene are associated with early infantile epileptic encephalopathy 38. [provided by RefSeq, Nov 2016].
Disorder MIM:

611647

Disorder Html: Epileptic encephalopathy, early infantile, 38, 617020 (3)

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_001346992.1 NP_001333921.1 protein ARV1 isoform 1
NM_022786.2 NP_073623.1 protein ARV1 isoform 2
NM_022786.1 NP_073623.1 protein ARV1
NM_022786.3 NP_073623.1 protein ARV1 isoform 2
NM_001346992.2 NP_001333921.1 protein ARV1 isoform 1
XM_024449202.1 XP_024304970.1 protein ARV1 isoform X1

Pathways from BioSystems


Homologies


LOC713975 XP_001106551.2
Bos taurus (cattle) ARV1 NP_001030379.1
Pan troglodytes (chimpanzee) ARV1 XP_514269.4
Danio rerio (zebrafish) arv1 NP_001107083.1
Mus musculus (house mouse) Arv1 NP_081131.1
Rattus norvegicus (Norway rat) Arv1 NP_001099667.1
Homo sapiens (human) ARV1 NP_073623.1
Canis lupus familiaris (dog) ARV1 XP_857065.1
Gallus gallus (chicken) ARV1 XP_419587.1
Xenopus tropicalis (tropical clawed frog) arv1 NP_001016452.1

Gene Ontology


Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy.
Palmer EE, Jarrett KE, Sachdev RK, Al Zahrani F, Hashem MO, Ibrahim N, Sampaio H, Kandula T, Macintosh R, Gupta R, Conlon DM, Billheimer JT, Rader DJ, Funato K, Walkey CJ, Lee CS, Loo C, Brammah S, Elakis G, Zhu Y, Buckley M, Kirk EP, Bye A, Alkuraya FS, Roscioli T, Lagor WR
Human molecular genetics25(14)3042-3054(2016 07)

Complementation analysis reveals a potential role of human ARV1 in GPI anchor biosynthesis.
Ikeda A, Kajiwara K, Iwamoto K, Makino A, Kobayashi T, Mizuta K, Funato K
Yeast (Chichester, England)33(2)37-42(2016 Feb)

Arv1 promotes cell division by recruiting IQGAP1 and myosin to the cleavage furrow.
Sundvold H, Sundvold-Gjerstad V, Maler?d-Fjeld H, Haglund K, Stenmark H, Maler?d L
Cell cycle (Georgetown, Tex.)15(5)628-43(2016)

A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance.
Ruggles KV, Garbarino J, Liu Y, Moon J, Schneider K, Henneberry A, Billheimer J, Millar JS, Marchadier D, Valasek MA, Joblin-Mills A, Gulati S, Munkacsi AB, Repa JJ, Rader D, Sturley SL
The Journal of biological chemistry289(7)4417-31(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In contrast to wild type human ARV1, neither variant expressed detectable levels of protein in mammalian cells. Mice with a neuronal deletion of Arv1 recapitulated the human phenotype, exhibiting seizures and a severe survival defect in adulthood. Our data support ARV1 deficiency as a cause of autosomal recessive epileptic encephalopathy
Title: Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy.

Overexpression of human ARV1 could rescue the phenotypes associated with GPI anchor synthesis defect in the yeast arv1Delta mutant. Arv1 function in GPI biosynthesis may be conserved in all eukaryotes, from yeast to humans.
Title: Complementation analysis reveals a potential role of human ARV1 in GPI anchor biosynthesis.

A novel function for Arv1 in regulation of cell division through promotion of the contractile actomyosin ring, which is independent of its lipid transporter activity.
Title: Arv1 promotes cell division by recruiting IQGAP1 and myosin to the cleavage furrow.

These results implicate ARV1 as a protective factor in lipotoxic diseases due to modulation of fatty acid metabolism.
Title: A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance.

Arv1p has a role in sterol movement from the ER and in the ensuing regulation of hepatic cholesterol and bile acid metabolism
Title: Decreased expression of ARV1 results in cholesterol retention in the endoplasmic reticulum and abnormal bile acid metabolism.

