Gene Symbol | SLC6A12 |
Entrez Gene ID | 6539 |
Full Name | solute carrier family 6 member 12 |
Synonyms | BGT-1,BGT1,GAT2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » SLC6A12 cDNA ORF clone
gRNAs
Gene Symbol | SLC6A12 |
Entrez Gene ID | 6539 |
Full Name | solute carrier family 6 member 12 |
Synonyms | BGT-1,BGT1,GAT2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_001122848.3 | NP_001116320.1 | sodium- and chloride-dependent betaine transporter |
NM_001122847.3 | NP_001116319.1 | sodium- and chloride-dependent betaine transporter |
NM_001206931.1 | NP_001193860.1 | sodium- and chloride-dependent betaine transporter |
NM_001122847.2 | NP_001116319.1 | sodium- and chloride-dependent betaine transporter |
XM_011521010.1 | XP_011519312.1 | sodium- and chloride-dependent betaine transporter isoform X1 |
XM_005253748.4 | XP_005253805.1 | sodium- and chloride-dependent betaine transporter isoform X3 |
XM_017019841.1 | XP_016875330.1 | sodium- and chloride-dependent betaine transporter isoform X5 |
NM_003044.5 | NP_003035.3 | sodium- and chloride-dependent betaine transporter |
XM_005253747.4 | XP_005253804.1 | sodium- and chloride-dependent betaine transporter isoform X2 |
NM_001122848.2 | NP_001116320.1 | sodium- and chloride-dependent betaine transporter |
NM_003044.4 | NP_003035.3 | sodium- and chloride-dependent betaine transporter |
NM_001206931.2 | NP_001193860.1 | sodium- and chloride-dependent betaine transporter |
XM_006719005.3 | XP_006719068.1 | sodium- and chloride-dependent betaine transporter isoform X4 |
Canis lupus familiaris (dog) | SLC6A12 | NP_001003322.1 |
Pan troglodytes (chimpanzee) | SLC6A12 | XP_003313471.1 |
Mus musculus (house mouse) | Slc6a12 | NP_598422.2 |
Rattus norvegicus (Norway rat) | Slc6a12 | NP_059031.1 |
SLC6A12 | XP_001093673.1 | |
Homo sapiens (human) | SLC6A12 | NP_001116320.1 |
Gallus gallus (chicken) | SLC6A13 | XP_004937977.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100492029 | XP_002941944.2 |
Combined effect between two functional polymorphisms of SLC6A12 gene is associated with temporal lobe epilepsy.
Li J, Lin H, Niu F, Zhu X, Shen N, Wang X, Li L, Liu A, Wu X, Sun W, Wang Y, Liu Y
Journal of genetics94(4)637-42(2015 Dec)
Mutation of a single threonine in the cytoplasmic NH2 terminus disrupts trafficking of renal betaine-GABA transporter 1 during hypertonic stress.
Schweikhard ES, Kempson SA, Ziegler C, Burckhardt BC
American journal of physiology. Renal physiology307(1)F107-15(2014 Jul)
An atlas of genetic influences on human blood metabolites.
Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E, , Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ, Gieger C, Kastenm?ller G, Spector TD, Soranzo N
Nature genetics46(6)543-550(2014 Jun)
Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.
Ivarsson Y, Arnold R, McLaughlin M, Nim S, Joshi R, Ray D, Liu B, Teyra J, Pawson T, Moffat J, Li SS, Sidhu SS, Kim PM
Proceedings of the National Academy of Sciences of the United States of America111(7)2542-7(2014 Feb)
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
Xie W, Wood AR, Lyssenko V, Weedon MN, Knowles JW, Alkayyali S, Assimes TL, Quertermous T, Abbasi F, Paananen J, H?ring H, Hansen T, Pedersen O, Smith U, Laakso M, , , , , Dekker JM, Nolan JJ, Groop L, Ferrannini E, Adam KP, Gall WE, Frayling TM, Walker M
Diabetes62(6)2141-50(2013 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The SLC6A12 expression levels in peripheral blood mononuclear cells were significantly higher in TLE patients.
Title: Combined effect between two functional polymorphisms of SLC6A12 gene is associated with temporal lobe epilepsy.
