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SNAI2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol SNAI2
Entrez Gene ID 6591
Full Name snail family zinc finger 2
Synonyms SLUG, SLUGH1, SNAIL2, WS2D
General protein information
Preferred Names
zinc finger protein SNAI2
Names
zinc finger protein SNAI2
snail homolog 2
protein snail homolog 2
neural crest transcription factor SLUG
slug (chicken homolog), zinc finger protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8q11

Summary This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

602150

Disorder Html: Waardenburg syndrome, type 2D, 608890 (3); Piebaldism, 172800 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_003068 NP_003059 zinc finger protein SNAI2



Homo sapiens (human) SNAI2 NP_003059.1
Pan troglodytes (chimpanzee) SNAI2 XP_003951309.1
Macaca mulatta (Rhesus monkey) SNAI2 XP_001101435.1
Canis lupus familiaris (dog) SNAI2 NP_001091450.1
Bos taurus (cattle) SNAI2 NP_001029710.1
Mus musculus (house mouse) Snai2 NP_035545.1
Rattus norvegicus (Norway rat) Snai2 NP_037167.1
Gallus gallus (chicken) SNAI2 XP_419196.1
Danio rerio (zebrafish) snai2 NP_001008581.1
Caenorhabditis elegans K02D7.2 NP_499902.2
Xenopus (Silurana) tropicalis (western clawed frog) snai2 NP_989424.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SNAI2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SNAI2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu22833
NM_003068 Homo sapiens snail family zinc finger 2 (SNAI2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$154.50-$216.30
$309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu22833
Clone ID Related Accession (Same CDS sequence) NM_003068
Accession Version NM_003068.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 807bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product zinc finger protein SNAI2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA522147.1, BC015895.1 and AC013701.6. This sequence is a reference standard in the RefSeqGene project. On Feb 25, 2011 this sequence version replaced gi:24497625. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223368.1, BC014890.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA962337, SAMEA962343 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGCCGCGCT CCTTCCTGGT CAAGAAGCAT TTCAACGCCT CCAAAAAGCC AAACTACAGC 
GAACTGGACA CACATACAGT GATTATTTCC CCGTATCTCT ATGAGAGTTA CTCCATGCCT
GTCATACCAC AACCAGAGAT CCTCAGCTCA GGAGCATACA GCCCCATCAC TGTGTGGACT
ACCGCTGCTC CATTCCACGC CCAGCTACCC AATGGCCTCT CTCCTCTTTC CGGATACTCC
TCATCTTTGG GGCGAGTGAG TCCCCCTCCT CCATCTGACA CCTCCTCCAA GGACCACAGT
GGCTCAGAAA GCCCCATTAG TGATGAAGAG GAAAGACTAC AGTCCAAGCT TTCAGACCCC
CATGCCATTG AAGCTGAAAA GTTTCAGTGC AATTTATGCA ATAAGACCTA TTCAACTTTT
TCTGGGCTGG CCAAACATAA GCAGCTGCAC TGCGATGCCC AGTCTAGAAA ATCTTTCAGC
TGTAAATACT GTGACAAGGA ATATGTGAGC CTGGGCGCCC TGAAGATGCA TATTCGGACC
CACACATTAC CTTGTGTTTG CAAGATCTGC GGCAAGGCGT TTTCCAGACC CTGGTTGCTT
CAAGGACACA TTAGAACTCA CACGGGGGAG AAGCCTTTTT CTTGCCCTCA CTGCAACAGA
GCATTTGCAG ACAGGTCAAA TCTGAGGGCT CATCTGCAGA CCCATTCTGA TGTAAAGAAA
TACCAGTGCA AAAACTGCTC CAAAACCTTC TCCAGAATGT CTCTCCTGCA CAAACATGAG
GAATCTGGCT GCTGTGTAGC ACACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003059.1
CDS176..982
Misc Feature(1)68..70(+)
Misc Feature(2)176..235(+)
Misc Feature(3)563..625(+)
Misc Feature(4)563..625(+)
Misc Feature(5)578..715(+)
Misc Feature(6)656..718(+)
Misc Feature(7)656..718(+)
Misc Feature(8)656..718(+)
Misc Feature(9)656..718(+)
Misc Feature(10)671..793(+)
Misc Feature(11)719..>949(+)
Misc Feature(12)734..796(+)
Misc Feature(13)734..796(+)
Misc Feature(14)734..796(+)
Misc Feature(15)734..796(+)
Misc Feature(16)749..952(+)
Misc Feature(17)773..844(+)
Misc Feature(18)818..880(+)
Misc Feature(19)818..877(+)
Misc Feature(20)854..931(+)
Misc Feature(21)902..952(+)
Misc Feature(22)902..952(+)
Exon (1)1..254
Gene:SNAI2
Gene Synonym:
Exon (2)255..800
Gene:SNAI2
Gene Synonym:
Exon (3)801..2112
Gene:SNAI2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_003068
Organism Homo sapiens (human)
Definition Homo sapiens snail family zinc finger 2 (SNAI2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003068

