TMEM163 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Gene Symbol	TMEM163
Entrez Gene ID	81615
Full Name	transmembrane protein 163
Synonyms	DC29,SV31
General protein information	Preferred Names transmembrane protein 163 Names transmembrane protein 163
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q21.3

mRNA and Protein(s)

mRNA	Protein	Name
XM_017005062.1	XP_016860551.1	transmembrane protein 163 isoform X3
XM_017005060.1	XP_016860549.1	transmembrane protein 163 isoform X1
XM_017005060.2	XP_016860549.1	transmembrane protein 163 isoform X1
NM_030923.4	NP_112185.1	transmembrane protein 163
XM_017005061.1	XP_016860550.1	transmembrane protein 163 isoform X2
XM_011511950.2	XP_011510252.1	transmembrane protein 163 isoform X2
NM_030923.5	NP_112185.1	transmembrane protein 163

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TMEM163	XP_515803.2
Canis lupus familiaris (dog)	TMEM163	XP_848513.2
Bos taurus (cattle)	TMEM163	NP_001094630.1
Gallus gallus (chicken)	TMEM163	XP_422132.2
Homo sapiens (human)	TMEM163	NP_112185.1
Rattus norvegicus (Norway rat)	Tmem163	NP_001104233.2
Mus musculus (house mouse)	Tmem163	NP_082411.1
Xenopus tropicalis (tropical clawed frog)	tmem163	NP_001106455.1
	LOC709015	XP_001098396.1
Danio rerio (zebrafish)	tmem163b	XP_005174068.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetics of the human face: Identification of large-effect single gene variants.
Crouch DJM, Winney B, Koppen WP, Christmas WJ, Hutnik K, Day T, Meena D, Boumertit A, Hysi P, Nessa A, Spector TD, Kittler J, Bodmer WF
Proceedings of the National Academy of Sciences of the United States of America(2018 Jan)

Replication of newly identified type 2 diabetes susceptible loci in Northwest Indian population.
Sharma V, Sharma I, Sethi I, Mahajan A, Singh G, Angural A, Bhanwer AJS, Dhar MK, Singh V, Rai E, Sharma S
Diabetes research and clinical practice126160-163(2017 Apr)

The mucolipin-1 (TRPML1) ion channel, transmembrane-163 (TMEM163) protein, and lysosomal zinc handling.
Cuajungco MP, Kiselyov K
Frontiers in bioscience (Landmark edition)221330-1343(2017 Mar)

Cellular zinc levels are modulated by TRPML1-TMEM163 interaction.
Cuajungco MP, Basilio LC, Silva J, Hart T, Tringali J, Chen CC, Biel M, Grimm C
Traffic (Copenhagen, Denmark)15(11)1247-65(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SNPs of TMEM-163 i.e. rs998451 and rs6723108 didnot show any significant association with T2D
Title: Replication of newly identified type 2 diabetes susceptible loci in Northwest Indian population.

TMEM163 is a putative zinc transporter, a novel interacting partner for TRPML1, essential for zinc homeostasis.
Title: Cellular zinc levels are modulated by TRPML1-TMEM163 interaction.

Data suggest that SNP within TMEM163 (rs998451) and SNP near TMEM163 (rs6723108) are associated with type 2 diabetes and insulin resistance in subjects in India (versus Indo-Europeans and Dravidians). [META-ANALYSIS; Genome-Wide Association Studies]
Title: Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.

