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DNLZ cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol DNLZ
Entrez Gene ID 728489
Full Name DNL-type zinc finger
Synonyms C9orf151,HEP,HEP1,TIMM15,ZIM17,bA413M3.2
General protein information
Preferred Names

DNL-type zinc finger

Names

DNL-type zinc finger protein
HSP70 escort protein
RP11-413M3.2
hsp70-escort protein 1
mtHsp70-escort protein
translocase of inner mitochondrial membrane 15 homolog
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

9

9q34.3

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_001080849.2 NP_001074318.1 DNL-type zinc finger protein
NM_001080849.3 NP_001074318.1 DNL-type zinc finger protein

Pathways from BioSystems


Homologies


Bos taurus (cattle) DNLZ XP_003586730.1
Homo sapiens (human) DNLZ NP_001074318.1
Canis lupus familiaris (dog) DNLZ XP_849286.1
Rattus norvegicus (Norway rat) Dnlz NP_001124462.1
Gallus gallus (chicken) DNLZ XP_001235328.1
Xenopus tropicalis (tropical clawed frog) dnlz XP_002935266.1
DNLZ XP_001117966.1
Mus musculus (house mouse) Dnlz NP_081104.1
Pan troglodytes (chimpanzee) DNLZ XP_520365.2

Gene Ontology


Bibliography

Related articles in PubMed

Structural and stability studies of the human mtHsp70-escort protein 1: an essential mortalin co-chaperone.
Dores-Silva PR, Minari K, Ramos CH, Barbosa LR, Borges JC
International journal of biological macromolecules56140-8(2013 May)

The DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9.
Vu MT, Zhai P, Lee J, Guerra C, Liu S, Gustin MC, Silberg JJ
Protein science : a publication of the Protein Society21(2)258-67(2012 Feb)

A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity.
Zhai P, Vu MT, Hoff KG, Silberg JJ
Biochemical and biophysical research communications408(4)589-94(2011 May)

The human escort protein Hep binds to the ATPase domain of mitochondrial hsp70 and regulates ATP hydrolysis.
Zhai P, Stanworth C, Liu S, Silberg JJ
The Journal of biological chemistry283(38)26098-106(2008 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results indicate that hHep1 shares some structural similarities with the yeast ortholog despite the low identity and functional differences.
Title: Structural and stability studies of the human mtHsp70-escort protein 1: an essential mortalin co-chaperone.

DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9. Human DNLZ partially complements the growth of Deltazim17 Saccharomyces cerevisiae.
Title: The DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9.

These findings implicate a conserved histidine as critical for DNLZ regulation of mitochondrial HSPA9 catalytic activity.
Title: A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity.

The following DNLZ gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DNLZ cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu15454 NM_001080849.3
Latest version!		 Homo sapiens DNL-type zinc finger (DNLZ), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
View Old Accession Versions >>
OHu15454 NM_001080849.2 Homo sapiens DNL-type zinc finger (DNLZ), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu15454
Clone ID Related Accession (Same CDS sequence) NM_001080849.2 , NM_001080849.3
Accession Version NM_001080849.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 537bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-10-02
Organism Homo sapiens(human)
Product DNL-type zinc finger protein
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC146915.1, AI435052.1 and AI696701.1. On Jan 5, 2013 this sequence version replaced NM_001080849.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the a protein. ##Evidence-Data-START## Transcript exon combination :: BC146915.1, BI827090.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
ATGCTGCGGA CTGCGCTGCG CGGCGCGCCG AGGTTGCTGA GTCGCGTGCA GCCCCGGGCG 
CCCTGCCTGA GGCGGCTGTG GGGCCGCGGG GCCCGTCCAG AGGTCGCGGG GAGGCGGCGG 
GCCTGGGCCT GGGGCTGGCG GCGCTCAAGC TCCGAGCAGG GGCCGGGGCC CGCGGCGGCT 
CTGGGGCGCG TGGAGGCGGC GCACTACCAG CTCGTCTACA CCTGCAAGGT CTGCGGGACT 
AGGTCCTCCA AGCGCATCTC CAAGCTGGCC TATCACCAAG GCGTGGTCAT TGTGACCTGC 
CCCGGCTGCC AGAACCACCA TATCATCGCT GACAACCTGG GCTGGTTCTC GGACCTGAAT 
GGGAAGAGAA ATATCGAAGA GATCCTGACG GCCAGAGGCG AGCAGGTGCA CCGTGTGGCG 
GGCGAGGGGG CCCTGGAACT GGTTCTGGAG GCTGCAGGGG CCCCCACATC CACTGCAGCT 
CCGGAAGCGG GTGAGGATGA GGGTCCCCCC AGCCCTGGCA AGACGGAGCC GAGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001074318.1
CDS98..634
Translation

Target ORF information:

