Gene Symbol | SLC9A5 |
Entrez Gene ID | 6553 |
Full Name | solute carrier family 9 member A5 |
Synonyms | NHE5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » SLC9A5 cDNA ORF clone
Gene Symbol | SLC9A5 |
Entrez Gene ID | 6553 |
Full Name | solute carrier family 9 member A5 |
Synonyms | NHE5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_004594.2 | NP_004585.1 | sodium/hydrogen exchanger 5 isoform 1 precursor |
NM_004594.3 | NP_004585.1 | sodium/hydrogen exchanger 5 isoform 1 precursor |
NM_001323972.2 | NP_001310901.1 | sodium/hydrogen exchanger 5 isoform 3 precursor |
NM_001323971.2 | NP_001310900.1 | sodium/hydrogen exchanger 5 isoform 2 precursor |
NM_001323971.1 | NP_001310900.1 | sodium/hydrogen exchanger 5 isoform 2 precursor |
NM_001323973.1 | NP_001310902.1 | sodium/hydrogen exchanger 5 isoform 4 precursor |
NM_001323972.1 | NP_001310901.1 | sodium/hydrogen exchanger 5 isoform 3 precursor |
NM_001323974.2 | NP_001310903.1 | sodium/hydrogen exchanger 5 isoform 5 |
XM_017023594.1 | XP_016879083.1 | sodium/hydrogen exchanger 5 isoform X1 |
NM_001323975.1 | NP_001310904.1 | sodium/hydrogen exchanger 5 isoform 6 |
NM_001323974.1 | NP_001310903.1 | sodium/hydrogen exchanger 5 isoform 5 |
NM_001323973.2 | NP_001310902.1 | sodium/hydrogen exchanger 5 isoform 4 precursor |
NM_001323975.2 | NP_001310904.1 | sodium/hydrogen exchanger 5 isoform 6 |
Homo sapiens (human) | SLC9A5 | NP_004585.1 |
SLC9A5 | XP_002808348.1 | |
Bos taurus (cattle) | SLC9A5 | NP_001192658.1 |
Rattus norvegicus (Norway rat) | Slc9a5 | NP_620213.1 |
Xenopus tropicalis (tropical clawed frog) | slc9a5 | XP_002931737.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP009036 | XP_552951.2 |
Canis lupus familiaris (dog) | SLC9A5 | XP_851881.1 |
Gallus gallus (chicken) | SLC9A5 | XP_003641949.1 |
Danio rerio (zebrafish) | slc9a5 | NP_001106943.1 |
Gallus gallus (chicken) | SLC9A5 | XP_003643230.2 |
Pan troglodytes (chimpanzee) | SLC9A5 | XP_003952922.1 |
Mus musculus (house mouse) | Slc9a5 | NP_001074801.1 |
Drosophila melanogaster (fruit fly) | Nhe2 | NP_001137847.1 |
Activation of AMP-activated protein kinase regulates hippocampal neuronal pH by recruiting Na(+)/H(+) exchanger NHE5 to the cell surface.
Jinadasa T, Szab? EZ, Numat M, Orlowski J
The Journal of biological chemistry289(30)20879-97(2014 Jul)
Regulation of dendritic spine growth through activity-dependent recruitment of the brain-enriched Na?/H? exchanger NHE5.
Diering GH, Mills F, Bamji SX, Numata M
Molecular biology of the cell22(13)2246-57(2011 Jul)
CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis.
Lukashova V, Szab? EZ, Jinadasa T, Mokhov A, Litchfield DW, Orlowski J
The Journal of biological chemistry286(13)11456-68(2011 Apr)
Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5.
Diering GH, Church J, Numata M
The Journal of biological chemistry284(20)13892-903(2009 May)
RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity.
Onishi I, Lin PJ, Diering GH, Williams WP, Numata M
Cellular signalling19(1)194-203(2007 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These data reveal a unique role for AMPK and NHE5 in regulating the pH homeostasis of hippocampal neurons during metabolic stress.
