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XRCC1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol XRCC1
Entrez Gene ID 7515
Full Name X-ray repair complementing defective repair in Chinese hamster cells 1
Synonyms RCC
General protein information
Preferred Names
DNA repair protein XRCC1
Names
DNA repair protein XRCC1
X-ray repair cross-complementing protein 1
X-ray-repair, complementing defective, repair in Chinese hamster
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.2

Summary The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

194360


mRNA and Protein(s)

mRNA Protein Name
NM_006297 NP_006288 DNA repair protein XRCC1



Homo sapiens (human) XRCC1 NP_006288.2
Pan troglodytes (chimpanzee) XRCC1 XP_001156934.3
Macaca mulatta (Rhesus monkey) XRCC1 XP_001100256.2
Canis lupus familiaris (dog) XRCC1 XP_533653.3
Bos taurus (cattle) XRCC1 XP_005219459.1
Mus musculus (house mouse) Xrcc1 NP_033558.3
Rattus norvegicus (Norway rat) Xrcc1 NP_445887.1
Danio rerio (zebrafish) xrcc1 NP_001003988.1
Xenopus (Silurana) tropicalis (western clawed frog) xrcc1 XP_002939185.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following XRCC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the XRCC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu20078
NM_006297 Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu20078
Clone ID Related Accession (Same CDS sequence) NM_006297
Accession Version NM_006297.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1902bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product DNA repair protein XRCC1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP349667.1, AB208781.1 and AK315332.1. This sequence is a reference standard in the RefSeqGene project. On Jun 19, 2008 this sequence version replaced gi:5454171. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB208781.1, AK315332.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGCCGGAGA TCCGCCTCCG CCATGTCGTG TCCTGCAGCA GCCAGGACTC GACTCACTGT 
GCAGAAAATC TTCTCAAGGC AGACACTTAC CGAAAATGGC GGGCAGCCAA GGCAGGCGAG
AAGACCATCT CTGTGGTCCT ACAGTTGGAG AAGGAGGAGC AGATACACAG TGTGGACATT
GGGAATGATG GCTCAGCTTT CGTGGAGGTG CTGGTGGGCA GTTCAGCTGG AGGCGCTGGG
GAGCAAGACT ATGAGGTCCT TCTGGTCACC TCATCTTTCA TGTCCCCTTC CGAGAGCCGC
AGTGGCTCAA ACCCCAACCG CGTTCGCATG TTTGGGCCTG ACAAGCTGGT CCGGGCAGCC
GCCGAGAAGC GCTGGGACCG GGTCAAAATT GTTTGCAGCC AGCCCTACAG CAAGGACTCC
CCCTTTGGCT TGAGTTTTGT ACGGTTTCAT AGCCCCCCAG ACAAAGATGA GGCAGAGGCC
CCGTCCCAGA AGGTGACAGT GACCAAGCTT GGCCAGTTCC GTGTGAAGGA GGAGGATGAG
AGCGCCAACT CTCTGAGGCC GGGGGCTCTC TTCTTCAGCC GGATCAACAA GACATCCCCA
GTCACAGCCA GCGACCCAGC AGGACCTAGC TATGCAGCTG CTACCCTCCA GGCTTCTAGT
GCTGCCTCCT CAGCCTCTCC AGTCTCCAGG GCCATAGGCA GCACCTCCAA GCCCCAGGAG
TCTCCCAAAG GGAAGAGGAA GTTGGATTTG AACCAAGAAG AAAAGAAGAC CCCCAGCAAA
CCACCAGCCC AGCTGTCGCC ATCTGTTCCC AAGAGACCTA AATTGCCAGC TCCAACTCGT
ACCCCAGCCA CAGCCCCAGT CCCTGCCCGA GCACAGGGGG CAGTGACAGG CAAACCCCGA
GGAGAAGGCA CCGAGCCCAG ACGACCCCGA GCTGGCCCAG AGGAGCTGGG GAAGATCCTT