The following TMEM163 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMEM163 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu72951	XM_011511950.2 Latest version!	Homo sapiens transmembrane protein 163 (TMEM163), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu72951	XM_017005061.1 Latest version!	Homo sapiens transmembrane protein 163 (TMEM163), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu13558	NM_030923.5 Latest version!	Homo sapiens transmembrane protein 163 (TMEM163), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu89972	XM_017005060.2 Latest version!	Homo sapiens transmembrane protein 163 (TMEM163), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu89973	XM_017005062.1 Latest version!	Homo sapiens transmembrane protein 163 (TMEM163), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu89972	XM_017005060.1	Homo sapiens transmembrane protein 163 (TMEM163), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu13558	NM_030923.4	Homo sapiens transmembrane protein 163 (TMEM163), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMEM163 ( XM_017005061.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016860550.1 Homo sapiens transmembrane protein 163 (TMEM163), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu72951
Clone ID Related Accession (Same CDS sequence)	XM_017005061.1 , XM_011511950.2
Accession Version	XM_017005061.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	transmembrane protein 163 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGTACA GCGCCTCTGC TTTTGGGTTT GCATTTGATG CCATCCTGGA CGTCCTGTCA 
TCGGCGATTG TCCTGTGGCG TTACAGCAAC GCGGCCGCTG TGCACTCTGC CCATAGGGAG 
TACATAGCCT GTGTCATCTT GGGGGTGATA TTCCTTCTGT CATCCATATG TATAGTGGTC 
AAAGCCATCC ATGACCTCTC AACTAGGCTG CTCCCAGAAG TGGACGATTT CCTGTTCAGT 
GTCTCCATTT TAAGTGGGAT TCTTTGCAGC ATCCTGGCCG TGTTGAAGTT CATGCTGGGG 
AAGGTTCTGA CCAGTAGAGC ACTCATAACA GATGGGTTTA ACTCCCTCGT GGGTGGCGTG 
ATGGGCTTCT CCATTCTTCT GAGCGCGGAA GTGTTCAAGC ATGACTCGGC GGTCTGGTAC 
CTGGACGGCA GCATAGGCGT TCTGATCGGC CTCACCATAT TTGCCTATGG GGTCAAACTC 
CTCATCGACA TGGTGCCGAG GGTGAGGCAG ACACGTCACT ACGAGATGTT TGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016860550.1
CDS	376..912
Translation	MRYSASAFGFAFDAILDVLSSAIVLWRYSNAAAVHSAHREYIACVILGVIFLLSSICIVVKAIHDLSTRLLPEVDDFLFSVSILSGILCSILAVLKFMLGKVLTSRALITDGFNSLVGGVMGFSILLSAEVFKHDSAVWYLDGSIGVLIGLTIFAYGVKLLIDMVPRVRQTRHYEMFE

Target ORF information:

RefSeq Version	XM_017005061.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 163 (TMEM163), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017005061.1

ORF Insert Sequence:

ATGAGGTACA GCGCCTCTGC TTTTGGGTTT GCATTTGATG CCATCCTGGA CGTCCTGTCA 
TCGGCGATTG TCCTGTGGCG TTACAGCAAC GCGGCCGCTG TGCACTCTGC CCATAGGGAG 
TACATAGCCT GTGTCATCTT GGGGGTGATA TTCCTTCTGT CATCCATATG TATAGTGGTC 
AAAGCCATCC ATGACCTCTC AACTAGGCTG CTCCCAGAAG TGGACGATTT CCTGTTCAGT 
GTCTCCATTT TAAGTGGGAT TCTTTGCAGC ATCCTGGCCG TGTTGAAGTT CATGCTGGGG 
AAGGTTCTGA CCAGTAGAGC ACTCATAACA GATGGGTTTA ACTCCCTCGT GGGTGGCGTG 
ATGGGCTTCT CCATTCTTCT GAGCGCGGAA GTGTTCAAGC ATGACTCGGC GGTCTGGTAC 
CTGGACGGCA GCATAGGCGT TCTGATCGGC CTCACCATAT TTGCCTATGG GGTCAAACTC 
CTCATCGACA TGGTGCCGAG GGTGAGGCAG ACACGTCACT ACGAGATGTT TGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM163 ( XM_011511950.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011510252.1 Homo sapiens transmembrane protein 163 (TMEM163), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu72951
Clone ID Related Accession (Same CDS sequence)	XM_017005061.1 , XM_011511950.2
Accession Version	XM_011511950.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	transmembrane protein 163 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011511950.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGTACA GCGCCTCTGC TTTTGGGTTT GCATTTGATG CCATCCTGGA CGTCCTGTCA 
TCGGCGATTG TCCTGTGGCG TTACAGCAAC GCGGCCGCTG TGCACTCTGC CCATAGGGAG 
TACATAGCCT GTGTCATCTT GGGGGTGATA TTCCTTCTGT CATCCATATG TATAGTGGTC 
AAAGCCATCC ATGACCTCTC AACTAGGCTG CTCCCAGAAG TGGACGATTT CCTGTTCAGT 
GTCTCCATTT TAAGTGGGAT TCTTTGCAGC ATCCTGGCCG TGTTGAAGTT CATGCTGGGG 
AAGGTTCTGA CCAGTAGAGC ACTCATAACA GATGGGTTTA ACTCCCTCGT GGGTGGCGTG 
ATGGGCTTCT CCATTCTTCT GAGCGCGGAA GTGTTCAAGC ATGACTCGGC GGTCTGGTAC 
CTGGACGGCA GCATAGGCGT TCTGATCGGC CTCACCATAT TTGCCTATGG GGTCAAACTC 
CTCATCGACA TGGTGCCGAG GGTGAGGCAG ACACGTCACT ACGAGATGTT TGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011510252.1
CDS	506..1042
Translation	MRYSASAFGFAFDAILDVLSSAIVLWRYSNAAAVHSAHREYIACVILGVIFLLSSICIVVKAIHDLSTRLLPEVDDFLFSVSILSGILCSILAVLKFMLGKVLTSRALITDGFNSLVGGVMGFSILLSAEVFKHDSAVWYLDGSIGVLIGLTIFAYGVKLLIDMVPRVRQTRHYEMFE

