SLIT1 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | SLIT1 |
| Entrez Gene ID | 6585 |
| Full Name | slit guidance ligand 1 |
| Synonyms | MEGF4,SLIL1,SLIT-1,SLIT3 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_003061.2 | NP_003052.2 | slit homolog 1 protein precursor |
| NM_003061.3 | NP_003052.2 | slit homolog 1 protein precursor |
| Pan troglodytes (chimpanzee) | SLIT1 | XP_003312806.1 |
| Homo sapiens (human) | SLIT1 | NP_003052.2 |
| Bos taurus (cattle) | SLIT1 | XP_002698459.1 |
| Xenopus tropicalis (tropical clawed frog) | slit1 | NP_001090702.1 |
| SLIT1 | XP_001094231.2 | |
| Canis lupus familiaris (dog) | SLIT1 | XP_005637640.1 |
| Mus musculus (house mouse) | Slit1 | NP_056563.2 |
| Rattus norvegicus (Norway rat) | Slit1 | NP_075242.1 |
| Gallus gallus (chicken) | SLIT1 | NP_001264265.1 |
| Danio rerio (zebrafish) | slit1a | NP_001030140.1 |
Related articles in PubMed
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
Simino J, Sung YJ, Kume R, Schwander K, Rao DC
Frontiers in genetics4277(2013)
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Lauc G, Huffman JE, Pu?i? M, Zgaga L, Adamczyk B, Mu?ini? A, Novokmet M, Pola?ek O, Gornik O, Kri?ti? J, Keser T, Vitart V, Scheijen B, Uh HW, Molokhia M, Patrick AL, McKeigue P, Kol?i? I, Luki? IK, Swann O, van Leeuwen FN, Ruhaak LR, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, de Craen AJ, Deelder AM, Zeng Q, Wang W, Hastie ND, Gyllensten U, Wilson JF, Wuhrer M, Wright AF, Rudd PM, Hayward C, Aulchenko Y, Campbell H, Rudan I
PLoS genetics9(1)e1003225(2013)
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)
SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium.
Marlow R, Strickland P, Lee JS, Wu X, Pebenito M, Binnewies M, Le EK, Moran A, Macias H, Cardiff RD, Sukumar S, Hinck L
Cancer research68(19)7819-27(2008 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Slits are negative regulators of Sdf1 and Cxcr4 in breast cancer cells.
Title: SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium.
heparin/HS is an integral component of the minimal Slit-Robo signaling complex and serves to stabilize the relatively weak Slit-Robo interaction
Title: A molecular mechanism for the heparan sulfate dependence of slit-robo signaling.
In fetal and embryonic stem cell cultures Slit-1 inhibited neurite outgrowth.
Title: Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits.
Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
evidence showing that Slit1 and Slit2 proteins are selective inhibitors and repellents for dorsally projecting, but not for ventrally projecting, cranial motor axons
Title: Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain.
The following SLIT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLIT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu24321 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_003061.2 , NM_003061.3 | |
| Accession Version | NM_003061.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4605bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-10-01 | |
| Organism | Homo sapiens(human) | |
| Product | slit homolog 1 protein precursor | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC146761.1, BC028105.1, AL512424.14 and CD671648.1. On May 17, 2008 this sequence version replaced NM_003061.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC146761.1, AB017167.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCGCTGA CTCCCGGGTG GGGGTCCTCG GCGGGGCCGG TCCGGCCGGA GCTCTGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_003052.2 |
| CDS | 253..4857 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_003061.2 |
ORF Insert Sequence:
1 | ATGGCGCTGA CTCCCGGGTG GGGGTCCTCG GCGGGGCCGG TCCGGCCGGA GCTCTGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu24321 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_003061.2 , NM_003061.3 | |
| Accession Version | NM_003061.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4605bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-05-20 | |
| Organism | Homo sapiens(human) | |
| Product | slit homolog 1 protein precursor | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL512424.14, BC146761.1, BC028105.1 and CD671648.1. On Nov 22, 2018 this sequence version replaced NM_003061.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC146761.1, AB017167.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000266058.9/ ENSP00000266058.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGGCGCTGA CTCCCGGGTG GGGGTCCTCG GCGGGGCCGG TCCGGCCGGA GCTCTGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_003052.2 |
| CDS | 286..4890 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_003061.3 |
ORF Insert Sequence:
1 | ATGGCGCTGA CTCCCGGGTG GGGGTCCTCG GCGGGGCCGG TCCGGCCGGA GCTCTGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. |
|
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
|
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. |
|
SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium. |