Gene Symbol | SLC7A1 |
Entrez Gene ID | 6541 |
Full Name | solute carrier family 7 member 1 |
Synonyms | ATRC1,CAT-1,ERR,HCAT1,REC1L |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » SLC7A1 cDNA ORF clone
Gene Symbol | SLC7A1 |
Entrez Gene ID | 6541 |
Full Name | solute carrier family 7 member 1 |
Synonyms | ATRC1,CAT-1,ERR,HCAT1,REC1L |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_003045.4 | NP_003036.1 | high affinity cationic amino acid transporter 1 |
NM_003045.5 | NP_003036.1 | high affinity cationic amino acid transporter 1 |
XM_017020716.1 | XP_016876205.1 | high affinity cationic amino acid transporter 1 isoform X2 |
XM_017020713.2 | XP_016876202.1 | high affinity cationic amino acid transporter 1 isoform X1 |
XM_017020714.1 | XP_016876203.1 | high affinity cationic amino acid transporter 1 isoform X1 |
XM_017020713.1 | XP_016876202.1 | high affinity cationic amino acid transporter 1 isoform X1 |
XM_005266507.3 | XP_005266564.1 | high affinity cationic amino acid transporter 1 isoform X2 |
XM_017020715.1 | XP_016876204.1 | high affinity cationic amino acid transporter 1 isoform X1 |
Bos taurus (cattle) | SLC7A1 | NP_001129264.1 |
Rattus norvegicus (Norway rat) | Slc7a1 | NP_037243.1 |
Pan troglodytes (chimpanzee) | SLC7A1 | XP_001139004.1 |
Danio rerio (zebrafish) | slc7a1 | XP_005155334.1 |
Homo sapiens (human) | SLC7A1 | NP_003036.1 |
SLC7A1 | XP_002800751.1 | |
Gallus gallus (chicken) | SLC7A1 | NP_001138962.1 |
Drosophila melanogaster (fruit fly) | slif | NP_649428.1 |
Xenopus tropicalis (tropical clawed frog) | slc7a1 | XP_002934074.1 |
Drosophila melanogaster (fruit fly) | CG5535 | NP_730312.1 |
Canis lupus familiaris (dog) | SLC7A1 | XP_005635552.1 |
Mus musculus (house mouse) | Slc7a1 | NP_031539.3 |
Arabidopsis thaliana (thale cress) | CAT4 | NP_187022.5 |
The prognostic biomarker L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B.
Chafai A, Fromm MF, K?nig J, Maas R
Scientific reports7(1)4767(2017 Jul)
Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)
ZMPSTE24 defends against influenza and other pathogenic viruses.
Fu B, Wang L, Li S, Dorf ME
The Journal of experimental medicine214(4)919-929(2017 Apr)
Estradiol augments while progesterone inhibits arginine transport in human endothelial cells through modulation of cationic amino acid transporter-1.
Bentur OS, Schwartz D, Chernichovski T, Ingbir M, Weinstein T, Chernin G, Schwartz IF
American journal of physiology. Regulatory, integrative and comparative physiology309(4)R421-7(2015 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Estradiol increases arginine transport and CAT-1 activity through modulation of constitutive signaling transduction pathways involving ERK. Progesterone inhibits arginine transport and CAT-1 via both PKCalpha and ERK1/2 phosphorylation.
Title: Estradiol augments while progesterone inhibits arginine transport in human endothelial cells through modulation of cationic amino acid transporter-1.
The rs41318021 polymorphism in the SLC7A1 gene was not associated with essential hypertension in 50-year-old subjects.
Title: Contribution of SLC7A1 genetic variant to hypertension, the TAMRISK study.
CAT1, CAT2, and CAT3 localized in adult brains but with uneven distribution.
Title: Differential topochemistry of three cationic amino acid transporter proteins, hCAT1, hCAT2 and hCAT3, in the adult human brain.
mRNA levels for high-affinity CAT-1, expressed as a percentage of the wild-type value, are increased by an average 12% and 32% in mdx and transgenic mdx:utr mice respectively.
Title: Nitric oxide signalling pathway in Duchenne muscular dystrophy mice: up-regulation of L-arginine transporters.
Overexpression of arginine transporter CAT-1 is associated with accumulation of L-arginine and cell growth in human colorectal cancer tissue.
Title: Overexpression of arginine transporter CAT-1 is associated with accumulation of L-arginine and cell growth in human colorectal cancer tissue.
