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YWHAH cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol YWHAH
Entrez Gene ID 7533
Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
Synonyms YWHA1
General protein information
Preferred Names

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta

Names

14-3-3 protein eta
14-3-3 eta
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

22

22q12.3
Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009].
Disorder MIM:

113508


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_003405.3 NP_003396.1 14-3-3 protein eta
NM_003405.4 NP_003396.1 14-3-3 protein eta

Pathways from BioSystems


Homologies


Homo sapiens (human) YWHAH NP_003396.1
Pan troglodytes (chimpanzee) YWHAH XP_001151423.1
Bos taurus (cattle) YWHAH NP_776917.2
Mus musculus (house mouse) Ywhah NP_035868.1
Danio rerio (zebrafish) ywhah NP_998329.1
Rattus norvegicus (Norway rat) Ywhah NP_037184.1
YWHAH XP_001111998.1
Gallus gallus (chicken) YWHAH NP_001007840.1
Canis lupus familiaris (dog) YWHAH XP_003433473.2
Xenopus tropicalis (tropical clawed frog) ywhah NP_001016868.1

Gene Ontology


Bibliography

Related articles in PubMed

AKT1 has dual actions on the glucocorticoid receptor by cooperating with 14-3-3.
Habib T, Sadoun A, Nader N, Suzuki S, Liu W, Jithesh PV, Kino T
Molecular and cellular endocrinology439431-443(2017 Jan)

14-3-3 eta isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis.
Umahara T, Uchihara T, Shibata N, Nakamura A, Hanyu H
Brain research1646132-138(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The impact of AKT1 on glucocorticoid receptor (GR)-induced transcriptional activity in cooperation with phospho-serine/threonine-binding protein 14-3-3, was examined.
Title: AKT1 has dual actions on the glucocorticoid receptor by cooperating with 14-3-3.

14-3-3 eta isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis.
Title: 14-3-3 eta isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis.

This study identified YWHAH significantly associated loci with a biologically plausible role in schizophrenia.
Title: Combined analysis of exon splicing and genome wide polymorphism data predict schizophrenia risk loci.

Extracellular 14-3-3eta activates key signalling cascades and induces factors associated with the pathogenesis of rheumatoid arthritis
Title: 14-3-3? is a novel mediator associated with the pathogenesis of rheumatoid arthritis and joint damage.

14-3-3eta may be required for mitotic progression and may be considered as a novel anti-cancer strategy in combination with microtubule inhibitors.
Title: Roles of 14-3-3? in mitotic progression and its potential use as a therapeutic target for cancers.

The following YWHAH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the YWHAH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu29420 NM_003405.4
Latest version!		 Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta (YWHAH), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
View Old Accession Versions >>
OHu29420 NM_003405.3 Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta (YWHAH), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu29420
Clone ID Related Accession (Same CDS sequence) NM_003405.3 , NM_003405.4
Accession Version NM_003405.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 741bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-11-19
Organism Homo sapiens(human)
Product 14-3-3 protein eta
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z82248.1, BC003047.1 and AY007132.1. On Mar 24, 2005 this sequence version replaced NM_003405.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.310288.1, SRR1163658.424075.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGGGGACC GGGAGCAGCT GCTGCAGCGG GCGCGGCTGG CCGAGCAGGC GGAGCGCTAC 
GACGACATGG CCTCCGCTAT GAAGGCGGTG ACAGAGCTGA ATGAACCTCT CTCCAATGAA 
GATCGAAATC TCCTCTCTGT GGCCTACAAG AATGTGGTTG GTGCCAGGCG ATCTTCCTGG 
AGGGTCATTA GCAGCATTGA GCAGAAAACC ATGGCTGATG GAAACGAAAA GAAATTGGAG 
AAAGTTAAAG CTTACCGGGA GAAGATTGAG AAGGAGCTGG AGACAGTTTG CAATGATGTC 
CTGTCTCTGC TTGACAAGTT CCTGATCAAG AACTGCAATG ATTTCCAGTA TGAGAGCAAG 
GTGTTTTACC TGAAAATGAA GGGTGATTAC TACCGCTACT TAGCAGAGGT CGCTTCTGGG 
GAGAAGAAAA ACAGTGTGGT CGAAGCTTCT GAAGCTGCCT ACAAGGAAGC CTTTGAAATC 
AGCAAAGAGC AGATGCAACC CACGCATCCC ATCCGGCTGG GCCTGGCCCT CAACTTCTCC 
GTGTTCTACT ATGAGATCCA GAATGCACCT GAGCAAGCCT GCCTCTTAGC CAAACAAGCC 
TTCGATGATG CCATAGCTGA GCTGGACACA CTAAACGAGG ATTCCTATAA GGACTCCACG 
CTGATCATGC AGTTGCTGCG AGACAACCTC ACCCTCTGGA CGAGCGACCA GCAGGATGAA 
GAAGCAGGAG AAGGCAACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003396.1
CDS242..982
Translation

Target ORF information:

RefSeq Version NM_003405.3
Organism Homo sapiens(human)
Definition Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta (YWHAH), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_003405.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGGGGACC GGGAGCAGCT GCTGCAGCGG GCGCGGCTGG CCGAGCAGGC GGAGCGCTAC 
GACGACATGG CCTCCGCTAT GAAGGCGGTG ACAGAGCTGA ATGAACCTCT CTCCAATGAA 
GATCGAAATC TCCTCTCTGT GGCCTACAAG AATGTGGTTG GTGCCAGGCG ATCTTCCTGG 
AGGGTCATTA GCAGCATTGA GCAGAAAACC ATGGCTGATG GAAACGAAAA GAAATTGGAG 
AAAGTTAAAG CTTACCGGGA GAAGATTGAG AAGGAGCTGG AGACAGTTTG CAATGATGTC 
CTGTCTCTGC TTGACAAGTT CCTGATCAAG AACTGCAATG ATTTCCAGTA TGAGAGCAAG 
GTGTTTTACC TGAAAATGAA GGGTGATTAC TACCGCTACT TAGCAGAGGT CGCTTCTGGG 
GAGAAGAAAA ACAGTGTGGT CGAAGCTTCT GAAGCTGCCT ACAAGGAAGC CTTTGAAATC 
AGCAAAGAGC AGATGCAACC CACGCATCCC ATCCGGCTGG GCCTGGCCCT CAACTTCTCC 
GTGTTCTACT ATGAGATCCA GAATGCACCT GAGCAAGCCT GCCTCTTAGC CAAACAAGCC 
TTCGATGATG CCATAGCTGA GCTGGACACA CTAAACGAGG ATTCCTATAA GGACTCCACG 
CTGATCATGC AGTTGCTGCG AGACAACCTC ACCCTCTGGA CGAGCGACCA GCAGGATGAA 
GAAGCAGGAG AAGGCAACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu29420
Clone ID Related Accession (Same CDS sequence) NM_003405.3 , NM_003405.4
Accession Version NM_003405.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 741bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-07-05
Organism Homo sapiens(human)
Product 14-3-3 protein eta
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z82248.1, BC003047.1 and AY007132.1. On Nov 23, 2018 this sequence version replaced NM_003405.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.310288.1, SRR3476690.534567.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000248975.6/ ENSP00000248975.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGGGGACC GGGAGCAGCT GCTGCAGCGG GCGCGGCTGG CCGAGCAGGC GGAGCGCTAC 
GACGACATGG CCTCCGCTAT GAAGGCGGTG ACAGAGCTGA ATGAACCTCT CTCCAATGAA 
GATCGAAATC TCCTCTCTGT GGCCTACAAG AATGTGGTTG GTGCCAGGCG ATCTTCCTGG 
AGGGTCATTA GCAGCATTGA GCAGAAAACC ATGGCTGATG GAAACGAAAA GAAATTGGAG 
AAAGTTAAAG CTTACCGGGA GAAGATTGAG AAGGAGCTGG AGACAGTTTG CAATGATGTC 
CTGTCTCTGC TTGACAAGTT CCTGATCAAG AACTGCAATG ATTTCCAGTA TGAGAGCAAG 
GTGTTTTACC TGAAAATGAA GGGTGATTAC TACCGCTACT TAGCAGAGGT CGCTTCTGGG 
GAGAAGAAAA ACAGTGTGGT CGAAGCTTCT GAAGCTGCCT ACAAGGAAGC CTTTGAAATC 
AGCAAAGAGC AGATGCAACC CACGCATCCC ATCCGGCTGG GCCTGGCCCT CAACTTCTCC 
GTGTTCTACT ATGAGATCCA GAATGCACCT GAGCAAGCCT GCCTCTTAGC CAAACAAGCC 
TTCGATGATG CCATAGCTGA GCTGGACACA CTAAACGAGG ATTCCTATAA GGACTCCACG 
CTGATCATGC AGTTGCTGCG AGACAACCTC ACCCTCTGGA CGAGCGACCA GCAGGATGAA 
GAAGCAGGAG AAGGCAACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003396.1
CDS200..940
Translation

Target ORF information:

RefSeq Version NM_003405.4
Organism Homo sapiens(human)
Definition Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta (YWHAH), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_003405.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGGGGACC GGGAGCAGCT GCTGCAGCGG GCGCGGCTGG CCGAGCAGGC GGAGCGCTAC 
GACGACATGG CCTCCGCTAT GAAGGCGGTG ACAGAGCTGA ATGAACCTCT CTCCAATGAA 
GATCGAAATC TCCTCTCTGT GGCCTACAAG AATGTGGTTG GTGCCAGGCG ATCTTCCTGG 
AGGGTCATTA GCAGCATTGA GCAGAAAACC ATGGCTGATG GAAACGAAAA GAAATTGGAG 
AAAGTTAAAG CTTACCGGGA GAAGATTGAG AAGGAGCTGG AGACAGTTTG CAATGATGTC 
CTGTCTCTGC TTGACAAGTT CCTGATCAAG AACTGCAATG ATTTCCAGTA TGAGAGCAAG 
GTGTTTTACC TGAAAATGAA GGGTGATTAC TACCGCTACT TAGCAGAGGT CGCTTCTGGG 
GAGAAGAAAA ACAGTGTGGT CGAAGCTTCT GAAGCTGCCT ACAAGGAAGC CTTTGAAATC 
AGCAAAGAGC AGATGCAACC CACGCATCCC ATCCGGCTGG GCCTGGCCCT CAACTTCTCC 
GTGTTCTACT ATGAGATCCA GAATGCACCT GAGCAAGCCT GCCTCTTAGC CAAACAAGCC 
TTCGATGATG CCATAGCTGA GCTGGACACA CTAAACGAGG ATTCCTATAA GGACTCCACG 
CTGATCATGC AGTTGCTGCG AGACAACCTC ACCCTCTGGA CGAGCGACCA GCAGGATGAA 
GAAGCAGGAG AAGGCAACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

AKT1 has dual actions on the glucocorticoid receptor by cooperating with 14-3-3.
Molecular and cellular endocrinology439431-443(2017 Jan)
Habib T,Sadoun A,Nader N,Suzuki S,Liu W,Jithesh PV,Kino T


book

14-3-3 eta isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis.
Brain research1646132-138(2016 09)
Umahara T,Uchihara T,Shibata N,Nakamura A,Hanyu H