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VPS51 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol VPS51
Entrez Gene ID 738
Full Name VPS51, GARP complex subunit
Synonyms ANG2,ANG3,C11orf2,C11orf3,FFR
General protein information
Preferred Names

VPS51, GARP complex subunit

Names

vacuolar protein sorting-associated protein 51 homolog
another new gene 2 protein
protein fat-free homolog
vacuolar protein sorting 51 homolog

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

11

11q13.1

Summary This gene encodes a member of the vacuolar protein sorting-associated protein 51 family. The encoded protein is a component of the Golgi-associated retrograde protein complex which acts as a tethering factor for carriers in retrograde transport from the early and late endosomes to the trans-Golgi network. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].
Disorder MIM:

615738


mRNA and Protein(s)

mRNA Protein Name
NM_013265.3 NP_037397.2 vacuolar protein sorting-associated protein 51 homolog



Bos taurus (cattle) VPS51 NP_001095563.1
Drosophila melanogaster (fruit fly) CG15087 NP_611363.2
Homo sapiens (human) VPS51 NP_037397.2
Pan troglodytes (chimpanzee) VPS51 XP_001168116.2
Rattus norvegicus (Norway rat) Vps51 XP_002728870.2
Anopheles gambiae (African malaria mosquito) AgaP_AGAP005584 XP_315595.3
Mus musculus (house mouse) Vps51 NP_001074510.1
Danio rerio (zebrafish) vps51 NP_001036200.1
Xenopus tropicalis (tropical clawed frog) vps51 NP_001027521.1
Canis lupus familiaris (dog) VPS51 XP_533237.2
Caenorhabditis elegans (roundworm) vps-51 NP_001020972.1


Related articles in PubMed

EARP is a multisubunit tethering complex involved in endocytic recycling.
Schindler C, Chen Y, Pu J, Guo X, Bonifacino JS
Nature cell biology17(5)639-50(2015 May)

Structural basis for the interaction of the Golgi-Associated Retrograde Protein Complex with the t-SNARE Syntaxin 6.
Abascal-Palacios G, Schindler C, Rojas AL, Bonifacino JS, Hierro A
Structure (London, England : 1993)21(9)1698-706(2013 Sep)

Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex.
Pérez-Victoria FJ, Schindler C, Magadán JG, Mardones GA, Delevoye C, Romao M, Raposo G, Bonifacino JS
Molecular biology of the cell21(19)3386-95(2010 Oct)

Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1.
Lemmens I, Merregaert J, Van de Ven WJ, Kas K, Zhang CX, Giraud S, Wautot V, Buisson N, De Witte K, Salandre J, Lenoir G, Calender A, Parente F, Quincey D, Courseaux A, Carle GF, Gaudray P, De Wit MJ, Lips CJ, Höppener JW, Khodaei S, Grant AL, Weber G, Kytölä S, Thakker RV
Genomics44(1)94-100(1997 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A dityrosine motif of Ang2 interacts with a highly conserved groove in Syntaxin 6.
Title: Structural basis for the interaction of the Golgi-Associated Retrograde Protein Complex with the t-SNARE Syntaxin 6.

Ang2 is the missing component of the Golgi-associated retrograde protein complex in most eukaryotes.
Title: Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex.