The following SLC7A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC7A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu24438 | |
Clone ID Related Accession (Same CDS sequence) | NM_003045.4 | |
Accession Version | NM_003045.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1890bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | high affinity cationic amino acid transporter 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA337847.1, DA394628.1, BP356532.1, BC063303.1, AL596114.10 and BC012895.1. On Oct 17, 2008 this sequence version replaced NM_003045.3. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB105377.1, BC063303.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGGGTGCA AAGTCCTGCT CAACATTGGG CAGCAGATGC TGCGGCGGAA GGTGGTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_003036.1 |
CDS | 388..2277 |
Translation |
Target ORF information:
Target ORF information:
|
NM_003045.4 |
1 | ATGGGGTGCA AAGTCCTGCT CAACATTGGG CAGCAGATGC TGCGGCGGAA GGTGGTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu47255 | |
Clone ID Related Accession (Same CDS sequence) | NM_003045.5 , XM_017020716.1 , XM_005266507.3 | |
Accession Version | NM_003045.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1890bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-16 | |
Organism | Homo sapiens(human) | |
Product | high affinity cationic amino acid transporter 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL596114.10. On Nov 24, 2018 this sequence version replaced NM_003045.4. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB105377.1, BC063303.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380752.10/ ENSP00000370128.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGGGTGCA AAGTCCTGCT CAACATTGGG CAGCAGATGC TGCGGCGGAA GGTGGTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_003036.1 |
CDS | 388..2277 |
Translation |
Target ORF information:
Target ORF information:
|
NM_003045.5 |
1 | ATGGGGTGCA AAGTCCTGCT CAACATTGGG CAGCAGATGC TGCGGCGGAA GGTGGTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu47255 | |
Clone ID Related Accession (Same CDS sequence) | NM_003045.5 , XM_017020716.1 , XM_005266507.3 | |
Accession Version | XM_017020716.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1890bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | high affinity cationic amino acid transporter 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGTGCA AAGTCCTGCT CAACATTGGG CAGCAGATGC TGCGGCGGAA GGTGGTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016876205.1 |
CDS | 399..2288 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017020716.1 |
1 | ATGGGGTGCA AAGTCCTGCT CAACATTGGG CAGCAGATGC TGCGGCGGAA GGTGGTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu47255 | |
Clone ID Related Accession (Same CDS sequence) | NM_003045.5 , XM_017020716.1 , XM_005266507.3 | |
Accession Version | XM_005266507.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1890bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | high affinity cationic amino acid transporter 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005266507.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGTGCA AAGTCCTGCT CAACATTGGG CAGCAGATGC TGCGGCGGAA GGTGGTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005266564.1 |
CDS | 183..2072 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005266507.3 |
1 | ATGGGGTGCA AAGTCCTGCT CAACATTGGG CAGCAGATGC TGCGGCGGAA GGTGGTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu84621 | |
Clone ID Related Accession (Same CDS sequence) | XM_017020713.2 , XM_017020714.1 , XM_017020713.1 , XM_017020715.1 | |
Accession Version | XM_017020713.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1932bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | high affinity cationic amino acid transporter 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017020713.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGTGCA AAGTCCTGCT CAACATTGGG CAGCAGATGC TGCGGCGGAA GGTGGTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016876202.1 |
CDS | 380..2311 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017020713.2 |
1 | ATGGGGTGCA AAGTCCTGCT CAACATTGGG CAGCAGATGC TGCGGCGGAA GGTGGTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu84621 | |
Clone ID Related Accession (Same CDS sequence) | XM_017020713.2 , XM_017020714.1 , XM_017020713.1 , XM_017020715.1 | |
Accession Version | XM_017020714.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1932bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | high affinity cationic amino acid transporter 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGTGCA AAGTCCTGCT CAACATTGGG CAGCAGATGC TGCGGCGGAA GGTGGTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016876203.1 |
CDS | 327..2258 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017020714.1 |
1 | ATGGGGTGCA AAGTCCTGCT CAACATTGGG CAGCAGATGC TGCGGCGGAA GGTGGTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu84621 | |
Clone ID Related Accession (Same CDS sequence) | XM_017020713.2 , XM_017020714.1 , XM_017020713.1 , XM_017020715.1 | |
Accession Version | XM_017020713.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1932bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | high affinity cationic amino acid transporter 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGTGCA AAGTCCTGCT CAACATTGGG CAGCAGATGC TGCGGCGGAA GGTGGTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016876202.1 |
CDS | 388..2319 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017020713.1 |
1 | ATGGGGTGCA AAGTCCTGCT CAACATTGGG CAGCAGATGC TGCGGCGGAA GGTGGTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu84621 | |
Clone ID Related Accession (Same CDS sequence) | XM_017020713.2 , XM_017020714.1 , XM_017020713.1 , XM_017020715.1 | |
Accession Version | XM_017020715.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1932bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | high affinity cationic amino acid transporter 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGTGCA AAGTCCTGCT CAACATTGGG CAGCAGATGC TGCGGCGGAA GGTGGTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016876204.1 |
CDS | 209..2140 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017020715.1 |
1 | ATGGGGTGCA AAGTCCTGCT CAACATTGGG CAGCAGATGC TGCGGCGGAA GGTGGTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The prognostic biomarker L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B. |
Architecture of the human interactome defines protein communities and disease networks. |
ZMPSTE24 defends against influenza and other pathogenic viruses. |
Estradiol augments while progesterone inhibits arginine transport in human endothelial cells through modulation of cationic amino acid transporter-1. |