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YWHAH cDNA ORF clone, Homo sapiens (human)

Gene Symbol YWHAH
Entrez Gene ID 7533
Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
Synonyms YWHA1
General protein information
Preferred Names
14-3-3 protein eta
Names
14-3-3 protein eta
14-3-3 eta
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q12.3

Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]. lac of sum
Disorder MIM:

113508


mRNA and Protein(s)

mRNA Protein Name
NM_003405 NP_003396 14-3-3 protein eta



Homo sapiens (human) YWHAH NP_003396.1
Pan troglodytes (chimpanzee) YWHAH XP_001151423.1
Macaca mulatta (Rhesus monkey) YWHAH XP_001111998.1
Canis lupus familiaris (dog) YWHAH XP_003433473.2
Bos taurus (cattle) YWHAH NP_776917.2
Mus musculus (house mouse) Ywhah NP_035868.1
Rattus norvegicus (Norway rat) Ywhah NP_037184.1
Gallus gallus (chicken) YWHAH NP_001007840.1
Danio rerio (zebrafish) ywhah NP_998329.1
Xenopus (Silurana) tropicalis (western clawed frog) ywhah NP_001016868.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following YWHAH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the YWHAH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu29420
NM_003405 Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta (YWHAH), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu29420
Clone ID Related Accession (Same CDS sequence) NM_003405
Accession Version NM_003405.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 741bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product 14-3-3 protein eta
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z82248.1, BC003047.1 and AY007132.1. On Mar 24, 2005 this sequence version replaced gi:21464102. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003047.1, S80794.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGGGGACC GGGAGCAGCT GCTGCAGCGG GCGCGGCTGG CCGAGCAGGC GGAGCGCTAC 
GACGACATGG CCTCCGCTAT GAAGGCGGTG ACAGAGCTGA ATGAACCTCT CTCCAATGAA
GATCGAAATC TCCTCTCTGT GGCCTACAAG AATGTGGTTG GTGCCAGGCG ATCTTCCTGG
AGGGTCATTA GCAGCATTGA GCAGAAAACC ATGGCTGATG GAAACGAAAA GAAATTGGAG
AAAGTTAAAG CTTACCGGGA GAAGATTGAG AAGGAGCTGG AGACAGTTTG CAATGATGTC
CTGTCTCTGC TTGACAAGTT CCTGATCAAG AACTGCAATG ATTTCCAGTA TGAGAGCAAG
GTGTTTTACC TGAAAATGAA GGGTGATTAC TACCGCTACT TAGCAGAGGT CGCTTCTGGG
GAGAAGAAAA ACAGTGTGGT CGAAGCTTCT GAAGCTGCCT ACAAGGAAGC CTTTGAAATC
AGCAAAGAGC AGATGCAACC CACGCATCCC ATCCGGCTGG GCCTGGCCCT CAACTTCTCC
GTGTTCTACT ATGAGATCCA GAATGCACCT GAGCAAGCCT GCCTCTTAGC CAAACAAGCC
TTCGATGATG CCATAGCTGA GCTGGACACA CTAAACGAGG ATTCCTATAA GGACTCCACG
CTGATCATGC AGTTGCTGCG AGACAACCTC ACCCTCTGGA CGAGCGACCA GCAGGATGAA
GAAGCAGGAG AAGGCAACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003396.1
CDS242..982
Misc Feature(1)209..211(+)
Misc Feature(2)245..247(+)
Misc Feature(3)245..247(+)
Misc Feature(4)248..964(+)
Misc Feature(5)269..517(+)
Misc Feature(6)314..316(+)
Misc Feature(7)389..928(+)
Misc Feature(8)410..412(+)
Misc Feature(9)416..418(+)
Misc Feature(10)635..637(+)
Exon (1)1..328
Gene:YWHAH
Gene Synonym:
Exon (2)329..1793
Gene:YWHAH
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_003405
Organism Homo sapiens (human)
Definition Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta (YWHAH), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003405