CAGGGTGTGG TAGTGGTGCT GAGTGGCTTC CAGAACCCCT TCCGCTCCGA GCTGCGAGAT
AAGGCCCTAG AGCTTGGGGC CAAGTATCGG CCAGACTGGA CCCGGGACAG CACGCACCTC
ATCTGTGCCT TTGCCAACAC CCCCAAGTAC AGCCAGGTCC TAGGCCTGGG AGGCCGCATC
GTGCGTAAGG AGTGGGTGCT GGACTGTCAC CGCATGCGTC GGCGGCTGCC CTCCCAGAGG
TACCTCATGG CAGGGCCAGG TTCCAGCAGT GAGGAGGATG AGGCCTCTCA CAGCGGTGGC
AGCGGAGATG AAGCCCCCAA GCTTCCTCAG AAGCAACCCC AGACCAAAAC CAAGCCCACT
CAGGCAGCTG GACCCAGCTC ACCCCAGAAG CCCCCAACCC CTGAAGAGAC CAAAGCAGCC
TCACCAGTGC TCCAGGAAGA TATAGACATT GAGGGGGTAC AGTCAGAAGG ACAGGACAAT
GGGGCGGAAG ATTCTGGGGA CACAGAGGAT GAGCTGAGGA GGGTGGCAGA GCAGAAGGAA
CACAGACTGC CCCCTGGCCA GGAGGAGAAT GGGGAAGACC CGTATGCAGG CTCCACGGAT
GAGAACACGG ACAGTGAGGA ACACCAGGAG CCTCCTGATC TGCCAGTCCC TGAGCTCCCA
GATTTCTTCC AGGGCAAGCA CTTCTTTCTT TACGGGGAGT TCCCTGGGGA CGAGCGGCGG
AAACTCATCC GATACGTCAC AGCCTTCAAT GGGGAGCTCG AGGACTATAT GAGTGACCGG
GTTCAGTTTG TGATCACAGC ACAGGAATGG GATCCCAGCT TTGAGGAGGC CCTGATGGAC
AACCCCTCCC TGGCATTCGT TCGTCCCCGA TGGATCTACA GTTGCAATGA GAAGCAGAAG
TTACTTCCTC ACCAGCTCTA TGGGGTGGTG CCGCAAGCCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006288.2
CDS121..2022
Misc Feature(1)121..573(+)
Misc Feature(2)538..540(+)
Misc Feature(3)712..714(+)
Misc Feature(4)715..717(+)
Misc Feature(5)724..726(+)
Misc Feature(6)730..732(+)
Misc Feature(7)751..753(+)
Misc Feature(8)796..798(+)
Misc Feature(9)841..843(+)
Misc Feature(10)889..891(+)
Misc Feature(11)895..897(+)
Misc Feature(12)916..918(+)
Misc Feature(13)1084..1287(+)
Misc Feature(14)1126..1164(+)
Misc Feature(15)1231..1233(+)
Misc Feature(16)1273..1287(+)
Misc Feature(17)1342..1344(+)
Misc Feature(18)1345..1347(+)
Misc Feature(19)1348..1350(+)
Misc Feature(20)1366..1368(+)
Misc Feature(21)1372..1374(+)
Misc Feature(22)1381..1383(+)
Misc Feature(23)1456..1458(+)
Misc Feature(24)1459..1461(+)
Misc Feature(25)1477..1479(+)
Misc Feature(26)1489..1491(+)
Misc Feature(27)1501..1503(+)
Misc Feature(28)1573..1575(+)
Misc Feature(29)1582..1584(+)
Misc Feature(30)1672..1674(+)
Misc Feature(31)1675..1677(+)
Misc Feature(32)1687..1689(+)
Misc Feature(33)1753..1965(+)
Misc Feature(34)1798..1836(+)
Misc Feature(35)1951..1965(+)
Exon (1)1..171
Gene:XRCC1
Gene Synonym:
Exon (2)172..264
Gene:XRCC1
Gene Synonym:
Exon (3)265..375
Gene:XRCC1
Gene Synonym:
Exon (4)376..534
Gene:XRCC1
Gene Synonym:
Exon (5)535..609
Gene:XRCC1
Gene Synonym:
Exon (6)610..721
Gene:XRCC1
Gene Synonym:
Exon (7)722..831
Gene:XRCC1
Gene Synonym:
Exon (8)832..943
Gene:XRCC1
Gene Synonym:
Exon (9)944..1202
Gene:XRCC1
Gene Synonym:
Exon (10)1203..1319
Gene:XRCC1
Gene Synonym:
Exon (11)1320..1413
Gene:XRCC1
Gene Synonym:
Exon (12)1414..1546
Gene:XRCC1
Gene Synonym:
Exon (13)1547..1601
Gene:XRCC1
Gene Synonym:
Exon (14)1602..1741
Gene:XRCC1
Gene Synonym:
Exon (15)1742..1832
Gene:XRCC1
Gene Synonym:
Exon (16)1833..1908
Gene:XRCC1
Gene Synonym:
Exon (17)1909..2102
Gene:XRCC1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_006297
Organism Homo sapiens (human)
Definition Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_006297