The following VPS51 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VPS51 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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OHu16042 NM_013265.3
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Homo sapiens VPS51, GARP complex subunit (VPS51), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $391.30
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu16042
Clone ID Related Accession (Same CDS sequence) NM_013265.3
Accession Version NM_013265.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2349bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product vacuolar protein sorting-associated protein 51 homolog
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX401315.2, BI823833.1, AF024631.2, HY270070.1 and AW007399.1. On Dec 16, 2012 this sequence version replaced NM_013265.2. Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein. ##Evidence-Data-START## Transcript exon combination :: AF024631.2, BC010540.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGGCGGCGG CAGCTGCCGC CGGGCCTAGC CCGGGGTCTG GACCTGGGGA CTCCCCAGAA 
GGGCCCGAGG GGGAGGCTCC GGAGCGTCGG CGGAAGGCGC ACGGGATGCT GAAGCTTTAC
TACGGCCTCT CGGAAGGGGA GGCGGCGGGA CGCCCCGCGG GGCCCGACCC CCTGGACCCG
ACTGATCTGA ACGGGGCGCA CTTCGACCCG GAAGTTTACC TAGACAAGCT GCGTAGAGAG
TGCCCTCTGG CCCAGTTGAT GGACAGTGAG ACGGACATGG TGCGGCAGAT CCGGGCTCTA
GACAGCGACA TGCAGACCCT GGTCTATGAG AACTACAACA AGTTCATCTC AGCCACAGAC
ACCATCCGGA AGATGAAGAA CGATTTCCGG AAGATGGAGG ATGAGATGGA CCGGCTGGCC
ACCAACATGG CAGTGATCAC CGACTTCAGC GCTCGCATCA GCGCCACGCT GCAGGACCGC
CACGAGCGCA TCACCAAGCT GGCAGGGGTC CACGCGCTGC TGCGGAAGCT GCAGTTCCTC
TTTGAGCTGC CCTCGCGCCT CACCAAGTGC GTGGAACTGG GCGCCTATGG GCAGGCGGTG
CGCTACCAGG GCCGCGCGCA GGCCGTGCTG CAGCAGTACC AACACCTGCC CTCGTTCCGC
GCCATCCAGG ACGACTGCCA GGTCATCACG GCCCGCCTGG CCCAGCAGCT GCGGCAGCGC
TTTAGGGAGG GCGGCTCAGG CGCCCCGGAG CAGGCAGAGT GCGTGGAGCT GCTGCTGGCC
CTGGGCGAGC CTGCGGAGGA GCTGTGCGAG GAGTTCCTGG CGCACGCCCG CGGCCGGCTG
GAGAAGGAGC TGAGAAACCT GGAGGCCGAG CTGGGGCCCT CACCTCCGGC TCCCGACGTG
TTAGAGTTCA CCGACCATGG AGGCAGTGGC TTCGTGGGCG GCCTCTGCCA GGTGGCGGCG
GCCTACCAGG AGCTGTTTGC GGCCCAGGGC CCAGCAGGTG CCGAGAAGCT GGCGGCCTTC
GCCCGGCAGC TGGGCAGCCG CTATTTTGCG CTGGTGGAGC GGCGGCTGGC GCAGGAGCAG
GGTGGTGGTG ACAACTCACT GCTGGTGCGG GCGCTGGACC GCTTCCACCG GCGCTTGCGG
GCTCCCGGGG CCCTGCTGGC CGCTGCCGGG CTCGCAGACG CTGCCACGGA GATCGTGGAA
CGAGTGGCCC GCGAGCGCCT GGGCCACCAC CTGCAGGGTC TCCGGGCGGC CTTCCTGGGC
TGCCTGACAG ACGTCCGCCA GGCGCTGGCA GCACCTCGCG TGGCTGGGAA GGAGGGCCCT
GGCCTGGCCG AGTTGCTGGC CAATGTGGCC AGCTCCATCC TGAGCCACAT TAAGGCCTCT
CTGGCAGCAG TGCACCTTTT CACCGCCAAA GAGGTGTCCT TCTCCAACAA GCCCTACTTC
CGGGGTGAGT TCTGCAGTCA GGGTGTCCGT GAGGGCCTCA TCGTGGGCTT CGTCCACTCT
ATGTGCCAGA CGGCTCAGAG CTTCTGCGAC AGCCCTGGGG AGAAGGGGGG TGCCACACCA
CCTGCCCTGC TCCTGCTGCT CTCCCGCCTC TGCCTGGACT ACGAGACGGC CACCATCTCC
TACATCCTCA CTCTCACTGA TGAACAGTTT CTGGTGCAGG ATCAGTTCCC AGTGACGCCC
GTGAGCACGC TGTGTGCAGA GGCCAGGGAA ACGGCGCGGC GGCTGCTGAC CCACTACGTG
AAGGTGCAGG GCCTGGTCAT ATCACAGATG CTGCGCAAGA GCGTGGAGAC TCGCGACTGG
CTCAGCACTC TGGAGCCCCG GAATGTGCGG GCCGTCATGA AGCGGGTGGT GGAGGATACC
ACCGCCATCG ACGTGCAGGT GGGGCTCCTG TACGAAGAGG GTGTTCGCAA GGCCCAGAGC
AGCGACTCCA GCAAGAGGAC TTTCTCCGTG TACAGCAGCT CTCGGCAGCA GGGCCGCTAC
GCCCCCAGCT ATACCCCCAG TGCCCCGATG GACACCAACC TCTTGAGCAA TATCCAGAAG
CTATTCTCTG AACGTATTGA TGTGTTCAGC CCTGTGGAGT TCAACAAGGT GTCGGTGCTG
ACCGGCATCA TCAAGATCAG CCTGAAGACG CTGCTGGAGT GTGTGCGGCT GCGCACCTTT
GGGCGCTTCG GGCTGCAGCA GGTGCAAGTG GACTGCCACT TTCTGCAGCT CTACCTGTGG
CGTTTTGTGG CCGACGAAGA ACTCGTGCAC TTGCTGCTGG ACGAAGTGGT GGCCTCTGCT
GCCCTGCGCT GCCCAGACCC TGTGCCCATG GAGCCCAGTG TGGTTGAGGT CATCTGCGAG
CGCGGCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_037397.2
CDS137..2485
Misc Feature(1)140..142
Misc Feature(2)188..190
Misc Feature(3)266..268
Misc Feature(4)323..577
Misc Feature(5)437..922
Misc Feature(6)2081..2083
Exon (1)1..364
Exon (2)365..494
Exon (3)495..641
Exon (4)642..861
Exon (5)862..1579
Exon (6)1580..1795
Exon (7)1796..2014
Exon (8)2015..2136
Exon (9)2137..2224
Exon (10)2225..2758
Translation

