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SLC22A4 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol SLC22A4
Entrez Gene ID 6583
Full Name solute carrier family 22 member 4
Synonyms DFNB60,OCTN1
General protein information
Preferred Names

solute carrier family 22 member 4

Names

solute carrier family 22 member 4
ET transporter
deafness, autosomal recessive 60
ergothioneine transporter
integral membrane transport protein
organic cation/carnitine transporter 1
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
solute carrier family 22 (organic cation/zwitterion transporter), member 4

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

5

5q31.1

Summary Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008].
Disorder MIM:

604190

Disorder Html: {Rheumatoid arthritis, susceptibility to}, 180300 (3)

mRNA and Protein(s)

mRNA Protein Name
XM_006714675.3 XP_006714738.1 solute carrier family 22 member 4 isoform X2
XM_011543589.2 XP_011541891.1 solute carrier family 22 member 4 isoform X1
XM_017009776.1 XP_016865265.1 solute carrier family 22 member 4 isoform X2
NM_003059.2 NP_003050.2 solute carrier family 22 member 4



Macaca mulatta (rhesus monkey) LOC710179 XP_002804554.1
Canis lupus familiaris (dog) SLC22A4 XP_005626572.1
Homo sapiens (human) SLC22A4 NP_003050.2
Pan troglodytes (chimpanzee) SLC22A4 XP_001163062.1
Bos taurus (cattle) SLC22A4 NP_001193918.1
Mus musculus (house mouse) Slc22a4 NP_062661.1
Rattus norvegicus (Norway rat) Slc22a4 NP_071606.1
Danio rerio (zebrafish) LOC100000685 XP_005170394.1
Gallus gallus (chicken) SLC22A4 NP_001139603.1


Related articles in PubMed

A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60.
Ben Said M, Grati M, Ishimoto T, Zou B, Chakchouk I, Ma Q, Yao Q, Hammami B, Yan D, Mittal R, Nakamichi N, Ghorbel A, Neng L, Tekin M, Shi XR, Kato Y, Masmoudi S, Lu Z, Hmani M, Liu X
Human genetics135(5)513-24(2016 May)

Functional activity of L-carnitine transporters in human airway epithelial cells.
Ingoglia F, Visigalli R, Rotoli BM, Barilli A, Riccardi B, Puccini P, Dall'Asta V
Biochimica et biophysica acta1858(2)210-9(2016 Feb)

Immuno-detection of OCTN1 (SLC22A4) in HeLa cells and characterization of transport function.
Pochini L, Scalise M, Indiveri C
International immunopharmacology29(1)21-6(2015 Nov)

Association of single nucleotide polymorphism rs3792876 in SLC22A4 gene with autoimmune thyroid disease in a Chinese Han population.
Hou X, Mao J, Li Y, Li J, Wang W, Fan C, Wang H, Zhang H, Shan Z, Teng W
BMC medical genetics1676(2015 Sep)

Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice.
Shimizu T, Masuo Y, Takahashi S, Nakamichi N, Kato Y
Drug metabolism and pharmacokinetics30(3)231-9(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Studies confirmed OCTN1-mediated transport of cytarabine and various structurally related cytidine analogues, such as 2'deoxycytidine and gemcitabine, occurs through a saturable process that is highly sensitive to inhibition by the classic nucleoside transporter inhibitors.
Title: OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues.

mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss.
Title: A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60.

Functional activity of L-carnitine transporters in human airway epithelial cells.
Title: Functional activity of L-carnitine transporters in human airway epithelial cells.

A lack of association between the SLC22A4 gene polymorphism rs3792876 and susceptibility to autoimmune thyroid diseases in a Chinese Han population.
Title: Association of single nucleotide polymorphism rs3792876 in SLC22A4 gene with autoimmune thyroid disease in a Chinese Han population.

Functional expression of OCTN1 was confirmed in LPS-stimulated human macrophage-like cell line, THP-1.
Title: Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice.