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGCCGGAGA TCCGCCTCCG CCATGTCGTG TCCTGCAGCA GCCAGGACTC GACTCACTGT 
GCAGAAAATC TTCTCAAGGC AGACACTTAC CGAAAATGGC GGGCAGCCAA GGCAGGCGAG
AAGACCATCT CTGTGGTCCT ACAGTTGGAG AAGGAGGAGC AGATACACAG TGTGGACATT
GGGAATGATG GCTCAGCTTT CGTGGAGGTG CTGGTGGGCA GTTCAGCTGG AGGCGCTGGG
GAGCAAGACT ATGAGGTCCT TCTGGTCACC TCATCTTTCA TGTCCCCTTC CGAGAGCCGC
AGTGGCTCAA ACCCCAACCG CGTTCGCATG TTTGGGCCTG ACAAGCTGGT CCGGGCAGCC
GCCGAGAAGC GCTGGGACCG GGTCAAAATT GTTTGCAGCC AGCCCTACAG CAAGGACTCC
CCCTTTGGCT TGAGTTTTGT ACGGTTTCAT AGCCCCCCAG ACAAAGATGA GGCAGAGGCC
CCGTCCCAGA AGGTGACAGT GACCAAGCTT GGCCAGTTCC GTGTGAAGGA GGAGGATGAG
AGCGCCAACT CTCTGAGGCC GGGGGCTCTC TTCTTCAGCC GGATCAACAA GACATCCCCA
GTCACAGCCA GCGACCCAGC AGGACCTAGC TATGCAGCTG CTACCCTCCA GGCTTCTAGT
GCTGCCTCCT CAGCCTCTCC AGTCTCCAGG GCCATAGGCA GCACCTCCAA GCCCCAGGAG
TCTCCCAAAG GGAAGAGGAA GTTGGATTTG AACCAAGAAG AAAAGAAGAC CCCCAGCAAA
CCACCAGCCC AGCTGTCGCC ATCTGTTCCC AAGAGACCTA AATTGCCAGC TCCAACTCGT
ACCCCAGCCA CAGCCCCAGT CCCTGCCCGA GCACAGGGGG CAGTGACAGG CAAACCCCGA
GGAGAAGGCA CCGAGCCCAG ACGACCCCGA GCTGGCCCAG AGGAGCTGGG GAAGATCCTT
CAGGGTGTGG TAGTGGTGCT GAGTGGCTTC CAGAACCCCT TCCGCTCCGA GCTGCGAGAT
AAGGCCCTAG AGCTTGGGGC CAAGTATCGG CCAGACTGGA CCCGGGACAG CACGCACCTC
ATCTGTGCCT TTGCCAACAC CCCCAAGTAC AGCCAGGTCC TAGGCCTGGG AGGCCGCATC
GTGCGTAAGG AGTGGGTGCT GGACTGTCAC CGCATGCGTC GGCGGCTGCC CTCCCAGAGG
TACCTCATGG CAGGGCCAGG TTCCAGCAGT GAGGAGGATG AGGCCTCTCA CAGCGGTGGC
AGCGGAGATG AAGCCCCCAA GCTTCCTCAG AAGCAACCCC AGACCAAAAC CAAGCCCACT
CAGGCAGCTG GACCCAGCTC ACCCCAGAAG CCCCCAACCC CTGAAGAGAC CAAAGCAGCC
TCACCAGTGC TCCAGGAAGA TATAGACATT GAGGGGGTAC AGTCAGAAGG ACAGGACAAT
GGGGCGGAAG ATTCTGGGGA CACAGAGGAT GAGCTGAGGA GGGTGGCAGA GCAGAAGGAA
CACAGACTGC CCCCTGGCCA GGAGGAGAAT GGGGAAGACC CGTATGCAGG CTCCACGGAT
GAGAACACGG ACAGTGAGGA ACACCAGGAG CCTCCTGATC TGCCAGTCCC TGAGCTCCCA
GATTTCTTCC AGGGCAAGCA CTTCTTTCTT TACGGGGAGT TCCCTGGGGA CGAGCGGCGG
AAACTCATCC GATACGTCAC AGCCTTCAAT GGGGAGCTCG AGGACTATAT GAGTGACCGG
GTTCAGTTTG TGATCACAGC ACAGGAATGG GATCCCAGCT TTGAGGAGGC CCTGATGGAC
AACCCCTCCC TGGCATTCGT TCGTCCCCGA TGGATCTACA GTTGCAATGA GAAGCAGAAG
TTACTTCCTC ACCAGCTCTA TGGGGTGGTG CCGCAAGCCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Association of XRCC1 genetic polymorphism (Arg399Gln) with laryngeal cancer: a meta-analysis based on 4,031 subjects
Tumour Biol. 35 (2), 1637-1640 (2014)
Chen W, Wang ZY, Xu FL, Wu KM, Zhang Y, Xu L and Wang QP.


