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ACTC1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol ACTC1
Entrez Gene ID 70
Full Name actin, alpha, cardiac muscle 1
Synonyms ACTC, ASD5, CMD1R, CMH11, LVNC4
General protein information
Preferred Names
actin, alpha cardiac muscle 1
Names
actin, alpha cardiac muscle 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q14

Summary Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

102540

Disorder Html: Cardiomyopathy, dilated, 1R, 613424 (3); Cardiomyopathy, familial

mRNA and Protein(s)

mRNA Protein Name
NM_005159 NP_005150 actin, alpha cardiac muscle 1 proprotein



Homo sapiens (human) ACTC1 NP_005150.1
Pan troglodytes (chimpanzee) ACTC1 XP_510285.1
Macaca mulatta (Rhesus monkey) ACTC1 XP_001088409.2
Canis lupus familiaris (dog) ACTC1 XP_535424.1
Bos taurus (cattle) ACTC1 NP_001029757.1
Mus musculus (house mouse) Actc1 NP_033738.1
Rattus norvegicus (Norway rat) Actc1 NP_062056.1
Gallus gallus (chicken) ACTC1 NP_001072949.1
Danio rerio (zebrafish) actc1a NP_001001409.2
Danio rerio (zebrafish) hm:zewp0073 XP_002665778.1
Danio rerio (zebrafish) zgc:86709 NP_001002066.1
Danio rerio (zebrafish) actc1b NP_571666.1
Arabidopsis thaliana (thale cress) ACT7 NP_196543.1
Xenopus (Silurana) tropicalis (western clawed frog) actc1 NP_989094.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ACTC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ACTC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19196
NM_005159 Homo sapiens actin, alpha, cardiac muscle 1 (ACTC1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19196
Clone ID Related Accession (Same CDS sequence) NM_005159
Accession Version NM_005159.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1134bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product actin, alpha cardiac muscle 1 proprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB504220.1, BC009978.2, AK056592.1, CR737466.1 and AI222203.1. This sequence is a reference standard in the RefSeqGene project. On Aug 31, 2006 this sequence version replaced gi:46411161. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009978.2, AK129902.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155550, SAMEA2159607 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGTGTGACG ACGAGGAGAC CACCGCCCTG GTGTGCGACA ACGGCTCTGG GCTGGTGAAG 
GCCGGCTTTG CGGGCGATGA CGCGCCCCGC GCTGTCTTCC CGTCCATCGT GGGCCGCCCG
CGGCACCAGG GAGTTATGGT GGGTATGGGT CAGAAGGACT CCTACGTAGG TGATGAAGCC
CAGAGCAAGA GAGGCATCCT GACCCTGAAG TATCCCATCG AGCATGGTAT CATCACCAAC
TGGGACGACA TGGAGAAGAT CTGGCACCAC ACCTTCTACA ATGAGCTCCG TGTGGCTCCC
GAGGAGCACC CCACCCTGCT CACAGAGGCC CCGCTGAACC CCAAGGCCAA CCGGGAGAAG
ATGACTCAGA TCATGTTTGA GACCTTCAAT GTCCCTGCCA TGTACGTGGC CATCCAGGCA
GTGCTATCCC TGTATGCTTC TGGCCGTACC ACAGGCATTG TTCTGGACTC TGGGGATGGT
GTAACTCACA ATGTCCCCAT CTATGAGGGC TACGCTTTGC CCCATGCCAT CATGCGTCTG
GATCTGGCTG GTCGGGACCT CACTGACTAC CTCATGAAGA TCCTCACTGA GCGTGGCTAC
TCCTTTGTCA CCACTGCTGA ACGTGAAATT GTCCGTGACA TTAAAGAGAA GCTGTGCTAT
GTCGCCCTGG ATTTTGAGAA TGAGATGGCC ACAGCTGCCT CTTCCTCCTC CCTGGAGAAG
AGCTATGAAC TGCCTGATGG CCAAGTCATC ACTATTGGCA ATGAGCGCTT CCGCTGTCCT
GAGACACTCT TCCAGCCCTC CTTCATTGGT ATGGAATCTG CTGGCATCCA TGAAACAACT
TACAATAGCA TCATGAAGTG TGACATTGAT ATCCGCAAGG ACCTGTATGC CAACAATGTC
TTATCTGGAG GCACCACTAT GTACCCTGGT ATTGCTGATC GTATGCAGAA GGAAATCACT
GCTCTGGCTC CTAGCACCAT GAAGATTAAG ATTATTGCTC CCCCTGAGCG TAAATACTCT
GTCTGGATTG GGGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAAAT GTGGATTAGC
AAGCAAGAGT ACGATGAGGC AGGCCCATCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005150.1
CDS244..1377
Misc Feature(1)229..231(+)
Misc Feature(2)256..1374(+)
Misc Feature(3)271..792(+)
Misc Feature(4)280..720(+)
Misc Feature(5)499..501(+)
Exon (1)1..221
Gene:ACTC1
Gene Synonym:
Exon (2)222..372
Gene:ACTC1
Gene Synonym:
Exon (3)373..697
Gene:ACTC1
Gene Synonym:
Exon (4)698..859
Gene:ACTC1
Gene Synonym:
Exon (5)860..1051
Gene:ACTC1
Gene Synonym:
Exon (6)1052..1233
Gene:ACTC1
Gene Synonym:
Exon (7)1234..3693
Gene:ACTC1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_005159
Organism Homo sapiens (human)
Definition Homo sapiens actin, alpha, cardiac muscle 1 (ACTC1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005159