The following SLC22A4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC22A4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19646 NM_003059.2
Latest version!
Homo sapiens solute carrier family 22 member 4 (SLC22A4), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
OHu39678 XM_006714675.3
Latest version!
Homo sapiens solute carrier family 22 member 4 (SLC22A4), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $223.30
$319.00
OHu39678 XM_017009776.1
Latest version!
Homo sapiens solute carrier family 22 member 4 (SLC22A4), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $223.30
$319.00
OHu60625 XM_011543589.2
Latest version!
Homo sapiens solute carrier family 22 member 4 (SLC22A4), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19646
Clone ID Related Accession (Same CDS sequence) NM_003059.2
Accession Version NM_003059.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1656bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-25
Organism Homo sapiens(Human)
Product solute carrier family 22 member 4
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC028313.1. This sequence is a reference standard in the RefSeqGene project. On Nov 3, 2002 this sequence version replaced NM_003059.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028313.1, Y09881.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
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601
661
721
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841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGCGGGACT ACGACGAGGT GATCGCCTTC CTGGGCGAGT GGGGGCCCTT CCAGCGCCTC 
ATCTTCTTCC TGCTCAGCGC CAGCATCATC CCCAATGGCT TCAATGGTAT GTCAGTCGTG
TTCCTGGCGG GGACCCCGGA GCACCGCTGT CGAGTGCCGG ACGCCGCGAA CCTGAGCAGC
GCCTGGCGCA ACAACAGTGT CCCGCTGCGG CTGCGGGACG GCCGCGAGGT GCCCCACAGC
TGCAGCCGCT ACCGGCTCGC CACCATCGCC AACTTCTCGG CGCTCGGGCT GGAGCCGGGG
CGCGACGTGG ACCTGGGGCA GCTGGAGCAG GAGAGCTGCC TGGATGGCTG GGAGTTCAGC
CAGGACGTCT ACCTGTCCAC CGTCGTGACC GAGTGGAATC TGGTGTGTGA GGACAACTGG
AAGGTGCCCC TCACCACCTC CCTGTTCTTC GTAGGCGTGC TCCTCGGCTC CTTCGTGTCC
GGGCAGCTGT CAGACAGGTT TGGCAGGAAG AACGTTCTCT TCGCAACCAT GGCTGTACAG
ACTGGCTTCA GCTTCCTGCA GATTTTCTCC ATCAGCTGGG AGATGTTCAC TGTGTTATTT
GTCATCGTGG GCATGGGCCA GATCTCCAAC TATGTGGTAG CCTTCATACT AGGAACAGAA
ATTCTTGGCA AGTCAGTTCG TATTATATTC TCTACATTAG GAGTGTGCAC ATTTTTTGCA
GTTGGCTATA TGCTGCTGCC ACTGTTTGCT TACTTCATCA GAGACTGGCG GATGCTGCTG
CTGGCGCTGA CGGTGCCGGG AGTGCTGTGT GTCCCGCTGT GGTGGTTCAT TCCTGAATCT
CCCCGATGGC TGATATCCCA GAGAAGATTT AGAGAGGCTG AAGATATCAT CCAAAAAGCT
GCAAAAATGA ACAACATAGC TGTACCAGCA GTGATATTTG ATTCTGTGGA GGAGCTAAAT
CCCCTGAAGC AGCAGAAAGC TTTCATTCTG GACCTGTTCA GGACTCGGAA TATTGCCATA
ATGACCATTA TGTCTTTGCT GCTATGGATG CTGACCTCAG TGGGTTACTT TGCTCTGTCT
CTGGATGCTC CTAATTTACA TGGAGATGCC TACCTGAACT GTTTCCTCTC TGCCTTGATT
GAAATTCCAG CTTACATTAC AGCCTGGCTG CTATTGCGAA CCCTGCCCAG GCGTTATATC
ATAGCTGCAG TACTGTTCTG GGGAGGAGGT GTGCTTCTCT TCATTCAACT GGTACCTGTG
GATTATTACT TCTTATCCAT TGGTCTGGTC ATGCTGGGAA AATTTGGGAT CACCTCTGCT
TTCTCCATGC TGTATGTCTT CACTGCTGAG CTCTACCCAA CCCTGGTCAG GAACATGGCG
GTGGGGGTCA CATCCACGGC CTCCAGAGTG GGCAGCATCA TTGCCCCCTA CTTTGTTTAC
CTCGGTGCTT ACAACAGAAT GCTGCCCTAC ATCGTCATGG GTAGTCTGAC TGTCCTGATT
GGAATCCTCA CCCTTTTTTT CCCTGAAAGT TTGGGAATGA CTCTTCCAGA AACCTTAGAG
CAGATGCAGA AAGTGAAATG GTTCAGATCT GGGAAAAAAA CAAGAGACTC AATGGAGACA
GAAGAAAATC CCAAGGTTCT AATAACTGCA TTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003050.2
CDS166..1821
Misc Feature(1)73..75
Misc Feature(2)199..1719
Misc Feature(3)226..288
Misc Feature(4)532..1689
Misc Feature(5)order(532..534,538..543,601..603,610..615,622..624,634..639,643..648,784..789,796..801,808..813,820..822,856..861,871..876,892..894,1222..1224,1231..1236,1243..1248,1255..1257,1273..1275,1285..1287,1297..1299,1306..1308,1318..1320,1462..1464,1474..1479,1486..1488,1498..1503,1510..1512,1543..1548,1555..1560,1567..1572,1579..1581)
Misc Feature(6)589..651
Misc Feature(7)679..741
Misc Feature(8)757..819
Misc Feature(9)862..924
Misc Feature(10)937..999
Misc Feature(11)1177..1239
Misc Feature(12)1279..1341
Misc Feature(13)1363..1425
Misc Feature(14)1444..1506
Misc Feature(15)1546..1608
Misc Feature(16)1624..1686
Exon (1)1..558
Exon (2)559..662
Exon (3)663..817
Exon (4)818..989
Exon (5)990..1116
Exon (6)1117..1211
Exon (7)1212..1426
Exon (8)1427..1609
Exon (9)1610..1745
Exon (10)1746..2192
Translation

