Gene Symbol | ZNF70 |
Entrez Gene ID | 7621 |
Full Name | zinc finger protein 70 |
Synonyms | Cos17 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » ZNF70 cDNA ORF clone
gRNAs
Gene Symbol | ZNF70 |
Entrez Gene ID | 7621 |
Full Name | zinc finger protein 70 |
Synonyms | Cos17 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_024452270.1 | XP_024308038.1 | zinc finger protein 70 isoform X1 |
NM_021916.3 | NP_068735.1 | zinc finger protein 70 |
NM_021916.4 | NP_068735.1 | zinc finger protein 70 |
XM_024452269.1 | XP_024308037.1 | zinc finger protein 70 isoform X1 |
XM_024452271.1 | XP_024308039.1 | zinc finger protein 70 isoform X1 |
ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression.
Watanabe K, Nakayama K, Ohta S, Tago K, Boonvisut S, Millings EJ, Fischer SG, LeDuc CA, Leibel RL, Iwamoto S
Biochemical and biophysical research communications477(4)712-716(2016 09)
Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2).
Aubry M, Marineau C, Zhang FR, Zahed L, Figlewicz D, Delattre O, Thomas G, de Jong PJ, Julien JP, Rouleau GA
Genomics13(3)641-8(1992 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
We demonstrated that ZNF70 interacts with ZFP64 and activates HES1 transcription by binding to the HES1 promoter. In addition, HES1 gene expression is increased in ILDR2-knockdown HepG2 cells, in which ZNF70 is translocated from the cytoplasm to the nucleus, suggesting that ZNF70 migration to the nucleus after dissociating from the ILDR2-ZNF70 complex activates HES1 transcription. These results support a novel link betwee
Title: ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression.
The following ZNF70 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ZNF70 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu05990![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_024452270.1 , NM_021916.3 , NM_021916.4 , XM_024452269.1 , XM_024452271.1 | |
Accession Version | NM_021916.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1341bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Homo sapiens(human) | |
Product | zinc finger protein 70 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC040161.1 and AK122721.1. On Feb 10, 2015 this sequence version replaced NM_021916.2. ##Evidence-Data-START## Transcript exon combination :: BC040161.1, SRR1803612.243713.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGGTTC CCCCAGCAAC AAAGTTTGGT GAGACCTTTG CATTTGAGAA CAGGTTAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_068735.1 |
CDS | 462..1802 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGGTTC CCCCAGCAAC AAAGTTTGGT GAGACCTTTG CATTTGAGAA CAGGTTAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu05990![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_024452270.1 , NM_021916.3 , NM_021916.4 , XM_024452269.1 , XM_024452271.1 | |
Accession Version | NM_021916.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1341bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-25 | |
Organism | Homo sapiens(human) | |
Product | zinc finger protein 70 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AP000348.1, BC040161.1 and AK122721.1. On Nov 22, 2018 this sequence version replaced NM_021916.3. ##Evidence-Data-START## Transcript exon combination :: BC040161.1, SRR1803612.243713.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000341976.5/ ENSP00000339314.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGAGGTTC CCCCAGCAAC AAAGTTTGGT GAGACCTTTG CATTTGAGAA CAGGTTAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_068735.1 |
CDS | 482..1822 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGGTTC CCCCAGCAAC AAAGTTTGGT GAGACCTTTG CATTTGAGAA CAGGTTAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu05990![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_024452270.1 , NM_021916.3 , NM_021916.4 , XM_024452269.1 , XM_024452271.1 | |
Accession Version | XM_024452270.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1341bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | zinc finger protein 70 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000022.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGGTTC CCCCAGCAAC AAAGTTTGGT GAGACCTTTG CATTTGAGAA CAGGTTAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024308038.1 |
CDS | 128..1468 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGGTTC CCCCAGCAAC AAAGTTTGGT GAGACCTTTG CATTTGAGAA CAGGTTAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu05990![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_024452270.1 , NM_021916.3 , NM_021916.4 , XM_024452269.1 , XM_024452271.1 | |
Accession Version | XM_024452269.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1341bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | zinc finger protein 70 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000022.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGGTTC CCCCAGCAAC AAAGTTTGGT GAGACCTTTG CATTTGAGAA CAGGTTAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024308037.1 |
CDS | 243..1583 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGGTTC CCCCAGCAAC AAAGTTTGGT GAGACCTTTG CATTTGAGAA CAGGTTAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu05990![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_024452270.1 , NM_021916.3 , NM_021916.4 , XM_024452269.1 , XM_024452271.1 | |
Accession Version | XM_024452271.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1341bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | zinc finger protein 70 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000022.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGGTTC CCCCAGCAAC AAAGTTTGGT GAGACCTTTG CATTTGAGAA CAGGTTAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024308039.1 |
CDS | 100..1440 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGGTTC CCCCAGCAAC AAAGTTTGGT GAGACCTTTG CATTTGAGAA CAGGTTAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression. |
Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). |