Gene Symbol | LRRTM4 |
Entrez Gene ID | 80059 |
Full Name | leucine rich repeat transmembrane neuronal 4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » LRRTM4 cDNA ORF clone
gRNAs
Gene Symbol | LRRTM4 |
Entrez Gene ID | 80059 |
Full Name | leucine rich repeat transmembrane neuronal 4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_024993.5 | NP_079269.4 | leucine-rich repeat transmembrane neuronal protein 4 isoform b precursor |
NM_001282928.2 | NP_001269857.1 | leucine-rich repeat transmembrane neuronal protein 4 isoform c precursor |
NM_001282924.2 | NP_001269853.1 | leucine-rich repeat transmembrane neuronal protein 4 isoform a precursor |
NM_024993.4 | NP_079269.4 | leucine-rich repeat transmembrane neuronal protein 4 isoform b precursor |
NM_001330370.1 | NP_001317299.1 | leucine-rich repeat transmembrane neuronal protein 4 isoform d precursor |
NM_001134745.2 | NP_001128217.1 | leucine-rich repeat transmembrane neuronal protein 4 isoform a precursor |
NM_001282928.3 | NP_001269857.1 | leucine-rich repeat transmembrane neuronal protein 4 isoform c precursor |
NM_024993.6 | NP_079269.4 | leucine-rich repeat transmembrane neuronal protein 4 isoform b precursor |
Homo sapiens (human) | LRRTM4 | NP_001128217.1 |
Mus musculus (house mouse) | Lrrtm4 | NP_001128215.1 |
Gallus gallus (chicken) | LRRTM4 | XP_004947696.1 |
Danio rerio (zebrafish) | lrrtm4 | XP_692159.4 |
Pan troglodytes (chimpanzee) | LRRTM4 | XP_001163369.2 |
LRRTM4 | XP_001112174.2 | |
Canis lupus familiaris (dog) | LRRTM4 | XP_005630557.1 |
Rattus norvegicus (Norway rat) | Lrrtm4 | NP_001128218.1 |
Danio rerio (zebrafish) | LOC100333709 | XP_005172519.1 |
Bos taurus (cattle) | LRRTM4 | XP_003586684.1 |
Xenopus tropicalis (tropical clawed frog) | lrrtm4 | XP_002932606.1 |
Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development.
de Wit J, O'Sullivan ML, Savas JN, Condomitti G, Caccese MC, Vennekens KM, Yates JR 3rd, Ghosh A
Neuron79(4)696-711(2013 Aug)
A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system.
Laur?n J, Airaksinen MS, Saarma M, Timmusk T
Genomics81(4)411-21(2003 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
The following LRRTM4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LRRTM4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu04308![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_024993.5 , NM_024993.4 , NM_024993.6 | |
Accession Version | NM_024993.5 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1557bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-25 | |
Organism | Homo sapiens(human) | |
Product | leucine-rich repeat transmembrane neuronal protein 4 isoform b precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC079614.7. On Aug 29, 2016 this sequence version replaced NM_024993.4. Transcript Variant: This variant (2) lacks the 3' terminal exon and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform a. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK126961.1, SRR1803616.222453.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGTTTCC ATTTAATTAC GCAGCTGAAA GGCATGAGTG TGGTGCTGGT GCTACTTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_079269.4 |
CDS | 473..2029 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGTTTCC ATTTAATTAC GCAGCTGAAA GGCATGAGTG TGGTGCTGGT GCTACTTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu04308![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_024993.5 , NM_024993.4 , NM_024993.6 | |
Accession Version | NM_024993.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1557bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-14 | |
Organism | Homo sapiens(Human) | |
Product | leucine-rich repeat transmembrane neuronal protein 4 isoform b precursor | |
Comment |
1 | ATGGGTTTCC ATTTAATTAC GCAGCTGAAA GGCATGAGTG TGGTGCTGGT GCTACTTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_079269.4 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGTTTCC ATTTAATTAC GCAGCTGAAA GGCATGAGTG TGGTGCTGGT GCTACTTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu04308![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_024993.5 , NM_024993.4 , NM_024993.6 | |
Accession Version | NM_024993.6 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1557bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-28 | |
Organism | Homo sapiens(human) | |
Product | leucine-rich repeat transmembrane neuronal protein 4 isoform b precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC079614.7. On Jun 2, 2019 this sequence version replaced NM_024993.5. Transcript Variant: This variant (2) lacks the 3' terminal exon and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform a. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK126961.1, SRR1660803.190778.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGTTTCC ATTTAATTAC GCAGCTGAAA GGCATGAGTG TGGTGCTGGT GCTACTTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_079269.4 |
CDS | 416..1972 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGTTTCC ATTTAATTAC GCAGCTGAAA GGCATGAGTG TGGTGCTGGT GCTACTTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu07998 | |
Clone ID Related Accession (Same CDS sequence) | NM_001282928.2 , NM_001282928.3 | |
Accession Version | NM_001282928.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1560bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-06-30 | |
Organism | Homo sapiens(human) | |
