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ULBP3 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol ULBP3
Entrez Gene ID 79465
Full Name UL16 binding protein 3
Synonyms N2DL-3,NKG2DL3,RAET1N
General protein information
Preferred Names

UL16 binding protein 3

Names

NKG2D ligand 3
ALCAN-gamma
retinoic acid early transcript 1N

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

6

6q25.1

Disorder MIM:

605699


mRNA and Protein(s)

mRNA Protein Name
NM_024518.2 NP_078794.1 NKG2D ligand 3



Bos taurus (cattle) LOC783508 NP_001193675.1
Bos taurus (cattle) ULBP27 NP_001162087.1
Bos taurus (cattle) LOC101903261 XP_005211099.1
Homo sapiens (human) ULBP3 NP_078794.1
Pan troglodytes (chimpanzee) ULBP3 XP_003950985.1
Bos taurus (cattle) RAET1G NP_991354.1
Bos taurus (cattle) ULBP11 NP_001162081.1
Macaca mulatta (rhesus monkey) LOC694135 XP_001082838.1
Bos taurus (cattle) ULBP15 XP_005211086.1
Bos taurus (cattle) RAET1L XP_002695685.3
Bos taurus (cattle) ULBP3 NP_001096703.1
Bos taurus (cattle) LOC100126815 XP_005220120.1
Bos taurus (cattle) ULBP21 XP_005211101.1


Related articles in PubMed

Transfer of the human NKG2D ligands UL16 binding proteins (ULBP) 1-3 is related to lytic granule release and leads to ligand retransfer and killing of ULBP-recipient natural killer cells.
López-Cobo S, Romera-Cárdenas G, García-Cuesta EM, Reyburn HT, Valés-Gómez M
Immunology146(1)70-80(2015 Sep)

Varicella-Zoster Virus and Herpes Simplex Virus 1 Differentially Modulate NKG2D Ligand Expression during Productive Infection.
Campbell TM, McSharry BP, Steain M, Slobedman B, Abendroth A
Journal of virology89(15)7932-43(2015 Aug)

The regulatory effect of UL-16 binding protein-3 expression on the cytotoxicity of NK cells in cancer patients.
Mou X, Zhou Y, Jiang P, Zhou T, Jiang Q, Xu C, Liu H, Zheng T, Yuan G, Zhang Y, Chen D, Mao C
Scientific reports46138(2014 Aug)

c-Myc regulates expression of NKG2D ligands ULBP1/2/3 in AML and modulates their susceptibility to NK-mediated lysis.
Nanbakhsh A, Pochon C, Mallavialle A, Amsellem S, Bourhis JH, Chouaib S
Blood123(23)3585-95(2014 Jun)

Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
Luykx JJ, Bakker SC, Lentjes E, Neeleman M, Strengman E, Mentink L, DeYoung J, de Jong S, Sul JH, Eskin E, van Eijk K, van Setten J, Buizer-Voskamp JE, Cantor RM, Lu A, van Amerongen M, van Dongen EP, Keijzers P, Kappen T, Borgdorff P, Bruins P, Derks EM, Kahn RS, Ophoff RA
Molecular psychiatry19(2)228-34(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows an increase in ULBP3 level in alopecia areata incognita patients, which positively correlates with the age and duration of the disease
Title: ULBP3: a marker for alopecia areata incognita.

Varicella-Zoster Virus differentially modulates expression of the NKG2D ligands by upregulating MICA expression and reducing ULBP2 and ULBP3 expression in the infected cells.
Title: Varicella-Zoster Virus and Herpes Simplex Virus 1 Differentially Modulate NKG2D Ligand Expression during Productive Infection.

This study provides for the first time, the c-Myc dependent regulation of NKG2D ligands, ULBP1/2/3 in acute myeloid leukemia.
Title: c-Myc regulates expression of NKG2D ligands ULBP1/2/3 in AML and modulates their susceptibility to NK-mediated lysis.

A greater expression of ULBP3 has also been found in hair follicles in scalp biopsy specimens from patients with active disease
Title: Treatment of alopecia areata: "What is new on the horizon?".

A miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination.
Title: An identical miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination.

