UBE2Z cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | UBE2Z |
| Entrez Gene ID | 65264 |
| Full Name | ubiquitin conjugating enzyme E2 Z |
| Synonyms | HOYS7,USE1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_023079.4 | NP_075567.2 | ubiquitin-conjugating enzyme E2 Z |
| NM_023079.5 | NP_075567.2 | ubiquitin-conjugating enzyme E2 Z |
| Homo sapiens (human) | UBE2Z | NP_075567.2 |
| Bos taurus (cattle) | UBE2Z | NP_001192415.1 |
| Mus musculus (house mouse) | Ube2z | NP_758504.3 |
| Rattus norvegicus (Norway rat) | Ube2z | NP_001032732.2 |
| Danio rerio (zebrafish) | ube2z | NP_001002330.2 |
| Gallus gallus (chicken) | UBE2Z | XP_418113.1 |
| Xenopus tropicalis (tropical clawed frog) | ube2z | NP_001007969.2 |
| Pan troglodytes (chimpanzee) | UBE2Z | XP_511942.3 |
Related articles in PubMed
Association of Uba6-Specific-E2 (USE1) With Lung Tumorigenesis.
Kim SJ, Hyeong Lee T, Hee Nam S, Kim JH, Oh S, Sook Cho Y, Sup Lee M, Choi S, Lee PC
Journal of the National Cancer Institute109(3)1-11(2017 03)
Rs46522 in the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with the Risk of Coronary Artery Disease in Individuals of Chinese Han Population with Type 2 Diabetes.
Lu D, Huang J, Ma X, Gu N, Zhang J, Zhang H, Guo X
Journal of diabetes research20174501794(2017)
Evaluating the association of common UBE2Z variants with coronary artery disease in an ian population.
Bastami M, Ghaderian SM, Omrani MD, Mirfakhraie R, Nariman-Saleh-Fam Z, Mansoori Y, Masotti A
Cellular and molecular biology (Noisy-le-Grand, France)61(7)50-4(2015 Nov)
Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1.
Aichem A, Catone N, Groettrup M
The FEBS journal281(7)1848-59(2014 Apr)
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
Schunkert H, K?nig IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, Andersen K, Anderson JL, Ardissino D, Ball SG, Balmforth AJ, Barnes TA, Becker DM, Becker LC, Berger K, Bis JC, Boekholdt SM, Boerwinkle E, Braund PS, Brown MJ, Burnett MS, Buysschaert I, , Carlquist JF, Chen L, Cichon S, Codd V, Davies RW, Dedoussis G, Dehghan A, Demissie S, Devaney JM, Diemert P, Do R, Doering A, Eifert S, Mokhtari NE, Ellis SG, Elosua R, Engert JC, Epstein SE, de Faire U, Fischer M, Folsom AR, Freyer J, Gigante B, Girelli D, Gretarsdottir S, Gudnason V, Gulcher JR, Halperin E, Hammond N, Hazen SL, Hofman A, Horne BD, Illig T, Iribarren C, Jones GT, Jukema JW, Kaiser MA, Kaplan LM, Kastelein JJ, Khaw KT, Knowles JW, Kolovou G, Kong A, Laaksonen R, Lambrechts D, Leander K, Lettre G, Li M, Lieb W, Loley C, Lotery AJ, Mannucci PM, Maouche S, Martinelli N, McKeown PP, Meisinger C, Meitinger T, Melander O, Merlini PA, Mooser V, Morgan T, M?hleisen TW, Muhlestein JB, M?nzel T, Musunuru K, Nahrstaedt J, Nelson CP, N?then MM, Olivieri O, Patel RS, Patterson CC, Peters A, Peyvandi F, Qu L, Quyyumi AA, Rader DJ, Rallidis LS, Rice C, Rosendaal FR, Rubin D, Salomaa V, Sampietro ML, Sandhu MS, Schadt E, Sch?fer A, Schillert A, Schreiber S, Schrezenmeir J, Schwartz SM, Siscovick DS, Sivananthan M, Sivapalaratnam S, Smith A, Smith TB, Snoep JD, Soranzo N, Spertus JA, Stark K, Stirrups K, Stoll M, Tang WH, Tennstedt S, Thorgeirsson G, Thorleifsson G, Tomaszewski M, Uitterlinden AG, van Rij AM, Voight BF, Wareham NJ, Wells GA, Wichmann HE, Wild PS, Willenborg C, Witteman JC, Wright BJ, Ye S, Zeller T, Ziegler A, Cambien F, Goodall AH, Cupples LA, Quertermous T, M?rz W, Hengstenberg C, Blankenberg S, Ouwehand WH, Hall AS, Deloukas P, Thompson JR, Stefansson K, Roberts R, Thorsteinsdottir U, O'Donnell CJ, McPherson R, Erdmann J, , Samani NJ
Nature genetics43(4)333-8(2011 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
we found that USE1 proteins were frequently overexpressed in human lung cancer. Furthermore, overexpression of USE1 promoted in vivo and in vitro proliferation, migration, and invasion.
