Gene Symbol | CYB5B |
Entrez Gene ID | 80777 |
Full Name | cytochrome b5 type B |
Synonyms | CYB5-M,CYPB5M,OMB5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » CYB5B cDNA ORF clone
Gene Symbol | CYB5B |
Entrez Gene ID | 80777 |
Full Name | cytochrome b5 type B |
Synonyms | CYB5-M,CYPB5M,OMB5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_030579.2 | NP_085056.2 | cytochrome b5 type B |
NM_030579.3 | NP_085056.2 | cytochrome b5 type B |
CYB5B | XP_001100954.1 | |
Rattus norvegicus (Norway rat) | Cyb5b | NP_085075.1 |
Homo sapiens (human) | CYB5B | NP_085056.2 |
Pan troglodytes (chimpanzee) | CYB5B | NP_001229538.1 |
Schizosaccharomyces pombe (fission yeast) | oca8 | NP_587997.1 |
Arabidopsis thaliana (thale cress) | CB5-D | NP_199692.1 |
Danio rerio (zebrafish) | cyb5b | NP_998041.1 |
Caenorhabditis elegans (roundworm) | cytb-5.2 | NP_491931.1 |
Eremothecium gossypii | AGOS_AFL223W | NP_985327.1 |
Bos taurus (cattle) | CYB5B | NP_001157254.1 |
Gallus gallus (chicken) | CYB5B | NP_001025752.1 |
Kluyveromyces lactis | KLLA0F23672g | XP_456135.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_06510 | XP_003717049.1 |
Xenopus tropicalis (tropical clawed frog) | cyb5b | NP_001011009.2 |
Mus musculus (house mouse) | Cyb5b | NP_079834.2 |
Saccharomyces cerevisiae (baker's yeast) | CYB5 | NP_014288.3 |
Neurospora crassa | NCU03910 | XP_957549.2 |
Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.
Sung YJ, de Las Fuentes L, Schwander KL, Simino J, Rao DC
American journal of hypertension28(3)343-54(2015 Mar)
A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay.
Ramage HR, Kumar GR, Verschueren E, Johnson JR, Von Dollen J, Johnson T, Newton B, Shah P, Horner J, Krogan NJ, Ott M
Molecular cell57(2)329-340(2015 Jan)
The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells.
Plitzko B, Ott G, Reichmann D, Henderson CJ, Wolf CR, Mendel R, Bittner F, Clement B, Havemeyer A
The Journal of biological chemistry288(28)20228-37(2013 Jul)
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
Zheng JS, Arnett DK, Lee YC, Shen J, Parnell LD, Smith CE, Richardson K, Li D, Borecki IB, Ordov?s JM, Lai CQ
PloS one8(10)e77442(2013)
Accommodating a nonconservative internal mutation by water-mediated hydrogen bonding between ?-sheet strands: a comparison of human and rat type B (mitochondrial) cytochrome b5.
Parthasarathy S, Altuve A, Terzyan S, Zhang X, Kuczera K, Rivera M, Benson DR
Biochemistry50(24)5544-54(2011 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data indicate that mitochondrial amidoxime reducing components 1 and 2 together with the electron transport proteins NADH-cytochrome b5 reductase (CYB5R) and cytochrome b5 (CYB5) catalyze the reduction of N-hydroxylated compounds such as amidoximes.
Title: The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells.
comparison of X-ray crystal structures of human and rat CYB5B reveals a striking difference in packing involving the five-strand beta-sheet, which can be attributed to fully buried residue 21 in strand beta4
Title: Accommodating a nonconservative internal mutation by water-mediated hydrogen bonding between ?-sheet strands: a comparison of human and rat type B (mitochondrial) cytochrome b5.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
The 21 kDa protein overexpressed in Hodgkin Lymphoma and aggressive non-Hodgkin Lymphomas is identical to CYB5B.
Title: Constitutively overexpressed 21 kDa protein in Hodgkin lymphoma and aggressive non-Hodgkin lymphomas identified as cytochrome B5b (CYB5B).
microsomal cytochrome b5 interacts with neuronal calcium sensor protein visinin-like protein-3 in a Ca2+-dependent manner
Title: Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner.
The following CYB5B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYB5B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu11936 | |
Clone ID Related Accession (Same CDS sequence) | NM_030579.2 , NM_030579.3 | |
Accession Version | NM_030579.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-04 | |
Organism | Homo sapiens(human) | |
Product | cytochrome b5 type B | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC026464.7, BC014431.1 and AC009032.8. On Dec 23, 2005 this sequence version replaced NM_030579.1. CCDS Note: This CCDS representation uses the 5'-most in-frame start codon, which is conserved in higher primates. An alternative downstream start codon, which is more widely conserved, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 4 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.188261.1, SRR1803617.112788.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## |
1 | ATGTCCGGTT CAATGGCGAC TGCGGAAGCT AGCGGCAGCG ATGGGAAAGG GCAGGAAGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_085056.2 |
CDS | 90..542 |
Translation |
Target ORF information:
Target ORF information:
|
NM_030579.2 |
1 | ATGTCCGGTT CAATGGCGAC TGCGGAAGCT AGCGGCAGCG ATGGGAAAGG GCAGGAAGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu11936 | |
Clone ID Related Accession (Same CDS sequence) | NM_030579.2 , NM_030579.3 | |
Accession Version | NM_030579.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-14 | |
Organism | Homo sapiens(human) | |
Product | cytochrome b5 type B | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC026464.7 and AC009032.8. On Jul 17, 2019 this sequence version replaced NM_030579.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. CCDS Note: This CCDS representation uses the 5'-most in-frame start codon, which is conserved in higher primates. An alternative downstream start codon, which is more widely conserved, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 4 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.97796.1, SRR1803615.105744.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## |
1 | ATGTCCGGTT CAATGGCGAC TGCGGAAGCT AGCGGCAGCG ATGGGAAAGG GCAGGAAGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_085056.2 |
CDS | 66..518 |
Translation |
Target ORF information:
Target ORF information:
|
NM_030579.3 |
1 | ATGTCCGGTT CAATGGCGAC TGCGGAAGCT AGCGGCAGCG ATGGGAAAGG GCAGGAAGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. |
A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay. |
The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells. |
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits. |
Accommodating a nonconservative internal mutation by water-mediated hydrogen bonding between ?-sheet strands: a comparison of human and rat type B (mitochondrial) cytochrome b5. |