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGTGTGACG ACGAGGAGAC CACCGCCCTG GTGTGCGACA ACGGCTCTGG GCTGGTGAAG 
GCCGGCTTTG CGGGCGATGA CGCGCCCCGC GCTGTCTTCC CGTCCATCGT GGGCCGCCCG
CGGCACCAGG GAGTTATGGT GGGTATGGGT CAGAAGGACT CCTACGTAGG TGATGAAGCC
CAGAGCAAGA GAGGCATCCT GACCCTGAAG TATCCCATCG AGCATGGTAT CATCACCAAC
TGGGACGACA TGGAGAAGAT CTGGCACCAC ACCTTCTACA ATGAGCTCCG TGTGGCTCCC
GAGGAGCACC CCACCCTGCT CACAGAGGCC CCGCTGAACC CCAAGGCCAA CCGGGAGAAG
ATGACTCAGA TCATGTTTGA GACCTTCAAT GTCCCTGCCA TGTACGTGGC CATCCAGGCA
GTGCTATCCC TGTATGCTTC TGGCCGTACC ACAGGCATTG TTCTGGACTC TGGGGATGGT
GTAACTCACA ATGTCCCCAT CTATGAGGGC TACGCTTTGC CCCATGCCAT CATGCGTCTG
GATCTGGCTG GTCGGGACCT CACTGACTAC CTCATGAAGA TCCTCACTGA GCGTGGCTAC
TCCTTTGTCA CCACTGCTGA ACGTGAAATT GTCCGTGACA TTAAAGAGAA GCTGTGCTAT
GTCGCCCTGG ATTTTGAGAA TGAGATGGCC ACAGCTGCCT CTTCCTCCTC CCTGGAGAAG
AGCTATGAAC TGCCTGATGG CCAAGTCATC ACTATTGGCA ATGAGCGCTT CCGCTGTCCT
GAGACACTCT TCCAGCCCTC CTTCATTGGT ATGGAATCTG CTGGCATCCA TGAAACAACT
TACAATAGCA TCATGAAGTG TGACATTGAT ATCCGCAAGG ACCTGTATGC CAACAATGTC
TTATCTGGAG GCACCACTAT GTACCCTGGT ATTGCTGATC GTATGCAGAA GGAAATCACT
GCTCTGGCTC CTAGCACCAT GAAGATTAAG ATTATTGCTC CCCCTGAGCG TAAATACTCT
GTCTGGATTG GGGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAAAT GTGGATTAGC
AAGCAAGAGT ACGATGAGGC AGGCCCATCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Exome sequencing identifies a novel variant in ACTC1 associated with familial atrial septal defect
Can J Cardiol 30 (2), 181-187 (2014)
Greenway SC, McLeod R, Hume S, Roslin NM, Alvarez N, Giuffre M, Zhan SH, Shen Y, Preuss C, Andelfinger G, Jones SJ and Gerull B.