Target ORF information:

RefSeq Version NM_013265.3
Organism Homo sapiens(Human)
Definition Homo sapiens VPS51, GARP complex subunit (VPS51), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_013265.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGGCGGCGG CAGCTGCCGC CGGGCCTAGC CCGGGGTCTG GACCTGGGGA CTCCCCAGAA 
GGGCCCGAGG GGGAGGCTCC GGAGCGTCGG CGGAAGGCGC ACGGGATGCT GAAGCTTTAC
TACGGCCTCT CGGAAGGGGA GGCGGCGGGA CGCCCCGCGG GGCCCGACCC CCTGGACCCG
ACTGATCTGA ACGGGGCGCA CTTCGACCCG GAAGTTTACC TAGACAAGCT GCGTAGAGAG
TGCCCTCTGG CCCAGTTGAT GGACAGTGAG ACGGACATGG TGCGGCAGAT CCGGGCTCTA
GACAGCGACA TGCAGACCCT GGTCTATGAG AACTACAACA AGTTCATCTC AGCCACAGAC
ACCATCCGGA AGATGAAGAA CGATTTCCGG AAGATGGAGG ATGAGATGGA CCGGCTGGCC
ACCAACATGG CAGTGATCAC CGACTTCAGC GCTCGCATCA GCGCCACGCT GCAGGACCGC
CACGAGCGCA TCACCAAGCT GGCAGGGGTC CACGCGCTGC TGCGGAAGCT GCAGTTCCTC
TTTGAGCTGC CCTCGCGCCT CACCAAGTGC GTGGAACTGG GCGCCTATGG GCAGGCGGTG
CGCTACCAGG GCCGCGCGCA GGCCGTGCTG CAGCAGTACC AACACCTGCC CTCGTTCCGC
GCCATCCAGG ACGACTGCCA GGTCATCACG GCCCGCCTGG CCCAGCAGCT GCGGCAGCGC
TTTAGGGAGG GCGGCTCAGG CGCCCCGGAG CAGGCAGAGT GCGTGGAGCT GCTGCTGGCC
CTGGGCGAGC CTGCGGAGGA GCTGTGCGAG GAGTTCCTGG CGCACGCCCG CGGCCGGCTG
GAGAAGGAGC TGAGAAACCT GGAGGCCGAG CTGGGGCCCT CACCTCCGGC TCCCGACGTG
TTAGAGTTCA CCGACCATGG AGGCAGTGGC TTCGTGGGCG GCCTCTGCCA GGTGGCGGCG
GCCTACCAGG AGCTGTTTGC GGCCCAGGGC CCAGCAGGTG CCGAGAAGCT GGCGGCCTTC
GCCCGGCAGC TGGGCAGCCG CTATTTTGCG CTGGTGGAGC GGCGGCTGGC GCAGGAGCAG
GGTGGTGGTG ACAACTCACT GCTGGTGCGG GCGCTGGACC GCTTCCACCG GCGCTTGCGG
GCTCCCGGGG CCCTGCTGGC CGCTGCCGGG CTCGCAGACG CTGCCACGGA GATCGTGGAA
CGAGTGGCCC GCGAGCGCCT GGGCCACCAC CTGCAGGGTC TCCGGGCGGC CTTCCTGGGC
TGCCTGACAG ACGTCCGCCA GGCGCTGGCA GCACCTCGCG TGGCTGGGAA GGAGGGCCCT
GGCCTGGCCG AGTTGCTGGC CAATGTGGCC AGCTCCATCC TGAGCCACAT TAAGGCCTCT
CTGGCAGCAG TGCACCTTTT CACCGCCAAA GAGGTGTCCT TCTCCAACAA GCCCTACTTC
CGGGGTGAGT TCTGCAGTCA GGGTGTCCGT GAGGGCCTCA TCGTGGGCTT CGTCCACTCT
ATGTGCCAGA CGGCTCAGAG CTTCTGCGAC AGCCCTGGGG AGAAGGGGGG TGCCACACCA