book

Association of XRCC1 Arg399Gln polymorphism with bladder cancer susceptibility: a meta-analysis
Gene 534 (1), 17-23 (2014)
Yang D, Liu C, Shi J, Wang N, Du X, Yin Q and Wang Y.


book

XRCC1 R399Q polymorphism and risk of normal tissue injury after radiotherapy in breast cancer patients
Tumour Biol. 35 (1), 21-25 (2014)
Zhou Y, Zhou W, Liu Q, Fan Z, Yang Z, Tu Q, Li L and Liu H.


book

Meta-analysis of genetic polymorphisms and ophthalmologic disease risk in Asian populations: a case of DNA repair XRCC1 gene
Pak. J. Biol. Sci. 16 (21), 1226-1237 (2013)
Saki N, Galehdari H, Feghhi M, Larijani FA and Rahim F.


book

Lys751Gln XPD and Arg399Gln XRCC1 in Romanians. Association with sporadic colorectal cancer risk and different stages of carcinomas
Chirurgia (Bucur) 108 (5), 711-718 (2013)
Procopciuc,L.M. and Osian,G.


book

Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR
Cancer Res. 55 (21), 5025-5029 (1995)
Wei Q, Xu X, Cheng L, Legerski RJ and Ali-Osman F.


book

Genomic sequence comparison of the human and mouse XRCC1 DNA repair gene regions
Genomics 25 (2), 547-554 (1995)
Lamerdin JE, Montgomery MA, Stilwagen SA, Scheidecker LK, Tebbs RS, Brookman KW, Thompson LH and Carrano AV.


book

The 1993-94 Genethon human genetic linkage map
Nat. Genet. 7 (2 SPEC NO), 246-339 (1994)
Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M and Weissenbach J.


book

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange
Mol. Cell. Biol. 10 (12), 6160-6171 (1990)
Thompson LH, Brookman KW, Jones NJ, Allen SA and Carrano AV.


book

Complementation of repair gene mutations on the hemizygous chromosome 9 in CHO: a third repair gene on human chromosome 19
Genomics 5 (4), 670-679 (1989)
Thompson LH, Bachinski LL, Stallings RL, Dolf G, Weber CA, Westerveld A and Siciliano MJ.


 
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