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SOX9 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol SOX9
Entrez Gene ID 6662
Full Name SRY-box 9
Synonyms CMD1,CMPD1,SRA1,SRXX2,SRXY10
General protein information
Preferred Names

SRY-box 9

Names

transcription factor SOX-9
SRY (sex determining region Y)-box9
SRY (sex-determining region Y)-box 9 protein
SRY-related HMG-box, gene 9

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

17

17q24.3

Summary The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008].
Disorder MIM:

608160

Disorder Html: Campomelic dysplasia with autosomal sex reversal, 114290 (3);

mRNA and Protein(s)

mRNA Protein Name
NM_000346.3 NP_000337.1 transcription factor SOX-9



Canis lupus familiaris (dog) SOX9 NP_001002978.1
Bos taurus (cattle) SOX9 XP_005221394.1
Xenopus tropicalis (tropical clawed frog) sox9 NP_001016853.1
Macaca mulatta (rhesus monkey) SOX9 NP_001028040.1
Pan troglodytes (chimpanzee) SOX9 NP_001009029.1
Mus musculus (house mouse) Sox9 NP_035578.3
Rattus norvegicus (Norway rat) Sox9 XP_003750998.1
Gallus gallus (chicken) SOX9 NP_989612.1
Homo sapiens (human) SOX9 NP_000337.1
Danio rerio (zebrafish) sox9a NP_571718.1


Related articles in PubMed

The role of beta-catenin mutation and SOX9 expression in sex cord-stromal tumours of the testis.
Bremmer F, Behnes CL, Schildhaus HU, Gaisa NT, Reis H, Jarry H, Radzun HJ, Stroebel P, Schweyer S
Virchows Archiv : an international journal of pathology470(4)421-428(2017 Apr)

Transcription Factor SOX9 Promotes Osteosarcoma Cell Growth by Repressing Claudin-8 Expression.
Qi J, Yang Y, Hao P, Xu J
The Tohoku journal of experimental medicine241(1)55-63(2017 01)

Knockdown of SOX9 Inhibits the Proliferation, Invasion, and EMT in Thyroid Cancer Cells.
Huang J, Guo L
Oncology research25(2)167-176(2017 Jan)

Assignment of an autosomal sex reversal locus (SRA1) and campomelic dysplasia (CMPD1) to 17q24.3-q25.1.
Tommerup N, Schempp W, Meinecke P, Pedersen S, Bolund L, Brandt C, Goodpasture C, Guldberg P, Held KR, Reinwein H
Nature genetics4(2)170-4(1993 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the signaling pathway study confirmed that Sox9 protected MRC-5 from lipopolysaccharide injury through the AKT/GSK3beta pathway.
Title: Sox9 Protects against Human Lung Fibroblast Cell Apoptosis Induced by LPS through Activation of the AKT/GSK3β Pathway.

SOX9 is almost exclusively expressed by astrocytes in the adult brain except for ependymal cells and in the neurogenic regions, where SOX9 is also expressed by neural progenitor cells
Title: SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions.

immunohistochemical analyses of beta-catenin and SOX9 are useful to distinguish Sertoli cell tumours from other sex cord-stromal tumours of the testis
Title: The role of beta-catenin mutation and SOX9 expression in sex cord-stromal tumours of the testis.

SOX9 may promote cell growth by repressing the expression of CLDN8.
Title: Transcription Factor SOX9 Promotes Osteosarcoma Cell Growth by Repressing Claudin-8 Expression.

results first showed that the gene polymorphism and gene expression of SOX9 were significantly associated with the risk and clinical phenotypes of ONFH and also indicate that the SOX9 gene may play a key role in the development of Osteonecrosis of the Femoral Head.
Title: Significant Associations of SOX9 Gene Polymorphism and Gene Expression with the Risk of Osteonecrosis of the Femoral Head in a Han Population in Northern China.