Target ORF information:

RefSeq Version	XM_011511950.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 163 (TMEM163), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011511950.2

ORF Insert Sequence:

ATGAGGTACA GCGCCTCTGC TTTTGGGTTT GCATTTGATG CCATCCTGGA CGTCCTGTCA 
TCGGCGATTG TCCTGTGGCG TTACAGCAAC GCGGCCGCTG TGCACTCTGC CCATAGGGAG 
TACATAGCCT GTGTCATCTT GGGGGTGATA TTCCTTCTGT CATCCATATG TATAGTGGTC 
AAAGCCATCC ATGACCTCTC AACTAGGCTG CTCCCAGAAG TGGACGATTT CCTGTTCAGT 
GTCTCCATTT TAAGTGGGAT TCTTTGCAGC ATCCTGGCCG TGTTGAAGTT CATGCTGGGG 
AAGGTTCTGA CCAGTAGAGC ACTCATAACA GATGGGTTTA ACTCCCTCGT GGGTGGCGTG 
ATGGGCTTCT CCATTCTTCT GAGCGCGGAA GTGTTCAAGC ATGACTCGGC GGTCTGGTAC 
CTGGACGGCA GCATAGGCGT TCTGATCGGC CTCACCATAT TTGCCTATGG GGTCAAACTC 
CTCATCGACA TGGTGCCGAG GGTGAGGCAG ACACGTCACT ACGAGATGTT TGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM163 ( NM_030923.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_112185.1 Homo sapiens transmembrane protein 163 (TMEM163), mRNA.