Title: Association of Uba6-Specific-E2 (USE1) With Lung Tumorigenesis.
Association of UBE2Z single nucleotide polymorphism rs46522 with the susceptibility to coronary artery disease in an ian population.
Title: Evaluating the association of common UBE2Z variants with coronary artery disease in an ian population.
UBE2Z was widely expressed in human tissues and is located on chromosome 17q21.
Title: Cloning and characterization of a gene encoding the human putative ubiquitin conjugating enzyme E2Z (UBE2Z).
In tissue culture cells, Uba6 is required for charging a previously uncharacterized Uba6-specific E2 (Use1), whereas Ube1 is required for charging the cell-cycle E2s Cdc34A and Cdc34B
Title: Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.
The following UBE2Z gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UBE2Z cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu00731 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_023079.4 , NM_023079.5 | |
| Accession Version | NM_023079.4 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-10-01 | |
| Organism | Homo sapiens(human) | |
| Product | ubiquitin-conjugating enzyme E2 Z | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC091133.11, BC015890.1, AL713782.1, AK122770.1 and AA845421.1. On Aug 5, 2010 this sequence version replaced NM_023079.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC015890.1, SRR1163658.207730.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCGGAGA GTCCGACTGA GGAGGCGGCA ACGGCGGGCG CCGGGGCGGC GGGCCCCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_075567.2 |
| CDS | 136..1200 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_023079.4 |
ORF Insert Sequence:
1 | ATGGCGGAGA GTCCGACTGA GGAGGCGGCA ACGGCGGGCG CCGGGGCGGC GGGCCCCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu00731 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_023079.4 , NM_023079.5 | |
| Accession Version | NM_023079.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-05-01 | |
| Organism | Homo sapiens(human) | |
| Product | ubiquitin-conjugating enzyme E2 Z | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC091133.11, BC015890.1, AL713782.1 and AK122770.1. On Nov 23, 2018 this sequence version replaced NM_023079.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC015890.1, SRR1163658.207730.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000360943.10/ ENSP00000354201.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGGCGGAGA GTCCGACTGA GGAGGCGGCA ACGGCGGGCG CCGGGGCGGC GGGCCCCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_075567.2 |
| CDS | 98..1162 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_023079.5 |
ORF Insert Sequence:
1 | ATGGCGGAGA GTCCGACTGA GGAGGCGGCA ACGGCGGGCG CCGGGGCGGC GGGCCCCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Association of Uba6-Specific-E2 (USE1) With Lung Tumorigenesis. |
|
Rs46522 in the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with the Risk of Coronary Artery Disease in Individuals of Chinese Han Population with Type 2 Diabetes. |
|
Evaluating the association of common UBE2Z variants with coronary artery disease in an Iranian population. |
|
Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1. |
|
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. |