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SIX1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol SIX1
Entrez Gene ID 6495
Full Name SIX homeobox 1
Synonyms BOS3, DFNA23, TIP39
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q23.1

Summary The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

601205

Disorder Html: Brachiootic syndrome 3, 608389 (3); Deafness, autosomal dominant 23,

mRNA and Protein(s)

mRNA Protein Name
NM_005982 NP_005973 homeobox protein SIX1



Homo sapiens (human) SIX1 NP_005973.1
Pan troglodytes (chimpanzee) SIX1 XP_509988.2
Macaca mulatta (Rhesus monkey) SIX1 XP_001096585.1
Canis lupus familiaris (dog) SIX1 XP_547841.3
Bos taurus (cattle) SIX1 XP_002691065.3
Mus musculus (house mouse) Six1 NP_033215.2
Rattus norvegicus (Norway rat) Six1 NP_446211.1
Gallus gallus (chicken) SIX1 NP_001038150.1
Danio rerio (zebrafish) six1b NP_996978.1
Drosophila melanogaster (fruit fly) so NP_476733.1
Xenopus (Silurana) tropicalis (western clawed frog) six1 NP_001093693.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SIX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SIX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu26939
NM_005982 Homo sapiens SIX homeobox 1 (SIX1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$154.50-$216.30
$309.00
Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu26939
Clone ID Related Accession (Same CDS sequence) NM_005982
Accession Version NM_005982.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 855bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product homeobox protein SIX1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC008874.2, X91868.1 and AL049874.3. This sequence is a reference standard in the RefSeqGene project. On Apr 29, 2008 this sequence version replaced gi:142345106. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008874.2, X91868.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGTCGATGC TGCCGTCGTT TGGCTTTACG CAGGAGCAAG TGGCGTGCGT GTGCGAGGTT 
CTGCAGCAAG GCGGAAACCT GGAGCGCCTG GGCAGGTTCC TGTGGTCACT GCCCGCCTGC
GACCACCTGC ACAAGAACGA GAGCGTACTC AAGGCCAAGG CGGTGGTCGC CTTCCACCGC
GGCAACTTCC GTGAGCTCTA CAAGATCCTG GAGAGCCACC AGTTCTCGCC TCACAACCAC
CCCAAACTGC AGCAACTGTG GCTGAAGGCG CATTACGTGG AGGCCGAGAA GCTGCGCGGC
CGACCCCTGG GCGCCGTGGG CAAATATCGG GTGCGCCGAA AATTTCCACT GCCGCGCACC
ATCTGGGACG GCGAGGAGAC CAGCTACTGC TTCAAGGAGA AGTCGAGGGG TGTCCTGCGG
GAGTGGTACG CGCACAATCC CTACCCATCG CCGCGTGAGA AGCGGGAGCT GGCCGAGGCC
ACCGGCCTCA CCACCACCCA GGTCAGCAAC TGGTTTAAGA ACCGGAGGCA AAGAGACCGG
GCCGCGGAGG CCAAGGAAAG GGAGAACACC GAAAACAATA ACTCCTCCTC CAACAAGCAG
AACCAACTCT CTCCTCTGGA AGGGGGCAAG CCGCTCATGT CCAGCTCAGA AGAGGAATTC
TCACCTCCCC AAAGTCCAGA CCAGAACTCG GTCCTTCTGC TGCAGGGCAA TATGGGCCAC
GCCAGGAGCT CAAACTATTC TCTCCCGGGC TTAACAGCCT CGCAGCCCAG TCACGGCCTG
CAGACCCACC AGCATCAGCT CCAAGACTCT CTGCTCGGCC CCCTCACCTC CAGTCTGGTG
GACTTGGGGT CCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005973.1
CDS249..1103
Misc Feature(1)147..149(+)
Misc Feature(2)633..788(+)
Misc Feature(3)633..788(+)
Misc Feature(4)636..779(+)
Exon (1)1..808
Gene:SIX1
Gene Synonym:
Exon (2)809..2687
Gene:SIX1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_005982
Organism Homo sapiens (human)
Definition Homo sapiens SIX homeobox 1 (SIX1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005982