CCTGCCCTGC TCCTGCTGCT CTCCCGCCTC TGCCTGGACT ACGAGACGGC CACCATCTCC
TACATCCTCA CTCTCACTGA TGAACAGTTT CTGGTGCAGG ATCAGTTCCC AGTGACGCCC
GTGAGCACGC TGTGTGCAGA GGCCAGGGAA ACGGCGCGGC GGCTGCTGAC CCACTACGTG
AAGGTGCAGG GCCTGGTCAT ATCACAGATG CTGCGCAAGA GCGTGGAGAC TCGCGACTGG
CTCAGCACTC TGGAGCCCCG GAATGTGCGG GCCGTCATGA AGCGGGTGGT GGAGGATACC
ACCGCCATCG ACGTGCAGGT GGGGCTCCTG TACGAAGAGG GTGTTCGCAA GGCCCAGAGC
AGCGACTCCA GCAAGAGGAC TTTCTCCGTG TACAGCAGCT CTCGGCAGCA GGGCCGCTAC
GCCCCCAGCT ATACCCCCAG TGCCCCGATG GACACCAACC TCTTGAGCAA TATCCAGAAG
CTATTCTCTG AACGTATTGA TGTGTTCAGC CCTGTGGAGT TCAACAAGGT GTCGGTGCTG
ACCGGCATCA TCAAGATCAG CCTGAAGACG CTGCTGGAGT GTGTGCGGCT GCGCACCTTT
GGGCGCTTCG GGCTGCAGCA GGTGCAAGTG GACTGCCACT TTCTGCAGCT CTACCTGTGG
CGTTTTGTGG CCGACGAAGA ACTCGTGCAC TTGCTGCTGG ACGAAGTGGT GGCCTCTGCT
GCCCTGCGCT GCCCAGACCC TGTGCCCATG GAGCCCAGTG TGGTTGAGGT CATCTGCGAG
CGCGGCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

EARP is a multisubunit tethering complex involved in endocytic recycling.
Nature cell biology17(5)639-50(2015 May)
Schindler C,Chen Y,Pu J,Guo X,Bonifacino JS


book

Structural basis for the interaction of the Golgi-Associated Retrograde Protein Complex with the t-SNARE Syntaxin 6.
Structure (London, England : 1993)21(9)1698-706(2013 Sep)
Abascal-Palacios G,Schindler C,Rojas AL,Bonifacino JS,Hierro A


book

Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex.
Molecular biology of the cell21(19)3386-95(2010 Oct)
Pérez-Victoria FJ,Schindler C,Magadán JG,Mardones GA,Delevoye C,Romao M,Raposo G,Bonifacino JS


book

Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1.
Genomics44(1)94-100(1997 Aug)
Lemmens I,Merregaert J,Van de Ven WJ,Kas K,Zhang CX,Giraud S,Wautot V,Buisson N,De Witte K,Salandre J,Lenoir G,Calender A,Parente F,Quincey D,Courseaux A,Carle GF,Gaudray P,De Wit MJ,Lips CJ,Höppener JW,Khodaei S,Grant AL,Weber G,Kytölä S,Thakker RV


 
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