Title: Activation of AMP-activated protein kinase regulates hippocampal neuronal pH by recruiting Na(+)/H(+) exchanger NHE5 to the cell surface.
overexpression of NHE5 inhibits spine growth in response to neuronal activity
Title: Regulation of dendritic spine growth through activity-dependent recruitment of the brain-enriched Na?/H? exchanger NHE5.
discrete elements of an elaborate sorting signal in NHE5 contribute to beta-arrestin2 binding and trafficking along the recycling endosomal pathway.
Title: CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis.
SCAMP2 regulates NHE5 transit through recycling endosomes and promotes its surface targeting in an Arf6-dependent manner.
Title: Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5.
RACK1 activates NHE5 both by integrin-dependent and independent pathways, which may coordinate cellular ion homeostasis during cell-matrix adhesion.
Title: RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity.
The following SLC9A5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC9A5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu31170 | |
Clone ID Related Accession (Same CDS sequence) | NM_004594.2 , NM_004594.3 | |
Accession Version | NM_004594.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2691bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | sodium/hydrogen exchanger 5 isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB475730.1, AF111173.1 and AL137689.1. On Jul 14, 2006 this sequence version replaced NM_004594.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF111173.1, SRR1803613.105520.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146236, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length. |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_004585.1 |
CDS | 64..2754 |
Translation |
Target ORF information:
Target ORF information:
|
NM_004594.2 |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu31170 | |
Clone ID Related Accession (Same CDS sequence) | NM_004594.2 , NM_004594.3 | |
Accession Version | NM_004594.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2691bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-25 | |
Organism | Homo sapiens(human) | |
Product | sodium/hydrogen exchanger 5 isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB475730.1, AF111173.1 and AL137689.1. On Nov 22, 2018 this sequence version replaced NM_004594.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF111173.1, SRR1803613.246168.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146236, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000299798.16/ ENSP00000299798.11 RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_004585.1 |
CDS | 37..2727 |
Translation |
Target ORF information:
Target ORF information:
|
NM_004594.3 |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu60595 | |
Clone ID Related Accession (Same CDS sequence) | NM_001323975.1 , NM_001323975.2 | |
Accession Version | NM_001323975.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1806bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-24 | |
Organism | Homo sapiens(human) | |
Product | sodium/hydrogen exchanger 5 isoform 6 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC040160.4. On Apr 23, 2016 this sequence version replaced XM_011523304.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.234545.1, SRR1803613.6071.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCCTCGC TCTCCGCCAT TCTTGCGGTG ACCATGTGTG GCCTGGGCTG TAAGAAGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001310904.1 |
CDS | 943..2748 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001323975.1 |
1 | ATGGCCTCGC TCTCCGCCAT TCTTGCGGTG ACCATGTGTG GCCTGGGCTG TAAGAAGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu60595 | |
Clone ID Related Accession (Same CDS sequence) | NM_001323975.1 , NM_001323975.2 | |
Accession Version | NM_001323975.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1806bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-27 | |
Organism | Homo sapiens(human) | |
Product | sodium/hydrogen exchanger 5 isoform 6 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC040160.4. On May 31, 2019 this sequence version replaced NM_001323975.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.245502.1, SRR1803614.195867.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCCTCGC TCTCCGCCAT TCTTGCGGTG ACCATGTGTG GCCTGGGCTG TAAGAAGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001310904.1 |
CDS | 836..2641 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001323975.2 |
1 | ATGGCCTCGC TCTCCGCCAT TCTTGCGGTG ACCATGTGTG GCCTGGGCTG TAAGAAGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu60592 | |
Clone ID Related Accession (Same CDS sequence) | NM_001323973.1 , NM_001323973.2 | |
Accession Version | NM_001323973.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2688bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-24 | |
Organism | Homo sapiens(human) | |
Product | sodium/hydrogen exchanger 5 isoform 4 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC040160.4. On Apr 23, 2016 this sequence version replaced XM_011523301.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.226697.1, SRR1803611.56293.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146236, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001310902.1 |
CDS | 144..2831 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001323973.1 |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu60592 | |
Clone ID Related Accession (Same CDS sequence) | NM_001323973.1 , NM_001323973.2 | |
Accession Version | NM_001323973.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2688bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-27 | |
Organism | Homo sapiens(human) | |
