SOX9 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | SOX9 |
| Entrez Gene ID | 6662 |
| Full Name | SRY-box 9 |
| Synonyms | CMD1,CMPD1,SRA1,SRXX2,SRXY10 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: | |
| Disorder Html: | Campomelic dysplasia with autosomal sex reversal, 114290 (3); Acampomelic campomelic dysplasia, 114290 (3); Campomelic dysplasia, 114290 (3) |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_000346.3 | NP_000337.1 | transcription factor SOX-9 |
| NM_000346.4 | NP_000337.1 | transcription factor SOX-9 |
| Canis lupus familiaris (dog) | SOX9 | NP_001002978.1 |
| Bos taurus (cattle) | SOX9 | XP_005221394.1 |
| Xenopus tropicalis (tropical clawed frog) | sox9 | NP_001016853.1 |
| SOX9 | NP_001028040.1 | |
| Pan troglodytes (chimpanzee) | SOX9 | NP_001009029.1 |
| Mus musculus (house mouse) | Sox9 | NP_035578.3 |
| Rattus norvegicus (Norway rat) | Sox9 | XP_003750998.1 |
| Gallus gallus (chicken) | SOX9 | NP_989612.1 |
| Homo sapiens (human) | SOX9 | NP_000337.1 |
| Danio rerio (zebrafish) | sox9a | NP_571718.1 |
Related articles in PubMed
KLF15 regulates in?vitro chondrogenic differentiation of human mesenchymal stem cells by targeting SOX9.
Song Z, Lian X, Wang Y, Xiang Y, Li G
Biochemical and biophysical research communications493(2)1082-1088(2017 11)
SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types.
Richtig G, Aigelsreiter A, Schwarzenbacher D, Ress AL, Adiprasito JB, Stiegelbauer V, Hoefler G, Schauer S, Kiesslich T, Kornprat P, Winder T, Eisner F, Gerger A, Stoeger H, Stauber R, Lackner C, Pichler M
PloS one12(11)e0187814(2017)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Tomo-Seq Identifies SOX9 as a Key Regulator of Cardiac Fibrosis During Ischemic Injury
Title: Tomo-Seq Identifies SOX9 as a Key Regulator of Cardiac Fibrosis During Ischemic Injury.
the signaling pathway study confirmed that Sox9 protected MRC-5 from lipopolysaccharide injury through the AKT/GSK3beta pathway.
Title: Sox9 Protects against Human Lung Fibroblast Cell Apoptosis Induced by LPS through Activation of the AKT/GSK3? Pathway.
SOX9 is almost exclusively expressed by astrocytes in the adult brain except for ependymal cells and in the neurogenic regions, where SOX9 is also expressed by neural progenitor cells
Title: SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions.
SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types
Title: SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types.
Knockdown of SOX9 inhibited papillary thyroid cancer cell proliferation, invasion and epithelial-mesenchymal transition.
Title: Knockdown of SOX9 Inhibits the Proliferation, Invasion, and EMT in Thyroid Cancer Cells.
The following SOX9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOX9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu19789 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_000346.3 , NM_000346.4 | |
| Accession Version | NM_000346.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1530bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-05 | |
| Organism | Homo sapiens(human) | |
| Product | transcription factor SOX-9 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007461.8, Z46629.1, BC007951.2 and BC018276.1. This sequence is a reference standard in the RefSeqGene project. On Apr 12, 2008 this sequence version replaced NM_000346.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z46629.1, BC056420.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGAATCTCC TGGACCCCTT CATGAAGATG ACCGACGAGC AGGAGAAGGG CCTGTCCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_000337.1 |
| CDS | 373..1902 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_000346.3 |
ORF Insert Sequence:
1 | ATGAATCTCC TGGACCCCTT CATGAAGATG ACCGACGAGC AGGAGAAGGG CCTGTCCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu19789 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_000346.3 , NM_000346.4 | |
| Accession Version | NM_000346.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1530bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-23 | |
| Organism | Homo sapiens(human) | |
| Product | transcription factor SOX-9 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007461.8, Z46629.1, BC007951.2 and BC018276.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000346.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z46629.1, BC056420.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000245479.3/ ENSP00000245479.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGAATCTCC TGGACCCCTT CATGAAGATG ACCGACGAGC AGGAGAAGGG CCTGTCCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_000337.1 |
| CDS | 373..1902 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_000346.4 |
ORF Insert Sequence:
1 | ATGAATCTCC TGGACCCCTT CATGAAGATG ACCGACGAGC AGGAGAAGGG CCTGTCCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
KLF15 regulates in?vitro chondrogenic differentiation of human mesenchymal stem cells by targeting SOX9. |
|
SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types. |