The following ARV1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ARV1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu101285 NM_001346992.2
Latest version!		 Homo sapiens ARV1 homolog, fatty acid homeostasis modulator (ARV1), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$99.50-$139.30
$199.00
OHu19984 NM_022786.3
Latest version!		 Homo sapiens ARV1 homolog, fatty acid homeostasis modulator (ARV1), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$99.50-$139.30
$199.00
OHu105755 XM_024449202.1
Latest version!		 Homo sapiens ARV1 homolog, fatty acid homeostasis modulator (ARV1), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 9-11 $139.30
$199.00
View Old Accession Versions >>
OHu19984 NM_022786.1 Homo sapiens ARV1 homolog, fatty acid homeostatsis modulator (ARV1), mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$99.50-$139.30
$199.00
OHu19984 NM_022786.2 Homo sapiens ARV1 homolog, fatty acid homeostasis modulator (ARV1), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$99.50-$139.30
$199.00
OHu101285 NM_001346992.1 Homo sapiens ARV1 homolog, fatty acid homeostasis modulator (ARV1), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$99.50-$139.30
$199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu101285
Clone ID Related Accession (Same CDS sequence) NM_001346992.1 , NM_001346992.2
Accession Version NM_001346992.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 915bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-06-30
Organism Homo sapiens(human)
Product protein ARV1 isoform 1
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL844165.5, AL732414.17 and AF290878.1. On Nov 13, 2016 this sequence version replaced XM_017002106.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.102654.1, SRR1163655.464436.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGGCAACG GCGGGCGGAG CGGCCTGCAG CAGGGGAAGG GGAACGTGGA TGGGGTGGCA 
GCGACTCCTA CTGCTGCCTC GGCCTCCTGC CAGTACAGGT GCATCGAATG CAACCAGGAG 
GCCAAAGAGT TGTACCGAGA CTATAACCAC GGTGTGCTGA AGATAACCAT CTGTAAATCC 
TGCCAGAAAC CTGTAGACAA ATATATCGAG TATGATCCTG TTATCATCTT GATTAATGCT 
ATATTGTGCA AAGCTCAGGC CTACAGACAT ATTCTTTTCA ATACTCAAAT AAATATCCAT 
GGAAAACTCT GCATATTTTG TTTGCTTTGT GAAGCATACC TGAGGTGGTG GCAGCTTCAA 
GATTCCAACC AGAATACTGC CCCTGATGAC TTGATCAGAT ATGCTAAGGA ATGGGATTTC 
TATAGAATGT TTGCGATTGC TGCTTTAGGC TGGAGTGCAG TGGCACAGTC ACAGCTCACT 
GCAGCCCTGA ACTCCTGGGC TCAAGCAATC CTCCTGCCTC GGCCCCCCCA GGTAGCTGGA 
ACCACAGAAC AAACTGCCTA TTTTATTGGC ATTTTTACCT TCCTGTGGGT AGAACGGCCC 
ATGACGGCAA AAAAAAAGCC CAACTTCATT TTGCTGCTGA AAGCATTATT ATTATCTAGC 
TACGGAAAAC TCTTGCTGAT TCCAGCTGTC ATTTGGGAAC ATGACTACAC ATCTGTGTGC 
CTCAAACTCA TTAAAGTATT TGTTCTTACA TCAAATTTTC AGGCAATTAG AGTGACCCTA 
AACATCAACC GTAAGCTCTC CTTCTTGGCC GTGTTGAGTG GCTTACTGCT GGAAAGCATC 
ATGGTCTACT TCTTCCAGAG TATGGAATGG GATGTTGGAA GTGATTATGC CATCTTTAAA 
TCTCAGGACT TCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001333921.1
CDS58..972
Translation

Target ORF information:

RefSeq Version NM_001346992.1
Organism Homo sapiens(human)
Definition Homo sapiens ARV1 homolog, fatty acid homeostasis modulator (ARV1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001346992.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGGCAACG GCGGGCGGAG CGGCCTGCAG CAGGGGAAGG GGAACGTGGA TGGGGTGGCA 
GCGACTCCTA CTGCTGCCTC GGCCTCCTGC CAGTACAGGT GCATCGAATG CAACCAGGAG 
GCCAAAGAGT TGTACCGAGA CTATAACCAC GGTGTGCTGA AGATAACCAT CTGTAAATCC 
TGCCAGAAAC CTGTAGACAA ATATATCGAG TATGATCCTG TTATCATCTT GATTAATGCT 
ATATTGTGCA AAGCTCAGGC CTACAGACAT ATTCTTTTCA ATACTCAAAT AAATATCCAT 
GGAAAACTCT GCATATTTTG TTTGCTTTGT GAAGCATACC TGAGGTGGTG GCAGCTTCAA 
GATTCCAACC AGAATACTGC CCCTGATGAC TTGATCAGAT ATGCTAAGGA ATGGGATTTC 
TATAGAATGT TTGCGATTGC TGCTTTAGGC TGGAGTGCAG TGGCACAGTC ACAGCTCACT 
GCAGCCCTGA ACTCCTGGGC TCAAGCAATC CTCCTGCCTC GGCCCCCCCA GGTAGCTGGA 
ACCACAGAAC AAACTGCCTA TTTTATTGGC ATTTTTACCT TCCTGTGGGT AGAACGGCCC 
ATGACGGCAA AAAAAAAGCC CAACTTCATT TTGCTGCTGA AAGCATTATT ATTATCTAGC 
TACGGAAAAC TCTTGCTGAT TCCAGCTGTC ATTTGGGAAC ATGACTACAC ATCTGTGTGC 
CTCAAACTCA TTAAAGTATT TGTTCTTACA TCAAATTTTC AGGCAATTAG AGTGACCCTA 
AACATCAACC GTAAGCTCTC CTTCTTGGCC GTGTTGAGTG GCTTACTGCT GGAAAGCATC 
ATGGTCTACT TCTTCCAGAG TATGGAATGG GATGTTGGAA GTGATTATGC CATCTTTAAA 
TCTCAGGACT TCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu101285
Clone ID Related Accession (Same CDS sequence) NM_001346992.1 , NM_001346992.2
Accession Version NM_001346992.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 915bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-10
Organism Homo sapiens(human)
Product protein ARV1 isoform 1
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL844165.5, AL732414.17 and AF290878.1. On May 31, 2019 this sequence version replaced NM_001346992.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.460849.1, SRR1163655.464436.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGGCAACG GCGGGCGGAG CGGCCTGCAG CAGGGGAAGG GGAACGTGGA TGGGGTGGCA 
GCGACTCCTA CTGCTGCCTC GGCCTCCTGC CAGTACAGGT GCATCGAATG CAACCAGGAG 
GCCAAAGAGT TGTACCGAGA CTATAACCAC GGTGTGCTGA AGATAACCAT CTGTAAATCC 
TGCCAGAAAC CTGTAGACAA ATATATCGAG TATGATCCTG TTATCATCTT GATTAATGCT 
ATATTGTGCA AAGCTCAGGC CTACAGACAT ATTCTTTTCA ATACTCAAAT AAATATCCAT 
GGAAAACTCT GCATATTTTG TTTGCTTTGT GAAGCATACC TGAGGTGGTG GCAGCTTCAA 
GATTCCAACC AGAATACTGC CCCTGATGAC TTGATCAGAT ATGCTAAGGA ATGGGATTTC 
TATAGAATGT TTGCGATTGC TGCTTTAGGC TGGAGTGCAG TGGCACAGTC ACAGCTCACT 
GCAGCCCTGA ACTCCTGGGC TCAAGCAATC CTCCTGCCTC GGCCCCCCCA GGTAGCTGGA 
ACCACAGAAC AAACTGCCTA TTTTATTGGC ATTTTTACCT TCCTGTGGGT AGAACGGCCC 
ATGACGGCAA AAAAAAAGCC CAACTTCATT TTGCTGCTGA AAGCATTATT ATTATCTAGC 
TACGGAAAAC TCTTGCTGAT TCCAGCTGTC ATTTGGGAAC ATGACTACAC ATCTGTGTGC 
CTCAAACTCA TTAAAGTATT TGTTCTTACA TCAAATTTTC AGGCAATTAG AGTGACCCTA 
AACATCAACC GTAAGCTCTC CTTCTTGGCC GTGTTGAGTG GCTTACTGCT GGAAAGCATC 
ATGGTCTACT TCTTCCAGAG TATGGAATGG GATGTTGGAA GTGATTATGC CATCTTTAAA 
TCTCAGGACT TCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001333921.1
CDS13..927
Translation

Target ORF information:

RefSeq Version NM_001346992.2
Organism Homo sapiens(human)
Definition Homo sapiens ARV1 homolog, fatty acid homeostasis modulator (ARV1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001346992.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGGCAACG GCGGGCGGAG CGGCCTGCAG CAGGGGAAGG GGAACGTGGA TGGGGTGGCA 
GCGACTCCTA CTGCTGCCTC GGCCTCCTGC CAGTACAGGT GCATCGAATG CAACCAGGAG 
GCCAAAGAGT TGTACCGAGA CTATAACCAC GGTGTGCTGA AGATAACCAT CTGTAAATCC 
TGCCAGAAAC CTGTAGACAA ATATATCGAG TATGATCCTG TTATCATCTT GATTAATGCT 
ATATTGTGCA AAGCTCAGGC CTACAGACAT ATTCTTTTCA ATACTCAAAT AAATATCCAT 
GGAAAACTCT GCATATTTTG TTTGCTTTGT GAAGCATACC TGAGGTGGTG GCAGCTTCAA 
GATTCCAACC AGAATACTGC CCCTGATGAC TTGATCAGAT ATGCTAAGGA ATGGGATTTC 
TATAGAATGT TTGCGATTGC TGCTTTAGGC TGGAGTGCAG TGGCACAGTC ACAGCTCACT 
GCAGCCCTGA ACTCCTGGGC TCAAGCAATC CTCCTGCCTC GGCCCCCCCA GGTAGCTGGA 
ACCACAGAAC AAACTGCCTA TTTTATTGGC ATTTTTACCT TCCTGTGGGT AGAACGGCCC 
ATGACGGCAA AAAAAAAGCC CAACTTCATT TTGCTGCTGA AAGCATTATT ATTATCTAGC 
TACGGAAAAC TCTTGCTGAT TCCAGCTGTC ATTTGGGAAC ATGACTACAC ATCTGTGTGC 
CTCAAACTCA TTAAAGTATT TGTTCTTACA TCAAATTTTC AGGCAATTAG AGTGACCCTA 
AACATCAACC GTAAGCTCTC CTTCTTGGCC GTGTTGAGTG GCTTACTGCT GGAAAGCATC 
ATGGTCTACT TCTTCCAGAG TATGGAATGG GATGTTGGAA GTGATTATGC CATCTTTAAA 
TCTCAGGACT TCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19984
Clone ID Related Accession (Same CDS sequence) NM_022786.2 , NM_022786.1 , NM_022786.3
Accession Version NM_022786.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 816bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-09-14
Organism Homo sapiens(human)
Product protein ARV1 isoform 2
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF321442.1, AL844165.5 and AF290878.1. This sequence is a reference standard in the RefSeqGene project. On Nov 13, 2016 this sequence version replaced NM_022786.1. ##Evidence-Data-START## Transcript exon combination :: AF290878.1, SRR1803613.306333.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGGCAACG GCGGGCGGAG CGGCCTGCAG CAGGGGAAGG GGAACGTGGA TGGGGTGGCA 
GCGACTCCTA CTGCTGCCTC GGCCTCCTGC CAGTACAGGT GCATCGAATG CAACCAGGAG 
GCCAAAGAGT TGTACCGAGA CTATAACCAC GGTGTGCTGA AGATAACCAT CTGTAAATCC 
TGCCAGAAAC CTGTAGACAA ATATATCGAG TATGATCCTG TTATCATCTT GATTAATGCT 
ATATTGTGCA AAGCTCAGGC CTACAGACAT ATTCTTTTCA ATACTCAAAT AAATATCCAT 
GGAAAACTCT GCATATTTTG TTTGCTTTGT GAAGCATACC TGAGGTGGTG GCAGCTTCAA 
GATTCCAACC AGAATACTGC CCCTGATGAC TTGATCAGAT ATGCTAAGGA ATGGGATTTC 
TATAGAATGT TTGCGATTGC TGCTTTAGAA CAAACTGCCT ATTTTATTGG CATTTTTACC 
TTCCTGTGGG TAGAACGGCC CATGACGGCA AAAAAAAAGC CCAACTTCAT TTTGCTGCTG 
AAAGCATTAT TATTATCTAG CTACGGAAAA CTCTTGCTGA TTCCAGCTGT CATTTGGGAA 
CATGACTACA CATCTGTGTG CCTCAAACTC ATTAAAGTAT TTGTTCTTAC ATCAAATTTT 
CAGGCAATTA GAGTGACCCT AAACATCAAC CGTAAGCTCT CCTTCTTGGC CGTGTTGAGT 
GGCTTACTGC TGGAAAGCAT CATGGTCTAC TTCTTCCAGA GTATGGAATG GGATGTTGGA 
AGTGATTATG CCATCTTTAA ATCTCAGGAC TTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_073623.1
CDS58..873
Translation