Target ORF information:

RefSeq Version NM_003059.2
Organism Homo sapiens(Human)
Definition Homo sapiens solute carrier family 22 member 4 (SLC22A4), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003059.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGCGGGACT ACGACGAGGT GATCGCCTTC CTGGGCGAGT GGGGGCCCTT CCAGCGCCTC 
ATCTTCTTCC TGCTCAGCGC CAGCATCATC CCCAATGGCT TCAATGGTAT GTCAGTCGTG
TTCCTGGCGG GGACCCCGGA GCACCGCTGT CGAGTGCCGG ACGCCGCGAA CCTGAGCAGC
GCCTGGCGCA ACAACAGTGT CCCGCTGCGG CTGCGGGACG GCCGCGAGGT GCCCCACAGC
TGCAGCCGCT ACCGGCTCGC CACCATCGCC AACTTCTCGG CGCTCGGGCT GGAGCCGGGG
CGCGACGTGG ACCTGGGGCA GCTGGAGCAG GAGAGCTGCC TGGATGGCTG GGAGTTCAGC
CAGGACGTCT ACCTGTCCAC CGTCGTGACC GAGTGGAATC TGGTGTGTGA GGACAACTGG
AAGGTGCCCC TCACCACCTC CCTGTTCTTC GTAGGCGTGC TCCTCGGCTC CTTCGTGTCC
GGGCAGCTGT CAGACAGGTT TGGCAGGAAG AACGTTCTCT TCGCAACCAT GGCTGTACAG
ACTGGCTTCA GCTTCCTGCA GATTTTCTCC ATCAGCTGGG AGATGTTCAC TGTGTTATTT
GTCATCGTGG GCATGGGCCA GATCTCCAAC TATGTGGTAG CCTTCATACT AGGAACAGAA
ATTCTTGGCA AGTCAGTTCG TATTATATTC TCTACATTAG GAGTGTGCAC ATTTTTTGCA
GTTGGCTATA TGCTGCTGCC ACTGTTTGCT TACTTCATCA GAGACTGGCG GATGCTGCTG
CTGGCGCTGA CGGTGCCGGG AGTGCTGTGT GTCCCGCTGT GGTGGTTCAT TCCTGAATCT
CCCCGATGGC TGATATCCCA GAGAAGATTT AGAGAGGCTG AAGATATCAT CCAAAAAGCT
GCAAAAATGA ACAACATAGC TGTACCAGCA GTGATATTTG ATTCTGTGGA GGAGCTAAAT
CCCCTGAAGC AGCAGAAAGC TTTCATTCTG GACCTGTTCA GGACTCGGAA TATTGCCATA
ATGACCATTA TGTCTTTGCT GCTATGGATG CTGACCTCAG TGGGTTACTT TGCTCTGTCT
CTGGATGCTC CTAATTTACA TGGAGATGCC TACCTGAACT GTTTCCTCTC TGCCTTGATT
GAAATTCCAG CTTACATTAC AGCCTGGCTG CTATTGCGAA CCCTGCCCAG GCGTTATATC
ATAGCTGCAG TACTGTTCTG GGGAGGAGGT GTGCTTCTCT TCATTCAACT GGTACCTGTG
GATTATTACT TCTTATCCAT TGGTCTGGTC ATGCTGGGAA AATTTGGGAT CACCTCTGCT
TTCTCCATGC TGTATGTCTT CACTGCTGAG CTCTACCCAA CCCTGGTCAG GAACATGGCG
GTGGGGGTCA CATCCACGGC CTCCAGAGTG GGCAGCATCA TTGCCCCCTA CTTTGTTTAC
CTCGGTGCTT ACAACAGAAT GCTGCCCTAC ATCGTCATGG GTAGTCTGAC TGTCCTGATT
