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HIST1H2BG cDNA ORF clone, Homo sapiens (human)

Gene Symbol HIST1H2BG
Entrez Gene ID 8339
Full Name histone cluster 1, H2bg
Synonyms H2B.1A, H2B/a, H2BFA, dJ221C16.8
General protein information
Preferred Names
histone H2B type 1-C/E/F/G/I
Names
histone H2B type 1-C/E/F/G/I
histone H2B.a
histone 1, H2bg
histone H2B.1 A
H2B histone family, member A
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p22.2

Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]. lac of sum
Disorder MIM:

602798


mRNA and Protein(s)

mRNA Protein Name
NM_003518 NP_003509 histone H2B type 1-C/E/F/G/I



Homo sapiens (human) HIST1H2BG NP_003509.1
Pan troglodytes (chimpanzee) LOC100610052 XP_003311104.1
Macaca mulatta (Rhesus monkey) LOC696996 XP_001086637.2
Macaca mulatta (Rhesus monkey) LOC696506 XP_001086167.1
Macaca mulatta (Rhesus monkey) LOC696808 XP_002803690.1
Macaca mulatta (Rhesus monkey) LOC697857 XP_001087459.1
Macaca mulatta (Rhesus monkey) LOC697469 XP_001087112.1
Canis lupus familiaris (dog) LOC611482 XP_854244.1
Bos taurus (cattle) LOC787465 XP_005223854.1
Mus musculus (house mouse) Hist1h2bf NP_835502.1
Rattus norvegicus (Norway rat) Hist1h2bf XP_225384.1

The following HIST1H2BG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIST1H2BG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu30077
NM_003518 Homo sapiens histone cluster 1, H2bg (HIST1H2BG), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu30077
Clone ID Related Accession (Same CDS sequence) NM_003518
Accession Version NM_003518.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 381bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 18-AUG-2015
Organism Homo sapiens (human)
Product histone H2B type 1-C/E/F/G/I
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M60750.1. On Jun 21, 2002 this sequence version replaced gi:19923172. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12860195 replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGCCTGAAC CAGCTAAGTC AGCTCCTGCT CCGAAGAAGG GTTCCAAGAA GGCTGTGACC 
AAGGCGCAGA AGAAGGATGG CAAGAAGCGC AAGCGCAGTC GTAAGGAGAG CTACTCCGTG
TATGTGTACA AGGTGCTAAA ACAGGTTCAC CCCGATACTG GCATCTCATC CAAGGCCATG
GGCATCATGA ATTCCTTCGT TAACGACATC TTCGAACGCA TCGCAGGCGA GGCTTCCCGT
CTGGCCCACT ACAACAAGCG CTCGACCATT ACCTCCAGGG AGATCCAGAC CGCCGTGCGT
CTGCTGCTTC CCGGAGAGCT GGCCAAGCAC GCAGTGTCCG AAGGTACCAA GGCTGTCACC
AAGTATACAA GCTCCAAGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003509.1
CDS2..382
Misc Feature(1)5..7(+)
Misc Feature(2)17..19(+)
Misc Feature(3)17..19(+)
Misc Feature(4)35..37(+)
Misc Feature(5)35..37(+)
Misc Feature(6)38..40(+)
Misc Feature(7)38..40(+)
Misc Feature(8)44..46(+)
Misc Feature(9)47..49(+)
Misc Feature(10)47..49(+)
Misc Feature(11)50..52(+)
Misc Feature(12)50..52(+)
Misc Feature(13)62..64(+)
Misc Feature(14)62..64(+)
Misc Feature(15)71..73(+)
Misc Feature(16)71..73(+)
Misc Feature(17)83..373(+)
Misc Feature(18)104..106(+)
Misc Feature(19)110..112(+)
Misc Feature(20)140..142(+)
Misc Feature(21)173..175(+)
Misc Feature(22)239..241(+)
Misc Feature(23)257..259(+)
Misc Feature(24)257..259(+)
Misc Feature(25)260..262(+)
Misc Feature(26)278..280(+)
Misc Feature(27)326..328(+)
Misc Feature(28)347..349(+)
Misc Feature(29)350..352(+)
Exon (1)1..445
Gene:HIST1H2BG
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_003518
Organism Homo sapiens (human)
Definition Homo sapiens histone cluster 1, H2bg (HIST1H2BG), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003518

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGCCTGAAC CAGCTAAGTC AGCTCCTGCT CCGAAGAAGG GTTCCAAGAA GGCTGTGACC 
AAGGCGCAGA AGAAGGATGG CAAGAAGCGC AAGCGCAGTC GTAAGGAGAG CTACTCCGTG
TATGTGTACA AGGTGCTAAA ACAGGTTCAC CCCGATACTG GCATCTCATC CAAGGCCATG
GGCATCATGA ATTCCTTCGT TAACGACATC TTCGAACGCA TCGCAGGCGA GGCTTCCCGT
CTGGCCCACT ACAACAAGCG CTCGACCATT ACCTCCAGGG AGATCCAGAC CGCCGTGCGT
CTGCTGCTTC CCGGAGAGCT GGCCAAGCAC GCAGTGTCCG AAGGTACCAA GGCTGTCACC
AAGTATACAA GCTCCAAGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

A proteome-scale map of the human interactome network
Cell 159 (5), 1212-1226 (2014)
Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabasi AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP and Vidal M.


book

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
J Proteomics 82, 193-229 (2013)
Prunotto M, Farina A, Lane L, Pernin A, Schifferli J, Hochstrasser DF, Lescuyer P and Moll S.


book

Proteomic characterization of the human sperm nucleus
Proteomics 11 (13), 2714-2726 (2011)
de Mateo S, Castillo J, Estanyol JM, Ballesca JL and Oliva R.


book

Glucose metabolism induces mono-ubiquitination of histone H2B in mammalian cells
Biochem. Biophys. Res. Commun. 404 (1), 428-433 (2011)
Gao Z and Xu CW.


book

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
Immunol. Cell Biol. 88 (8), 851-856 (2010)
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and Stoorvogel W.


book

The human and mouse replication-dependent histone genes
Genomics 80 (5), 487-498 (2002)
Marzluff WF, Gongidi P, Woods KR, Jin J and Maltais LJ.


book

Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay
Biochim. Biophys. Acta 1296 (2), 219-227 (1996)
Diaz-Jullien C, Perez-Estevez A, Covelo G and Freire M.


book

Biochemical and antibacterial analysis of human wound and blister fluid
Eur. J. Biochem. 237 (1), 86-92 (1996)
Frohm M, Gunne H, Bergman AC, Agerberth B, Bergman T, Boman A, Liden S, Jornvall H and Boman HG.


book

Isolation and characterization of two human H1 histone genes within clusters of core histone genes
Genomics 10 (4), 940-948 (1991)
Albig W, Kardalinou E, Drabent B, Zimmer A and Doenecke D.


book

Human spleen histone H2B. Isolation and amino acid sequence
J. Biochem. 85 (2), 615-624 (1979)
Ohe,Y., Hayashi,H. and Iwai,K.


 
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