Price & Availability↑

CloneID	OHu13558
Clone ID Related Accession (Same CDS sequence)	NM_030923.4 , NM_030923.5
Accession Version	NM_030923.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	transmembrane protein 163
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AW131848.1, BC026170.2, CD705559.1, BM998960.1 and AI307369.1. On Nov 25, 2008 this sequence version replaced NM_030923.3. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.16199.1, BC026170.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCGG CCGCGGGCAT CCAGCGCCGC AGCTCCCAGG GGCCCACCGT CCCGCCGCCG 
CCCCGGGGCC ACGCGCCACC GGCTGCCGCC CCCGGCCCGG CCCCGCTGAG CTCCCCGGTG 
CGCGAGCCGC CCCAGCTGGA GGAGGAGCGG CAGGTGCGGA TCAGCGAGAG CGGCCAGTTC 
AGCGACGGGC TGGAGGACCG AGGCTTACTA GAAAGCAGCA CCCGCCTGAA ACCTCACGAA 
GCCCAGAACT ACAGGAAGAA GGCATTGTGG GTGTCCTGGT TCTCCATCAT TGTCACCCTG 
GCCCTCGCGG TGGCTGCCTT TACTGTCTCC GTTATGAGGT ACAGCGCCTC TGCTTTTGGG 
TTTGCATTTG ATGCCATCCT GGACGTCCTG TCATCGGCGA TTGTCCTGTG GCGTTACAGC 
AACGCGGCCG CTGTGCACTC TGCCCATAGG GAGTACATAG CCTGTGTCAT CTTGGGGGTG 
ATATTCCTTC TGTCATCCAT ATGTATAGTG GTCAAAGCCA TCCATGACCT CTCAACTAGG 
CTGCTCCCAG AAGTGGACGA TTTCCTGTTC AGTGTCTCCA TTTTAAGTGG GATTCTTTGC 
AGCATCCTGG CCGTGTTGAA GTTCATGCTG GGGAAGGTTC TGACCAGTAG AGCACTCATA 
ACAGATGGGT TTAACTCCCT CGTGGGTGGC GTGATGGGCT TCTCCATTCT TCTGAGCGCG 
GAAGTGTTCA AGCATGACTC GGCGGTCTGG TACCTGGACG GCAGCATAGG CGTTCTGATC 
GGCCTCACCA TATTTGCCTA TGGGGTCAAA CTCCTCATCG ACATGGTGCC GAGGGTGAGG 
CAGACACGTC ACTACGAGAT GTTTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112185.1
CDS	67..936
Translation	MEPAAGIQRRSSQGPTVPPPPRGHAPPAAAPGPAPLSSPVREPPQLEEERQVRISESGQFSDGLEDRGLLESSTRLKPHEAQNYRKKALWVSWFSIIVTLALAVAAFTVSVMRYSASAFGFAFDAILDVLSSAIVLWRYSNAAAVHSAHREYIACVILGVIFLLSSICIVVKAIHDLSTRLLPEVDDFLFSVSILSGILCSILAVLKFMLGKVLTSRALITDGFNSLVGGVMGFSILLSAEVFKHDSAVWYLDGSIGVLIGLTIFAYGVKLLIDMVPRVRQTRHYEMFE

Target ORF information:

RefSeq Version	NM_030923.4
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 163 (TMEM163), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030923.4

ORF Insert Sequence:

ATGGAGCCGG CCGCGGGCAT CCAGCGCCGC AGCTCCCAGG GGCCCACCGT CCCGCCGCCG 
CCCCGGGGCC ACGCGCCACC GGCTGCCGCC CCCGGCCCGG CCCCGCTGAG CTCCCCGGTG 
CGCGAGCCGC CCCAGCTGGA GGAGGAGCGG CAGGTGCGGA TCAGCGAGAG CGGCCAGTTC 
AGCGACGGGC TGGAGGACCG AGGCTTACTA GAAAGCAGCA CCCGCCTGAA ACCTCACGAA 
GCCCAGAACT ACAGGAAGAA GGCATTGTGG GTGTCCTGGT TCTCCATCAT TGTCACCCTG 
GCCCTCGCGG TGGCTGCCTT TACTGTCTCC GTTATGAGGT ACAGCGCCTC TGCTTTTGGG 
TTTGCATTTG ATGCCATCCT GGACGTCCTG TCATCGGCGA TTGTCCTGTG GCGTTACAGC 
AACGCGGCCG CTGTGCACTC TGCCCATAGG GAGTACATAG CCTGTGTCAT CTTGGGGGTG 
ATATTCCTTC TGTCATCCAT ATGTATAGTG GTCAAAGCCA TCCATGACCT CTCAACTAGG 
CTGCTCCCAG AAGTGGACGA TTTCCTGTTC AGTGTCTCCA TTTTAAGTGG GATTCTTTGC 
AGCATCCTGG CCGTGTTGAA GTTCATGCTG GGGAAGGTTC TGACCAGTAG AGCACTCATA 
ACAGATGGGT TTAACTCCCT CGTGGGTGGC GTGATGGGCT TCTCCATTCT TCTGAGCGCG 
GAAGTGTTCA AGCATGACTC GGCGGTCTGG TACCTGGACG GCAGCATAGG CGTTCTGATC 
GGCCTCACCA TATTTGCCTA TGGGGTCAAA CTCCTCATCG ACATGGTGCC GAGGGTGAGG 
CAGACACGTC ACTACGAGAT GTTTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM163 ( NM_030923.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_112185.1 Homo sapiens transmembrane protein 163 (TMEM163), mRNA.