GGAATCCTCA CCCTTTTTTT CCCTGAAAGT TTGGGAATGA CTCTTCCAGA AACCTTAGAG
CAGATGCAGA AAGTGAAATG GTTCAGATCT GGGAAAAAAA CAAGAGACTC AATGGAGACA
GAAGAAAATC CCAAGGTTCT AATAACTGCA TTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu39678
Clone ID Related Accession (Same CDS sequence) XM_006714675.3 , XM_017009776.1
Accession Version XM_006714675.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1128bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product solute carrier family 22 member 4 isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006714675.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCTGTAC AGACTGGCTT CAGCTTCCTG CAGATTTTCT CCATCAGCTG GGAGATGTTC 
ACTGTGTTAT TTGTCATCGT GGGCATGGGC CAGATCTCCA ACTATGTGGT AGCCTTCATA
CTAGGAACAG AAATTCTTGG CAAGTCAGTT CGTATTATAT TCTCTACATT AGGAGTGTGC
ACATTTTTTG CAGTTGGCTA TATGCTGCTG CCACTGTTTG CTTACTTCAT CAGAGACTGG
CGGATGCTGC TGCTGGCGCT GACGGTGCCG GGAGTGCTGT GTGTCCCGCT GTGGTGGTTC
ATTCCTGAAT CTCCCCGATG GCTGATATCC CAGAGAAGAT TTAGAGAGGC TGAAGATATC
ATCCAAAAAG CTGCAAAAAT GAACAACATA GCTGTACCAG CAGTGATATT TGATTCTGTG
GAGGAGCTAA ATCCCCTGAA GCAGCAGAAA GCTTTCATTC TGGACCTGTT CAGGACTCGG
AATATTGCCA TAATGACCAT TATGTCTTTG CTGCTATGGA TGCTGACCTC AGTGGGTTAC
TTTGCTCTGT CTCTGGATGC TCCTAATTTA CATGGAGATG CCTACCTGAA CTGTTTCCTC
TCTGCCTTGA TTGAAATTCC AGCTTACATT ACAGCCTGGC TGCTATTGCG AACCCTGCCC
AGGCGTTATA TCATAGCTGC AGTACTGTTC TGGGGAGGAG GTGTGCTTCT CTTCATTCAA
CTGGTACCTG TGGATTATTA CTTCTTATCC ATTGGTCTGG TCATGCTGGG AAAATTTGGG
ATCACCTCTG CTTTCTCCAT GCTGTATGTC TTCACTGCTG AGCTCTACCC AACCCTGGTC
AGGAACATGG CGGTGGGGGT CACATCCACG GCCTCCAGAG TGGGCAGCAT CATTGCCCCC
TACTTTGTTT ACCTCGGTGC TTACAACAGA ATGCTGCCCT ACATCGTCAT GGGTAGTCTG
ACTGTCCTGA TTGGAATCCT CACCCTTTTT TTCCCTGAAA GTTTGGGAAT GACTCTTCCA
GAAACCTTAG AGCAGATGCA GAAAGTGAAA TGGTTCAGAT CTGGGAAAAA AACAAGAGAC
TCAATGGAGA CAGAAGAAAA TCCCAAGGTT CTAATAACTG CATTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006714738.1
CDS101..1228
Misc Feature(1)101..1096
Translation