Product | sodium/hydrogen exchanger 5 isoform 4 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC040160.4. On May 31, 2019 this sequence version replaced NM_001323973.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.226697.1, SRR1803611.56293.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146236, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001310902.1 |
CDS | 37..2724 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001323973.2 |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu82894 | |
Clone ID Related Accession (Same CDS sequence) | NM_001323971.2 , NM_001323971.1 | |
Accession Version | NM_001323971.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2028bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-27 | |
Organism | Homo sapiens(human) | |
Product | sodium/hydrogen exchanger 5 isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC040160.4. On May 31, 2019 this sequence version replaced NM_001323971.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.57012.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001310900.1 |
CDS | 37..2064 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001323971.2 |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu82894 | |
Clone ID Related Accession (Same CDS sequence) | NM_001323971.2 , NM_001323971.1 | |
Accession Version | NM_001323971.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2028bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-25 | |
Organism | Homo sapiens(human) | |
Product | sodium/hydrogen exchanger 5 isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC040160.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.57012.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001310900.1 |
CDS | 144..2171 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001323971.1 |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu82897 | |
Clone ID Related Accession (Same CDS sequence) | NM_001323974.2 , NM_001323974.1 | |
Accession Version | NM_001323974.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1803bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-28 | |
Organism | Homo sapiens(human) | |
Product | sodium/hydrogen exchanger 5 isoform 5 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC040160.4. On Jun 1, 2019 this sequence version replaced NM_001323974.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.99020.1, SRR1803615.134617.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCCTCGC TCTCCGCCAT TCTTGCGGTG ACCATGTGTG GCCTGGGCTG TAAGAAGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001310903.1 |
CDS | 836..2638 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001323974.2 |
1 | ATGGCCTCGC TCTCCGCCAT TCTTGCGGTG ACCATGTGTG GCCTGGGCTG TAAGAAGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu82897 | |
Clone ID Related Accession (Same CDS sequence) | NM_001323974.2 , NM_001323974.1 | |
Accession Version | NM_001323974.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1803bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-24 | |
Organism | Homo sapiens(human) | |
Product | sodium/hydrogen exchanger 5 isoform 5 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC040160.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.99020.1, SRR1803615.134617.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCCTCGC TCTCCGCCAT TCTTGCGGTG ACCATGTGTG GCCTGGGCTG TAAGAAGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001310903.1 |
CDS | 943..2745 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001323974.1 |
1 | ATGGCCTCGC TCTCCGCCAT TCTTGCGGTG ACCATGTGTG GCCTGGGCTG TAAGAAGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu82898 | |
Clone ID Related Accession (Same CDS sequence) | NM_001323972.2 , NM_001323972.1 | |
Accession Version | NM_001323972.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2388bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-28 | |
Organism | Homo sapiens(human) | |
Product | sodium/hydrogen exchanger 5 isoform 3 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC040160.4. On Jun 1, 2019 this sequence version replaced NM_001323972.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.149933.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001310901.1 |
CDS | 37..2424 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001323972.2 |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu82898 | |
Clone ID Related Accession (Same CDS sequence) | NM_001323972.2 , NM_001323972.1 | |
Accession Version | NM_001323972.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2388bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-24 | |
Organism | Homo sapiens(human) | |
Product | sodium/hydrogen exchanger 5 isoform 3 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC040160.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.149933.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001310901.1 |
CDS | 144..2531 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001323972.1 |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu86232 | |
Clone ID Related Accession (Same CDS sequence) | XM_017023594.1 | |
Accession Version | XM_017023594.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1635bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | sodium/hydrogen exchanger 5 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016879083.1 |
CDS | 1467..3101 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017023594.1 |
1 | ATGCTGCGCG CCGCCCTGTC CCTGCTCGCG CTGCCCCTGG CGGGGGCGGC CGAAGAGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Activation of AMP-activated protein kinase regulates hippocampal neuronal pH by recruiting Na(+)/H(+) exchanger NHE5 to the cell surface. |
Regulation of dendritic spine growth through activity-dependent recruitment of the brain-enriched Na?/H? exchanger NHE5. |
CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis. |
Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5. |
RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity. |