Price & Availability↑

CloneID	OHu13558
Clone ID Related Accession (Same CDS sequence)	NM_030923.4 , NM_030923.5
Accession Version	NM_030923.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	transmembrane protein 163
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AW131848.1, BC026170.2, CD705559.1, BM998960.1 and AI307369.1. On Nov 22, 2018 this sequence version replaced NM_030923.4. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.159988.1, SRR1803616.16199.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000281924.6/ ENSP00000281924.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCCGG CCGCGGGCAT CCAGCGCCGC AGCTCCCAGG GGCCCACCGT CCCGCCGCCG 
CCCCGGGGCC ACGCGCCACC GGCTGCCGCC CCCGGCCCGG CCCCGCTGAG CTCCCCGGTG 
CGCGAGCCGC CCCAGCTGGA GGAGGAGCGG CAGGTGCGGA TCAGCGAGAG CGGCCAGTTC 
AGCGACGGGC TGGAGGACCG AGGCTTACTA GAAAGCAGCA CCCGCCTGAA ACCTCACGAA 
GCCCAGAACT ACAGGAAGAA GGCATTGTGG GTGTCCTGGT TCTCCATCAT TGTCACCCTG 
GCCCTCGCGG TGGCTGCCTT TACTGTCTCC GTTATGAGGT ACAGCGCCTC TGCTTTTGGG 
TTTGCATTTG ATGCCATCCT GGACGTCCTG TCATCGGCGA TTGTCCTGTG GCGTTACAGC 
AACGCGGCCG CTGTGCACTC TGCCCATAGG GAGTACATAG CCTGTGTCAT CTTGGGGGTG 
ATATTCCTTC TGTCATCCAT ATGTATAGTG GTCAAAGCCA TCCATGACCT CTCAACTAGG 
CTGCTCCCAG AAGTGGACGA TTTCCTGTTC AGTGTCTCCA TTTTAAGTGG GATTCTTTGC 
AGCATCCTGG CCGTGTTGAA GTTCATGCTG GGGAAGGTTC TGACCAGTAG AGCACTCATA 
ACAGATGGGT TTAACTCCCT CGTGGGTGGC GTGATGGGCT TCTCCATTCT TCTGAGCGCG 
GAAGTGTTCA AGCATGACTC GGCGGTCTGG TACCTGGACG GCAGCATAGG CGTTCTGATC 
GGCCTCACCA TATTTGCCTA TGGGGTCAAA CTCCTCATCG ACATGGTGCC GAGGGTGAGG 
CAGACACGTC ACTACGAGAT GTTTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112185.1
CDS	66..935
Translation	MEPAAGIQRRSSQGPTVPPPPRGHAPPAAAPGPAPLSSPVREPPQLEEERQVRISESGQFSDGLEDRGLLESSTRLKPHEAQNYRKKALWVSWFSIIVTLALAVAAFTVSVMRYSASAFGFAFDAILDVLSSAIVLWRYSNAAAVHSAHREYIACVILGVIFLLSSICIVVKAIHDLSTRLLPEVDDFLFSVSILSGILCSILAVLKFMLGKVLTSRALITDGFNSLVGGVMGFSILLSAEVFKHDSAVWYLDGSIGVLIGLTIFAYGVKLLIDMVPRVRQTRHYEMFE

Target ORF information:

RefSeq Version	NM_030923.5
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 163 (TMEM163), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030923.5

ORF Insert Sequence:

ATGGAGCCGG CCGCGGGCAT CCAGCGCCGC AGCTCCCAGG GGCCCACCGT CCCGCCGCCG 
CCCCGGGGCC ACGCGCCACC GGCTGCCGCC CCCGGCCCGG CCCCGCTGAG CTCCCCGGTG 
CGCGAGCCGC CCCAGCTGGA GGAGGAGCGG CAGGTGCGGA TCAGCGAGAG CGGCCAGTTC 
AGCGACGGGC TGGAGGACCG AGGCTTACTA GAAAGCAGCA CCCGCCTGAA ACCTCACGAA 
GCCCAGAACT ACAGGAAGAA GGCATTGTGG GTGTCCTGGT TCTCCATCAT TGTCACCCTG 
GCCCTCGCGG TGGCTGCCTT TACTGTCTCC GTTATGAGGT ACAGCGCCTC TGCTTTTGGG 
TTTGCATTTG ATGCCATCCT GGACGTCCTG TCATCGGCGA TTGTCCTGTG GCGTTACAGC 
AACGCGGCCG CTGTGCACTC TGCCCATAGG GAGTACATAG CCTGTGTCAT CTTGGGGGTG 
ATATTCCTTC TGTCATCCAT ATGTATAGTG GTCAAAGCCA TCCATGACCT CTCAACTAGG 
CTGCTCCCAG AAGTGGACGA TTTCCTGTTC AGTGTCTCCA TTTTAAGTGG GATTCTTTGC 
AGCATCCTGG CCGTGTTGAA GTTCATGCTG GGGAAGGTTC TGACCAGTAG AGCACTCATA 
ACAGATGGGT TTAACTCCCT CGTGGGTGGC GTGATGGGCT TCTCCATTCT TCTGAGCGCG 
GAAGTGTTCA AGCATGACTC GGCGGTCTGG TACCTGGACG GCAGCATAGG CGTTCTGATC 
GGCCTCACCA TATTTGCCTA TGGGGTCAAA CTCCTCATCG ACATGGTGCC GAGGGTGAGG 
CAGACACGTC ACTACGAGAT GTTTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM163 ( XM_017005060.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016860549.1 Homo sapiens transmembrane protein 163 (TMEM163), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu89972
Clone ID Related Accession (Same CDS sequence)	XM_017005060.1 , XM_017005060.2
Accession Version	XM_017005060.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	transmembrane protein 163 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCGG CCGCGGGCAT CCAGCGCCGC AGCTCCCAGG GGCCCACCGT CCCGCCGCCG 
CCCCGGGGCC ACGCGCCACC GGCTGCCGCC CCCGGCCCGG CCCCGCTGAG CTCCCCGGTG 
CGCGAGCCGC CCCAGCTGGA GGAGGAGCGG CAGGTGCGGA TCAGCGAGAG CGGCCAGTTC 
AGCGACGGGC TGGAGGACCG AGGCTTACTA GAAAGCAGCA CCCGCCTGAA ACCTCACGAA 
GCCCAGAACT ACAGGAAGAA GGCATTGTGG GTGTCCTGGT TCTCCATCAT TGTCACCCTG 
GCCCTCGCGG TGGCTGCCTT TACTGTCTCC GTTATGAGGT ACAGCGCCTC TGCTTTTGGG 
TTTGCATTTG ATGCCATCCT GGACGTCCTG TCATCGGCGA TTGTCCTGTG GCGTTACAGC 
AACGCGGCCG CTGTGCACTC TGCCCATAGG GAGTACATAG CCTGTGTCAT CTTGGGGGTG 
ATATTCCTTC TGTCATCCAT ATGTATAGTG GTCAAAGCCA TCCATGACCT CTCAACTAGG 
CTGCTCCCAG AAGTGGTGAA TGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016860549.1
CDS	154..720
Translation	MEPAAGIQRRSSQGPTVPPPPRGHAPPAAAPGPAPLSSPVREPPQLEEERQVRISESGQFSDGLEDRGLLESSTRLKPHEAQNYRKKALWVSWFSIIVTLALAVAAFTVSVMRYSASAFGFAFDAILDVLSSAIVLWRYSNAAAVHSAHREYIACVILGVIFLLSSICIVVKAIHDLSTRLLPEVVNG

Target ORF information:

RefSeq Version	XM_017005060.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 163 (TMEM163), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017005060.1

ORF Insert Sequence:

ATGGAGCCGG CCGCGGGCAT CCAGCGCCGC AGCTCCCAGG GGCCCACCGT CCCGCCGCCG 
CCCCGGGGCC ACGCGCCACC GGCTGCCGCC CCCGGCCCGG CCCCGCTGAG CTCCCCGGTG 
CGCGAGCCGC CCCAGCTGGA GGAGGAGCGG CAGGTGCGGA TCAGCGAGAG CGGCCAGTTC 
AGCGACGGGC TGGAGGACCG AGGCTTACTA GAAAGCAGCA CCCGCCTGAA ACCTCACGAA 
GCCCAGAACT ACAGGAAGAA GGCATTGTGG GTGTCCTGGT TCTCCATCAT TGTCACCCTG 
GCCCTCGCGG TGGCTGCCTT TACTGTCTCC GTTATGAGGT ACAGCGCCTC TGCTTTTGGG 
TTTGCATTTG ATGCCATCCT GGACGTCCTG TCATCGGCGA TTGTCCTGTG GCGTTACAGC 
AACGCGGCCG CTGTGCACTC TGCCCATAGG GAGTACATAG CCTGTGTCAT CTTGGGGGTG 
ATATTCCTTC TGTCATCCAT ATGTATAGTG GTCAAAGCCA TCCATGACCT CTCAACTAGG 
CTGCTCCCAG AAGTGGTGAA TGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM163 ( XM_017005060.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016860549.1 Homo sapiens transmembrane protein 163 (TMEM163), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu89972
Clone ID Related Accession (Same CDS sequence)	XM_017005060.1 , XM_017005060.2
Accession Version	XM_017005060.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	transmembrane protein 163 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017005060.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCGG CCGCGGGCAT CCAGCGCCGC AGCTCCCAGG GGCCCACCGT CCCGCCGCCG 
CCCCGGGGCC ACGCGCCACC GGCTGCCGCC CCCGGCCCGG CCCCGCTGAG CTCCCCGGTG 
CGCGAGCCGC CCCAGCTGGA GGAGGAGCGG CAGGTGCGGA TCAGCGAGAG CGGCCAGTTC 
AGCGACGGGC TGGAGGACCG AGGCTTACTA GAAAGCAGCA CCCGCCTGAA ACCTCACGAA 
GCCCAGAACT ACAGGAAGAA GGCATTGTGG GTGTCCTGGT TCTCCATCAT TGTCACCCTG 
GCCCTCGCGG TGGCTGCCTT TACTGTCTCC GTTATGAGGT ACAGCGCCTC TGCTTTTGGG 
TTTGCATTTG ATGCCATCCT GGACGTCCTG TCATCGGCGA TTGTCCTGTG GCGTTACAGC 
AACGCGGCCG CTGTGCACTC TGCCCATAGG GAGTACATAG CCTGTGTCAT CTTGGGGGTG 
ATATTCCTTC TGTCATCCAT ATGTATAGTG GTCAAAGCCA TCCATGACCT CTCAACTAGG 
CTGCTCCCAG AAGTGGTGAA TGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016860549.1
CDS	154..720
Translation	MEPAAGIQRRSSQGPTVPPPPRGHAPPAAAPGPAPLSSPVREPPQLEEERQVRISESGQFSDGLEDRGLLESSTRLKPHEAQNYRKKALWVSWFSIIVTLALAVAAFTVSVMRYSASAFGFAFDAILDVLSSAIVLWRYSNAAAVHSAHREYIACVILGVIFLLSSICIVVKAIHDLSTRLLPEVVNG

Target ORF information:

RefSeq Version	XM_017005060.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 163 (TMEM163), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017005060.2

ORF Insert Sequence:

ATGGAGCCGG CCGCGGGCAT CCAGCGCCGC AGCTCCCAGG GGCCCACCGT CCCGCCGCCG 
CCCCGGGGCC ACGCGCCACC GGCTGCCGCC CCCGGCCCGG CCCCGCTGAG CTCCCCGGTG 
CGCGAGCCGC CCCAGCTGGA GGAGGAGCGG CAGGTGCGGA TCAGCGAGAG CGGCCAGTTC 
AGCGACGGGC TGGAGGACCG AGGCTTACTA GAAAGCAGCA CCCGCCTGAA ACCTCACGAA 
GCCCAGAACT ACAGGAAGAA GGCATTGTGG GTGTCCTGGT TCTCCATCAT TGTCACCCTG 
GCCCTCGCGG TGGCTGCCTT TACTGTCTCC GTTATGAGGT ACAGCGCCTC TGCTTTTGGG 
TTTGCATTTG ATGCCATCCT GGACGTCCTG TCATCGGCGA TTGTCCTGTG GCGTTACAGC 
AACGCGGCCG CTGTGCACTC TGCCCATAGG GAGTACATAG CCTGTGTCAT CTTGGGGGTG 
ATATTCCTTC TGTCATCCAT ATGTATAGTG GTCAAAGCCA TCCATGACCT CTCAACTAGG 
CTGCTCCCAG AAGTGGTGAA TGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM163 ( XM_017005062.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016860551.1 Homo sapiens transmembrane protein 163 (TMEM163), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu89973
Clone ID Related Accession (Same CDS sequence)	XM_017005062.1
Accession Version	XM_017005062.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	transmembrane protein 163 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCGG CCGCGGGCAT CCAGCGCCGC AGCTCCCAGG GGCCCACCGT CCCGCCGCCG 
CCCCGGGGCC ACGCGCCACC GGCTGCCGCC CCCGGCCCGG CCCCGCTGAG CTCCCCGGTG 
CGCGAGCCGC CCCAGCTGGA GGAGGAGCGG CAGGTGCGGA TCAGCGAGAG CGGCCAGTTC 
AGCGACGGGC TGGAGGACCG AGGCTTACTA GAAAGCAGCA CCCGCCTGAA ACCTCACGAA 
GCCCAGAACT ACAGGAAGAA GGCATTGTGG GTGTCCTGGT TCTCCATCAT TGTCACCCTG 
GCCCTCGCGG TGGCTGCCTT TAATGTCAAT AACAGCCCAC ACTGGTGCTT CCTGCCGTCT 
CGTGACTGGG CCAGGAGTTC TGCTGCTGTT GCACCAATCC CACTGCAGCC CTGGCTGACG 
AGGCCTGGAT TCTGTCAACA GCTCTGTCAT GGGTTGAATT GTGTCCCTCC AAAATTCTCA 
TGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016860551.1
CDS	132..617
Translation	MEPAAGIQRRSSQGPTVPPPPRGHAPPAAAPGPAPLSSPVREPPQLEEERQVRISESGQFSDGLEDRGLLESSTRLKPHEAQNYRKKALWVSWFSIIVTLALAVAAFNVNNSPHWCFLPSRDWARSSAAVAPIPLQPWLTRPGFCQQLCHGLNCVPPKFSC

Target ORF information:

RefSeq Version	XM_017005062.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 163 (TMEM163), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017005062.1

ORF Insert Sequence:

ATGGAGCCGG CCGCGGGCAT CCAGCGCCGC AGCTCCCAGG GGCCCACCGT CCCGCCGCCG 
CCCCGGGGCC ACGCGCCACC GGCTGCCGCC CCCGGCCCGG CCCCGCTGAG CTCCCCGGTG 
CGCGAGCCGC CCCAGCTGGA GGAGGAGCGG CAGGTGCGGA TCAGCGAGAG CGGCCAGTTC 
AGCGACGGGC TGGAGGACCG AGGCTTACTA GAAAGCAGCA CCCGCCTGAA ACCTCACGAA 
GCCCAGAACT ACAGGAAGAA GGCATTGTGG GTGTCCTGGT TCTCCATCAT TGTCACCCTG 
GCCCTCGCGG TGGCTGCCTT TAATGTCAAT AACAGCCCAC ACTGGTGCTT CCTGCCGTCT 
CGTGACTGGG CCAGGAGTTC TGCTGCTGTT GCACCAATCC CACTGCAGCC CTGGCTGACG 
AGGCCTGGAT TCTGTCAACA GCTCTGTCAT GGGTTGAATT GTGTCCCTCC AAAATTCTCA 
TGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetics of the human face: Identification of large-effect single gene variants.
Proceedings of the National Academy of Sciences of the United States of America(2018 Jan)
Crouch DJM,Winney B,Koppen WP,Christmas WJ,Hutnik K,Day T,Meena D,Boumertit A,Hysi P,Nessa A,Spector TD,Kittler J,Bodmer WF

Replication of newly identified type 2 diabetes susceptible loci in Northwest Indian population.
Diabetes research and clinical practice126160-163(2017 Apr)
Sharma V,Sharma I,Sethi I,Mahajan A,Singh G,Angural A,Bhanwer AJS,Dhar MK,Singh V,Rai E,Sharma S

The mucolipin-1 (TRPML1) ion channel, transmembrane-163 (TMEM163) protein, and lysosomal zinc handling.
Frontiers in bioscience (Landmark edition)221330-1343(2017 Mar)
Cuajungco MP,Kiselyov K

Cellular zinc levels are modulated by TRPML1-TMEM163 interaction.
Traffic (Copenhagen, Denmark)15(11)1247-65(2014 Nov)
Cuajungco MP,Basilio LC,Silva J,Hart T,Tringali J,Chen CC,Biel M,Grimm C

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TMEM163 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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