Target ORF information:

RefSeq Version NM_022786.2
Organism Homo sapiens(human)
Definition Homo sapiens ARV1 homolog, fatty acid homeostasis modulator (ARV1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_022786.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGGCAACG GCGGGCGGAG CGGCCTGCAG CAGGGGAAGG GGAACGTGGA TGGGGTGGCA 
GCGACTCCTA CTGCTGCCTC GGCCTCCTGC CAGTACAGGT GCATCGAATG CAACCAGGAG 
GCCAAAGAGT TGTACCGAGA CTATAACCAC GGTGTGCTGA AGATAACCAT CTGTAAATCC 
TGCCAGAAAC CTGTAGACAA ATATATCGAG TATGATCCTG TTATCATCTT GATTAATGCT 
ATATTGTGCA AAGCTCAGGC CTACAGACAT ATTCTTTTCA ATACTCAAAT AAATATCCAT 
GGAAAACTCT GCATATTTTG TTTGCTTTGT GAAGCATACC TGAGGTGGTG GCAGCTTCAA 
GATTCCAACC AGAATACTGC CCCTGATGAC TTGATCAGAT ATGCTAAGGA ATGGGATTTC 
TATAGAATGT TTGCGATTGC TGCTTTAGAA CAAACTGCCT ATTTTATTGG CATTTTTACC 
TTCCTGTGGG TAGAACGGCC CATGACGGCA AAAAAAAAGC CCAACTTCAT TTTGCTGCTG 
AAAGCATTAT TATTATCTAG CTACGGAAAA CTCTTGCTGA TTCCAGCTGT CATTTGGGAA 
CATGACTACA CATCTGTGTG CCTCAAACTC ATTAAAGTAT TTGTTCTTAC ATCAAATTTT 
CAGGCAATTA GAGTGACCCT AAACATCAAC CGTAAGCTCT CCTTCTTGGC CGTGTTGAGT 
GGCTTACTGC TGGAAAGCAT CATGGTCTAC TTCTTCCAGA GTATGGAATG GGATGTTGGA 
AGTGATTATG CCATCTTTAA ATCTCAGGAC TTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19984
Clone ID Related Accession (Same CDS sequence) NM_022786.2 , NM_022786.1 , NM_022786.3
Accession Version NM_022786.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 816bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2015-07-15
Organism Homo sapiens(Human)
Product protein ARV1
Comment 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGGCAACG GCGGGCGGAG CGGCCTGCAG CAGGGGAAGG GGAACGTGGA TGGGGTGGCA 
GCGACTCCTA CTGCTGCCTC GGCCTCCTGC CAGTACAGGT GCATCGAATG CAACCAGGAG 
GCCAAAGAGT TGTACCGAGA CTATAACCAC GGTGTGCTGA AGATAACCAT CTGTAAATCC 
TGCCAGAAAC CTGTAGACAA ATATATCGAG TATGATCCTG TTATCATCTT GATTAATGCT 
ATATTGTGCA AAGCTCAGGC CTACAGACAT ATTCTTTTCA ATACTCAAAT AAATATCCAT 
GGAAAACTCT GCATATTTTG TTTGCTTTGT GAAGCATACC TGAGGTGGTG GCAGCTTCAA 
GATTCCAACC AGAATACTGC CCCTGATGAC TTGATCAGAT ATGCTAAGGA ATGGGATTTC 
TATAGAATGT TTGCGATTGC TGCTTTAGAA CAAACTGCCT ATTTTATTGG CATTTTTACC 
TTCCTGTGGG TAGAACGGCC CATGACGGCA AAAAAAAAGC CCAACTTCAT TTTGCTGCTG 
AAAGCATTAT TATTATCTAG CTACGGAAAA CTCTTGCTGA TTCCAGCTGT CATTTGGGAA 
CATGACTACA CATCTGTGTG CCTCAAACTC ATTAAAGTAT TTGTTCTTAC ATCAAATTTT 
CAGGCAATTA GAGTGACCCT AAACATCAAC CGTAAGCTCT CCTTCTTGGC CGTGTTGAGT 
GGCTTACTGC TGGAAAGCAT CATGGTCTAC TTCTTCCAGA GTATGGAATG GGATGTTGGA 
AGTGATTATG CCATCTTTAA ATCTCAGGAC TTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_073623.1
Translation