T40 may be important for the trafficking and insertion of BGT1 in the plasma membrane
Title: Mutation of a single threonine in the cytoplasmic NH2 terminus disrupts trafficking of renal betaine-GABA transporter 1 during hypertonic stress.
JAK2 is a novel regulator of the GABA transporter BGT1.
Title: Up-regulation of the betaine/GABA transporter BGT1 by JAK2.
This study found that rs216250 of SLC6A12 was correlated with the Scale for the Assessment of Negative Symptoms (SANS) scores.
Title: Association between the SLC6A12 gene and negative symptoms of schizophrenia in a Korean population.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Association of SLC6A12 variants with aspirin-intolerant asthma in a Korean population.
The following SLC6A12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC6A12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu08493 | |
Clone ID Related Accession (Same CDS sequence) | NM_001122848.3 , NM_001122847.3 , NM_001206931.1 , NM_001122847.2 , XM_011521010.1 , NM_003044.5 , NM_001122848.2 , NM_003044.4 , NM_001206931.2 | |
Accession Version | NM_001122848.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-29 | |
Organism | Homo sapiens(human) | |
Product | sodium- and chloride-dependent betaine transporter | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA406088.1, DA390883.1, L42300.1, AC007406.1, BC036838.1 and AI241640.1. On Jun 2, 2019 this sequence version replaced NM_001122848.2. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.68657.1, SRR1803614.3767.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001116320.1 |
CDS | 379..2223 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu08493 | |
Clone ID Related Accession (Same CDS sequence) | NM_001122848.3 , NM_001122847.3 , NM_001206931.1 , NM_001122847.2 , XM_011521010.1 , NM_003044.5 , NM_001122848.2 , NM_003044.4 , NM_001206931.2 | |
Accession Version | NM_001122847.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-28 | |
Organism | Homo sapiens(human) | |
Product | sodium- and chloride-dependent betaine transporter | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC007406.1, DA093632.1 and BC036838.1. On Jun 2, 2019 this sequence version replaced NM_001122847.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.67776.1, SRR1660803.129155.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001116319.1 |
CDS | 335..2179 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu08493 | |
Clone ID Related Accession (Same CDS sequence) | NM_001122848.3 , NM_001122847.3 , NM_001206931.1 , NM_001122847.2 , XM_011521010.1 , NM_003044.5 , NM_001122848.2 , NM_003044.4 , NM_001206931.2 | |
Accession Version | NM_001206931.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-22 | |
Organism | Homo sapiens(human) | |
Product | sodium- and chloride-dependent betaine transporter | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC007406.1 and AK313690.1. Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.126625.1, SRR1660807.161896.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001193860.1 |
CDS | 342..2186 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu08493 | |
Clone ID Related Accession (Same CDS sequence) | NM_001122848.3 , NM_001122847.3 , NM_001206931.1 , NM_001122847.2 , XM_011521010.1 , NM_003044.5 , NM_001122848.2 , NM_003044.4 , NM_001206931.2 | |
Accession Version | NM_001122847.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-22 | |
Organism | Homo sapiens(human) | |
Product | sodium- and chloride-dependent betaine transporter | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA093632.1, BC036838.1 and AC007406.1. On May 14, 2011 this sequence version replaced NM_001122847.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.67776.1, SRR1660803.129155.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001116319.1 |
CDS | 330..2174 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu08493 | |
Clone ID Related Accession (Same CDS sequence) | NM_001122848.3 , NM_001122847.3 , NM_001206931.1 , NM_001122847.2 , XM_011521010.1 , NM_003044.5 , NM_001122848.2 , NM_003044.4 , NM_001206931.2 | |
Accession Version | NM_003044.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-28 | |
Organism | Homo sapiens(human) | |
Product | sodium- and chloride-dependent betaine transporter | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC007406.1 and U27699.2. On Jun 2, 2019 this sequence version replaced NM_003044.4. Transcript Variant: This variant (1) and variants 2, 3 and 4 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U27699.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2162895 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_003035.3 |
CDS | 920..2764 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu08493 | |
Clone ID Related Accession (Same CDS sequence) | NM_001122848.3 , NM_001122847.3 , NM_001206931.1 , NM_001122847.2 , XM_011521010.1 , NM_003044.5 , NM_001122848.2 , NM_003044.4 , NM_001206931.2 | |
Accession Version | NM_001122848.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-22 | |
Organism | Homo sapiens(human) | |