Target ORF information:

RefSeq Version XM_006714675.3
Organism Homo sapiens(Human)
Definition Homo sapiens solute carrier family 22 member 4 (SLC22A4), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006714675.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCTGTAC AGACTGGCTT CAGCTTCCTG CAGATTTTCT CCATCAGCTG GGAGATGTTC 
ACTGTGTTAT TTGTCATCGT GGGCATGGGC CAGATCTCCA ACTATGTGGT AGCCTTCATA
CTAGGAACAG AAATTCTTGG CAAGTCAGTT CGTATTATAT TCTCTACATT AGGAGTGTGC
ACATTTTTTG CAGTTGGCTA TATGCTGCTG CCACTGTTTG CTTACTTCAT CAGAGACTGG
CGGATGCTGC TGCTGGCGCT GACGGTGCCG GGAGTGCTGT GTGTCCCGCT GTGGTGGTTC
ATTCCTGAAT CTCCCCGATG GCTGATATCC CAGAGAAGAT TTAGAGAGGC TGAAGATATC
ATCCAAAAAG CTGCAAAAAT GAACAACATA GCTGTACCAG CAGTGATATT TGATTCTGTG
GAGGAGCTAA ATCCCCTGAA GCAGCAGAAA GCTTTCATTC TGGACCTGTT CAGGACTCGG
AATATTGCCA TAATGACCAT TATGTCTTTG CTGCTATGGA TGCTGACCTC AGTGGGTTAC
TTTGCTCTGT CTCTGGATGC TCCTAATTTA CATGGAGATG CCTACCTGAA CTGTTTCCTC
TCTGCCTTGA TTGAAATTCC AGCTTACATT ACAGCCTGGC TGCTATTGCG AACCCTGCCC
AGGCGTTATA TCATAGCTGC AGTACTGTTC TGGGGAGGAG GTGTGCTTCT CTTCATTCAA
CTGGTACCTG TGGATTATTA CTTCTTATCC ATTGGTCTGG TCATGCTGGG AAAATTTGGG
ATCACCTCTG CTTTCTCCAT GCTGTATGTC TTCACTGCTG AGCTCTACCC AACCCTGGTC
AGGAACATGG CGGTGGGGGT CACATCCACG GCCTCCAGAG TGGGCAGCAT CATTGCCCCC
TACTTTGTTT ACCTCGGTGC TTACAACAGA ATGCTGCCCT ACATCGTCAT GGGTAGTCTG
ACTGTCCTGA TTGGAATCCT CACCCTTTTT TTCCCTGAAA GTTTGGGAAT GACTCTTCCA
GAAACCTTAG AGCAGATGCA GAAAGTGAAA TGGTTCAGAT CTGGGAAAAA AACAAGAGAC
TCAATGGAGA CAGAAGAAAA TCCCAAGGTT CTAATAACTG CATTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu39678
Clone ID Related Accession (Same CDS sequence) XM_006714675.3 , XM_017009776.1
Accession Version XM_017009776.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1128bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product solute carrier family 22 member 4 isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCTGTAC AGACTGGCTT CAGCTTCCTG CAGATTTTCT CCATCAGCTG GGAGATGTTC 
ACTGTGTTAT TTGTCATCGT GGGCATGGGC CAGATCTCCA ACTATGTGGT AGCCTTCATA
CTAGGAACAG AAATTCTTGG CAAGTCAGTT CGTATTATAT TCTCTACATT AGGAGTGTGC
ACATTTTTTG CAGTTGGCTA TATGCTGCTG CCACTGTTTG CTTACTTCAT CAGAGACTGG
CGGATGCTGC TGCTGGCGCT GACGGTGCCG GGAGTGCTGT GTGTCCCGCT GTGGTGGTTC
ATTCCTGAAT CTCCCCGATG GCTGATATCC CAGAGAAGAT TTAGAGAGGC TGAAGATATC
ATCCAAAAAG CTGCAAAAAT GAACAACATA GCTGTACCAG CAGTGATATT TGATTCTGTG
GAGGAGCTAA ATCCCCTGAA GCAGCAGAAA GCTTTCATTC TGGACCTGTT CAGGACTCGG
AATATTGCCA TAATGACCAT TATGTCTTTG CTGCTATGGA TGCTGACCTC AGTGGGTTAC
TTTGCTCTGT CTCTGGATGC TCCTAATTTA CATGGAGATG CCTACCTGAA CTGTTTCCTC
TCTGCCTTGA TTGAAATTCC AGCTTACATT ACAGCCTGGC TGCTATTGCG AACCCTGCCC
AGGCGTTATA TCATAGCTGC AGTACTGTTC TGGGGAGGAG GTGTGCTTCT CTTCATTCAA
CTGGTACCTG TGGATTATTA CTTCTTATCC ATTGGTCTGG TCATGCTGGG AAAATTTGGG
ATCACCTCTG CTTTCTCCAT GCTGTATGTC TTCACTGCTG AGCTCTACCC AACCCTGGTC
AGGAACATGG CGGTGGGGGT CACATCCACG GCCTCCAGAG TGGGCAGCAT CATTGCCCCC
TACTTTGTTT ACCTCGGTGC TTACAACAGA ATGCTGCCCT ACATCGTCAT GGGTAGTCTG
ACTGTCCTGA TTGGAATCCT CACCCTTTTT TTCCCTGAAA GTTTGGGAAT GACTCTTCCA
GAAACCTTAG AGCAGATGCA GAAAGTGAAA TGGTTCAGAT CTGGGAAAAA AACAAGAGAC
TCAATGGAGA CAGAAGAAAA TCCCAAGGTT CTAATAACTG CATTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016865265.1
CDS742..1869
Misc Feature(1)742..1737
Translation

