UBL4A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Gene Symbol	UBL4A
Entrez Gene ID	8266
Full Name	ubiquitin like 4A
Synonyms	DX254E,DXS254E,G6PD,GDX,GET5,MDY2,TMA24,UBL4
General protein information	Preferred Names ubiquitin like 4A Names ubiquitin-like protein 4A ubiquitin-like 4 ubiquitin-like protein GDX
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Disorder MIM:	312070

mRNA and Protein(s)

mRNA Protein Name

NM_014235.5 NP_055050.1 ubiquitin-like protein 4A

NM_014235.4 NP_055050.1 ubiquitin-like protein 4A
Pathways from BioSystems

mRNA	Protein	Name
NM_014235.5	NP_055050.1	ubiquitin-like protein 4A
NM_014235.4	NP_055050.1	ubiquitin-like protein 4A

Homologies

	UBL4A	XP_001094573.1
Mus musculus (house mouse)	Slc10a3-ubl4	NP_001265200.1
Bos taurus (cattle)	UBL4A	NP_001029386.1
Mus musculus (house mouse)	Ubl4	NP_663380.1
Xenopus tropicalis (tropical clawed frog)	ubl4a	NP_001096510.1
Homo sapiens (human)	UBL4A	NP_055050.1
Danio rerio (zebrafish)	zgc:56596	NP_956594.1
Pan troglodytes (chimpanzee)	UBL4A	NP_001229350.1
Canis lupus familiaris (dog)	UBL4A	XP_855388.3
Rattus norvegicus (Norway rat)	Ubl4a	NP_001099816.1

Gene Ontology
Bibliography

Related articles in PubMed

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis.
Kuwabara N, Minami R, Yokota N, Matsumoto H, Senda T, Kawahara H, Kato R
The Journal of biological chemistry290(15)9387-98(2015 Apr)

Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.
Mock JY, Chartron JW, Zaslaver M, Xu Y, Ye Y, Clemons WM Jr
Proceedings of the National Academy of Sciences of the United States of America112(1)106-11(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Both TRC35 and Ubl4A have distinct C-terminal binding sites on Bag6 defining a minimal Bag6 complex.
Title: Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.

Data show that molecular chaperone BAG6_ubiquitin-like domain (UBL) and ubiquitin-like 4A UBL4A_UBL compete for the same binding site on N-terminal dimerisation domain of SGTA protein (SGTA_NT).
Title: Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A.

The authors identify USP13 as a gp78-associated deubiquitinase that eliminates ubiquitin conjugates from Ubl4A to maintain the functionality of Bag6.
Title: USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.

Data indicate that BCL2-associated athanogene 6 (BAG6) appears to be the central component for the process, as depletion of BAG6 leads to the loss of both UBL4A and GET4 proteins and resistance to cell killing by DNA-damaging agents.
Title: Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death.

Data indicate that the Bag6-Ubl4A-Trc35 complex is localized to the endoplasmic reticulum (ER) membrane to regulate ER-associated degradation (ERAD).
Title: A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.

The following UBL4A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UBL4A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00604	NM_014235.5 Latest version!	Homo sapiens ubiquitin like 4A (UBL4A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu00604	NM_014235.4	Homo sapiens ubiquitin like 4A (UBL4A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UBL4A ( NM_014235.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055050.1 Homo sapiens ubiquitin like 4A (UBL4A), mRNA.

Price & Availability↑

CloneID	OHu00604
Clone ID Related Accession (Same CDS sequence)	NM_014235.5 , NM_014235.4
Accession Version	NM_014235.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	ubiquitin-like protein 4A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA012854.1, BC043346.2, DR003955.1, BM711450.1 and CK826435.1. On Nov 22, 2018 this sequence version replaced NM_014235.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.947839.1, SRR3476690.929292.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155550, SAMEA2163105 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000369660.9/ ENSP00000358674.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGCTGA CGGTGAAGGC GCTGCAGGGC CGCGAGTGCA GCCTGCAGGT GCCAGAGGAC 
GAGCTGGTGT CCACGCTGAA GCAGCTGGTC TCCGAGAAGC TGAACGTCCC AGTGCGCCAG 
CAGCGGCTGC TGTTCAAGGG CAAGGCCCTG GCAGATGGGA AACGACTCTC GGATTATAGC 
ATCGGGCCCA ACTCCAAGCT CAACCTAGTG GTCAAACCCC TGGAGAAGGT GCTACTAGAA 
GAAGGCGAGG CCCAGAGGCT GGCCGACTCC CCACCCCCGC AGGTCTGGCA GCTGATCTCC 
AAAGTCTTGG CCCGCCACTT CAGTGCGGCA GATGCCAGCA GGGTCCTGGA ACAGCTACAG 
AGGGATTACG AGAGGTCCCT GAGTCGCCTG ACGCTGGACG ACATCGAACG GTTGGCCAGC 
CGCTTCCTGC ACCCTGAAGT GACTGAGACA ATGGAGAAGG GCTTCTCCAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055050.1
CDS	32..505
Translation	MQLTVKALQGRECSLQVPEDELVSTLKQLVSEKLNVPVRQQRLLFKGKALADGKRLSDYSIGPNSKLNLVVKPLEKVLLEEGEAQRLADSPPPQVWQLISKVLARHFSAADASRVLEQLQRDYERSLSRLTLDDIERLASRFLHPEVTETMEKGFSK