The following SOX9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOX9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19789
NM_000346.3
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Homo sapiens SRY-box 9 (SOX9), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19789
Clone ID Related Accession (Same CDS sequence) NM_000346.3
Accession Version NM_000346.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1530bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-30
Organism Homo sapiens(Human)
Product transcription factor SOX-9
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007461.8, Z46629.1, BC007951.2 and BC018276.1. This sequence is a reference standard in the RefSeqGene project. On Apr 12, 2008 this sequence version replaced NM_000346.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z46629.1, BC056420.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGAATCTCC TGGACCCCTT CATGAAGATG ACCGACGAGC AGGAGAAGGG CCTGTCCGGC 
GCCCCCAGCC CCACCATGTC CGAGGACTCC GCGGGCTCGC CCTGCCCGTC GGGCTCCGGC
TCGGACACCG AGAACACGCG GCCCCAGGAG AACACGTTCC CCAAGGGCGA GCCCGATCTG
AAGAAGGAGA GCGAGGAGGA CAAGTTCCCC GTGTGCATCC GCGAGGCGGT CAGCCAGGTG
CTCAAAGGCT ACGACTGGAC GCTGGTGCCC ATGCCGGTGC GCGTCAACGG CTCCAGCAAG
AACAAGCCGC ACGTCAAGCG GCCCATGAAC GCCTTCATGG TGTGGGCGCA GGCGGCGCGC
AGGAAGCTCG CGGACCAGTA CCCGCACTTG CACAACGCCG AGCTCAGCAA GACGCTGGGC
AAGCTCTGGA GACTTCTGAA CGAGAGCGAG AAGCGGCCCT TCGTGGAGGA GGCGGAGCGG
CTGCGCGTGC AGCACAAGAA GGACCACCCG GATTACAAGT ACCAGCCGCG GCGGAGGAAG
TCGGTGAAGA ACGGGCAGGC GGAGGCAGAG GAGGCCACGG AGCAGACGCA CATCTCCCCC
AACGCCATCT TCAAGGCGCT GCAGGCCGAC TCGCCACACT CCTCCTCCGG CATGAGCGAG
GTGCACTCCC CCGGCGAGCA CTCGGGGCAA TCCCAGGGCC CACCGACCCC ACCCACCACC
CCCAAAACCG ACGTGCAGCC GGGCAAGGCT GACCTGAAGC GAGAGGGGCG CCCCTTGCCA
GAGGGGGGCA GACAGCCCCC TATCGACTTC CGCGACGTGG ACATCGGCGA GCTGAGCAGC
GACGTCATCT CCAACATCGA GACCTTCGAT GTCAACGAGT TTGACCAGTA CCTGCCGCCC
AACGGCCACC CGGGGGTGCC GGCCACGCAC GGCCAGGTCA CCTACACGGG CAGCTACGGC
ATCAGCAGCA CCGCGGCCAC CCCGGCGAGC GCGGGCCACG TGTGGATGTC CAAGCAGCAG
GCGCCGCCGC CACCCCCGCA GCAGCCCCCA CAGGCCCCGC CGGCCCCGCA GGCGCCCCCG
CAGCCGCAGG CGGCGCCCCC ACAGCAGCCG GCGGCACCCC CGCAGCAGCC ACAGGCGCAC
ACGCTGACCA CGCTGAGCAG CGAGCCGGGC CAGTCCCAGC GAACGCACAT CAAGACGGAG
CAGCTGAGCC CCAGCCACTA CAGCGAGCAG CAGCAGCACT CGCCCCAACA GATCGCCTAC
AGCCCCTTCA ACCTCCCACA CTACAGCCCC TCCTACCCGC CCATCACCCG CTCACAGTAC
GACTACACCG ACCACCAGAA CTCCAGCTCC TACTACAGCC ACGCGGCAGG CCAGGGCACC
GGCCTCTACT CCACCTTCAC CTACATGAAC CCCGCTCAGC GCCCCATGTA CACCCCCATC
GCCGACACCT CTGGGGTCCC TTCCATCCCG CAGACCCACA GCCCCCAGCA CTGGGAACAA
CCCGTCTACA CACAGCTCAC TCGACCTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000337.1
CDS373..1902
Misc Feature(1)229..231
Misc Feature(2)436..654
Misc Feature(3)682..894
Misc Feature(4)order(691..693,697..702,706..711,718..723,730..732,742..744,766..768,781..783,790..792,799..801,856..858)
Misc Feature(5)1003..1005
Exon (1)1..803
Exon (2)804..1057
Exon (3)1058..3935
Translation

Target ORF information:

RefSeq Version NM_000346.3
Organism Homo sapiens(Human)
Definition Homo sapiens SRY-box 9 (SOX9), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000346.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGAATCTCC TGGACCCCTT CATGAAGATG ACCGACGAGC AGGAGAAGGG CCTGTCCGGC 
GCCCCCAGCC CCACCATGTC CGAGGACTCC GCGGGCTCGC CCTGCCCGTC GGGCTCCGGC
TCGGACACCG AGAACACGCG GCCCCAGGAG AACACGTTCC CCAAGGGCGA GCCCGATCTG
AAGAAGGAGA GCGAGGAGGA CAAGTTCCCC GTGTGCATCC GCGAGGCGGT CAGCCAGGTG
CTCAAAGGCT ACGACTGGAC GCTGGTGCCC ATGCCGGTGC GCGTCAACGG CTCCAGCAAG
AACAAGCCGC ACGTCAAGCG GCCCATGAAC GCCTTCATGG TGTGGGCGCA GGCGGCGCGC
AGGAAGCTCG CGGACCAGTA CCCGCACTTG CACAACGCCG AGCTCAGCAA GACGCTGGGC
AAGCTCTGGA GACTTCTGAA CGAGAGCGAG AAGCGGCCCT TCGTGGAGGA GGCGGAGCGG
CTGCGCGTGC AGCACAAGAA GGACCACCCG GATTACAAGT ACCAGCCGCG GCGGAGGAAG
TCGGTGAAGA ACGGGCAGGC GGAGGCAGAG GAGGCCACGG AGCAGACGCA CATCTCCCCC
AACGCCATCT TCAAGGCGCT GCAGGCCGAC TCGCCACACT CCTCCTCCGG CATGAGCGAG
GTGCACTCCC CCGGCGAGCA CTCGGGGCAA TCCCAGGGCC CACCGACCCC ACCCACCACC
CCCAAAACCG ACGTGCAGCC GGGCAAGGCT GACCTGAAGC GAGAGGGGCG CCCCTTGCCA
GAGGGGGGCA GACAGCCCCC TATCGACTTC CGCGACGTGG ACATCGGCGA GCTGAGCAGC
GACGTCATCT CCAACATCGA GACCTTCGAT GTCAACGAGT TTGACCAGTA CCTGCCGCCC
AACGGCCACC CGGGGGTGCC GGCCACGCAC GGCCAGGTCA CCTACACGGG CAGCTACGGC
ATCAGCAGCA CCGCGGCCAC CCCGGCGAGC GCGGGCCACG TGTGGATGTC CAAGCAGCAG
GCGCCGCCGC CACCCCCGCA GCAGCCCCCA CAGGCCCCGC CGGCCCCGCA GGCGCCCCCG
CAGCCGCAGG CGGCGCCCCC ACAGCAGCCG GCGGCACCCC CGCAGCAGCC ACAGGCGCAC
ACGCTGACCA CGCTGAGCAG CGAGCCGGGC CAGTCCCAGC GAACGCACAT CAAGACGGAG
CAGCTGAGCC CCAGCCACTA CAGCGAGCAG CAGCAGCACT CGCCCCAACA GATCGCCTAC
AGCCCCTTCA ACCTCCCACA CTACAGCCCC TCCTACCCGC CCATCACCCG CTCACAGTAC
GACTACACCG ACCACCAGAA CTCCAGCTCC TACTACAGCC ACGCGGCAGG CCAGGGCACC
GGCCTCTACT CCACCTTCAC CTACATGAAC CCCGCTCAGC GCCCCATGTA CACCCCCATC
GCCGACACCT CTGGGGTCCC TTCCATCCCG CAGACCCACA GCCCCCAGCA CTGGGAACAA
CCCGTCTACA CACAGCTCAC TCGACCTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

The role of beta-catenin mutation and SOX9 expression in sex cord-stromal tumours of the testis.
Virchows Archiv : an international journal of pathology470(4)421-428(2017 Apr)
Bremmer F,Behnes CL,Schildhaus HU,Gaisa NT,Reis H,Jarry H,Radzun HJ,Stroebel P,Schweyer S


book

Transcription Factor SOX9 Promotes Osteosarcoma Cell Growth by Repressing Claudin-8 Expression.
The Tohoku journal of experimental medicine241(1)55-63(2017 01)
Qi J,Yang Y,Hao P,Xu J


book

Knockdown of SOX9 Inhibits the Proliferation, Invasion, and EMT in Thyroid Cancer Cells.
Oncology research25(2)167-176(2017 Jan)
Huang J,Guo L


book

Assignment of an autosomal sex reversal locus (SRA1) and campomelic dysplasia (CMPD1) to 17q24.3-q25.1.
Nature genetics4(2)170-4(1993 Jun)
Tommerup N,Schempp W,Meinecke P,Pedersen S,Bolund L,Brandt C,Goodpasture C,Guldberg P,Held KR,Reinwein H


 
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