Product | leucine-rich repeat transmembrane neuronal protein 4 isoform c precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC079614.7, AK122612.1 and BC098301.1. On Aug 29, 2016 this sequence version replaced NM_001282928.1. Transcript Variant: This variant (4) lacks an exon in the 5' region and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR. It initiates translation at an alternate start codon compared to variant 1 and encodes isoform c, which distinct N- and C-termini and is shorter than isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.178693.1, SRR1660807.138752.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154665, SAMEA2157437 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCAGGTT TCCATTTAAT TACGCAGCTG AAAGGCATGA GTGTGGTGCT GGTGCTACTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001269857.1 |
CDS | 319..1878 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCAGGTT TCCATTTAAT TACGCAGCTG AAAGGCATGA GTGTGGTGCT GGTGCTACTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu07998 | |
Clone ID Related Accession (Same CDS sequence) | NM_001282928.2 , NM_001282928.3 | |
Accession Version | NM_001282928.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1560bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-29 | |
Organism | Homo sapiens(human) | |
Product | leucine-rich repeat transmembrane neuronal protein 4 isoform c precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC079614.7, AK122612.1 and BC098301.1. On Jun 2, 2019 this sequence version replaced NM_001282928.2. Transcript Variant: This variant (4) lacks an exon in the 5' region and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR. It initiates translation at an alternate start codon compared to variant 1 and encodes isoform c, which distinct N- and C-termini and is shorter than isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.178693.1, SRR1660807.138752.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154665, SAMEA2157437 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCAGGTT TCCATTTAAT TACGCAGCTG AAAGGCATGA GTGTGGTGCT GGTGCTACTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001269857.1 |
CDS | 262..1821 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCAGGTT TCCATTTAAT TACGCAGCTG AAAGGCATGA GTGTGGTGCT GGTGCTACTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu07189 | |
Clone ID Related Accession (Same CDS sequence) | NM_001282924.2 , NM_001134745.2 | |
Accession Version | NM_001282924.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1773bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-24 | |
Organism | Homo sapiens(human) | |
Product | leucine-rich repeat transmembrane neuronal protein 4 isoform a precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC079614.7, AK122612.1, AY358324.1, AC068616.5 and AI079273.1. On Aug 29, 2016 this sequence version replaced NM_001282924.1. Transcript Variant: This variant (3) has an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK122612.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMN03465404 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGTTTCC ATTTAATTAC GCAGCTGAAA GGCATGAGTG TGGTGCTGGT GCTACTTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001269853.1 |
CDS | 403..2175 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGTTTCC ATTTAATTAC GCAGCTGAAA GGCATGAGTG TGGTGCTGGT GCTACTTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu07189 | |
Clone ID Related Accession (Same CDS sequence) | NM_001282924.2 , NM_001134745.2 | |
Accession Version | NM_001134745.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1773bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-11 | |
Organism | Homo sapiens(human) | |
Product | leucine-rich repeat transmembrane neuronal protein 4 isoform a precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC079614.7, AK126961.1, AY358324.1, AC068616.5 and AI079273.1. This sequence is a reference standard in the RefSeqGene project. On Aug 29, 2016 this sequence version replaced NM_001134745.1. Transcript Variant: This variant (1) and variant 3 encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.48027.1, SRR1803611.114833.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGTTTCC ATTTAATTAC GCAGCTGAAA GGCATGAGTG TGGTGCTGGT GCTACTTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001128217.1 |
CDS | 473..2245 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGTTTCC ATTTAATTAC GCAGCTGAAA GGCATGAGTG TGGTGCTGGT GCTACTTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu72524 | |
Clone ID Related Accession (Same CDS sequence) | NM_001330370.1 | |
Accession Version | NM_001330370.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1776bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-23 | |
Organism | Homo sapiens(human) | |
Product | leucine-rich repeat transmembrane neuronal protein 4 isoform d precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC079614.7 and AC068616.5. On Aug 29, 2016 this sequence version replaced XM_011533117.2. Transcript Variant: This variant (5) lacks an exon in the 5' region and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is longer than isoform a. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.21823.1, SRR1803615.122071.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154665, SAMEA2157437 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCAGGTT TCCATTTAAT TACGCAGCTG AAAGGCATGA GTGTGGTGCT GGTGCTACTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001317299.1 |
CDS | 319..2094 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCAGGTT TCCATTTAAT TACGCAGCTG AAAGGCATGA GTGTGGTGCT GGTGCTACTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development. |
A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. |