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGGGGACC GGGAGCAGCT GCTGCAGCGG GCGCGGCTGG CCGAGCAGGC GGAGCGCTAC 
GACGACATGG CCTCCGCTAT GAAGGCGGTG ACAGAGCTGA ATGAACCTCT CTCCAATGAA
GATCGAAATC TCCTCTCTGT GGCCTACAAG AATGTGGTTG GTGCCAGGCG ATCTTCCTGG
AGGGTCATTA GCAGCATTGA GCAGAAAACC ATGGCTGATG GAAACGAAAA GAAATTGGAG
AAAGTTAAAG CTTACCGGGA GAAGATTGAG AAGGAGCTGG AGACAGTTTG CAATGATGTC
CTGTCTCTGC TTGACAAGTT CCTGATCAAG AACTGCAATG ATTTCCAGTA TGAGAGCAAG
GTGTTTTACC TGAAAATGAA GGGTGATTAC TACCGCTACT TAGCAGAGGT CGCTTCTGGG
GAGAAGAAAA ACAGTGTGGT CGAAGCTTCT GAAGCTGCCT ACAAGGAAGC CTTTGAAATC
AGCAAAGAGC AGATGCAACC CACGCATCCC ATCCGGCTGG GCCTGGCCCT CAACTTCTCC
GTGTTCTACT ATGAGATCCA GAATGCACCT GAGCAAGCCT GCCTCTTAGC CAAACAAGCC
TTCGATGATG CCATAGCTGA GCTGGACACA CTAAACGAGG ATTCCTATAA GGACTCCACG
CTGATCATGC AGTTGCTGCG AGACAACCTC ACCCTCTGGA CGAGCGACCA GCAGGATGAA
GAAGCAGGAG AAGGCAACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Roles of 14-3-3eta in mitotic progression and its potential use as a therapeutic target for cancers
Oncogene 32 (12), 1560-1569 (2013)
Lee CG, Park GY, Han YK, Lee JH, Chun SH, Park HY, Lim KH, Kim EG, Choi YJ, Yang K and Lee CW.


book

A polymorphism in the YWHAH gene encoding 14-3-3 eta that is not associated with sporadic Creutzfeldt-Jakob disease (CJD)
Mol. Biol. Rep. 39 (4), 3619-3625 (2012)
Yun J, Jeong BH, Kim HJ, Park YJ, Lee YJ, Choi EK, Carp RI and Kim YS.


book

Dermal fibroblasts influence the expression profile of 14-3-3 proteins in human keratinocytes
Mol. Cell. Biochem. 353 (1-2), 205-214 (2011)
Carr M, Chavez-Munoz C, Lai A and Ghahary A.


book

Cytoplasmic expression of p33ING1b is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma
Histol. Histopathol. 26 (5), 597-607 (2011)
Li XH, Noguchi A, Nishida T, Takahashi H, Zheng Y, Yang XH, Masuda S, Kikuchi K and Takano Y.


book

The expression of seven 14-3-3 isoforms in human meningioma
Brain Res. 1336, 98-102 (2010)
Liu Y, Tian RF, Li YM, Liu WP, Cao L, Yang XL, Cao WD and Zhang X.


book

Identification of the site of interaction of the 14-3-3 protein with phosphorylated tryptophan hydroxylase
J. Biol. Chem. 270 (48), 28515-28518 (1995)
Ichimura T, Uchiyama J, Kunihiro O, Ito M, Horigome T, Omata S, Shinkai F, Kaji H and Isobe T.


book

Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins
FEBS Lett. 368 (1), 55-58 (1995)
Jones DH, Ley S and Aitken A.


book

cDNA clones contain autonomous replication activity
Biochim. Biophys. Acta 1174 (3), 241-257 (1993)
Wu C, Friedlander P, Lamoureux C, Zannis-Hadjopoulos M and Price GB.


book

cDNA cloning and chromosome assignment of the gene for human brain 14-3-3 protein eta chain
J. Neurosci. Res. 31 (4), 600-605 (1992)
Ichimura-Ohshima Y, Morii K, Ichimura T, Araki K, Takahashi Y, Isobe T, Minoshima S, Fukuyama R, Shimizu N and Kuwano R.


book

Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases
Proc. Natl. Acad. Sci. U.S.A. 85 (19), 7084-7088 (1988)
Ichimura T, Isobe T, Okuyama T, Takahashi N, Araki K, Kuwano R and Takahashi Y.


 
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