Product | sodium- and chloride-dependent betaine transporter | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA406088.1, DA390883.1, L42300.1, AC007406.1, BC036838.1 and AI241640.1. On May 14, 2011 this sequence version replaced NM_001122848.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK125026.1, SRR1803614.97802.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001116320.1 |
CDS | 427..2271 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu08493 | |
Clone ID Related Accession (Same CDS sequence) | NM_001122848.3 , NM_001122847.3 , NM_001206931.1 , NM_001122847.2 , XM_011521010.1 , NM_003044.5 , NM_001122848.2 , NM_003044.4 , NM_001206931.2 | |
Accession Version | NM_003044.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-22 | |
Organism | Homo sapiens(human) | |
Product | sodium- and chloride-dependent betaine transporter | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC007406.1 and U27699.2. On or before Aug 31, 2013 this sequence version replaced XM_005253745.1, NM_003044.3. Transcript Variant: This variant (1) and variants 2, 3 and 4 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U27699.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2162895 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_003035.3 |
CDS | 665..2509 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu08493 | |
Clone ID Related Accession (Same CDS sequence) | NM_001122848.3 , NM_001122847.3 , NM_001206931.1 , NM_001122847.2 , XM_011521010.1 , NM_003044.5 , NM_001122848.2 , NM_003044.4 , NM_001206931.2 | |
Accession Version | NM_001206931.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-28 | |
Organism | Homo sapiens(human) | |
Product | sodium- and chloride-dependent betaine transporter | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC007406.1 and AK313690.1. On Jun 2, 2019 this sequence version replaced NM_001206931.1. Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.126625.1, SRR1660807.161896.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001193860.1 |
CDS | 294..2138 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu08493 | |
Clone ID Related Accession (Same CDS sequence) | NM_001122848.3 , NM_001122847.3 , NM_001206931.1 , NM_001122847.2 , XM_011521010.1 , NM_003044.5 , NM_001122848.2 , NM_003044.4 , NM_001206931.2 | |
Accession Version | XM_011521010.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | sodium- and chloride-dependent betaine transporter isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011519312.1 |
CDS | 571..2415 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu46011 | |
Clone ID Related Accession (Same CDS sequence) | XM_005253747.4 | |
Accession Version | XM_005253747.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1833bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | sodium- and chloride-dependent betaine transporter isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005253747.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005253804.1 |
CDS | 379..2211 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu46012 | |
Clone ID Related Accession (Same CDS sequence) | XM_005253748.4 | |
Accession Version | XM_005253748.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1716bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | sodium- and chloride-dependent betaine transporter isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005253748.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005253805.1 |
CDS | 379..2094 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu46013 | |
Clone ID Related Accession (Same CDS sequence) | XM_006719005.3 | |
Accession Version | XM_006719005.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1713bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | sodium- and chloride-dependent betaine transporter isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006719005.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006719068.1 |
CDS | 379..2091 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGACGGGA AGGTGGCAGT GCAAGAGTGT GGGCCTCCTG CAGTCTCCTG GGTCCCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu84081 | |
Clone ID Related Accession (Same CDS sequence) | XM_017019841.1 | |
Accession Version | XM_017019841.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1281bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | sodium- and chloride-dependent betaine transporter isoform X5 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAATTCT GGGAGAGACG AGTTCTGGGC ATCACCTCGG GCATCCATGA CCTGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016875330.1 |
CDS | 1325..2605 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAATTCT GGGAGAGACG AGTTCTGGGC ATCACCTCGG GCATCCATGA CCTGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Combined effect between two functional polymorphisms of SLC6A12 gene is associated with temporal lobe epilepsy. |
Mutation of a single threonine in the cytoplasmic NH2 terminus disrupts trafficking of renal betaine-GABA transporter 1 during hypertonic stress. |
An atlas of genetic influences on human blood metabolites. |
Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes. |
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. |