Target ORF information:

RefSeq Version XM_017009776.1
Organism Homo sapiens(Human)
Definition Homo sapiens solute carrier family 22 member 4 (SLC22A4), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_017009776.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCTGTAC AGACTGGCTT CAGCTTCCTG CAGATTTTCT CCATCAGCTG GGAGATGTTC 
ACTGTGTTAT TTGTCATCGT GGGCATGGGC CAGATCTCCA ACTATGTGGT AGCCTTCATA
CTAGGAACAG AAATTCTTGG CAAGTCAGTT CGTATTATAT TCTCTACATT AGGAGTGTGC
ACATTTTTTG CAGTTGGCTA TATGCTGCTG CCACTGTTTG CTTACTTCAT CAGAGACTGG
CGGATGCTGC TGCTGGCGCT GACGGTGCCG GGAGTGCTGT GTGTCCCGCT GTGGTGGTTC
ATTCCTGAAT CTCCCCGATG GCTGATATCC CAGAGAAGAT TTAGAGAGGC TGAAGATATC
ATCCAAAAAG CTGCAAAAAT GAACAACATA GCTGTACCAG CAGTGATATT TGATTCTGTG
GAGGAGCTAA ATCCCCTGAA GCAGCAGAAA GCTTTCATTC TGGACCTGTT CAGGACTCGG
AATATTGCCA TAATGACCAT TATGTCTTTG CTGCTATGGA TGCTGACCTC AGTGGGTTAC
TTTGCTCTGT CTCTGGATGC TCCTAATTTA CATGGAGATG CCTACCTGAA CTGTTTCCTC
TCTGCCTTGA TTGAAATTCC AGCTTACATT ACAGCCTGGC TGCTATTGCG AACCCTGCCC
AGGCGTTATA TCATAGCTGC AGTACTGTTC TGGGGAGGAG GTGTGCTTCT CTTCATTCAA
CTGGTACCTG TGGATTATTA CTTCTTATCC ATTGGTCTGG TCATGCTGGG AAAATTTGGG
ATCACCTCTG CTTTCTCCAT GCTGTATGTC TTCACTGCTG AGCTCTACCC AACCCTGGTC
AGGAACATGG CGGTGGGGGT CACATCCACG GCCTCCAGAG TGGGCAGCAT CATTGCCCCC
TACTTTGTTT ACCTCGGTGC TTACAACAGA ATGCTGCCCT ACATCGTCAT GGGTAGTCTG
ACTGTCCTGA TTGGAATCCT CACCCTTTTT TTCCCTGAAA GTTTGGGAAT GACTCTTCCA
GAAACCTTAG AGCAGATGCA GAAAGTGAAA TGGTTCAGAT CTGGGAAAAA AACAAGAGAC
TCAATGGAGA CAGAAGAAAA TCCCAAGGTT CTAATAACTG CATTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu60625
Clone ID Related Accession (Same CDS sequence) XM_011543589.2