RefSeq Version NM_001080849.2
Organism Homo sapiens(human)
Definition Homo sapiens DNL-type zinc finger (DNLZ), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001080849.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGCTGCGGA CTGCGCTGCG CGGCGCGCCG AGGTTGCTGA GTCGCGTGCA GCCCCGGGCG 
CCCTGCCTGA GGCGGCTGTG GGGCCGCGGG GCCCGTCCAG AGGTCGCGGG GAGGCGGCGG 
GCCTGGGCCT GGGGCTGGCG GCGCTCAAGC TCCGAGCAGG GGCCGGGGCC CGCGGCGGCT 
CTGGGGCGCG TGGAGGCGGC GCACTACCAG CTCGTCTACA CCTGCAAGGT CTGCGGGACT 
AGGTCCTCCA AGCGCATCTC CAAGCTGGCC TATCACCAAG GCGTGGTCAT TGTGACCTGC 
CCCGGCTGCC AGAACCACCA TATCATCGCT GACAACCTGG GCTGGTTCTC GGACCTGAAT 
GGGAAGAGAA ATATCGAAGA GATCCTGACG GCCAGAGGCG AGCAGGTGCA CCGTGTGGCG 
GGCGAGGGGG CCCTGGAACT GGTTCTGGAG GCTGCAGGGG CCCCCACATC CACTGCAGCT 
CCGGAAGCGG GTGAGGATGA GGGTCCCCCC AGCCCTGGCA AGACGGAGCC GAGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15454
Clone ID Related Accession (Same CDS sequence) NM_001080849.2 , NM_001080849.3
Accession Version NM_001080849.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 537bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-04-30
Organism Homo sapiens(human)
Product DNL-type zinc finger protein
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC146915.1, AI435052.1, AI696701.1 and AL592301.14. On Nov 23, 2018 this sequence version replaced NM_001080849.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the a protein. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.513955.1, BI827090.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371738.4/ ENSP00000360803.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
ATGCTGCGGA CTGCGCTGCG CGGCGCGCCG AGGTTGCTGA GTCGCGTGCA GCCCCGGGCG 
CCCTGCCTGA GGCGGCTGTG GGGCCGCGGG GCCCGTCCAG AGGTCGCGGG GAGGCGGCGG 
GCCTGGGCCT GGGGCTGGCG GCGCTCAAGC TCCGAGCAGG GGCCGGGGCC CGCGGCGGCT 
CTGGGGCGCG TGGAGGCGGC GCACTACCAG CTCGTCTACA CCTGCAAGGT CTGCGGGACT 
AGGTCCTCCA AGCGCATCTC CAAGCTGGCC TATCACCAAG GCGTGGTCAT TGTGACCTGC 
CCCGGCTGCC AGAACCACCA TATCATCGCT GACAACCTGG GCTGGTTCTC GGACCTGAAT 
GGGAAGAGAA ATATCGAAGA GATCCTGACG GCCAGAGGCG AGCAGGTGCA CCGTGTGGCG 
GGCGAGGGGG CCCTGGAACT GGTTCTGGAG GCTGCAGGGG CCCCCACATC CACTGCAGCT 
CCGGAAGCGG GTGAGGATGA GGGTCCCCCC AGCCCTGGCA AGACGGAGCC GAGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001074318.1
CDS31..567
Translation

Target ORF information:

RefSeq Version NM_001080849.3
Organism Homo sapiens(human)
Definition Homo sapiens DNL-type zinc finger (DNLZ), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001080849.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGCTGCGGA CTGCGCTGCG CGGCGCGCCG AGGTTGCTGA GTCGCGTGCA GCCCCGGGCG 
CCCTGCCTGA GGCGGCTGTG GGGCCGCGGG GCCCGTCCAG AGGTCGCGGG GAGGCGGCGG 
GCCTGGGCCT GGGGCTGGCG GCGCTCAAGC TCCGAGCAGG GGCCGGGGCC CGCGGCGGCT 
CTGGGGCGCG TGGAGGCGGC GCACTACCAG CTCGTCTACA CCTGCAAGGT CTGCGGGACT 
AGGTCCTCCA AGCGCATCTC CAAGCTGGCC TATCACCAAG GCGTGGTCAT TGTGACCTGC 
CCCGGCTGCC AGAACCACCA TATCATCGCT GACAACCTGG GCTGGTTCTC GGACCTGAAT 
GGGAAGAGAA ATATCGAAGA GATCCTGACG GCCAGAGGCG AGCAGGTGCA CCGTGTGGCG 
GGCGAGGGGG CCCTGGAACT GGTTCTGGAG GCTGCAGGGG CCCCCACATC CACTGCAGCT 
CCGGAAGCGG GTGAGGATGA GGGTCCCCCC AGCCCTGGCA AGACGGAGCC GAGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Structural and stability studies of the human mtHsp70-escort protein 1: an essential mortalin co-chaperone.
International journal of biological macromolecules56140-8(2013 May)
Dores-Silva PR,Minari K,Ramos CH,Barbosa LR,Borges JC


book

The DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9.
Protein science : a publication of the Protein Society21(2)258-67(2012 Feb)
Vu MT,Zhai P,Lee J,Guerra C,Liu S,Gustin MC,Silberg JJ


book

A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity.
Biochemical and biophysical research communications408(4)589-94(2011 May)
Zhai P,Vu MT,Hoff KG,Silberg JJ


book

The human escort protein Hep binds to the ATPase domain of mitochondrial hsp70 and regulates ATP hydrolysis.
The Journal of biological chemistry283(38)26098-106(2008 Sep)
Zhai P,Stanworth C,Liu S,Silberg JJ