Target ORF information:

RefSeq Version NM_022786.1
Organism Homo sapiens(Human)
Definition Homo sapiens ARV1 homolog, fatty acid homeostatsis modulator (ARV1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_022786.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGGCAACG GCGGGCGGAG CGGCCTGCAG CAGGGGAAGG GGAACGTGGA TGGGGTGGCA 
GCGACTCCTA CTGCTGCCTC GGCCTCCTGC CAGTACAGGT GCATCGAATG CAACCAGGAG 
GCCAAAGAGT TGTACCGAGA CTATAACCAC GGTGTGCTGA AGATAACCAT CTGTAAATCC 
TGCCAGAAAC CTGTAGACAA ATATATCGAG TATGATCCTG TTATCATCTT GATTAATGCT 
ATATTGTGCA AAGCTCAGGC CTACAGACAT ATTCTTTTCA ATACTCAAAT AAATATCCAT 
GGAAAACTCT GCATATTTTG TTTGCTTTGT GAAGCATACC TGAGGTGGTG GCAGCTTCAA 
GATTCCAACC AGAATACTGC CCCTGATGAC TTGATCAGAT ATGCTAAGGA ATGGGATTTC 
TATAGAATGT TTGCGATTGC TGCTTTAGAA CAAACTGCCT ATTTTATTGG CATTTTTACC 
TTCCTGTGGG TAGAACGGCC CATGACGGCA AAAAAAAAGC CCAACTTCAT TTTGCTGCTG 
AAAGCATTAT TATTATCTAG CTACGGAAAA CTCTTGCTGA TTCCAGCTGT CATTTGGGAA 
CATGACTACA CATCTGTGTG CCTCAAACTC ATTAAAGTAT TTGTTCTTAC ATCAAATTTT 
CAGGCAATTA GAGTGACCCT AAACATCAAC CGTAAGCTCT CCTTCTTGGC CGTGTTGAGT 
GGCTTACTGC TGGAAAGCAT CATGGTCTAC TTCTTCCAGA GTATGGAATG GGATGTTGGA 
AGTGATTATG CCATCTTTAA ATCTCAGGAC TTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19984
Clone ID Related Accession (Same CDS sequence) NM_022786.2 , NM_022786.1 , NM_022786.3
Accession Version NM_022786.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 816bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-10
Organism Homo sapiens(human)
Product protein ARV1 isoform 2
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF290878.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_022786.2. ##Evidence-Data-START## Transcript exon combination :: AF290878.1, SRR1660807.408876.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000310256.7/ ENSP00000312458.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGGCAACG GCGGGCGGAG CGGCCTGCAG CAGGGGAAGG GGAACGTGGA TGGGGTGGCA 
GCGACTCCTA CTGCTGCCTC GGCCTCCTGC CAGTACAGGT GCATCGAATG CAACCAGGAG 
GCCAAAGAGT TGTACCGAGA CTATAACCAC GGTGTGCTGA AGATAACCAT CTGTAAATCC 
TGCCAGAAAC CTGTAGACAA ATATATCGAG TATGATCCTG TTATCATCTT GATTAATGCT 
ATATTGTGCA AAGCTCAGGC CTACAGACAT ATTCTTTTCA ATACTCAAAT AAATATCCAT 
GGAAAACTCT GCATATTTTG TTTGCTTTGT GAAGCATACC TGAGGTGGTG GCAGCTTCAA 
GATTCCAACC AGAATACTGC CCCTGATGAC TTGATCAGAT ATGCTAAGGA ATGGGATTTC 
TATAGAATGT TTGCGATTGC TGCTTTAGAA CAAACTGCCT ATTTTATTGG CATTTTTACC 
TTCCTGTGGG TAGAACGGCC CATGACGGCA AAAAAAAAGC CCAACTTCAT TTTGCTGCTG 
AAAGCATTAT TATTATCTAG CTACGGAAAA CTCTTGCTGA TTCCAGCTGT CATTTGGGAA 
CATGACTACA CATCTGTGTG CCTCAAACTC ATTAAAGTAT TTGTTCTTAC ATCAAATTTT 
CAGGCAATTA GAGTGACCCT AAACATCAAC CGTAAGCTCT CCTTCTTGGC CGTGTTGAGT 
GGCTTACTGC TGGAAAGCAT CATGGTCTAC TTCTTCCAGA GTATGGAATG GGATGTTGGA 
AGTGATTATG CCATCTTTAA ATCTCAGGAC TTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_073623.1
CDS13..828
Translation