book

Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error
Am. J. Hum. Genet. 93 (2), 264-277 (2013)
Cheng CY, Schache M, Ikram MK, Young TL, Guggenheim JA, Vitart V, MacGregor S, Verhoeven VJ, Barathi VA, Liao J, Hysi PG, Bailey-Wilson JE, St Pourcain B, Kemp JP, McMahon G, Timpson NJ, Evans DM, Montgomery GW, Mishra A, Wang YX, Wang JJ, Rochtchina E, Polasek O, Wright AF, Amin N, van Leeuwen EM, Wilson JF, Pennell CE, van Duijn CM, de Jong PT, Vingerling JR, Zhou X, Chen P, Li R, Tay WT, Zheng Y, Chew M, Burdon KP, Craig JE, Iyengar SK, Igo RP Jr, Lass JH Jr, Chew EY, Haller T, Mihailov E, Metspalu A, Wedenoja J, Simpson CL, Wojciechowski R, Hohn R, Mirshahi A, Zeller T, Pfeiffer N, Lackner KJ, Bettecken T, Meitinger T, Oexle K, Pirastu M, Portas L, Nag A, Williams KM, Yonova-Doing E, Klein R, Klein BE, Hosseini SM, Paterson AD, Makela KM, Lehtimaki T, Kahonen M, Raitakari O, Yoshimura N, Matsuda F, Chen LJ, Pang CP, Yip SP, Yap MK, Meguro A, Mizuki N, Inoko H, Foster PJ, Zhao JH, Vithana E, Tai ES, Fan Q, Xu L, Campbell H, Fleck B, Rudan I, Aung T, Hofman A, Uitterlinden AG, Bencic G, Khor CC, Forward H, Parssinen O, Mitchell P, Rivadeneira F, Hewitt AW, Williams C, Oostra BA, Teo YY, Hammond CJ, Stambolian D, Mackey DA, Klaver CC, Wong TY, Saw SM and Baird PN.


book

Functional characterization of the human alpha-cardiac actin mutations Y166C and M305L involved in hypertrophic cardiomyopathy
Cell. Mol. Life Sci. 69 (20), 3457-3479 (2012)
Muller M, Mazur AJ, Behrmann E, Diensthuber RP, Radke MB, Qu Z, Littwitz C, Raunser S, Schoenenberger CA, Manstein DJ and Mannherz HG.


book

Clathrin potentiates vaccinia-induced actin polymerization to facilitate viral spread
Cell Host Microbe 12 (3), 346-359 (2012)
Humphries AC, Dodding MP, Barry DJ, Collinson LM, Durkin CH and Way M.


book

Hypertrophic Cardiomyopathy Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Cirino,A.L. and Ho,C.


book

Dilated Cardiomyopathy Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Hershberger,R.E. and Morales,A.


book

Regional localization of the gene for cardiac muscle actin (ACTC) on chromosome 15q
Genomics 13 (3), 904-905 (1992)
Kramer PL, Luty JA and Litt M.


book

Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin
J. Infect. 24 (3), 317-320 (1992)
Dawson SJ and White LA.


book

Dinucleotide repeat polymorphism in the human alpha-cardiac actin gene, intron IV (ACTC), detected using the polymerase chain reaction
Nucleic Acids Res. 19 (24), 6980 (1991)
Watkins C, Bodfish P, Warne D, Nyberg K and Spurr NK.


book

Human heart and platelet actins are products of different genes
Science 191 (4222), 94-95 (1976)
Elzinga,M., Maron,B.J. and Adelstein,R.S.


 
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