Target ORF information:

RefSeq Version	NM_014235.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin like 4A (UBL4A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014235.5

ORF Insert Sequence:

ATGCAGCTGA CGGTGAAGGC GCTGCAGGGC CGCGAGTGCA GCCTGCAGGT GCCAGAGGAC 
GAGCTGGTGT CCACGCTGAA GCAGCTGGTC TCCGAGAAGC TGAACGTCCC AGTGCGCCAG 
CAGCGGCTGC TGTTCAAGGG CAAGGCCCTG GCAGATGGGA AACGACTCTC GGATTATAGC 
ATCGGGCCCA ACTCCAAGCT CAACCTAGTG GTCAAACCCC TGGAGAAGGT GCTACTAGAA 
GAAGGCGAGG CCCAGAGGCT GGCCGACTCC CCACCCCCGC AGGTCTGGCA GCTGATCTCC 
AAAGTCTTGG CCCGCCACTT CAGTGCGGCA GATGCCAGCA GGGTCCTGGA ACAGCTACAG 
AGGGATTACG AGAGGTCCCT GAGTCGCCTG ACGCTGGACG ACATCGAACG GTTGGCCAGC 
CGCTTCCTGC ACCCTGAAGT GACTGAGACA ATGGAGAAGG GCTTCTCCAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UBL4A ( NM_014235.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055050.1 Homo sapiens ubiquitin like 4A (UBL4A), mRNA.

Price & Availability↑

CloneID	OHu00604
Clone ID Related Accession (Same CDS sequence)	NM_014235.5 , NM_014235.4
Accession Version	NM_014235.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	ubiquitin-like protein 4A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA012854.1, BC043346.2, DR003955.1, BM711450.1 and CK826435.1. On Sep 11, 2013 this sequence version replaced NM_014235.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK000405.1, SRR1660803.252682.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155550, SAMEA2163105 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGCTGA CGGTGAAGGC GCTGCAGGGC CGCGAGTGCA GCCTGCAGGT GCCAGAGGAC 
GAGCTGGTGT CCACGCTGAA GCAGCTGGTC TCCGAGAAGC TGAACGTCCC AGTGCGCCAG 
CAGCGGCTGC TGTTCAAGGG CAAGGCCCTG GCAGATGGGA AACGACTCTC GGATTATAGC 
ATCGGGCCCA ACTCCAAGCT CAACCTAGTG GTCAAACCCC TGGAGAAGGT GCTACTAGAA 
GAAGGCGAGG CCCAGAGGCT GGCCGACTCC CCACCCCCGC AGGTCTGGCA GCTGATCTCC 
AAAGTCTTGG CCCGCCACTT CAGTGCGGCA GATGCCAGCA GGGTCCTGGA ACAGCTACAG 
AGGGATTACG AGAGGTCCCT GAGTCGCCTG ACGCTGGACG ACATCGAACG GTTGGCCAGC 
CGCTTCCTGC ACCCTGAAGT GACTGAGACA ATGGAGAAGG GCTTCTCCAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055050.1
CDS	87..560
Translation	MQLTVKALQGRECSLQVPEDELVSTLKQLVSEKLNVPVRQQRLLFKGKALADGKRLSDYSIGPNSKLNLVVKPLEKVLLEEGEAQRLADSPPPQVWQLISKVLARHFSAADASRVLEQLQRDYERSLSRLTLDDIERLASRFLHPEVTETMEKGFSK

Target ORF information:

RefSeq Version	NM_014235.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin like 4A (UBL4A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014235.4

ORF Insert Sequence:

ATGCAGCTGA CGGTGAAGGC GCTGCAGGGC CGCGAGTGCA GCCTGCAGGT GCCAGAGGAC 
GAGCTGGTGT CCACGCTGAA GCAGCTGGTC TCCGAGAAGC TGAACGTCCC AGTGCGCCAG 
CAGCGGCTGC TGTTCAAGGG CAAGGCCCTG GCAGATGGGA AACGACTCTC GGATTATAGC 
ATCGGGCCCA ACTCCAAGCT CAACCTAGTG GTCAAACCCC TGGAGAAGGT GCTACTAGAA 
GAAGGCGAGG CCCAGAGGCT GGCCGACTCC CCACCCCCGC AGGTCTGGCA GCTGATCTCC 
AAAGTCTTGG CCCGCCACTT CAGTGCGGCA GATGCCAGCA GGGTCCTGGA ACAGCTACAG 
AGGGATTACG AGAGGTCCCT GAGTCGCCTG ACGCTGGACG ACATCGAACG GTTGGCCAGC 
CGCTTCCTGC ACCCTGAAGT GACTGAGACA ATGGAGAAGG GCTTCTCCAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis.
The Journal of biological chemistry290(15)9387-98(2015 Apr)
Kuwabara N,Minami R,Yokota N,Matsumoto H,Senda T,Kawahara H,Kato R

Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.
Proceedings of the National Academy of Sciences of the United States of America112(1)106-11(2015 Jan)
Mock JY,Chartron JW,Zaslaver M,Xu Y,Ye Y,Clemons WM Jr

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UBL4A cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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