Target ORF information:

RefSeq Version NM_022786.3
Organism Homo sapiens(human)
Definition Homo sapiens ARV1 homolog, fatty acid homeostasis modulator (ARV1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_022786.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGGCAACG GCGGGCGGAG CGGCCTGCAG CAGGGGAAGG GGAACGTGGA TGGGGTGGCA 
GCGACTCCTA CTGCTGCCTC GGCCTCCTGC CAGTACAGGT GCATCGAATG CAACCAGGAG 
GCCAAAGAGT TGTACCGAGA CTATAACCAC GGTGTGCTGA AGATAACCAT CTGTAAATCC 
TGCCAGAAAC CTGTAGACAA ATATATCGAG TATGATCCTG TTATCATCTT GATTAATGCT 
ATATTGTGCA AAGCTCAGGC CTACAGACAT ATTCTTTTCA ATACTCAAAT AAATATCCAT 
GGAAAACTCT GCATATTTTG TTTGCTTTGT GAAGCATACC TGAGGTGGTG GCAGCTTCAA 
GATTCCAACC AGAATACTGC CCCTGATGAC TTGATCAGAT ATGCTAAGGA ATGGGATTTC 
TATAGAATGT TTGCGATTGC TGCTTTAGAA CAAACTGCCT ATTTTATTGG CATTTTTACC 
TTCCTGTGGG TAGAACGGCC CATGACGGCA AAAAAAAAGC CCAACTTCAT TTTGCTGCTG 
AAAGCATTAT TATTATCTAG CTACGGAAAA CTCTTGCTGA TTCCAGCTGT CATTTGGGAA 
CATGACTACA CATCTGTGTG CCTCAAACTC ATTAAAGTAT TTGTTCTTAC ATCAAATTTT 
CAGGCAATTA GAGTGACCCT AAACATCAAC CGTAAGCTCT CCTTCTTGGC CGTGTTGAGT 
GGCTTACTGC TGGAAAGCAT CATGGTCTAC TTCTTCCAGA GTATGGAATG GGATGTTGGA 
AGTGATTATG CCATCTTTAA ATCTCAGGAC TTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu105755
Clone ID Related Accession (Same CDS sequence) XM_024449202.1
Accession Version XM_024449202.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 939bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product protein ARV1 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGGCAACG GCGGGCGGAG CGGCCTGCAG CAGGGGAAGG GGAACGTGGA TGGGGTGGCA 
GCGACTCCTA CTGCTGCCTC GGCCTCCTGC CAGTACAGGT GCATCGAATG CAACCAGGAG 
GCCAAAGAGT TGTACCGAGA CTATAACCAC GGTGTGCTGA AGATAACCAT CTGTAAATCC 
TGCCAGAAAC CTGTAGACAA ATATATCGAG TATGATCCTG TTATCATCTT GATTAATGCT 
ATATTGTGCA AAGCTCAGGC CTACAGACAT ATTCTTTTCA ATACTCAAAT AAATATCCAT 
GGAAAACTCT GCATATTTTG TTTGCTTTGT GAAGCATACC TGAGGTGGTG GCAGCTTCAA 
GATTCCAACC AGAATACTGC CCCTGATGAC TTGATCAGAT ATGCTAAGGA ATGGGATTTC 
TATAGAATGT TTGCGATTGC TGCTTTAGAC AGGGTCTCAC TCTGTTGCCT AGGCTGGAGT 
GCAGTGGCAC AGTCACAGCT CACTGCAGCC CTGAACTCCT GGGCTCAAGC AATCCTCCTG 
CCTCGGCCCC CCCAGGTAGC TGGAACCACA GAACAAACTG CCTATTTTAT TGGCATTTTT 
ACCTTCCTGT GGGTAGAACG GCCCATGACG GCAAAAAAAA AGCCCAACTT CATTTTGCTG 
CTGAAAGCAT TATTATTATC TAGCTACGGA AAACTCTTGC TGATTCCAGC TGTCATTTGG 
GAACATGACT ACACATCTGT GTGCCTCAAA CTCATTAAAG TATTTGTTCT TACATCAAAT 
TTTCAGGCAA TTAGAGTGAC CCTAAACATC AACCGTAAGC TCTCCTTCTT GGCCGTGTTG 
AGTGGCTTAC TGCTGGAAAG CATCATGGTC TACTTCTTCC AGAGTATGGA ATGGGATGTT 
GGAAGTGATT ATGCCATCTT TAAATCTCAG GACTTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_024304970.1
CDS25..963
Translation