Accession Version XM_011543589.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1380bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product solute carrier family 22 member 4 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011543589.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCGGGACT ACGACGAGGT GATCGCCTTC CTGGGCGAGT GGGGGCCCTT CCAGCGCCTC 
ATCTTCTTCC TGCTCAGCGC CAGCATCATC CCCAATGGCT TCAATGGTAT GTCAGTCGTG
TTCCTGGCGG GGACCCCGGA GCACCGCTGT CGAGTGCCGG ACGCCGCGAA CCTGAGCAGC
GCCTGGCGCA ACAACAGTGT CCCGCTGCGG CTGCGGGACG GCCGCGAGGT GCCCCACAGC
TGCAGCCGCT ACCGGCTCGC CACCATCGCC AACTTCTCGG CGCTCGGGCT GGAGCCGGGG
CGCGACGTGG ACCTGGGGCA GCTGGAGCAG GAGAGCTGCC TGGATGGCTG GGAGTTCAGC
CAGGACGTCT ACCTGTCCAC CGTCGTGACC GAGGTTTGGC AGGAAGAACG TTCTCTTCGC
AACCATGGCT GTACAGACTG GCTTCAGCTT CCTGCAGATT TTCTCCATCA GCTGGGAGAT
GTTCACTGTG TTATTTGTCA TCGTGGGCAT GGGCCAGATC TCCAACTATG TGGTAGCCTT
CATACTAGGT TCATTCCTGA ATCTCCCCGA TGGCTGATAT CCCAGAGAAG ATTTAGAGAG
GCTGAAGATA TCATCCAAAA AGCTGCAAAA ATGAACAACA TAGCTGTACC AGCAGTGATA
TTTGATTCTG TGGAGGAGCT AAATCCCCTG AAGCAGCAGA AAGCTTTCAT TCTGGACCTG
TTCAGGACTC GGAATATTGC CATAATGACC ATTATGTCTT TGCTGCTATG GATGCTGACC
TCAGTGGGTT ACTTTGCTCT GTCTCTGGAT GCTCCTAATT TACATGGAGA TGCCTACCTG
AACTGTTTCC TCTCTGCCTT GATTGAAATT CCAGCTTACA TTACAGCCTG GCTGCTATTG
CGAACCCTGC CCAGGCGTTA TATCATAGCT GCAGTACTGT TCTGGGGAGG AGGTGTGCTT
CTCTTCATTC AACTGGTACC TGTGGATTAT TACTTCTTAT CCATTGGTCT GGTCATGCTG
GGAAAATTTG GGATCACCTC TGCTTTCTCC ATGCTGTATG TCTTCACTGC TGAGCTCTAC
CCAACCCTGG TCAGGAACAT GGCGGTGGGG GTCACATCCA CGGCCTCCAG AGTGGGCAGC
ATCATTGCCC CCTACTTTGT TTACCTCGGT GCTTACAACA GAATGCTGCC CTACATCGTC
ATGGGTAGTC TGACTGTCCT GATTGGAATC CTCACCCTTT TTTTCCCTGA AAGTTTGGGA
ATGACTCTTC CAGAAACCTT AGAGCAGATG CAGAAAGTGA AATGGTTCAG ATCTGGGAAA
AAAACAAGAG ACTCAATGGA GACAGAAGAA AATCCCAAGG TTCTAATAAC TGCATTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011541891.1
CDS234..1613
Misc Feature(1)267..1511
Misc Feature(2)<981..1481
Translation