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGCCGCGCT CCTTCCTGGT CAAGAAGCAT TTCAACGCCT CCAAAAAGCC AAACTACAGC 
GAACTGGACA CACATACAGT GATTATTTCC CCGTATCTCT ATGAGAGTTA CTCCATGCCT
GTCATACCAC AACCAGAGAT CCTCAGCTCA GGAGCATACA GCCCCATCAC TGTGTGGACT
ACCGCTGCTC CATTCCACGC CCAGCTACCC AATGGCCTCT CTCCTCTTTC CGGATACTCC
TCATCTTTGG GGCGAGTGAG TCCCCCTCCT CCATCTGACA CCTCCTCCAA GGACCACAGT
GGCTCAGAAA GCCCCATTAG TGATGAAGAG GAAAGACTAC AGTCCAAGCT TTCAGACCCC
CATGCCATTG AAGCTGAAAA GTTTCAGTGC AATTTATGCA ATAAGACCTA TTCAACTTTT
TCTGGGCTGG CCAAACATAA GCAGCTGCAC TGCGATGCCC AGTCTAGAAA ATCTTTCAGC
TGTAAATACT GTGACAAGGA ATATGTGAGC CTGGGCGCCC TGAAGATGCA TATTCGGACC
CACACATTAC CTTGTGTTTG CAAGATCTGC GGCAAGGCGT TTTCCAGACC CTGGTTGCTT
CAAGGACACA TTAGAACTCA CACGGGGGAG AAGCCTTTTT CTTGCCCTCA CTGCAACAGA
GCATTTGCAG ACAGGTCAAA TCTGAGGGCT CATCTGCAGA CCCATTCTGA TGTAAAGAAA
TACCAGTGCA AAAACTGCTC CAAAACCTTC TCCAGAATGT CTCTCCTGCA CAAACATGAG
GAATCTGGCT GCTGTGTAGC ACACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Slug expression inhibits calcitriol-mediated sensitivity to radiation in colorectal cancer
Mol. Carcinog. 53 (SUPPL 1), E130-E139 (2014)
Findlay VJ, Moretz RE, Wang C, Vaena SG, Bandurraga SG, Ashenafi M, Marshall DT, Watson DK and Camp ER.


book

Stress-induced cellular transcription factors expressed in trigeminal ganglionic neurons stimulate the herpes simplex virus 1 ICP0 promoter
J. Virol. 87 (23), 13042-13047 (2013)
Sinani D, Cordes E, Workman A, Thunuguntia P and Jones C.


book

Increased expression of Slug and Vimentin as novel predictive biomarkers for lymph node metastasis and poor prognosis in colorectal cancer
Carcinogenesis 34 (11), 2548-2557 (2013)
Toiyama Y, Yasuda H, Saigusa S, Tanaka K, Inoue Y, Goel A and Kusunoki M.


book

MicroRNA-181a suppresses salivary adenoid cystic carcinoma metastasis by targeting MAPK-Snai2 pathway
Biochim. Biophys. Acta 1830 (11), 5258-5266 (2013)
He Q, Zhou X, Li S, Jin Y, Chen Z, Chen D, Cai Y, Liu Z, Zhao T and Wang A.


book

Knockdown of Slug by RNAi inhibits the proliferation and invasion of HCT116 colorectal cancer cells
Mol Med Rep 8 (4), 1055-1059 (2013)
Qian J, Liu H, Chen W, Wen K, Lu W, Huang C and Fu Z.


book

Human Slug is a repressor that localizes to sites of active transcription
Mol. Cell. Biol. 20 (14), 5087-5095 (2000)
Hemavathy K, Guru SC, Harris J, Chen JD and Ip YT.


book

SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein
Mol. Cell 4 (3), 343-352 (1999)
Inukai T, Inoue A, Kurosawa H, Goi K, Shinjyo T, Ozawa K, Mao M, Inaba T and Look AT.


book

Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region
Mutat. Res. 406 (2-4), 63-69 (1999)
Stegmann K, Boecker J, Kosan C, Ermert A, Kunz J and Koch MC.


book

Human SLUG gene organization, expression, and chromosome map location on 8q
Genomics 51 (3), 468-471 (1998)
Cohen ME, Yin M, Paznekas WA, Schertzer M, Wood S and Jabs EW.


book

The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition
J. Cell Biol. 137 (6), 1403-1419 (1997)
Savagner P, Yamada KM and Thiery JP.


 
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