Target ORF information:

RefSeq Version XM_024449202.1
Organism Homo sapiens(human)
Definition Homo sapiens ARV1 homolog, fatty acid homeostasis modulator (ARV1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_024449202.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGGCAACG GCGGGCGGAG CGGCCTGCAG CAGGGGAAGG GGAACGTGGA TGGGGTGGCA 
GCGACTCCTA CTGCTGCCTC GGCCTCCTGC CAGTACAGGT GCATCGAATG CAACCAGGAG 
GCCAAAGAGT TGTACCGAGA CTATAACCAC GGTGTGCTGA AGATAACCAT CTGTAAATCC 
TGCCAGAAAC CTGTAGACAA ATATATCGAG TATGATCCTG TTATCATCTT GATTAATGCT 
ATATTGTGCA AAGCTCAGGC CTACAGACAT ATTCTTTTCA ATACTCAAAT AAATATCCAT 
GGAAAACTCT GCATATTTTG TTTGCTTTGT GAAGCATACC TGAGGTGGTG GCAGCTTCAA 
GATTCCAACC AGAATACTGC CCCTGATGAC TTGATCAGAT ATGCTAAGGA ATGGGATTTC 
TATAGAATGT TTGCGATTGC TGCTTTAGAC AGGGTCTCAC TCTGTTGCCT AGGCTGGAGT 
GCAGTGGCAC AGTCACAGCT CACTGCAGCC CTGAACTCCT GGGCTCAAGC AATCCTCCTG 
CCTCGGCCCC CCCAGGTAGC TGGAACCACA GAACAAACTG CCTATTTTAT TGGCATTTTT 
ACCTTCCTGT GGGTAGAACG GCCCATGACG GCAAAAAAAA AGCCCAACTT CATTTTGCTG 
CTGAAAGCAT TATTATTATC TAGCTACGGA AAACTCTTGC TGATTCCAGC TGTCATTTGG 
GAACATGACT ACACATCTGT GTGCCTCAAA CTCATTAAAG TATTTGTTCT TACATCAAAT 
TTTCAGGCAA TTAGAGTGAC CCTAAACATC AACCGTAAGC TCTCCTTCTT GGCCGTGTTG 
AGTGGCTTAC TGCTGGAAAG CATCATGGTC TACTTCTTCC AGAGTATGGA ATGGGATGTT 
GGAAGTGATT ATGCCATCTT TAAATCTCAG GACTTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW


book

Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy.
Human molecular genetics25(14)3042-3054(2016 07)
Palmer EE,Jarrett KE,Sachdev RK,Al Zahrani F,Hashem MO,Ibrahim N,Sampaio H,Kandula T,Macintosh R,Gupta R,Conlon DM,Billheimer JT,Rader DJ,Funato K,Walkey CJ,Lee CS,Loo C,Brammah S,Elakis G,Zhu Y,Buckley M,Kirk EP,Bye A,Alkuraya FS,Roscioli T,Lagor WR


book

Complementation analysis reveals a potential role of human ARV1 in GPI anchor biosynthesis.
Yeast (Chichester, England)33(2)37-42(2016 Feb)
Ikeda A,Kajiwara K,Iwamoto K,Makino A,Kobayashi T,Mizuta K,Funato K


book

Arv1 promotes cell division by recruiting IQGAP1 and myosin to the cleavage furrow.
Cell cycle (Georgetown, Tex.)15(5)628-43(2016)
Sundvold H,Sundvold-Gjerstad V,Maler?d-Fjeld H,Haglund K,Stenmark H,Maler?d L


book

A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance.
The Journal of biological chemistry289(7)4417-31(2014 Feb)
Ruggles KV,Garbarino J,Liu Y,Moon J,Schneider K,Henneberry A,Billheimer J,Millar JS,Marchadier D,Valasek MA,Joblin-Mills A,Gulati S,Munkacsi AB,Repa JJ,Rader D,Sturley SL