The following ULBP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ULBP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu17148 NM_024518.2
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Homo sapiens UL16 binding protein 3 (ULBP3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $139.30
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu17148
Clone ID Related Accession (Same CDS sequence) NM_024518.2
Accession Version NM_024518.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 735bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-10-08
Organism Homo sapiens(Human)
Product NKG2D ligand 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK315275.1, CA488356.1, AL355497.14 and AI298332.1. On Nov 25, 2015 this sequence version replaced NM_024518.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AK315275.1, BC098127.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGCAGCGG CCGCCAGCCC CGCGATCCTT CCGCGCCTCG CGATTCTTCC GTACCTGCTA 
TTCGACTGGT CCGGGACGGG GCGGGCCGAC GCTCACTCTC TCTGGTATAA CTTCACCATC
ATTCATTTGC CCAGACATGG GCAACAGTGG TGTGAGGTCC AGAGCCAGGT GGATCAGAAG
AATTTTCTCT CCTATGACTG TGGCAGTGAC AAGGTCTTAT CTATGGGTCA CCTAGAAGAG
CAGCTGTATG CCACAGATGC CTGGGGAAAA CAACTGGAAA TGCTGAGAGA GGTGGGGCAG
AGGCTCAGAC TGGAACTGGC TGACACTGAG CTGGAGGATT TCACACCCAG TGGACCCCTC
ACGCTGCAGG TCAGGATGTC TTGTGAGTGT GAAGCCGATG GATACATCCG TGGATCTTGG
CAGTTCAGCT TCGATGGACG GAAGTTCCTC CTCTTTGACT CAAACAACAG AAAGTGGACA
GTGGTTCACG CTGGAGCCAG GCGGATGAAA GAGAAGTGGG AGAAGGATAG CGGACTGACC
ACCTTCTTCA AGATGGTCTC AATGAGAGAC TGCAAGAGCT GGCTTAGGGA CTTCCTGATG
CACAGGAAGA AGAGGCTGGA ACCCACAGCA CCACCCACCA TGGCCCCAGG CTTAGCTCAA
CCCAAAGCCA TAGCCACCAC CCTCAGTCCC TGGAGCTTCC TCATCATCCT CTGCTTCATC
CTCCCTGGCA TCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_078794.1
CDS82..816
Misc Feature(1)175..699
Exon (1)1..169
Exon (2)170..433
Exon (3)434..709
Exon (4)710..838
Exon (5)839..3144
Translation

Target ORF information:

RefSeq Version NM_024518.2
Organism Homo sapiens(Human)
Definition Homo sapiens UL16 binding protein 3 (ULBP3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_024518.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGCAGCGG CCGCCAGCCC CGCGATCCTT CCGCGCCTCG CGATTCTTCC GTACCTGCTA 
TTCGACTGGT CCGGGACGGG GCGGGCCGAC GCTCACTCTC TCTGGTATAA CTTCACCATC
ATTCATTTGC CCAGACATGG GCAACAGTGG TGTGAGGTCC AGAGCCAGGT GGATCAGAAG
AATTTTCTCT CCTATGACTG TGGCAGTGAC AAGGTCTTAT CTATGGGTCA CCTAGAAGAG
CAGCTGTATG CCACAGATGC CTGGGGAAAA CAACTGGAAA TGCTGAGAGA GGTGGGGCAG
AGGCTCAGAC TGGAACTGGC TGACACTGAG CTGGAGGATT TCACACCCAG TGGACCCCTC
ACGCTGCAGG TCAGGATGTC TTGTGAGTGT GAAGCCGATG GATACATCCG TGGATCTTGG
CAGTTCAGCT TCGATGGACG GAAGTTCCTC CTCTTTGACT CAAACAACAG AAAGTGGACA
GTGGTTCACG CTGGAGCCAG GCGGATGAAA GAGAAGTGGG AGAAGGATAG CGGACTGACC
ACCTTCTTCA AGATGGTCTC AATGAGAGAC TGCAAGAGCT GGCTTAGGGA CTTCCTGATG
CACAGGAAGA AGAGGCTGGA ACCCACAGCA CCACCCACCA TGGCCCCAGG CTTAGCTCAA
CCCAAAGCCA TAGCCACCAC CCTCAGTCCC TGGAGCTTCC TCATCATCCT CTGCTTCATC
CTCCCTGGCA TCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Transfer of the human NKG2D ligands UL16 binding proteins (ULBP) 1-3 is related to lytic granule release and leads to ligand retransfer and killing of ULBP-recipient natural killer cells.
Immunology146(1)70-80(2015 Sep)
López-Cobo S,Romera-Cárdenas G,García-Cuesta EM,Reyburn HT,Valés-Gómez M


book

Varicella-Zoster Virus and Herpes Simplex Virus 1 Differentially Modulate NKG2D Ligand Expression during Productive Infection.
Journal of virology89(15)7932-43(2015 Aug)
Campbell TM,McSharry BP,Steain M,Slobedman B,Abendroth A


book

The regulatory effect of UL-16 binding protein-3 expression on the cytotoxicity of NK cells in cancer patients.
Scientific reports46138(2014 Aug)
Mou X,Zhou Y,Jiang P,Zhou T,Jiang Q,Xu C,Liu H,Zheng T,Yuan G,Zhang Y,Chen D,Mao C


book

c-Myc regulates expression of NKG2D ligands ULBP1/2/3 in AML and modulates their susceptibility to NK-mediated lysis.
Blood123(23)3585-95(2014 Jun)
Nanbakhsh A,Pochon C,Mallavialle A,Amsellem S,Bourhis JH,Chouaib S


book

Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
Molecular psychiatry19(2)228-34(2014 Feb)
Luykx JJ,Bakker SC,Lentjes E,Neeleman M,Strengman E,Mentink L,DeYoung J,de Jong S,Sul JH,Eskin E,van Eijk K,van Setten J,Buizer-Voskamp JE,Cantor RM,Lu A,van Amerongen M,van Dongen EP,Keijzers P,Kappen T,Borgdorff P,Bruins P,Derks EM,Kahn RS,Ophoff RA


 
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