Target ORF information:

RefSeq Version XM_011543589.2
Organism Homo sapiens(Human)
Definition Homo sapiens solute carrier family 22 member 4 (SLC22A4), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011543589.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCGGGACT ACGACGAGGT GATCGCCTTC CTGGGCGAGT GGGGGCCCTT CCAGCGCCTC 
ATCTTCTTCC TGCTCAGCGC CAGCATCATC CCCAATGGCT TCAATGGTAT GTCAGTCGTG
TTCCTGGCGG GGACCCCGGA GCACCGCTGT CGAGTGCCGG ACGCCGCGAA CCTGAGCAGC
GCCTGGCGCA ACAACAGTGT CCCGCTGCGG CTGCGGGACG GCCGCGAGGT GCCCCACAGC
TGCAGCCGCT ACCGGCTCGC CACCATCGCC AACTTCTCGG CGCTCGGGCT GGAGCCGGGG
CGCGACGTGG ACCTGGGGCA GCTGGAGCAG GAGAGCTGCC TGGATGGCTG GGAGTTCAGC
CAGGACGTCT ACCTGTCCAC CGTCGTGACC GAGGTTTGGC AGGAAGAACG TTCTCTTCGC
AACCATGGCT GTACAGACTG GCTTCAGCTT CCTGCAGATT TTCTCCATCA GCTGGGAGAT
GTTCACTGTG TTATTTGTCA TCGTGGGCAT GGGCCAGATC TCCAACTATG TGGTAGCCTT
CATACTAGGT TCATTCCTGA ATCTCCCCGA TGGCTGATAT CCCAGAGAAG ATTTAGAGAG
GCTGAAGATA TCATCCAAAA AGCTGCAAAA ATGAACAACA TAGCTGTACC AGCAGTGATA
TTTGATTCTG TGGAGGAGCT AAATCCCCTG AAGCAGCAGA AAGCTTTCAT TCTGGACCTG
TTCAGGACTC GGAATATTGC CATAATGACC ATTATGTCTT TGCTGCTATG GATGCTGACC
TCAGTGGGTT ACTTTGCTCT GTCTCTGGAT GCTCCTAATT TACATGGAGA TGCCTACCTG
AACTGTTTCC TCTCTGCCTT GATTGAAATT CCAGCTTACA TTACAGCCTG GCTGCTATTG
CGAACCCTGC CCAGGCGTTA TATCATAGCT GCAGTACTGT TCTGGGGAGG AGGTGTGCTT
CTCTTCATTC AACTGGTACC TGTGGATTAT TACTTCTTAT CCATTGGTCT GGTCATGCTG
GGAAAATTTG GGATCACCTC TGCTTTCTCC ATGCTGTATG TCTTCACTGC TGAGCTCTAC
CCAACCCTGG TCAGGAACAT GGCGGTGGGG GTCACATCCA CGGCCTCCAG AGTGGGCAGC
ATCATTGCCC CCTACTTTGT TTACCTCGGT GCTTACAACA GAATGCTGCC CTACATCGTC
ATGGGTAGTC TGACTGTCCT GATTGGAATC CTCACCCTTT TTTTCCCTGA AAGTTTGGGA
ATGACTCTTC CAGAAACCTT AGAGCAGATG CAGAAAGTGA AATGGTTCAG ATCTGGGAAA
AAAACAAGAG ACTCAATGGA GACAGAAGAA AATCCCAAGG TTCTAATAAC TGCATTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

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Drug metabolism and pharmacokinetics30(3)231-9(2015 Jun)
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