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGTCGATGC TGCCGTCGTT TGGCTTTACG CAGGAGCAAG TGGCGTGCGT GTGCGAGGTT 
CTGCAGCAAG GCGGAAACCT GGAGCGCCTG GGCAGGTTCC TGTGGTCACT GCCCGCCTGC
GACCACCTGC ACAAGAACGA GAGCGTACTC AAGGCCAAGG CGGTGGTCGC CTTCCACCGC
GGCAACTTCC GTGAGCTCTA CAAGATCCTG GAGAGCCACC AGTTCTCGCC TCACAACCAC
CCCAAACTGC AGCAACTGTG GCTGAAGGCG CATTACGTGG AGGCCGAGAA GCTGCGCGGC
CGACCCCTGG GCGCCGTGGG CAAATATCGG GTGCGCCGAA AATTTCCACT GCCGCGCACC
ATCTGGGACG GCGAGGAGAC CAGCTACTGC TTCAAGGAGA AGTCGAGGGG TGTCCTGCGG
GAGTGGTACG CGCACAATCC CTACCCATCG CCGCGTGAGA AGCGGGAGCT GGCCGAGGCC
ACCGGCCTCA CCACCACCCA GGTCAGCAAC TGGTTTAAGA ACCGGAGGCA AAGAGACCGG
GCCGCGGAGG CCAAGGAAAG GGAGAACACC GAAAACAATA ACTCCTCCTC CAACAAGCAG
AACCAACTCT CTCCTCTGGA AGGGGGCAAG CCGCTCATGT CCAGCTCAGA AGAGGAATTC
TCACCTCCCC AAAGTCCAGA CCAGAACTCG GTCCTTCTGC TGCAGGGCAA TATGGGCCAC
GCCAGGAGCT CAAACTATTC TCTCCCGGGC TTAACAGCCT CGCAGCCCAG TCACGGCCTG
CAGACCCACC AGCATCAGCT CCAAGACTCT CTGCTCGGCC CCCTCACCTC CAGTCTGGTG
GACTTGGGGT CCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Sine oculis homeobox homolog 1 promotes alpha5beta1-mediated invasive migration and metastasis of cervical cancer cells
Biochem. Biophys. Res. Commun. 446 (2), 549-554 (2014)
Liu D, Zhang XX, Wan DY, Xi BX, Ma D, Wang H and Gao QL.


book

Sineoculis homeobox homolog 1 protein overexpression as an independent biomarker for pancreatic ductal adenocarcinoma
Exp. Mol. Pathol. 96 (1), 54-60 (2014)
Jin A, Xu Y, Liu S, Jin T, Li Z, Jin H, Lin L and Lin Z.


book

Six1 mediates resistance to paclitaxel in breast cancer cells
Biochem. Biophys. Res. Commun. 441 (3), 538-543 (2013)
Li Z, Tian T, Hu X, Zhang X, Nan F, Chang Y, Lv F and Zhang M.


book

Six1 promotes proliferation of pancreatic cancer cells via upregulation of cyclin D1 expression
PLoS ONE 8 (3), E59203 (2013)
Li Z, Tian T, Lv F, Chang Y, Wang X, Zhang L, Li X, Li L, Ma W, Wu J and Zhang M.


book

A novel locus (DFNA23) for prelingual autosomal dominant nonsyndromic hearing loss maps to 14q21-q22 in a Swiss German kindred
Am. J. Hum. Genet. 66 (6), 1984-1988 (2000)
Salam AA, Hafner FM, Linder TE, Spillmann T, Schinzel AA and Leal SM.


book

Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesis
Proc. Natl. Acad. Sci. U.S.A. 95 (21), 12608-12613 (1998)
Ford HL, Kabingu EN, Bump EA, Mutter GL and Pardee AB.


book

Cloning of the human SIX1 gene and its assignment to chromosome 14
Genomics 33 (1), 140-142 (1996)
Boucher CA, Carey N, Edwards YH, Siciliano MJ and Johnson KJ.


book

Homeobox genes and connective tissue patterning
Development 121 (3), 693-705 (1995)
Oliver G, Wehr R, Jenkins NA, Copeland NG, Cheyette BN, Hartenstein V, Zipursky SL and Gruss P.


book

Deafness and Hereditary Hearing Loss Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Smith,R.J.H., Shearer,A.E., Hildebrand,M.S. and Van Camp,G.


book

Branchiootorenal Spectrum Disorders
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Smith,R.J.H.


 
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